ataluren 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4872 | 775304-57-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A nonsense mutation in DNA results in a premature stop codon within an mRNA. This premature stop codon in the mRNA causes disease by terminating translation before a full-length protein is generated. Ataluren enables ribosomal readthrough of mRNA containing such a premature stop codon, resulting in production of a full-length protein.
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Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 2.80 | g | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 31, 2014 | EMA | PTC Therapeutics International Limited |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M09AX03 | MUSCULO-SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM Other drugs for disorders of the musculo-skeletal system |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Duchenne muscular dystrophy | indication | 76670001 | DOID:11723 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.43 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Flavin reductase (NADPH) | Enzyme | Kd | 6.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| K16AME9I3V | UNII |
| D09323 | KEGG_DRUG |
| C2930764 | UMLSCUI |
| CHEBI:94805 | CHEBI |
| JBF | PDB_CHEM_ID |
| CHEMBL256997 | ChEMBL_ID |
| 11219835 | PUBCHEM_CID |
| DB05016 | DRUGBANK_ID |
| 8956 | INN_ID |
| C515878 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7341 | IUPHAR_LIGAND_ID |
| 015935 | NDDF |
| 1263915001 | SNOMEDCT_US |
| 718843009 | SNOMEDCT_US |
Pharmaceutical products:
None