calcium polystyrene sulfonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4871 37286-92-3

Description:

MoleculeDescription

Synonyms:

  • calcium polystyrene sulfonate
  • calcium polystyrene sulphonate
  • calcium polystyrenesulfonate
  • kalimate
  • Molecular weight:
  • Formula: (C16H14CaO6S2)n
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
45 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 82.53 34.08 38 1358 109458 90517593
Renal impairment 77.61 34.08 36 1360 105385 90521666
Hyperkalaemia 63.21 34.08 27 1369 64937 90562114
Shunt occlusion 44.10 34.08 8 1388 767 90626284
Hepatic function abnormal 37.72 34.08 17 1379 46271 90580780
Anaemia 35.94 34.08 35 1361 352767 90274284

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 110.67 25.45 64 2339 80394 42538538
Crystal deposit intestine 77.51 25.45 12 2391 111 42618821
Renal impairment 54.66 25.45 47 2356 110181 42508751
Interstitial lung disease 33.93 25.45 31 2372 78431 42540501
Shunt stenosis 33.72 25.45 8 2395 769 42618163
Cardiac failure 29.30 25.45 33 2370 106823 42512109
Hepatic function abnormal 27.56 25.45 23 2380 51544 42567388

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 167.12 28.04 87 3996 135709 110449507
Renal impairment 125.46 28.04 81 4002 188364 110396852
Cardiac failure 94.70 28.04 68 4015 187558 110397658
Crystal deposit intestine 80.09 28.04 13 4070 261 110584955
Shunt stenosis 64.34 28.04 14 4069 1402 110583814
Hepatic function abnormal 58.34 28.04 38 4045 89257 110495959
Interstitial lung disease 51.50 28.04 42 4041 139292 110445924
Acute kidney injury 47.06 28.04 84 3999 635346 109949870
Anaemia 46.64 28.04 77 4006 547009 110038207
Chronic kidney disease 41.52 28.04 29 4054 76262 110508954
Shunt occlusion 40.57 28.04 10 4073 1727 110583489
Cerebral infarction 36.16 28.04 23 4060 51815 110533401
Blood creatinine increased 31.11 28.04 36 4047 182853 110402363
Azotaemia 30.06 28.04 12 4071 10073 110575143

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AE01 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Drugs for treatment of hyperkalemia and hyperphosphatemia
MeSH PA D002411 Cation Exchange Resins
MeSH PA D002614 Chelating Agents
MeSH PA D007475 Ion Exchange Resins
MeSH PA D064449 Sequestering Agents

Related Drugs by ATC class:

V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia 10 drugs
calcium acetatecalcium acetate and magnesium carbonatecolestilanferric citratelanthanum carbonatepatiromer calciumsevelamersodium polystyrene sulfonatesodium zirconium cyclosilicatesucroferric oxyhydroxide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperkalemia indication 14140009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
HUI2S00793 UNII
D03270 KEGG_DRUG
C0108139 UMLSCUI
CHEBI:753934 CHEBI
CHEMBL2109033 ChEMBL_ID
169893 PUBCHEM_CID
C003321 MESH_SUPPLEMENTAL_RECORD_UI
DB01344 DRUGBANK_ID
1546437 RXNORM
003509 NDDF
006664 NDDF
1002242008 SNOMEDCT_US
395788004 SNOMEDCT_US
710808009 SNOMEDCT_US
C0137904 UMLSCUI
CHEMBL1201484 ChEMBL_ID
28210-41-5 SECONDARY_CAS_RN
58817179 PUBCHEM_CID
8324 INN_ID
ZSL2FB6GXN UNII
CHEBI:53277 CHEBI

Pharmaceutical products:

None