conjugated estrogens 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
estrogens	4855	12126-59-9

Description:

Molecule	Description
Synonyms: estrogen conjugated estrogenic substances, conjugated oestrogens conjugated conjugated estrogens premarin estrogens, conjugated estrogens conjugated conjugated oestrogens	A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate. Molecular weight: 3556.05 Formula: C180H202Na10O40S10 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 74.27 ALOGS: ROTB: None

Molecule

Description

Synonyms:

estrogen conjugated
estrogenic substances, conjugated
oestrogens conjugated
conjugated estrogens
premarin
estrogens, conjugated
estrogens conjugated
conjugated oestrogens

A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.

Molecular weight: 3556.05
Formula: C180H202Na10O40S10
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 74.27
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.63	mg	O
0.63	mg	V

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.09 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
May 8, 1942	FDA	WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coronary artery disease	285.15	10.70	273	80390	32104	63376255
Hot flush	258.67	10.70	322	80341	50837	63357522
Vulvovaginal burning sensation	243.15	10.70	94	80569	2015	63406344
Cerebrovascular accident	221.03	10.70	449	80214	107575	63300784
Breast cancer	215.49	10.70	286	80377	48097	63360262
Maternal exposure during pregnancy	215.42	10.70	17	80646	220045	63188314
Schizoaffective disorder	214.13	10.70	100	80563	3462	63404897
Depression	197.25	10.70	623	80040	195869	63212490
Vulvovaginal discomfort	168.94	10.70	75	80588	2303	63406056
Hyperlipidaemia	168.47	10.70	163	80500	19408	63388951
Exposure during pregnancy	152.22	10.70	12	80651	155535	63252824
Myocardial infarction	149.97	10.70	367	80296	99526	63308833
Pericarditis	141.37	10.70	6	80657	131573	63276786
Wound	136.28	10.70	22	80641	163241	63245118
Systemic lupus erythematosus	133.94	10.70	49	80614	208869	63199490
Glossodynia	132.77	10.70	32	80631	178844	63229515
Contraindicated product administered	129.81	10.70	57	80606	217591	63190768
Toxicity to various agents	125.05	10.70	80	80583	247170	63161189
Infusion related reaction	122.05	10.70	81	80582	245440	63162919
Death	116.48	10.70	185	80478	374196	63034163
Drug intolerance	115.76	10.70	133	80530	308528	63099831
Anxiety	115.18	10.70	564	80099	216977	63191382
Vulvovaginal dryness	108.32	10.70	59	80604	2842	63405517
Product prescribing error	107.30	10.70	149	80514	26140	63382219
Chest pain	105.94	10.70	548	80115	215411	63192948
Fibrocystic breast disease	105.77	10.70	44	80619	1148	63407211
Treatment failure	103.95	10.70	62	80601	198981	63209378
Osteopenia	103.92	10.70	127	80536	19658	63388701
Spinal osteoarthritis	98.45	10.70	112	80551	16074	63392285
Transient ischaemic attack	98.28	10.70	174	80489	37579	63370780
Low turnover osteopathy	98.09	10.70	63	80600	4122	63404237
Intervertebral disc degeneration	95.93	10.70	109	80554	15623	63392736
Gastrooesophageal reflux disease	93.75	10.70	301	80362	95338	63313021
Mitral valve incompetence	93.69	10.70	120	80543	19474	63388885
Oestrogen receptor assay positive	93.32	10.70	32	80631	480	63407879
Rheumatoid factor positive	90.15	10.70	4	80659	84402	63323957
Vulvovaginal pain	89.49	10.70	51	80612	2684	63405675
Abdominal discomfort	89.34	10.70	170	80493	320715	63087644
Osteoarthritis	85.35	10.70	291	80372	95052	63313307
Neutropenia	85.24	10.70	59	80604	174946	63233413
Carpal tunnel syndrome	84.97	10.70	118	80545	20699	63387660
Product complaint	81.95	10.70	91	80572	12718	63395641
Rotator cuff syndrome	81.39	10.70	93	80570	13409	63394950
Synovitis	80.93	10.70	71	80592	186847	63221512
Breast cancer in situ	80.45	10.70	39	80624	1469	63406890
Femur fracture	77.64	10.70	167	80496	41589	63366770
Breast tenderness	77.37	10.70	44	80619	2306	63406053
Drug level increased	77.00	10.70	118	80545	22618	63385741
Ventricular hypertrophy	76.29	10.70	50	80613	3386	63404973
Peripheral swelling	75.66	10.70	139	80524	265803	63142556
Stress fracture	75.54	10.70	70	80593	7893	63400466
Progesterone receptor assay positive	74.82	10.70	25	80638	345	63408014
Swelling	74.79	10.70	148	80515	275230	63133129
Angina unstable	74.43	10.70	66	80597	7029	63401330
Acute kidney injury	72.90	10.70	140	80523	263275	63145084
Febrile neutropenia	72.20	10.70	30	80633	118419	63289940
Spinal stenosis	70.72	10.70	91	80572	14834	63393525
General physical health deterioration	69.94	10.70	92	80571	201310	63207049
Feeling abnormal	68.88	10.70	371	80292	148021	63260338
Hypertension	68.78	10.70	597	80066	278706	63129653
Discomfort	68.40	10.70	67	80596	167307	63241052
Carotid artery stenosis	66.34	10.70	54	80609	5116	63403243
Arteriosclerosis	65.23	10.70	72	80591	9994	63398365
Folliculitis	64.55	10.70	7	80656	70310	63338049
Stress urinary incontinence	64.14	10.70	39	80624	2316	63406043
Lacunar infarction	63.88	10.70	44	80619	3236	63405123
Body height decreased	63.44	10.70	71	80592	10007	63398352
Cardiac failure congestive	63.41	10.70	259	80404	92174	63316185
Hepatic enzyme increased	62.80	10.70	100	80563	202228	63206131
Meniscus injury	62.63	10.70	60	80603	7054	63401305
Drug abuse	62.24	10.70	9	80654	72509	63335850
Completed suicide	62.24	10.70	56	80607	145617	63262742
Breast calcifications	62.06	10.70	31	80632	1247	63407112
Dental caries	61.21	10.70	72	80591	10707	63397652
Coronary artery occlusion	57.30	10.70	61	80602	8130	63400229
Insomnia	57.15	10.70	468	80195	214784	63193575
Lower respiratory tract infection	56.35	10.70	51	80612	132256	63276103
Disease progression	55.11	10.70	45	80618	122713	63285646
Vulvovaginal pruritus	55.05	10.70	40	80623	3203	63405156
Pyrexia	55.05	10.70	361	80302	470117	62938242
Stomatitis	54.99	10.70	57	80606	138668	63269691
Haemorrhoids	54.97	10.70	100	80563	22050	63386309
Alopecia	53.33	10.70	234	80429	337302	63071057
Angina pectoris	53.30	10.70	118	80545	29960	63378399
Temporomandibular joint syndrome	53.08	10.70	43	80620	4046	63404313
Fracture nonunion	52.43	10.70	34	80629	2261	63406098
Cystocele	52.26	10.70	27	80636	1167	63407192
Vaginal haemorrhage	51.17	10.70	110	80553	27377	63380982
Product dispensing error	50.67	10.70	64	80599	10241	63398118
Exostosis of jaw	50.31	10.70	27	80636	1262	63407097
Aortic valve incompetence	49.89	10.70	49	80614	5939	63402420
Bronchial neoplasm	49.63	10.70	20	80643	480	63407879
Joint swelling	48.87	10.70	232	80431	327434	63080925
Breast mass	48.48	10.70	55	80608	7867	63400492
Renal impairment	48.27	10.70	26	80637	88329	63320030
Anaemia postoperative	48.26	10.70	32	80631	2210	63406149
Diverticulum	47.49	10.70	67	80596	11924	63396435
Cardiac disorder	46.24	10.70	156	80507	50660	63357699
Arteriosclerosis coronary artery	46.01	10.70	55	80608	8318	63400041
Muscle injury	45.95	10.70	13	80650	65332	63343027
Infection	45.91	10.70	144	80519	229029	63179330
Cataract	45.76	10.70	168	80495	56885	63351474
Product quality issue	45.74	10.70	124	80539	35741	63372618
