conjugated estrogens ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4855 12126-59-9

Description:

MoleculeDescription

Synonyms:

  • estrogen conjugated
  • estrogenic substances, conjugated
  • oestrogens conjugated
  • conjugated estrogens
  • premarin
  • estrogens, conjugated
  • estrogens conjugated
  • conjugated oestrogens
A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
  • Molecular weight: 3556.05
  • Formula: C180H202Na10O40S10
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 74.27
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.63 mg O
0.63 mg V

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.09 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
May 8, 1942 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coronary artery disease 261.53 10.36 271 76126 29455 50499272
Vulvovaginal burning sensation 240.88 10.36 91 76306 1524 50527203
Hot flush 227.30 10.36 306 76091 43863 50484864
Cerebrovascular accident 197.12 10.36 439 75958 94241 50434486
Breast cancer 193.58 10.36 279 76118 42611 50486116
Depression 188.96 10.36 614 75783 164809 50363918
Maternal exposure during pregnancy 182.14 10.36 16 76381 159762 50368965
Vulvovaginal discomfort 154.86 10.36 71 76326 1970 50526757
Hyperlipidaemia 151.19 10.36 158 76239 17332 50511395
Exposure during pregnancy 143.84 10.36 10 76387 121005 50407722
Death 143.65 10.36 168 76229 325211 50203516
Toxicity to various agents 130.08 10.36 80 76317 212419 50316308
Schizoaffective disorder 128.53 10.36 64 76333 2142 50526585
Myocardial infarction 128.45 10.36 359 76038 88668 50440059
Anxiety 114.53 10.36 551 75846 177055 50351672
Osteoarthritis 104.24 10.36 282 76115 68324 50460403
Chest pain 103.58 10.36 534 75863 176348 50352379
Osteopenia 100.11 10.36 126 76271 16892 50511835
Vulvovaginal dryness 99.53 10.36 54 76343 2163 50526564
Fibrocystic breast disease 99.20 10.36 43 76354 1041 50527686
Gastrooesophageal reflux disease 96.58 10.36 294 76103 76134 50452593
Contraindicated product administered 95.47 10.36 53 76344 148905 50379822
Pericarditis 94.96 10.36 6 76391 78683 50450044
Wound 94.23 10.36 22 76375 105772 50422955
Systemic lupus erythematosus 93.11 10.36 48 76349 140574 50388153
Oestrogen receptor assay positive 92.45 10.36 32 76365 411 50528316
Spinal osteoarthritis 92.05 10.36 110 76287 13982 50514745
Transient ischaemic attack 91.50 10.36 170 76227 32040 50496687
Intervertebral disc degeneration 91.11 10.36 107 76290 13354 50515373
Glossodynia 90.05 10.36 31 76366 115538 50413189
Infusion related reaction 89.12 10.36 75 76322 169482 50359245
Vulvovaginal pain 88.81 10.36 50 76347 2155 50526572
Neutropenia 87.35 10.36 58 76339 147907 50380820
Hypertension 86.32 10.36 580 75817 210623 50318104
Low turnover osteopathy 86.22 10.36 61 76336 3933 50524794
Acute kidney injury 86.04 10.36 132 76265 227926 50300801
Treatment failure 83.91 10.36 52 76345 137585 50391142
Mitral valve incompetence 83.73 10.36 117 76280 17354 50511373
Carpal tunnel syndrome 80.77 10.36 113 76284 16780 50511947
Drug intolerance 80.57 10.36 129 76268 218975 50309752
Product complaint 77.37 10.36 91 76306 11375 50517352
Rotator cuff syndrome 76.87 10.36 91 76306 11453 50517274
Breast cancer in situ 76.01 10.36 39 76358 1392 50527335
Progesterone receptor assay positive 75.57 10.36 25 76372 277 50528450
