dexrabeprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 4867 177795-60-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • E3810
  • dexrabeprazole
  • dexrabeprazole sodium
  • dexpure
  • Molecular weight: 359.44
  • Formula: C18H21N3O3S
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 77.10
  • ALOGS: -3.03
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BC07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Duodenal ulcer disease indication 51868009 DOID:1724
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Peptic reflux disease indication 57643001
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric ulcer indication 397825006 DOID:10808
Gastric Hypersecretory Conditions indication
Maintenance of Healing Erosive Esophagitis indication
Duodenal Ulcer due to H. Pylori indication
Pathological Gastric Hypersecretory Condition indication
Upper gastrointestinal hemorrhage off-label use 37372002
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Osteoporosis contraindication 64859006 DOID:11476
Oliguria contraindication 83128009
Atrophic gastritis contraindication 84568007 DOID:8929
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Edema contraindication 267038008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.23 acidic
pKa2 3.9 Basic
pKa3 2.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Alpha-2B adrenergic receptor GPCR Ki 6.10 CHEMBL
D(3) dopamine receptor GPCR Ki 6.10 CHEMBL
Platelet-derived growth factor receptor beta Kinase Kd 6.56 CHEMBL
Pyridoxal kinase Kinase Kd 4.79 CHEMBL
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase Kd 8.30 CHEMBL
Vascular endothelial growth factor receptor 1 Kinase IC50 8.15 CHEMBL
Vascular endothelial growth factor receptor 2 Kinase IC50 7.60 CHEMBL
Vascular endothelial growth factor receptor 3 Kinase IC50 8 CHEMBL
Fibroblast growth factor receptor 3 Kinase IC50 6.62 CHEMBL
Tyrosine-protein kinase Lyn Kinase Kd 5.56 CHEMBL
Adenosine receptor A3 GPCR Ki 5.74 CHEMBL
Fatty acid synthase Enzyme Ki 5.23 CHEMBL
Fibroblast growth factor receptor 2 Kinase IC50 7.08 CHEMBL
Receptor-interacting serine/threonine-protein kinase 2 Kinase Kd 6.70 CHEMBL
Epithelial discoidin domain-containing receptor 1 Kinase Kd 7.85 CHEMBL
Discoidin domain-containing receptor 2 Kinase Kd 7.03 CHEMBL
Aurora kinase B Kinase Kd 4.64 CHEMBL
Insulin-degrading enzyme Enzyme IC50 4.96 CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Enzyme IC50 4.28 CHEMBL
Cytosolic endo-beta-N-acetylglucosaminidase Enzyme IC50 5.35 CHEMBL
Sterile alpha and TIR motif-containing protein 1 Unclassified IC50 5.50 CHEMBL
Fibroblast growth factor receptor 1 Kinase IC50 7.76 CHEMBL

External reference:

IDSource
65JK8810RM UNII
171440-18-9 SECONDARY_CAS_RN
C3661450 UMLSCUI
CHEBI:134729 CHEBI
CHEMBL1615209 ChEMBL_ID
9906855 PUBCHEM_CID
DB13762 DRUGBANK_ID
CHEMBL2220486 ChEMBL_ID
CHEMBL1219 ChEMBL_ID
CHEMBL1200930 ChEMBL_ID
D064750 MESH_DESCRIPTOR_UI
C000595232 MESH_SUPPLEMENTAL_RECORD_UI
1177188006 SNOMEDCT_US
1179585005 SNOMEDCT_US
RZX PDB_CHEM_ID

Pharmaceutical products:

None