Nervousness	45.57	10.70	113	80550	30866	63377493
Malignant neoplasm progression	45.11	10.70	24	80639	82097	63326262
Postmenopausal haemorrhage	44.73	10.70	30	80633	2112	63406247
Nasal turbinate hypertrophy	44.56	10.70	21	80642	742	63407617
Vulvovaginal swelling	44.42	10.70	19	80644	532	63407827
Breast cyst	44.13	10.70	28	80635	1793	63406566
Expired product administered	43.18	10.70	46	80617	6135	63402224
Urinary incontinence	43.17	10.70	113	80550	31901	63376458
Bronchial haemorrhage	43.11	10.70	19	80644	573	63407786
Breast cancer female	42.61	10.70	68	80595	13491	63394868
Seborrhoeic keratosis	42.30	10.70	30	80633	2312	63406047
Ventricular dysfunction	41.57	10.70	32	80631	2796	63405563
Mammogram abnormal	41.56	10.70	20	80643	741	63407618
Tricuspid valve incompetence	41.46	10.70	70	80593	14551	63393808
Blister	41.36	10.70	63	80600	129751	63278608
Cardiovascular disorder	40.97	10.70	62	80601	11750	63396609
Vaginal infection	40.68	10.70	49	80614	7469	63400890
Thrombocytopenia	40.34	10.70	82	80581	151075	63257284
Intramedullary rod insertion	40.22	10.70	28	80635	2095	63406264
Rash	40.15	10.70	488	80175	560383	62847976
Peptic ulcer	39.08	10.70	38	80625	4549	63403810
Liver injury	39.07	10.70	14	80649	60506	63347853
Emotional distress	39.00	10.70	110	80553	32439	63375920
Menopausal symptoms	38.72	10.70	29	80634	2432	63405927
Hiatus hernia	38.58	10.70	85	80578	21509	63386850
Rectocele	38.01	10.70	21	80642	1040	63407319
Breast disorder	38.01	10.70	29	80634	2501	63405858
Nocturia	37.57	10.70	49	80614	8092	63400267
Atrophic vulvovaginitis	37.49	10.70	25	80638	1743	63406616
Intentional overdose	37.42	10.70	24	80639	74128	63334231
Pancytopenia	37.10	10.70	41	80622	96892	63311467
Vulvovaginal erythema	36.92	10.70	14	80649	284	63408075
Chronic disease	36.85	10.70	12	80651	152	63408207
Migraine	36.13	10.70	240	80423	103106	63305253
Hospitalisation	35.98	10.70	33	80630	85048	63323311
Large intestine polyp	35.95	10.70	48	80615	8109	63400250
Arthropathy	35.71	10.70	165	80498	234627	63173732
Spondylolisthesis	35.32	10.70	32	80631	3504	63404855
Mitral valve prolapse	35.01	10.70	27	80636	2366	63405993
Bronchitis	34.95	10.70	275	80388	124660	63283699
Chronic obstructive pulmonary disease	34.87	10.70	165	80498	62521	63345838
Drug withdrawal syndrome	34.66	10.70	94	80569	27100	63381259
Endometrial ablation	34.32	10.70	19	80644	945	63407414
Jaw disorder	34.21	10.70	38	80625	5311	63403048
Cervicobrachial syndrome	34.08	10.70	19	80644	958	63407401
Vaginal prolapse	34.02	10.70	15	80648	453	63407906
Therapeutic response unexpected	33.69	10.70	74	80589	18685	63389674
Drug ineffective	33.42	10.70	1043	79620	1043722	62364637
Hypoacusis	33.34	10.70	86	80577	24065	63384294
Wrong strength	33.17	10.70	9	80654	57	63408302
Bladder prolapse	33.02	10.70	25	80638	2131	63406228
Mobility decreased	32.94	10.70	65	80598	121094	63287265
Breast hyperplasia	32.77	10.70	13	80650	299	63408060
Drug effective for unapproved indication	32.74	10.70	30	80633	3334	63405025
Muscle strain	32.42	10.70	46	80617	8228	63400131
Coma	32.25	10.70	21	80642	64343	63344016
Peripheral vascular disorder	32.11	10.70	39	80624	5996	63402363
Sepsis	31.51	10.70	95	80568	153028	63255331
Uterine leiomyoma	31.51	10.70	48	80615	9150	63399209
Osteonecrosis	31.47	10.70	85	80578	24445	63383914
Acute myocardial infarction	31.35	10.70	101	80562	32023	63376336
Morton's neuralgia	31.34	10.70	9	80654	72	63408287
Nasopharyngitis	31.25	10.70	192	80471	254065	63154294
Vomiting	30.47	10.70	514	80149	559103	62849256
Therapeutic product effect decreased	30.42	10.70	134	80529	193053	63215306
Ill-defined disorder	29.75	10.70	36	80627	81719	63326640
Scoliosis	29.66	10.70	43	80620	7845	63400514
Oral infection	29.57	10.70	34	80629	4934	63403425
Hyperhidrosis	29.41	10.70	236	80427	107600	63300759
Bronchial disorder	29.20	10.70	19	80644	1271	63407088
Burning sensation	28.67	10.70	141	80522	54266	63354093
Back pain	28.23	10.70	482	80181	263663	63144696
Blood triglycerides increased	28.01	10.70	54	80609	12434	63395925
Ischaemic cardiomyopathy	27.91	10.70	24	80639	2453	63405906
Hormone level abnormal	27.86	10.70	24	80639	2459	63405900
Premature delivery	27.83	10.70	3	80660	30278	63378081
Memory impairment	27.79	10.70	227	80436	104031	63304328
Psoriatic arthropathy	27.65	10.70	46	80617	91474	63316885
Blood cholesterol increased	27.41	10.70	209	80454	93823	63314536
Lumbar spinal stenosis	27.03	10.70	32	80631	4790	63403569
Vaginal disorder	26.97	10.70	15	80648	753	63407606
Cardiac valve disease	26.84	10.70	30	80633	4222	63404137
Panic disorder	26.64	10.70	24	80639	2609	63405750
Palpitations	26.63	10.70	239	80424	112531	63295828
Poor quality product administered	26.62	10.70	26	80637	3130	63405229
Aortic arteriosclerosis	26.55	10.70	36	80627	6173	63402186
Vulvovaginal injury	26.44	10.70	13	80650	505	63407854
Drug abuser	26.39	10.70	25	80638	2898	63405461
Thyroid disorder	26.31	10.70	59	80604	15103	63393256
Bone graft	26.24	10.70	16	80647	955	63407404
Hypotension	26.15	10.70	221	80442	272383	63135976
Tooth fracture	26.11	10.70	49	80614	11061	63397298
Device failure	25.92	10.70	35	80628	5976	63402383
Sinus rhythm	25.45	10.70	15	80648	841	63407518
Uterine polyp	25.44	10.70	21	80642	2029	63406330
Back disorder	25.16	10.70	48	80615	10969	63397390
Blood pressure abnormal	25.11	10.70	58	80605	15140	63393219
Breast conserving surgery	25.10	10.70	16	80647	1033	63407326
Hypothyroidism	25.02	10.70	114	80549	42518	63365841
Breast pain	24.78	10.70	42	80621	8756	63399603
Ligament sprain	24.71	10.70	52	80611	12748	63395611
Intervertebral disc protrusion	24.47	10.70	76	80587	23633	63384726
Chronic fatigue syndrome	24.17	10.70	16	80647	1102	63407257
Diabetes mellitus	24.16	10.70	137	80526	55673	63352686
Leukopenia	24.14	10.70	38	80625	77252	63331107
Blood oestrogen decreased	24.14	10.70	10	80653	258	63408101
Lumbar radiculopathy	24.08	10.70	20	80643	1949	63406410
Cardiac failure	24.08	10.70	48	80615	89094	63319265
Mucosal inflammation	23.94	10.70	15	80648	46913	63361446
Interstitial lung disease	23.89	10.70	26	80637	61882	63346477
Suspected counterfeit product	23.57	10.70	11	80652	380	63407979
Musculoskeletal stiffness	23.41	10.70	138	80525	184480	63223879
Non-cardiac chest pain	23.30	10.70	34	80629	6238	63402121
Vaginal odour	23.24	10.70	12	80651	518	63407841
Platelet count decreased	23.21	10.70	73	80590	116049	63292310
Rhonchi	23.19	10.70	22	80641	2554	63405805
Pain in extremity	22.89	10.70	567	80096	330919	63077440
Product use in unapproved indication	22.64	10.70	134	80529	178946	63229413
Coronary artery stenosis	22.59	10.70	29	80634	4715	63403644
Neoplasm progression	22.55	10.70	9	80654	36419	63371940
Granuloma	22.53	10.70	32	80631	5729	63402630
Septic shock	22.53	10.70	31	80632	66598	63341761
Intentional product use issue	22.45	10.70	85	80578	127807	63280552
Osteoporosis	22.40	10.70	137	80526	57201	63351158
Resorption bone increased	22.28	10.70	16	80647	1258	63407101
Tendonitis	22.25	10.70	65	80598	19550	63388809