Breast tenderness 75.15 10.36 44 76353 2044 50526683
Febrile neutropenia 73.02 10.36 28 76369 97639 50431088
Completed suicide 72.21 10.36 56 76341 131833 50396894
Peripheral swelling 71.32 10.36 126 76271 205810 50322917
Ventricular hypertrophy 69.16 10.36 49 76348 3166 50525561
Angina unstable 67.88 10.36 66 76331 6640 50522087
Breast cancer female 66.60 10.36 66 76331 6796 50521931
Stress fracture 66.49 10.36 66 76331 6809 50521918
Abdominal discomfort 66.41 10.36 158 76239 231483 50297244
Blood cholesterol increased 64.74 10.36 207 76190 55008 50473719
Femur fracture 64.06 10.36 161 76236 37303 50491424
Spinal stenosis 63.83 10.36 90 76307 13460 50515267
Drug abuse 60.63 10.36 9 76388 59837 50468890
Carotid artery stenosis 60.38 10.36 53 76344 4678 50524049
Meniscus injury 60.03 10.36 60 76337 6242 50522485
Breast calcifications 59.97 10.36 31 76366 1124 50527603
Rheumatoid factor positive 59.57 10.36 4 76393 49855 50478872
Arteriosclerosis 59.52 10.36 71 76326 9006 50519721
Stress urinary incontinence 57.66 10.36 37 76360 2028 50526699
Swelling 57.58 10.36 137 76260 200735 50327992
Lacunar infarction 57.22 10.36 43 76354 3044 50525683
Dental caries 56.36 10.36 72 76325 9795 50518932
Pyrexia 55.78 10.36 341 76056 379862 50148865
Feeling abnormal 55.07 10.36 351 76046 125141 50403586
Insomnia 54.22 10.36 450 75947 174415 50354312
Renal impairment 52.83 10.36 24 76373 75637 50453090
Body height decreased 52.46 10.36 66 76331 8842 50519885
General physical health deterioration 52.19 10.36 84 76313 142350 50386377
Temporomandibular joint syndrome 52.03 10.36 43 76354 3496 50525231
Coronary artery occlusion 51.37 10.36 60 76337 7443 50521284
Cardiac failure congestive 50.87 10.36 257 76140 84125 50444602
Disease progression 50.83 10.36 42 76355 95824 50432903
Angina pectoris 49.52 10.36 117 76280 26071 50502656
Vulvovaginal pruritus 49.03 10.36 36 76361 2460 50526267
Haemorrhoids 48.50 10.36 96 76301 18957 50509770
Synovitis 48.30 10.36 70 76327 123795 50404932
Breast mass 48.26 10.36 54 76343 6395 50522332
Cystocele 47.43 10.36 26 76371 1063 50527664
Exostosis of jaw 47.36 10.36 27 76370 1192 50527535
Fracture nonunion 46.05 10.36 33 76364 2171 50526556
Bronchial neoplasm 45.68 10.36 19 76378 414 50528313
Lower respiratory tract infection 45.38 10.36 46 76351 95155 50433572
Vaginal haemorrhage 44.60 10.36 108 76289 24443 50504284
Discomfort 44.51 10.36 59 76338 108321 50420406
Migraine 44.48 10.36 228 76169 75052 50453675
Product quality issue 44.02 10.36 124 76273 30734 50497993
Malignant neoplasm progression 43.96 10.36 24 76373 68100 50460627
Breast cyst 43.94 10.36 28 76369 1516 50527211
Seborrhoeic keratosis 43.83 10.36 30 76367 1833 50526894
Thrombocytopenia 43.37 10.36 79 76318 127594 50401133
Aortic valve incompetence 42.96 10.36 47 76350 5429 50523298
Anaemia postoperative 42.72 10.36 31 76366 2080 50526647
Diverticulum 42.06 10.36 65 76332 10549 50518178
Vulvovaginal swelling 42.06 10.36 18 76379 422 50528305
Pancytopenia 40.74 10.36 40 76357 83990 50444737
Nasal turbinate hypertrophy 40.70 10.36 20 76377 650 50528077
Mammogram abnormal 40.64 10.36 20 76377 652 50528075
Cataract 40.54 10.36 160 76237 47140 50481587
Stomatitis 39.78 10.36 57 76340 101287 50427440
Arteriosclerosis coronary artery 39.39 10.36 53 76344 7583 50521144
