calfactant Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4884 183325-78-2

Description:

MoleculeDescription

Synonyms:

  • calfactant
  • infasurf
Infasurf is tradename; a lung surfactant extract from new born calves containing 35 mg/mL phospholipid & 2% surfactant-associated proteins B & C (wt/wt)
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 1, 1998 FDA ONY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Endotracheal intubation complication 106.38 84.02 10 5 421 46685626

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Endotracheal intubation complication 82.36 72.02 8 5 335 29952130

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000000079 Surfactant Activity
FDA PE N0000008294 Alveolar Surface Tension Reduction
FDA EPC N0000175778 Surfactant
MeSH PA D011663 Pulmonary Surfactants
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Respiratory distress syndrome in the newborn indication 46775006

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03317 KEGG_DRUG
4021124 VUID
N0000148578 NUI
4021124 VANDF
C0763530 UMLSCUI
CHEMBL1201447 ChEMBL_ID
DB06415 DRUGBANK_ID
C117342 MESH_SUPPLEMENTAL_RECORD_UI
Q4K217VGA9 UNII
232538 RXNORM
31288 MMSL
8294 MMSL
d04330 MMSL
007864 NDDF
108641008 SNOMEDCT_US
409376009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
INFASURF HUMAN PRESCRIPTION DRUG LABEL 1 61938-456 SUSPENSION 35.70 mg ENDOTRACHEAL BLA 13 sections