Pollakiuria	22.17	10.70	82	80581	27855	63380504
Hepatocellular injury	22.14	10.70	4	80659	27377	63380982
Gingivitis	22.12	10.70	39	80624	8390	63399969
Intervertebral disc disorder	22.12	10.70	29	80634	4814	63403545
Hypertonic bladder	22.11	10.70	25	80638	3563	63404796
Muscle spasms	22.11	10.70	299	80364	155851	63252508
Cerebrovascular disorder	22.10	10.70	22	80641	2710	63405649
Ventricular extrasystoles	22.01	10.70	47	80616	11640	63396719
Vitamin D deficiency	21.84	10.70	52	80611	13840	63394519
Dilatation atrial	21.84	10.70	19	80644	1972	63406387
Calcium deficiency	21.83	10.70	15	80648	1099	63407260
Epilepsy	21.79	10.70	4	80659	27061	63381298
Cardiomegaly	21.56	10.70	60	80603	17554	63390805
Bone density abnormal	21.49	10.70	24	80639	3374	63404985
Subclavian artery embolism	21.44	10.70	5	80658	15	63408344
Varicose vein	21.41	10.70	29	80634	4966	63403393
Foot fracture	21.39	10.70	73	80590	23841	63384518
Lactic acidosis	21.30	10.70	11	80652	38276	63370083
Diarrhoea	21.14	10.70	721	79942	714645	62693714
Breast cancer metastatic	21.12	10.70	47	80616	11971	63396388
Uterine disorder	21.11	10.70	23	80640	3146	63405213
Eye disorder	20.95	10.70	70	80593	22615	63385744
Blood pressure increased	20.80	10.70	305	80358	161757	63246602
Rhinitis allergic	20.76	10.70	46	80617	11681	63396678
Post procedural complication	20.74	10.70	58	80605	17016	63391343
Carotid artery disease	20.69	10.70	17	80646	1632	63406727
Gingival disorder	20.68	10.70	24	80639	3518	63404841
Libido decreased	20.67	10.70	21	80642	2651	63405708
Crying	20.65	10.70	71	80592	23272	63385087
Gastritis	20.61	10.70	98	80565	37205	63371154
Melanocytic naevus	20.60	10.70	27	80636	4481	63403878
Myelosuppression	20.20	10.70	3	80660	23700	63384659
Cervical spinal stenosis	20.15	10.70	19	80644	2189	63406170
Hepatotoxicity	20.08	10.70	11	80652	37030	63371329
Endometrial hyperplasia	20.01	10.70	13	80650	867	63407492
Confusional state	19.90	10.70	198	80465	236182	63172177
Toxic epidermal necrolysis	19.85	10.70	4	80659	25330	63383029
Intentional product misuse	19.81	10.70	139	80524	60778	63347581
Homicidal ideation	19.79	10.70	17	80646	1735	63406624
Dysuria	19.64	10.70	90	80573	33648	63374711
Oedema peripheral	19.57	10.70	344	80319	189167	63219192
Bursitis	19.52	10.70	96	80567	36945	63371414
Plantar fasciitis	19.44	10.70	24	80639	3751	63404608
Stevens-Johnson syndrome	19.42	10.70	4	80659	24946	63383413
Neutrophil count decreased	19.32	10.70	26	80637	56380	63351979
Cardiac murmur	19.24	10.70	51	80612	14501	63393858
Defaecation urgency	19.07	10.70	25	80638	4150	63404209
Vulvovaginal mycotic infection	19	10.70	29	80634	5537	63402822
Encephalopathy	18.81	10.70	13	80650	38607	63369752
Biopsy breast abnormal	18.80	10.70	5	80658	29	63408330
Radicular pain	18.80	10.70	10	80653	459	63407900
Helicobacter infection	18.77	10.70	58	80605	92727	63315632
Hepatic function abnormal	18.77	10.70	12	80651	37130	63371229
Modified radical mastectomy	18.64	10.70	4	80659	7	63408352
Hyperkalaemia	18.55	10.70	25	80638	54178	63354181
Labile hypertension	18.47	10.70	10	80653	476	63407883
Product residue present	18.44	10.70	24	80639	3955	63404404
Dizziness	18.29	10.70	693	79970	429232	62979127
Exostosis	18.20	10.70	57	80606	17805	63390554
Vaginal cyst	18.19	10.70	8	80655	240	63408119
Amnesia	18.17	10.70	127	80536	55458	63352901
Gallbladder disorder	18.17	10.70	59	80604	18783	63389576
Influenza like illness	18.07	10.70	146	80517	66678	63341681
Urinary tract infection	18.04	10.70	452	80211	264232	63144127
Musculoskeletal discomfort	18.00	10.70	57	80606	17910	63390449
Drug-induced liver injury	17.72	10.70	15	80648	40207	63368152
Spinal disorder	17.71	10.70	39	80624	9863	63398496
Cardiolipin antibody positive	17.69	10.70	7	80656	160	63408199
Agranulocytosis	17.67	10.70	5	80658	25129	63383230
Nerve compression	17.64	10.70	37	80626	9050	63399309
Lung neoplasm	17.50	10.70	29	80634	5937	63402422
Vertigo	17.38	10.70	133	80530	59754	63348605
Vision blurred	17.38	10.70	186	80477	91738	63316621
Urethral stenosis	17.37	10.70	8	80655	268	63408091
Vaginal discharge	17.33	10.70	37	80626	9161	63399198
Oral discomfort	17.33	10.70	37	80626	9164	63399195
Road traffic accident	17.25	10.70	92	80571	36540	63371819
Osteomyelitis	17.11	10.70	72	80591	25948	63382411
Tooth disorder	17.05	10.70	76	80587	28081	63380278
Vulvovaginal rash	17.03	10.70	7	80656	177	63408182
Vaginal cancer metastatic	17.01	10.70	3	80660	0	63408359
Essential hypertension	16.87	10.70	26	80637	5007	63403352
Affective disorder	16.86	10.70	29	80634	6117	63402242
Emotional disorder	16.80	10.70	46	80617	13333	63395026
Open reduction of fracture	16.76	10.70	13	80650	1149	63407210
Thyroid neoplasm	16.72	10.70	23	80640	3996	63404363
Product dose omission issue	16.65	10.70	204	80459	234109	63174250
Bone fragmentation	16.64	10.70	11	80652	756	63407603
Electrocardiogram QT prolonged	16.61	10.70	131	80532	59399	63348960
Anxiety disorder	16.59	10.70	23	80640	4027	63404332
Malabsorption	16.49	10.70	23	80640	4049	63404310
Bone disorder	16.43	10.70	62	80601	21264	63387095
Limb injury	16.37	10.70	70	80593	25407	63382952
Lip neoplasm	16.26	10.70	4	80659	16	63408343
Mitral valve calcification	16.24	10.70	12	80651	986	63407373
Metabolic acidosis	16.23	10.70	20	80643	45049	63363310
Hyponatraemia	16.19	10.70	80	80583	111820	63296539
Kyphosis	16.17	10.70	18	80645	2522	63405837
Altered state of consciousness	16.01	10.70	6	80657	25224	63383135
Irritability	15.89	10.70	81	80582	31613	63376746
Anger	15.81	10.70	43	80620	12413	63395946
Uterine prolapse	15.68	10.70	13	80650	1264	63407095
Cholestasis	15.58	10.70	9	80654	29425	63378934
White blood cell count decreased	15.57	10.70	108	80555	138996	63269363
Pneumonia	15.47	10.70	452	80211	456315	62952044
Tooth abscess	15.46	10.70	48	80615	14921	63393438
Suicide attempt	15.44	10.70	34	80629	60884	63347475
Condition aggravated	15.44	10.70	391	80272	401826	63006533
Palmar-plantar erythrodysaesthesia syndrome	15.41	10.70	5	80658	23010	63385349
Dyslipidaemia	15.41	10.70	31	80632	7362	63400997
Nerve injury	15.39	10.70	37	80626	9909	63398450
Breast disorder female	15.25	10.70	6	80657	135	63408224
Oedema mouth	15.19	10.70	17	80646	2396	63405963
Hypersensitivity	15.18	10.70	271	80392	292414	63115945
Eosinophilia	15.14	10.70	5	80658	22751	63385608
Micturition urgency	15.14	10.70	36	80627	9575	63398784
Deep vein thrombosis	15.12	10.70	168	80495	83632	63324727
Lipoma	15.08	10.70	17	80646	2414	63405945
Myocardial ischaemia	14.96	10.70	43	80620	12816	63395543
Dyspareunia	14.95	10.70	17	80646	2438	63405921
Plague	14.93	10.70	3	80660	3	63408356
Device dislocation	14.88	10.70	7	80656	25698	63382661
Haemoglobin decreased	14.83	10.70	116	80547	145369	63262990
Decreased appetite	14.81	10.70	227	80436	250825	63157534
Rheumatoid arthritis	14.80	10.70	230	80433	253589	63154770
Thyrotoxic periodic paralysis	14.79	10.70	4	80659	25	63408334
Laryngeal pain	14.74	10.70	23	80640	4475	63403884
Alanine aminotransferase abnormal	14.72	10.70	23	80640	4481	63403878