Breast disorder 39.35 10.36 29 76368 1993 50526734
Bronchial haemorrhage 39.17 10.36 18 76379 502 50528225
Peptic ulcer 39.04 10.36 38 76359 3828 50524899
Intentional overdose 38.93 10.36 23 76374 62481 50466246
Infection 38.49 10.36 133 76264 172821 50355906
Cardiac disorder 38.15 10.36 147 76250 42832 50485895
Rectocele 38.10 10.36 21 76376 868 50527859
Product prescribing error 37.85 10.36 92 76305 20869 50507858
Bursitis 37.70 10.36 95 76302 22040 50506687
Folliculitis 37.29 10.36 7 76390 39218 50489509
Cardiovascular disorder 37.27 10.36 61 76336 10393 50518334
Vulvovaginal erythema 37.19 10.36 14 76383 232 50528495
Tricuspid valve incompetence 37.01 10.36 68 76329 12702 50516025
Urinary incontinence 37.00 10.36 110 76287 28098 50500629
Menopausal symptoms 36.85 10.36 28 76369 2015 50526712
Ventricular dysfunction 36.78 10.36 31 76366 2590 50526137
Coma 36.76 10.36 20 76377 56859 50471868
Sepsis 36.23 10.36 93 76304 132832 50395895
Hepatic enzyme increased 36.01 10.36 98 76299 137282 50391445
Atrophic vulvovaginitis 35.90 10.36 25 76372 1571 50527156
Hiatus hernia 35.82 10.36 83 76314 18261 50510466
Hospitalisation 35.72 10.36 30 76367 67907 50460820
Nervousness 35.49 10.36 107 76290 27544 50501183
Postmenopausal haemorrhage 35.42 10.36 27 76370 1953 50526774
Joint swelling 35.38 10.36 221 76176 245065 50283662
Vaginal infection 34.82 10.36 45 76352 6191 50522536
Rash 34.33 10.36 460 75937 437011 50091716
Vaginal prolapse 34.08 10.36 15 76382 377 50528350
Emotional distress 34.08 10.36 108 76289 28555 50500172
Fibromyalgia 33.71 10.36 146 76251 44832 50483895
Mitral valve prolapse 33.45 10.36 27 76370 2123 50526604
Alopecia 33.20 10.36 225 76172 244822 50283905
Intramedullary rod insertion 33.00 10.36 26 76371 1974 50526753
Breast hyperplasia 32.24 10.36 13 76384 261 50528466
Nocturia 32.14 10.36 45 76352 6685 50522042
Vomiting 32.11 10.36 496 75901 460262 50068465
Drug level increased 32.09 10.36 82 76315 19186 50509541
Spondylolisthesis 31.98 10.36 31 76366 3106 50525621
Cervicobrachial syndrome 31.82 10.36 18 76379 783 50527944
Hypotension 31.50 10.36 217 76180 235252 50293475
Jaw disorder 31.32 10.36 38 76359 4905 50523822
Rhinitis allergic 31.24 10.36 46 76351 7154 50521573
Uterine leiomyoma 30.81 10.36 48 76349 7843 50520884
Large intestine polyp 30.60 10.36 46 76351 7286 50521441
Endometrial ablation 30.57 10.36 18 76379 845 50527882
Muscle strain 30.35 10.36 45 76352 7043 50521684
Nasopharyngitis 29.82 10.36 170 76227 192757 50335970
Morton's neuralgia 29.81 10.36 9 76388 72 50528655
Product dispensing error 29.19 10.36 50 76347 8841 50519886
Bronchitis 29.08 10.36 262 76135 103897 50424830
Chronic obstructive pulmonary disease 28.92 10.36 158 76239 53277 50475450
Drug withdrawal syndrome 28.45 10.36 93 76304 24988 50503739
Peripheral vascular disorder 28.28 10.36 38 76359 5429 50523298
Vaginal discharge 28.00 10.36 37 76360 5203 50523524
Therapeutic response unexpected 27.83 10.36 69 76328 15846 50512881
Cardiac failure 27.69 10.36 45 76352 75995 50452732
Lactic acidosis 27.65 10.36 8 76389 33347 50495380
Exostosis 27.61 10.36 57 76340 11596 50517131
Leukopenia 27.47 10.36 37 76360 67491 50461236
Road traffic accident 27.36 10.36 90 76307 24262 50504465
Drug ineffective 27.33 10.36 988 75409 818345 49710382
