estrone sulphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| estrogens | 4857 | 7280-37-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
used therapeutically in menopausal patients
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 19, 1977 | FDA | PHARMACIA AND UPJOHN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003270 | Contraceptive Agents |
| MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
| MeSH PA | D012102 | Reproductive Control Agents |
| MeSH PA | D004967 | Estrogens |
| MeSH PA | D006728 | Hormones |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:50114 | estrogens |
| CHEBI has role | CHEBI:50646 | antiosteoporotic |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Female hypogonadism syndrome | indication | 16041008 | |
| Atrophic vaginitis | indication | 52441000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Estrogen receptor | Nuclear hormone receptor | AGONIST | DRUG LABEL | DRUG LABEL | |||||
| Estrogen receptor beta | Nuclear hormone receptor | AGONIST | DRUG LABEL | DRUG LABEL | |||||
| Steryl-sulfatase | Enzyme | Ki | 4.22 | CHEMBL | |||||
| Solute carrier family 22 member 20 | Transporter | Ki | 4.24 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00948 | KEGG_DRUG |
| 4018490 | VUID |
| N0000146812 | NUI |
| 438-67-5 | SECONDARY_CAS_RN |
| 4018489 | VANDF |
| 4018490 | VANDF |
| 4018711 | VANDF |
| 4022631 | VANDF |
| C0059668 | UMLSCUI |
| CHEBI:17474 | CHEBI |
| CHEBI:17263 | CHEBI |
| J3Z | PDB_CHEM_ID |
| CHEMBL494753 | ChEMBL_ID |
| 3001028 | PUBCHEM_CID |
| DB04574 | DRUGBANK_ID |
| CHEMBL2106240 | ChEMBL_ID |
| C009927 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB00655 | DRUGBANK_ID |
| 33747 | RXNORM |
| 17244 | MMSL |
| 2450 | MMSL |
| 2464 | MMSL |
| 4688 | MMSL |
| 4689 | MMSL |
| d00534 | MMSL |
| d00543 | MMSL |
| 001270 | NDDF |
| 001287 | NDDF |
| 115502007 | SNOMEDCT_US |
| 127381003 | SNOMEDCT_US |
| 395829001 | SNOMEDCT_US |
| 51775003 | SNOMEDCT_US |
| 784234005 | SNOMEDCT_US |
| 90017009 | SNOMEDCT_US |
| C0014942 | UMLSCUI |
| CHEMBL1200980 | ChEMBL_ID |
| 407 | INN_ID |
| 5870 | PUBCHEM_CID |
| D004970 | MESH_DESCRIPTOR_UI |
| 6K6FDA543A | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Esterified Estrogens and Methyltestosterone | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50220-001 | TABLET, FILM COATED | 0.63 mg | ORAL | Unapproved drug other | 13 sections |
| Esterified Estrogens and Methyltestosterone | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50220-002 | TABLET, FILM COATED | 1.25 mg | ORAL | Unapproved drug other | 13 sections |
| Estropipate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-3114 | TABLET | 0.75 mg | ORAL | ANDA | 23 sections |
| Estropipate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4149 | TABLET | 1.50 mg | ORAL | ANDA | 23 sections |
| Estropipate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4761 | TABLET | 3 mg | ORAL | ANDA | 23 sections |