Tonsillar disorder	14.70	10.70	12	80651	1141	63407218
Periodontal disease	14.70	10.70	14	80649	1634	63406725
Gastrointestinal disorder	14.64	10.70	102	80561	131137	63277222
Carotid bruit	14.60	10.70	10	80653	729	63407630
Tinnitus	14.47	10.70	86	80577	35542	63372817
Oestrogen deficiency	14.37	10.70	6	80657	158	63408201
Sleep apnoea syndrome	14.29	10.70	74	80589	29059	63379300
Therapy non-responder	14.27	10.70	49	80614	75852	63332507
Salpingo-oophorectomy bilateral	14.23	10.70	6	80657	162	63408197
Mixed incontinence	14.23	10.70	5	80658	81	63408278
Glucose tolerance impaired	14.22	10.70	28	80635	6549	63401810
Cholelithiasis	14.15	10.70	100	80563	43825	63364534
Multiple organ dysfunction syndrome	14.12	10.70	32	80631	56720	63351639
COVID-19	14.09	10.70	85	80578	113018	63295341
Intestinal adhesion lysis	14.07	10.70	3	80660	5	63408354
Arthritis	14.03	10.70	216	80447	115705	63292654
Jaw fracture	13.98	10.70	17	80646	2617	63405742
Intermenstrual bleeding	13.93	10.70	31	80632	7895	63400464
Depressed level of consciousness	13.88	10.70	37	80626	62041	63346318
Joint injury	13.74	10.70	74	80589	29498	63378861
Gait disturbance	13.74	10.70	317	80346	182861	63225498
Fungal cystitis	13.72	10.70	3	80660	6	63408353
Skin abrasion	13.69	10.70	34	80629	9295	63399064
Nasal septum deviation	13.61	10.70	13	80650	1523	63406836
Amaurosis fugax	13.58	10.70	8	80655	448	63407911
Restless legs syndrome	13.56	10.70	53	80610	18478	63389881
Bladder disorder	13.54	10.70	33	80630	8913	63399446
Barrett's oesophagus	13.52	10.70	9	80654	626	63407733
Migraine with aura	13.44	10.70	17	80646	2723	63405636
Multiple sclerosis	13.44	10.70	64	80599	24308	63384051
Hip arthroplasty	13.43	10.70	25	80638	47621	63360738
Intermittent claudication	13.40	10.70	14	80649	1825	63406534
Red blood cell sedimentation rate increased	13.38	10.70	22	80641	43960	63364399
Cervical radiculopathy	13.36	10.70	11	80652	1059	63407300
Meniscus removal	13.32	10.70	4	80659	38	63408321
Vulval oedema	13.25	10.70	5	80658	100	63408259
Hypercholesterolaemia	13.23	10.70	58	80605	21276	63387083
Limb asymmetry	13.23	10.70	10	80653	850	63407509
Rhinitis	13.21	10.70	38	80625	11328	63397031
Chromaturia	13.21	10.70	49	80614	16668	63391691
Mood altered	13.18	10.70	45	80618	14698	63393661
Fistula discharge	13.15	10.70	11	80652	1082	63407277
Osteoma	13.14	10.70	4	80659	40	63408319
Frustration tolerance decreased	13.04	10.70	28	80635	6960	63401399
Seasonal allergy	13.03	10.70	57	80606	20893	63387466
Gallbladder oedema	13.03	10.70	6	80657	201	63408158
Disseminated intravascular coagulation	13.01	10.70	4	80659	19047	63389312
Anaemia	12.99	10.70	279	80384	293151	63115208
Angiopathy	12.96	10.70	22	80641	4591	63403768
Rib fracture	12.94	10.70	60	80603	22537	63385822
Aortic stenosis	12.88	10.70	23	80640	4997	63403362
Skin indentation	12.88	10.70	4	80659	43	63408316
Feelings of worthlessness	12.85	10.70	7	80656	337	63408022
Off label use	12.77	10.70	714	79949	673748	62734611
Coronary artery thrombosis	12.76	10.70	11	80652	1128	63407231
Urge incontinence	12.75	10.70	10	80653	898	63407461
Endometrial cancer	12.74	10.70	18	80645	3207	63405152
Neurotoxicity	12.67	10.70	3	80660	16987	63391372
Major depression	12.59	10.70	30	80633	7988	63400371
Pneumocystis jirovecii pneumonia	12.59	10.70	3	80660	16911	63391448
Hypersexuality	12.58	10.70	8	80655	514	63407845
Pulpitis dental	12.56	10.70	10	80653	918	63407441
Fungal infection	12.50	10.70	85	80578	36789	63371570
Tender joint count	12.40	10.70	6	80657	225	63408134
Gamma-glutamyltransferase increased	12.36	10.70	15	80648	34016	63374343
Aortic valve sclerosis	12.30	10.70	11	80652	1185	63407174
Stress	12.27	10.70	135	80528	67032	63341327
Osteomalacia	12.22	10.70	9	80654	736	63407623
Fibromyalgia	12.21	10.70	156	80507	80264	63328095
Cystitis	12.19	10.70	115	80548	54876	63353483
Oesophageal disorder	12.08	10.70	15	80648	2358	63406001
Otitis media	12.03	10.70	22	80641	4869	63403490
Creatinine renal clearance decreased	11.92	10.70	3	80660	16305	63392054
Vascular calcification	11.92	10.70	9	80654	764	63407595
Multiple injuries	11.89	10.70	13	80650	1785	63406574
Postmenopause	11.85	10.70	4	80659	57	63408302
Fracture delayed union	11.84	10.70	15	80648	2407	63405952
Breast reconstruction	11.84	10.70	6	80657	249	63408110
Fatigue	11.81	10.70	970	79693	887058	62521301
Urethral disorder	11.79	10.70	5	80658	137	63408222
Hyperaesthesia teeth	11.77	10.70	13	80650	1805	63406554
Cardio-respiratory arrest	11.76	10.70	38	80625	59921	63348438
Heart rate irregular	11.73	10.70	58	80605	22363	63385996
Bundle branch block left	11.73	10.70	27	80636	7032	63401327
Hypertensive heart disease	11.69	10.70	15	80648	2437	63405922
Cytomegalovirus infection	11.68	10.70	6	80657	20946	63387413
Medical device removal	11.68	10.70	11	80652	1266	63407093
Neck pain	11.62	10.70	137	80526	69181	63339178
Withdrawal bleed	11.60	10.70	4	80659	61	63408298
Endometrial cancer stage I	11.58	10.70	6	80657	261	63408098
Prescribed overdose	11.43	10.70	16	80647	34137	63374222
Change of bowel habit	11.39	10.70	14	80649	2179	63406180
Drug tolerance decreased	11.35	10.70	4	80659	17469	63390890
Platelet aggregation increased	11.34	10.70	3	80660	17	63408342
Gastroenteritis	11.33	10.70	65	80598	26525	63381834
Hysterectomy	11.28	10.70	32	80631	9467	63398892
Eating disorder	11.27	10.70	51	80612	18965	63389394
Arterial occlusive disease	11.27	10.70	24	80639	5934	63402425
Emphysema	11.23	10.70	35	80628	10903	63397456
Posterior reversible encephalopathy syndrome	11.21	10.70	4	80659	17341	63391018
Transaminases increased	11.21	10.70	14	80649	31353	63377006
Suicidal ideation	11.19	10.70	125	80538	62296	63346063
Clubbing	11.16	10.70	7	80656	439	63407920
Tooth loss	11.15	10.70	26	80637	6830	63401529
Abnormal dreams	11.12	10.70	34	80629	10482	63397877
Breast enlargement	11.12	10.70	12	80651	1624	63406735
Therapy interrupted	11.07	10.70	15	80648	32440	63375919
Marital problem	10.98	10.70	5	80658	163	63408196
Ecchymosis	10.93	10.70	35	80628	11059	63397300
Traumatic liver injury	10.86	10.70	6	80657	297	63408062
Therapeutic product effect incomplete	10.83	10.70	104	80559	124952	63283407
Fracture malunion	10.82	10.70	5	80658	169	63408190
Intentional self-injury	10.81	10.70	10	80653	25677	63382682
Nipple pain	10.77	10.70	6	80657	302	63408057
Impaired driving ability	10.73	10.70	20	80643	4491	63403868

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hot flush	244.17	10.90	254	61158	54623	79628353
Vulvovaginal burning sensation	209.30	10.90	69	61343	1548	79681428
Coronary artery disease	201.00	10.90	250	61162	65224	79617752
Depression	193.61	10.90	479	60933	216311	79466665
Cerebrovascular accident	190.01	10.90	389	61023	154903	79528073
Vulvovaginal discomfort	155.09	10.90	57	61355	1781	79681195
Hyperlipidaemia	150.04	10.90	139	61273	25954	79657022
Toxicity to various agents	149.31	10.90	69	61343	421471	79261505
Acute kidney injury	141.07	10.90	116	61296	519288	79163688
Death	136.73	10.90	141	61271	566373	79116603