Hormone level abnormal 27.28 10.36 24 76373 2125 50526602
Expired product administered 27.22 10.36 37 76360 5345 50523382
Scoliosis 27.08 10.36 41 76356 6535 50522192
Hyperhidrosis 27.07 10.36 229 76168 89197 50439530
Platelet count decreased 27.03 10.36 71 76326 100655 50428072
Osteonecrosis 26.91 10.36 85 76312 22432 50506295
Oral infection 26.68 10.36 32 76365 4082 50524645
Bladder prolapse 26.51 10.36 22 76375 1799 50526928
Hypercholesterolaemia 26.28 10.36 56 76341 11647 50517080
Interstitial lung disease 26.13 10.36 25 76372 53151 50475576
Vaginal disorder 26.07 10.36 15 76382 674 50528053
Hepatocellular injury 26.05 10.36 4 76393 25943 50502784
Bronchial disorder 25.95 10.36 18 76379 1124 50527603
Ischaemic cardiomyopathy 25.77 10.36 24 76373 2288 50526439
Hypothyroidism 25.75 10.36 111 76286 34014 50494713
Aortic arteriosclerosis 25.72 10.36 36 76361 5346 50523381
Breast conserving surgery 25.59 10.36 16 76381 838 50527889
Muscle injury 25.55 10.36 12 76385 37099 50491628
Cardiac valve disease 25.46 10.36 30 76367 3756 50524971
Premature delivery 25.30 10.36 3 76394 23660 50505067
Blood triglycerides increased 25.25 10.36 54 76343 11258 50517469
Acute myocardial infarction 25.06 10.36 99 76298 29174 50499553
Burning sensation 25.01 10.36 135 76262 45311 50483416
Lumbar spinal stenosis 24.81 10.36 31 76366 4123 50524604
Mucosal inflammation 24.67 10.36 15 76382 40127 50488600
Muscle spasms 24.67 10.36 294 76103 125259 50403468
Back pain 24.05 10.36 466 75931 219564 50309163
Diarrhoea 24.02 10.36 691 75706 587785 49940942
Panic disorder 23.94 10.36 23 76374 2280 50526447
Vulvovaginal injury 23.87 10.36 12 76385 410 50528317
Tooth fracture 23.81 10.36 48 76349 9603 50519124
Septic shock 23.59 10.36 31 76366 57144 50471583
Poor quality product administered 23.52 10.36 25 76372 2794 50525933
Drug abuser 23.46 10.36 25 76372 2803 50525924
Blood oestrogen decreased 23.42 10.36 10 76387 233 50528494
Hepatic function abnormal 23.39 10.36 10 76387 32671 50496056
Memory impairment 23.37 10.36 202 76195 79158 50449569
Thyroid disorder 23.27 10.36 56 76341 12621 50516106
Lumbar radiculopathy 23.17 10.36 20 76377 1726 50527001
Resorption bone increased 23.12 10.36 16 76381 995 50527732
Breast pain 22.91 10.36 41 76356 7503 50521224
Amnesia 22.90 10.36 125 76272 42135 50486592
Drug effective for unapproved indication 22.67 10.36 21 76376 1988 50526739
Intervertebral disc protrusion 22.58 10.36 75 76322 20318 50508409
Osteoporosis 22.50 10.36 130 76267 44749 50483978
Cardiac murmur 22.39 10.36 50 76347 10734 50517993
Neoplasm progression 22.39 10.36 8 76389 29149 50499578
Blister 22.32 10.36 61 76336 85357 50443370
Hyperkalaemia 22.05 10.36 24 76373 48065 50480662
Sinus rhythm 21.76 10.36 13 76384 627 50528100
Encephalopathy 21.57 10.36 12 76385 33699 50495028
Back disorder 21.44 10.36 45 76352 9260 50519467
Gingivitis 21.38 10.36 39 76358 7245 50521482
Uterine disorder 21.20 10.36 23 76374 2632 50526095
Off label use 21.17 10.36 550 75847 473876 50054851
Neutrophil count decreased 21.07 10.36 23 76374 46003 50482724
Pain in extremity 21.04 10.36 550 75847 272315 50256412
Granuloma 21.02 10.36 31 76366 4827 50523900
Bone graft 21.01 10.36 14 76383 818 50527909
Product dose omission issue 20.99 10.36 177 76220 183661 50345066
