calfactant 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4884	183325-78-2

Description:

Molecule

Description

Synonyms:

calfactant
infasurf

Infasurf is tradename; a lung surfactant extract from new born calves containing 35 mg/mL phospholipid & 2% surfactant-associated proteins B & C (wt/wt)

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 1, 1998	FDA	ONY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Endotracheal intubation complication	109.09	84.85	10	5	437	63488570

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Endotracheal intubation complication	93.53	77.42	9	5	380	34956537

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA MoA	N0000000079	Surfactant Activity
FDA PE	N0000008294	Alveolar Surface Tension Reduction
MeSH PA	D011663	Pulmonary Surfactants
MeSH PA	D019141	Respiratory System Agents
FDA EPC	N0000175778	Surfactant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Respiratory distress syndrome in the newborn	indication	46775006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
Q4K217VGA9	UNII
D03317	KEGG_DRUG
4021124	VUID
N0000148578	NUI
4021124	VANDF
C0763530	UMLSCUI
CHEMBL1201447	ChEMBL_ID
DB06415	DRUGBANK_ID
C117342	MESH_SUPPLEMENTAL_RECORD_UI
232538	RXNORM
31288	MMSL
8294	MMSL
d04330	MMSL
007864	NDDF
108641008	SNOMEDCT_US
409376009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
INFASURF	HUMAN PRESCRIPTION DRUG LABEL	1	61938-456	SUSPENSION	35.70 mg	ENDOTRACHEAL	BLA	13 sections