Carpal tunnel syndrome	114.16	10.90	105	61307	19423	79663553
Vulvovaginal dryness	113.72	10.90	48	61364	2176	79680800
Neutropenia	108.33	10.90	43	61369	287667	79395309
Febrile neutropenia	104.03	10.90	25	61387	230974	79452002
Oestrogen receptor assay positive	103.92	10.90	28	61384	302	79682674
Anxiety	103.51	10.90	422	60990	248090	79434886
Chest pain	102.64	10.90	460	60952	281844	79401132
Product prescribing error	102.09	10.90	148	61264	44665	79638311
Breast cancer	102.05	10.90	128	61284	33653	79649323
Drug abuse	101.17	10.90	6	61406	162685	79520291
Osteoarthritis	101.17	10.90	214	61198	87095	79595881
Gastrooesophageal reflux disease	97.88	10.90	235	61177	104011	79578965
Breast cancer in situ	97.40	10.90	34	61378	912	79682064
Fibrocystic breast disease	96.49	10.90	31	61381	639	79682337
Transient ischaemic attack	94.75	10.90	156	61256	52539	79630437
Osteopenia	94.47	10.90	92	61320	18272	79664704
Intervertebral disc degeneration	94.46	10.90	86	61326	15699	79667277
Mitral valve incompetence	90.72	10.90	111	61301	28454	79654522
Hypertension	85.58	10.90	490	60922	330502	79352474
Vulvovaginal pain	84.77	10.90	39	61373	2176	79680800
Spinal osteoarthritis	83.72	10.90	83	61329	16844	79666132
Progesterone receptor assay positive	77.90	10.90	21	61391	227	79682749
Pyrexia	76.19	10.90	268	61144	678441	79004535
Myocardial infarction	76.08	10.90	312	61100	183817	79499159
Drug interaction	75.78	10.90	127	61285	415056	79267920
Meniscus injury	75.15	10.90	53	61359	6715	79676261
Rotator cuff syndrome	75.11	10.90	72	61340	14023	79668953
Spinal stenosis	73.64	10.90	75	61337	15716	79667260
Low turnover osteopathy	72.99	10.90	34	61378	1952	79681024
Body height decreased	72.45	10.90	57	61355	8523	79674453
Completed suicide	68.96	10.90	53	61359	245714	79437262
Feeling abnormal	67.53	10.90	272	61140	158927	79524049
Pericarditis	67.46	10.90	3	61409	104233	79578743
Thrombocytopenia	67.33	10.90	63	61349	265196	79417780
Ventricular hypertrophy	67.17	10.90	50	61362	6888	79676088
Vulvovaginal pruritus	66.73	10.90	35	61377	2598	79680378
Dental caries	66.08	10.90	62	61350	11758	79671218
Stress urinary incontinence	65.98	10.90	31	61381	1815	79681161
Product complaint	65.18	10.90	65	61347	13284	79669692
Blood cholesterol increased	63.32	10.90	174	61238	83546	79599430
Carotid artery stenosis	60.97	10.90	52	61360	8706	79674270
Sepsis	60.50	10.90	71	61341	269357	79413619
General physical health deterioration	59.20	10.90	75	61337	275163	79407813
Renal impairment	58.66	10.90	24	61388	157759	79525217
Vaginal haemorrhage	58.58	10.90	78	61334	21739	79661237
Exostosis of jaw	57.31	10.90	25	61387	1229	79681747
Breast mass	57.31	10.90	45	61367	6709	79676267
Maternal exposure during pregnancy	57.24	10.90	17	61395	136521	79546455
Stress fracture	56.78	10.90	44	61368	6436	79676540
Temporomandibular joint syndrome	56.39	10.90	36	61376	3869	79679107
Nasal turbinate hypertrophy	56.02	10.90	21	61391	694	79682282
Pancytopenia	55.75	10.90	29	61383	165716	79517260
Migraine	55.72	10.90	171	61241	87322	79595654
Lacunar infarction	55.60	10.90	42	61370	5915	79677061
Bronchial neoplasm	55.17	10.90	19	61393	489	79682487
Femur fracture	54.67	10.90	103	61309	38549	79644427
Disease progression	53.98	10.90	38	61374	184324	79498652
Insomnia	53.81	10.90	348	61064	244822	79438154
Malignant neoplasm progression	51.67	10.90	20	61392	135970	79547006
Cystocele	50.81	10.90	20	61392	756	79682220
Angina unstable	50.51	10.90	63	61349	16464	79666512
Product dispensing error	49.52	10.90	56	61356	13207	79669769
Expired product administered	49.36	10.90	42	61370	7009	79675967
Breast calcifications	48.33	10.90	20	61392	862	79682114
Cardiac disorder	48.07	10.90	135	61277	65622	79617354
Haemorrhoids	48.06	10.90	83	61329	29045	79653931
Tricuspid valve incompetence	47.68	10.90	67	61345	19645	79663331
Emotional distress	47.47	10.90	99	61313	39870	79643106
Exposure during pregnancy	47.39	10.90	10	61402	101122	79581854
Arteriosclerosis	47.16	10.90	64	61348	18163	79664813
Menopausal symptoms	46.66	10.90	25	61387	1938	79681038
Breast cancer female	45.56	10.90	50	61362	11411	79671565
Endometrial ablation	44.75	10.90	19	61393	874	79682102
Nervousness	44.74	10.90	87	61325	33328	79649648
Mammogram abnormal	44.37	10.90	16	61396	473	79682503
Wound	44.28	10.90	17	61395	116162	79566814
Angina pectoris	43.65	10.90	112	61300	51620	79631356
Spondylolisthesis	42.72	10.90	28	61384	3147	79679829
Mitral valve prolapse	42.28	10.90	24	61388	2083	79680893
Cataract	41.99	10.90	124	61288	61996	79620980
Back disorder	41.73	10.90	48	61364	11530	79671446
Jaw disorder	41.72	10.90	33	61379	4973	79678003
Hypotension	41.59	10.90	186	61226	440131	79242845
Treatment failure	41.49	10.90	42	61370	170444	79512532
Back pain	41.22	10.90	386	61026	303794	79379182
Hypoacusis	40.98	10.90	79	61333	30071	79652905
Breast tenderness	40.64	10.90	24	61388	2244	79680732
Osteonecrosis	40.47	10.90	80	61332	31015	79651961
Postmenopausal haemorrhage	40.39	10.90	21	61391	1531	79681445
Aortic valve incompetence	40.37	10.90	43	61369	9487	79673489
Fibromyalgia	40.26	10.90	125	61287	64215	79618761
Bronchitis	40.19	10.90	203	61209	130441	79552535
Cardiac failure congestive	40.17	10.90	216	61196	142186	79540790
Breast disorder	39.88	10.90	23	61389	2058	79680918
Morton's neuralgia	39.61	10.90	9	61403	44	79682932
Vaginal infection	39.08	10.90	34	61378	5846	79677130
Infusion related reaction	38.73	10.90	74	61338	230163	79452813
Hyperkalaemia	38.48	10.90	20	61392	114378	79568598
Atrophic vulvovaginitis	38.48	10.90	19	61393	1242	79681734
Chronic disease	38.47	10.90	11	61401	150	79682826
Coronary artery occlusion	38.45	10.90	53	61359	15262	79667714
Uterine leiomyoma	38.34	10.90	35	61377	6408	79676568
Fracture nonunion	37.91	10.90	20	61392	1502	79681474
Headache	37.87	10.90	710	60702	653062	79029914
Bronchial haemorrhage	37.65	10.90	19	61393	1301	79681675
Rectocele	37.07	10.90	15	61397	610	79682366
Hiatus hernia	36.60	10.90	65	61347	23247	79659729
Diverticulum	36.57	10.90	51	61361	14845	79668131
Urinary tract infection	36.02	10.90	346	61066	274166	79408810
Urinary incontinence	36.00	10.90	90	61322	40819	79642157
Platelet count decreased	35.96	10.90	59	61353	194605	79488371
Oral infection	35.93	10.90	32	61380	5675	79677301
Contraindicated product administered	35.89	10.90	41	61371	157497	79525479
Vaginal disorder	35.62	10.90	14	61398	527	79682449
Breast cyst	35.18	10.90	18	61394	1269	79681707
Pain in extremity	35.12	10.90	432	60980	364106	79318870
Septic shock	35.04	10.90	26	61386	122775	79560201
Rheumatoid factor positive	34.90	10.90	3	61409	59836	79623140
Coma	34.75	10.90	17	61395	100632	79582344
Memory impairment	34.63	10.90	174	61238	111560	79571416
Cardiac failure	34.52	10.90	41	61371	154801	79528175
Anaemia postoperative	34.02	10.90	20	61392	1854	79681122
Peripheral vascular disorder	33.61	10.90	36	61376	7994	79674982
Intentional overdose	33.51	10.90	20	61392	105940	79577036
Interstitial lung disease	33.22	10.90	23	61389	112577	79570399