Chronic disease 20.96 10.36 7 76390 80 50528647
Ligament sprain 20.96 10.36 48 76349 10477 50518250
Uterine polyp 20.96 10.36 19 76378 1749 50526978
Coronary artery stenosis 20.96 10.36 29 76368 4260 50524467
Varicose vein 20.90 10.36 29 76368 4271 50524456
Suspected counterfeit product 20.85 10.36 10 76387 308 50528419
Device failure 20.72 10.36 33 76364 5495 50523232
Subclavian artery embolism 20.58 10.36 5 76392 15 50528712
Hypertonic bladder 20.55 10.36 24 76373 2976 50525751
Chronic fatigue syndrome 20.49 10.36 15 76382 1020 50527707
Vaginal odour 20.47 10.36 11 76386 432 50528295
Stevens-Johnson syndrome 20.42 10.36 4 76393 21748 50506979
Breast cancer metastatic 20.35 10.36 47 76350 10317 50518410
Wrong strength 20.33 10.36 6 76391 44 50528683
Bone density abnormal 20.26 10.36 24 76373 3021 50525706
Haemoglobin decreased 20.24 10.36 111 76286 127105 50401622
Rhonchi 20.22 10.36 21 76376 2286 50526441
Epilepsy 20.18 10.36 4 76393 21563 50507164
Diabetes mellitus 20.17 10.36 135 76262 48898 50479829
Pneumonia 20.11 10.36 427 75970 377974 50150753
Cerebrovascular disorder 20.00 10.36 22 76375 2556 50526171
Endometrial hyperplasia 19.99 10.36 13 76384 729 50527998
Non-cardiac chest pain 19.83 10.36 33 76364 5699 50523028
Palpitations 19.76 10.36 224 76173 94282 50434445
Libido decreased 19.70 10.36 21 76376 2355 50526372
Mobility decreased 19.49 10.36 59 76338 79889 50448838
Cervical spinal stenosis 19.43 10.36 19 76378 1924 50526803
Toxic epidermal necrolysis 19.42 10.36 4 76393 20988 50507739
Plantar fasciitis 19.40 10.36 23 76374 2898 50525829
Dizziness 19.38 10.36 671 75726 345698 50183029
Gingival disorder 19.28 10.36 24 76373 3181 50525546
Carotid artery disease 19.16 10.36 17 76380 1522 50527205
Intervertebral disc disorder 19.13 10.36 28 76369 4332 50524395
Pollakiuria 19.09 10.36 79 76318 23772 50504955
Ventricular extrasystoles 18.82 10.36 46 76351 10470 50518257
Oedema peripheral 18.78 10.36 339 76058 157622 50371105
Hyponatraemia 18.73 10.36 78 76319 96061 50432666
Altered state of consciousness 18.64 10.36 5 76392 21905 50506822
Hypoacusis 18.63 10.36 71 76326 20576 50508151
Melanocytic naevus 18.59 10.36 26 76371 3858 50524869
Radicular pain 18.44 10.36 10 76387 400 50528327
Dilatation atrial 18.41 10.36 18 76379 1823 50526904
Intentional product misuse 18.23 10.36 127 76270 46607 50482120
Anaemia 18.14 10.36 270 76127 252186 50276541
Biopsy breast abnormal 18.09 10.36 5 76392 28 50528699
Agranulocytosis 18.01 10.36 5 76392 21416 50507311
Breast cancer stage II 17.99 10.36 17 76380 1650 50527077
Cardiomegaly 17.97 10.36 59 76338 15886 50512841
Modified radical mastectomy 17.95 10.36 4 76393 7 50528720
Blood pressure increased 17.74 10.36 291 76106 132841 50395886
Homicidal ideation 17.69 10.36 17 76380 1685 50527042
Ill-defined disorder 17.51 10.36 35 76362 54619 50474108
Vitamin D deficiency 17.43 10.36 47 76350 11355 50517372
Injury 17.38 10.36 130 76267 48795 50479932
Eye disorder 17.37 10.36 65 76332 18674 50510053
Urethral stenosis 17.25 10.36 8 76389 228 50528499
Vaginal cyst 17.15 10.36 8 76389 231 50528496
Metabolic acidosis 17.12 10.36 20 76377 38805 50489922
Calcium deficiency 17.09 10.36 13 76384 937 50527790
Vulval oedema 16.90 10.36 5 76392 37 50528690
Therapeutic product effect decreased 16.90 10.36 128 76269 135922 50392805