Hepatic function abnormal	32.71	10.90	8	61404	73099	79609877
Ventricular dysfunction	32.53	10.90	31	61381	5992	79676984
Wrong strength	32.44	10.90	10	61402	179	79682797
Multiple organ dysfunction syndrome	32.36	10.90	27	61385	120219	79562757
Seborrhoeic keratosis	32.21	10.90	21	61391	2339	79680637
Bone density abnormal	31.76	10.90	23	61389	3037	79679939
Cervicobrachial syndrome	31.25	10.90	16	61396	1130	79681846
Drug intolerance	31.08	10.90	102	61310	264017	79418959
Palpitations	31.05	10.90	185	61227	126425	79556551
Uterine disorder	31.01	10.90	20	61392	2187	79680789
Tooth fracture	30.61	10.90	41	61371	11489	79671487
Cardiovascular disorder	30.57	10.90	52	61360	17973	79665003
Therapeutic response unexpected	30.53	10.90	55	61357	19891	79663085
Scoliosis	30.43	10.90	33	61379	7431	79675545
Product quality issue	30.22	10.90	75	61337	33865	79649111
Glossodynia	29.32	10.90	22	61390	103315	79579661
Uterine polyp	29.01	10.90	17	61395	1567	79681409
Drug effective for unapproved indication	28.89	10.90	29	61383	5972	79677004
Intervertebral disc protrusion	28.63	10.90	59	61353	23562	79659414
Blood pressure abnormal	28.42	10.90	49	61363	17120	79665856
Vulvovaginal swelling	28.25	10.90	11	61401	404	79682572
Decreased appetite	28.06	10.90	152	61260	342266	79340710
Peptic ulcer	28.01	10.90	29	61383	6194	79676782
Leukopenia	28.00	10.90	29	61383	116484	79566492
Respiratory failure	27.99	10.90	61	61351	180850	79502126
Exostosis	27.76	10.90	48	61364	16810	79666166
Vaginal prolapse	27.72	10.90	10	61402	296	79682680
Bursitis	27.59	10.90	75	61337	35769	79647207
Stomatitis	27.55	10.90	44	61368	146713	79536263
Resorption bone increased	27.46	10.90	16	61396	1459	79681517
Vaginal cyst	27.46	10.90	8	61404	117	79682859
Lactic acidosis	27.30	10.90	10	61402	70349	79612627
Rhinitis allergic	27.18	10.90	40	61372	12229	79670747
Ligament sprain	27.13	10.90	42	61370	13422	79669554
Arteriosclerosis coronary artery	27.11	10.90	49	61363	17767	79665209
Bronchial disorder	26.50	10.90	19	61393	2470	79680506
Vulvovaginal erythema	25.90	10.90	9	61403	238	79682738
Muscle spasms	25.81	10.90	226	61186	174504	79508472
Breast hyperplasia	25.81	10.90	8	61404	146	79682830
Pneumonia	25.75	10.90	356	61056	659890	79023086
Mucosal inflammation	25.73	10.90	13	61399	75567	79607409
Thyroid disorder	25.73	10.90	42	61370	14037	79668939
Hospitalisation	25.55	10.90	21	61391	94215	79588761
Panic disorder	25.53	10.90	20	61392	2972	79680004
Metabolic acidosis	25.51	10.90	16	61396	82513	79600463
Muscle strain	25.40	10.90	34	61378	9521	79673455
Hormone level abnormal	25.35	10.90	17	61395	1985	79680991
Bladder prolapse	25.11	10.90	15	61397	1432	79681544
Crying	24.97	10.90	55	61357	22988	79659988
Folliculitis	24.89	10.90	6	61406	55374	79627602
Peripheral swelling	24.76	10.90	115	61297	269502	79413474
Nerve compression	24.75	10.90	33	61379	9206	79673770
Vaginal odour	24.52	10.90	10	61402	415	79682561
Cardiac valve disease	24.49	10.90	26	61386	5715	79677261
Lumbar spinal stenosis	24.47	10.90	25	61387	5257	79677719
Breast pain	24.45	10.90	31	61381	8234	79674742
Tooth disorder	24.45	10.90	59	61353	26174	79656802
Foot fracture	24.43	10.90	53	61359	21928	79661048
Agranulocytosis	24.34	10.90	3	61409	45027	79637949
Rhonchi	24.17	10.90	22	61390	4014	79678962
Aortic arteriosclerosis	24.12	10.90	32	61380	8886	79674090
Subclavian artery embolism	23.93	10.90	5	61407	15	79682961
Nocturia	23.91	10.90	40	61372	13641	79669335
Cystitis	23.87	10.90	92	61320	52640	79630336
Encephalopathy	23.85	10.90	11	61401	67386	79615590
Cerebrovascular disorder	23.77	10.90	21	61391	3684	79679292
Seasonal allergy	23.54	10.90	44	61368	16362	79666614
Osteoporosis	23.35	10.90	93	61319	54019	79628957
Arthritis	23.31	10.90	160	61252	114720	79568256
Haemoglobin decreased	23.31	10.90	90	61322	222029	79460947
Vertigo	23.13	10.90	110	61302	68972	79614004
Multiple sclerosis	22.82	10.90	52	61360	22230	79660746
Hyponatraemia	22.82	10.90	66	61346	177782	79505194
Cytomegalovirus infection	22.67	10.90	3	61409	42641	79640335
Varicose vein	22.47	10.90	22	61390	4397	79678579
Modified radical mastectomy	22.44	10.90	4	61408	3	79682973
Drug resistance	22.37	10.90	3	61409	42210	79640766
Gingivitis	22.32	10.90	31	61381	8990	79673986
Cholelithiasis	22.32	10.90	90	61322	52574	79630402
Bone disorder	22.30	10.90	47	61365	19066	79663910
Eosinophilia	22.26	10.90	4	61408	45341	79637635
Gallbladder disorder	21.91	10.90	47	61365	19293	79663683
Anaemia	21.90	10.90	228	61184	444787	79238189
Drug abuser	21.79	10.90	25	61387	5988	79676988
Toxic epidermal necrolysis	21.74	10.90	4	61408	44577	79638399
Chronic obstructive pulmonary disease	21.70	10.90	126	61286	85293	79597683
Blood oestrogen decreased	21.53	10.90	7	61405	150	79682826
Hypertonic bladder	21.52	10.90	21	61391	4180	79678796
Hypoglycaemia	21.49	10.90	28	61384	101566	79581410
Confusional state	21.44	10.90	150	61262	317847	79365129
Suspected counterfeit product	21.43	10.90	10	61402	576	79682400
Epilepsy	21.42	10.90	3	61409	40857	79642119
Vulval oedema	21.39	10.90	6	61406	76	79682900
Granuloma	21.26	10.90	29	61383	8268	79674708
Altered state of consciousness	21.23	10.90	4	61408	43818	79639158
Dyspareunia	21.11	10.90	15	61397	1923	79681053
Non-cardiac chest pain	21.02	10.90	31	61381	9493	79673483
Cholestasis	20.92	10.90	7	61405	52102	79630874
Vulvovaginal injury	20.88	10.90	8	61404	281	79682695
Cardio-respiratory arrest	20.87	10.90	32	61380	108478	79574498
Intervertebral disc disorder	20.84	10.90	22	61390	4803	79678173
Neutrophil count decreased	20.81	10.90	25	61387	93934	79589042
Defaecation urgency	20.74	10.90	24	61388	5800	79677176
Lumbar radiculopathy	20.69	10.90	15	61397	1984	79680992
Blood pressure increased	20.55	10.90	251	61161	211109	79471867
Vaginal discharge	20.52	10.90	27	61385	7436	79675540
Road traffic accident	20.44	10.90	77	61335	43587	79639389
Hepatotoxicity	20.43	10.90	7	61405	51345	79631631
Frustration tolerance decreased	20.41	10.90	27	61385	7475	79675501
Vulvovaginal rash	20.33	10.90	6	61406	92	79682884
Gastritis	20.32	10.90	82	61330	47911	79635065
Stevens-Johnson syndrome	20.24	10.90	3	61409	39163	79643813
Rhabdomyolysis	20.24	10.90	30	61382	103101	79579875
Cardiolipin antibody positive	20.19	10.90	7	61405	184	79682792
Lung neoplasm	20.10	10.90	26	61386	7043	79675933
Eye disorder	20.07	10.90	51	61361	23361	79659615
Essential hypertension	19.99	10.90	24	61388	6029	79676947
Musculoskeletal discomfort	19.99	10.90	46	61366	19789	79663187
Dilatation atrial	19.88	10.90	19	61393	3685	79679291
Cardiac murmur	19.74	10.90	40	61372	15784	79667192
Joint injury	19.71	10.90	61	61351	31274	79651702
Affective disorder	19.71	10.90	28	61384	8291	79674685
Post procedural complication	19.49	10.90	51	61361	23778	79659198
Tendonitis	19.49	10.90	51	61361	23779	79659197
Systemic lupus erythematosus	19.44	10.90	40	61372	121109	79561867
Mixed incontinence	19.37	10.90	5	61407	45	79682931
Synovitis	19.29	10.90	56	61356	150678	79532298
Blood triglycerides increased	19.26	10.90	47	61365	20993	79661983
Carotid artery disease	19.03	10.90	15	61397	2249	79680727
Oedema mouth	18.99	10.90	17	61395	3034	79679942
Neoplasm progression	18.97	10.90	8	61404	51674	79631302
Drug-induced liver injury	18.85	10.90	14	61398	66103	79616873
Melaena	18.55	10.90	12	61400	60878	79622098
Dyslexia	18.54	10.90	7	61405	236	79682740
Vaginal cancer metastatic	18.51	10.90	3	61409	0	79682976
Sinusitis	18.50	10.90	231	61181	195270	79487706
Product use in unapproved indication	18.43	10.90	115	61297	250244	79432732
Infection	18.33	10.90	110	61302	241602	79441374
Large intestine polyp	18.13	10.90	34	61378	12674	79670302
Dizziness	18.11	10.90	532	60880	525909	79157067
Lower respiratory tract infection	18.04	10.90	46	61366	129174	79553802
Tooth abscess	17.92	10.90	39	61373	16171	79666805
Sleep disorder	17.78	10.90	120	61292	85557	79597419
Device failure	17.76	10.90	23	61389	6238	79676738
Mitral valve calcification	17.44	10.90	12	61400	1461	79681515
Pain	17.33	10.90	684	60728	703118	78979858
Discomfort	17.32	10.90	45	61367	125572	79557404
Hypothyroidism	17.23	10.90	83	61329	52309	79630667
Ascites	16.84	10.90	20	61392	75542	79607434
Blood creatinine increased	16.80	10.90	62	61350	154995	79527981
Skin indentation	16.77	10.90	4	61408	25	79682951
Upper respiratory tract infection	16.76	10.90	124	61288	91044	79591932
Ankle fracture	16.72	10.90	39	61373	16930	79666046
Migraine with aura	16.70	10.90	15	61397	2690	79680286
Oestrogen deficiency	16.69	10.90	5	61407	81	79682895
Spinal disorder	16.61	10.90	29	61383	10231	79672745
Thyroid neoplasm	16.55	10.90	16	61396	3148	79679828
Cervical spinal stenosis	16.41	10.90	14	61398	2345	79680631
Injury	16.36	10.90	109	61303	77387	79605589
Phyllodes tumour	16.26	10.90	4	61408	29	79682947
Endometrial cancer stage I	16.16	10.90	6	61406	193	79682783
Vomiting	16.16	10.90	390	61022	665438	79017538
Chronic fatigue syndrome	16.01	10.90	11	61401	1336	79681640
Melanocytic naevus	15.99	10.90	19	61393	4722	79678254
Pollakiuria	15.99	10.90	64	61348	37253	79645723
Labile hypertension	15.95	10.90	8	61404	541	79682435
Carotid bruit	15.93	10.90	9	61403	774	79682202
Vaginal dysplasia	15.92	10.90	4	61408	32	79682944
Tender joint count	15.87	10.90	6	61406	203	79682773
Rash maculo-papular	15.83	10.90	12	61400	56066	79626910
Breast disorder female	15.80	10.90	5	61407	98	79682878
Neurotoxicity	15.68	10.90	3	61409	32515	79650461
Bone marrow failure	15.66	10.90	10	61402	51097	79631879
Intentional self-injury	15.61	10.90	3	61409	32416	79650560
Illness	15.53	10.90	74	61338	46437	79636539
Gait disturbance	15.48	10.90	235	61177	207271	79475705
Urge incontinence	15.47	10.90	10	61402	1098	79681878
Uterine prolapse	15.43	10.90	9	61403	822	79682154
Osteomyelitis	15.42	10.90	58	61354	32807	79650169
Radicular pain	15.38	10.90	7	61405	381	79682595
Burning sensation	15.23	10.90	87	61325	58545	79624431
Diabetes mellitus	15.21	10.90	108	61304	78282	79604694
Vision blurred	15.13	10.90	136	61276	105762	79577214
Hepatic enzyme increased	14.97	10.90	81	61331	182529	79500447
Bladder disorder	14.96	10.90	26	61386	9139	79673837
Endometrial hyperplasia	14.84	10.90	8	61404	628	79682348
Kyphosis	14.82	10.90	14	61398	2677	79680299
Poor quality product administered	14.66	10.90	16	61396	3629	79679347
Gingival disorder	14.63	10.90	16	61396	3635	79679341
Hypercholesterolaemia	14.56	10.90	45	61367	23050	79659926
Nerve injury	14.50	10.90	26	61386	9366	79673610
Cardiomegaly	14.49	10.90	49	61363	26303	79656673
Bone fragmentation	14.45	10.90	8	61404	662	79682314
Sinus disorder	14.38	10.90	44	61368	22420	79660556
Plague	14.36	10.90	3	61409	9	79682967
Blood bilirubin increased	14.27	10.90	18	61394	66214	79616762
Gingival recession	14.25	10.90	10	61402	1257	79681719
Abdominal discomfort	14.21	10.90	124	61288	250603	79432373
White blood cell count decreased	14.10	10.90	86	61326	188202	79494774
Emotional disorder	14.10	10.90	33	61379	14354	79668622
Intentional product misuse	14.00	10.90	123	61289	95042	79587934
Urethral disorder	13.96	10.90	5	61407	145	79682831
Hyperhidrosis	13.90	10.90	178	61234	151314	79531662
Depressed level of consciousness	13.81	10.90	34	61378	96618	79586358
Limb injury	13.76	10.90	52	61360	29476	79653500
Cardiac arrest	13.75	10.90	77	61335	172019	79510957
Diarrhoea	13.72	10.90	547	60865	879942	78803034
Liver injury	13.70	10.90	14	61398	56600	79626376
Endometrial cancer	13.70	10.90	12	61400	2082	79680894
Drug withdrawal syndrome	13.66	10.90	58	61354	34660	79648316
Plantar fasciitis	13.59	10.90	15	61397	3445	79679531
Electrocardiogram QT prolonged	13.54	10.90	31	61381	90355	79592621
Biopsy breast abnormal	13.50	10.90	3	61409	13	79682963
Fungal cystitis	13.50	10.90	3	61409	13	79682963
Amnesia	13.49	10.90	89	61323	62968	79620008
Rhinitis	13.47	10.90	33	61379	14774	79668202
Jaw fracture	13.47	10.90	14	61398	3003	79679973
Overdose	13.35	10.90	85	61327	184121	79498855
Vaginal erosion	13.32	10.90	3	61409	14	79682962
Glucose tolerance impaired	13.29	10.90	23	61389	8061	79674915
Arthralgia	13.19	10.90	552	60860	571251	79111725
Cerebral haemorrhage	13.14	10.90	15	61397	57658	79625318
Post procedural cellulitis	13.06	10.90	4	61408	70	79682906
Barrett's oesophagus	13.04	10.90	8	61404	801	79682175
Hyperaesthesia teeth	12.93	10.90	11	61401	1835	79681141
COVID-19	12.89	10.90	70	61342	157604	79525372
Periodontal disease	12.81	10.90	11	61401	1859	79681117
Blister	12.79	10.90	48	61364	119428	79563548
Suicide attempt	12.79	10.90	28	61384	82904	79600072
Ischaemic cardiomyopathy	12.79	10.90	22	61390	7673	79675303
Major depression	12.78	10.90	24	61388	8956	79674020
Gamma-glutamyltransferase increased	12.70	10.90	14	61398	54666	79628310
Gastroenteritis	12.69	10.90	56	61356	34026	79648950
Change of bowel habit	12.68	10.90	13	61399	2744	79680232
Skin laceration	12.67	10.90	50	61362	28912	79654064
Coronary artery stenosis	12.64	10.90	29	61383	12455	79670521
Benign breast neoplasm	12.58	10.90	8	61404	854	79682122
Visual impairment	12.49	10.90	117	61295	92014	79590962
Neck pain	12.43	10.90	100	61312	75317	79607659
Micturition urgency	12.39	10.90	29	61383	12612	79670364
Palmar-plantar erythrodysaesthesia syndrome	12.37	10.90	5	61407	33129	79649847
Progressive multiple sclerosis	12.30	10.90	9	61403	1208	79681768
Vulval disorder	12.30	10.90	7	61405	611	79682365
Transaminases increased	12.29	10.90	13	61399	51730	79631246
Stress	12.28	10.90	104	61308	79508	79603468
Calcium deficiency	12.27	10.90	8	61404	891	79682085
Lymphocyte count decreased	12.25	10.90	11	61401	47278	79635698
Laryngeal pain	12.22	10.90	19	61393	6095	79676881
Goitre	12.18	10.90	18	61394	5521	79677455
Postmenopause	12.05	10.90	3	61409	23	79682953
Costochondritis	12.04	10.90	12	61400	2449	79680527
Marital problem	12.01	10.90	5	61407	219	79682757
Tonsillar disorder	11.98	10.90	9	61403	1257	79681719
Sciatica	11.93	10.90	54	61358	33168	79649808
Mobility decreased	11.87	10.90	51	61361	122124	79560852
Knee deformity	11.86	10.90	9	61403	1276	79681700
Cervical radiculopathy	11.86	10.90	9	61403	1276	79681700
Intermittent claudication	11.86	10.90	14	61398	3457	79679519
Radiculopathy	11.84	10.90	23	61389	8801	79674175
Vulvovaginal mycotic infection	11.76	10.90	16	61396	4550	79678426
Menopause	11.70	10.90	11	61401	2091	79680885
Breast reconstruction	11.69	10.90	4	61408	101	79682875
Salpingo-oophorectomy bilateral	11.53	10.90	3	61409	28	79682948
Posterior reversible encephalopathy syndrome	11.52	10.90	3	61409	26278	79656698
Psoriatic arthropathy	11.49	10.90	27	61385	77972	79605004
Swelling	11.49	10.90	109	61303	216602	79466374
Shock	11.44	10.90	10	61402	43538	79639438
Agitation	11.38	10.90	39	61373	99676	79583300
Red blood cells urine	11.37	10.90	7	61405	706	79682270
Loose tooth	11.36	10.90	13	61399	3104	79679872
COVID-19 pneumonia	11.36	10.90	4	61408	28845	79654131
Intermenstrual bleeding	11.36	10.90	18	61394	5866	79677110
Clubbing	11.35	10.90	7	61405	708	79682268
Pelvic pain	11.31	10.90	29	61383	13352	79669624
Generalised anxiety disorder	11.29	10.90	11	61401	2186	79680790
Anxiety disorder	11.29	10.90	15	61397	4172	79678804
Cystitis interstitial	11.27	10.90	9	61403	1374	79681602
Back injury	11.27	10.90	25	61387	10498	79672478
Therapy interrupted	11.27	10.90	5	61407	31336	79651640
Asthma	11.26	10.90	156	61256	134939	79548037
Face injury	11.25	10.90	14	61398	3650	79679326
Aortic valve sclerosis	11.24	10.90	10	61402	1770	79681206
Influenza like illness	11.24	10.90	94	61318	71613	79611363
Skin abrasion	11.21	10.90	29	61383	13427	79669549
Tibia fracture	11.19	10.90	17	61395	5344	79677632
Bradycardia	11.18	10.90	60	61352	135497	79547479
Erythema	11.13	10.90	114	61298	223176	79459800
Procedural pain	11.04	10.90	41	61371	23043	79659933
Musculoskeletal chest pain	11.04	10.90	43	61369	24721	79658255
Low density lipoprotein increased	11.00	10.90	22	61390	8600	79674376
Meningioma	10.98	10.90	15	61397	4283	79678693
Piriformis syndrome	10.97	10.90	4	61408	122	79682854
Dyspepsia	10.96	10.90	130	61282	108557	79574419
Giant cell arteritis	10.93	10.90	12	61400	2739	79680237
Urticaria pressure	10.92	10.90	3	61409	35	79682941
Heart rate irregular	10.91	10.90	52	61360	32627	79650349

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G03CA57	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM ESTROGENS Natural and semisynthetic estrogens, plain
ATC	G03CC07	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM ESTROGENS Estrogens, combinations with other drugs
FDA CS	M0007792	Estrogens, Conjugated (USP)
FDA MoA	N0000000100	Estrogen Receptor Agonists
MeSH PA	D004967	Estrogens
MeSH PA	D006728	Hormones
FDA EPC	N0000175825	Estrogen

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Dyspareunia	indication	71315007
Menopausal flushing	indication	198436008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
EQ 20MG BASE;0.45MG	DUAVEE	WYETH PHARMS	N022247	Oct. 3, 2013	RX	TABLET	ORAL	6479535	May 6, 2024	PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS
EQ 20MG BASE;0.45MG	DUAVEE	WYETH PHARMS	N022247	Oct. 3, 2013	RX	TABLET	ORAL	6479535	May 6, 2024	TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
EQ 20MG BASE;0.45MG	DUAVEE	WYETH PHARMS	N022247	Oct. 3, 2013	RX	TABLET	ORAL	7683051	March 10, 2027	PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS
EQ 20MG BASE;0.45MG	DUAVEE	WYETH PHARMS	N022247	Oct. 3, 2013	RX	TABLET	ORAL	7683051	March 10, 2027	TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Estrogen receptor	Nuclear hormone receptor	P03372	ESR1_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL
Estrogen receptor beta	Nuclear hormone receptor	Q92731	ESR2_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D04070	KEGG_DRUG
4018403	VUID
N0000167510	NUI
4018403	VANDF
CHEBI:8389	CHEBI
CHEMBL1201649	ChEMBL_ID
DB00286	DRUGBANK_ID
202896	RXNORM
307	MMSL
4500	MMSL
d00541	MMSL
001272	NDDF
126098001	SNOMEDCT_US
16832004	SNOMEDCT_US
C0014938	UMLSCUI
D004966	MESH_DESCRIPTOR_UI
3001028	PUBCHEM_CID
IU5QR144QX	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Duavee	HUMAN PRESCRIPTION DRUG LABEL	2	0008-1123	TABLET, FILM COATED	0.45 mg	ORAL	NDA	34 sections
Duavee	HUMAN PRESCRIPTION DRUG LABEL	2	0008-1123	TABLET, FILM COATED	0.45 mg	ORAL	NDA	34 sections
Duavee	HUMAN PRESCRIPTION DRUG LABEL	2	0008-1123	TABLET, FILM COATED	0.45 mg	ORAL	NDA	34 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	0046-0749	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	25 mg	INTRAVENOUS	NDA	26 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	0046-0749	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	25 mg	INTRAVENOUS	NDA	26 sections
Premarin Vaginal	HUMAN PRESCRIPTION DRUG LABEL	1	0046-0872	CREAM	0.63 mg	VAGINAL	NDA	32 sections
Premarin Vaginal	HUMAN PRESCRIPTION DRUG LABEL	1	0046-0872	CREAM	0.63 mg	VAGINAL	NDA	32 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	0046-1100	TABLET, FILM COATED	0.30 mg	ORAL	NDA	32 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	0046-1101	TABLET, FILM COATED	0.45 mg	ORAL	NDA	32 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	0046-1102	TABLET, FILM COATED	0.63 mg	ORAL	NDA	32 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	0046-1103	TABLET, FILM COATED	0.90 mg	ORAL	NDA	32 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	0046-1104	TABLET, FILM COATED	1.25 mg	ORAL	NDA	32 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1105	TABLET, SUGAR COATED	0.30 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1105	TABLET, SUGAR COATED	0.30 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1106	TABLET, SUGAR COATED	0.45 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1106	TABLET, SUGAR COATED	0.45 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1107	TABLET, SUGAR COATED	0.63 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1107	TABLET, SUGAR COATED	0.63 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1108	TABLET, SUGAR COATED	0.63 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1108	TABLET, SUGAR COATED	0.63 mg	ORAL	NDA	30 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	43353-687	TABLET, FILM COATED	0.30 mg	ORAL	NDA	25 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	43353-688	TABLET, FILM COATED	0.63 mg	ORAL	NDA	25 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0167	TABLET, FILM COATED	0.63 mg	ORAL	NDA	31 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0167	TABLET, FILM COATED	0.63 mg	ORAL	NDA	31 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	50090-0573	TABLET, SUGAR COATED	0.63 mg	ORAL	NDA	30 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1853	TABLET, FILM COATED	0.30 mg	ORAL	NDA	31 sections
Esterified Estrogens and Methyltestosterone	HUMAN PRESCRIPTION DRUG LABEL	2	51293-639	TABLET	0.63 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Esterified Estrogens and Methyltestosterone	HUMAN PRESCRIPTION DRUG LABEL	2	51293-640	TABLET	1.25 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	53808-0770	TABLET, FILM COATED	0.63 mg	ORAL	NDA	25 sections
Premarin	HUMAN PRESCRIPTION DRUG LABEL	1	54868-0365	TABLET, FILM COATED	0.90 mg	ORAL	NDA	14 sections