Spinal disorder 16.79 10.36 38 76359 8232 50520495
Product residue present 16.72 10.36 24 76373 3648 50525079
Suicide attempt 16.68 10.36 33 76364 51699 50477028
Dysuria 16.59 10.36 86 76311 28418 50500309
Drug-induced liver injury 16.58 10.36 11 76386 28084 50500643
Vulvovaginal rash 16.56 10.36 7 76390 159 50528568
Cardiolipin antibody positive 16.52 10.36 7 76390 160 50528567
Plague 16.49 10.36 3 76394 0 50528727
Vaginal cancer metastatic 16.49 10.36 3 76394 0 50528727
Oral discomfort 16.45 10.36 37 76360 7980 50520747
Breast disorder female 16.42 10.36 6 76391 91 50528636
Tendonitis 16.37 10.36 59 76338 16646 50512081
Palmar-plantar erythrodysaesthesia syndrome 16.33 10.36 5 76392 20093 50508634
Multiple organ dysfunction syndrome 16.33 10.36 32 76365 50305 50478422
Osteomyelitis 16.32 10.36 72 76325 22281 50506446
Cholestasis 16.31 10.36 9 76388 25392 50503335
Dyslipidaemia 16.25 10.36 31 76366 5957 50522770
Post procedural complication 16.24 10.36 55 76342 15049 50513678
Thyroid neoplasm 16.08 10.36 23 76374 3484 50525243
Blood pressure abnormal 16.05 10.36 49 76348 12698 50516029
Lung neoplasm 16.03 10.36 29 76368 5353 50523374
Lip neoplasm 15.99 10.36 4 76393 14 50528713
White blood cell count decreased 15.87 10.36 107 76290 116615 50412112
Bone fragmentation 15.78 10.36 11 76386 692 50528035
Joint injury 15.77 10.36 70 76327 21719 50507008
Hepatotoxicity 15.61 10.36 11 76386 27215 50501512
Tooth disorder 15.44 10.36 75 76322 24153 50504574
Decreased appetite 15.44 10.36 212 76185 200711 50328016
Sleep disorder 15.42 10.36 143 76254 57140 50471587
Arthritis 15.28 10.36 199 76198 86522 50442205
Open reduction of fracture 15.26 10.36 13 76384 1102 50527625
Radiculopathy 15.19 10.36 27 76370 4914 50523813
Crying 15.09 10.36 66 76331 20350 50508377
Arthropathy 15.03 10.36 159 76238 157747 50370980
Uterine prolapse 15.00 10.36 13 76384 1128 50527599
Musculoskeletal discomfort 14.93 10.36 53 76344 14845 50513882
Gastritis 14.90 10.36 93 76304 32890 50495837
Foot fracture 14.88 10.36 65 76332 20026 50508701
Nerve compression 14.83 10.36 34 76363 7428 50521299
Device dislocation 14.78 10.36 7 76390 21539 50507188
Rheumatoid arthritis 14.76 10.36 216 76181 202334 50326393
Confusional state 14.71 10.36 195 76202 185733 50342994
Thyrotoxic periodic paralysis 14.69 10.36 4 76393 21 50528706
Micturition urgency 14.63 10.36 36 76361 8228 50520499
Lipoma 14.60 10.36 17 76380 2102 50526625
Labile hypertension 14.56 10.36 9 76388 462 50528265
Rhinitis 14.52 10.36 36 76361 8265 50520462
Eosinophilia 14.52 10.36 5 76392 18647 50510080
Onychomadesis 14.50 10.36 22 76375 3514 50525213
Cardio-respiratory arrest 14.44 10.36 38 76359 53854 50474873
Therapy non-responder 14.43 10.36 35 76362 50987 50477740
Tinnitus 14.43 10.36 82 76315 28050 50500677
Depressed level of consciousness 14.41 10.36 36 76361 51917 50476810
Disseminated intravascular coagulation 14.40 10.36 4 76393 17131 50511596
Carotid bruit 14.37 10.36 10 76387 628 50528099
Nasal septum deviation 14.31 10.36 13 76384 1200 50527527
Affective disorder 14.28 10.36 27 76370 5154 50523573
Dyspareunia 14.21 10.36 17 76380 2162 50526565
Tension headache 14.15 10.36 19 76378 2712 50526015
Tonsillar disorder 14.04 10.36 12 76385 1022 50527705
Tooth abscess 13.97 10.36 47 76350 12813 50515914
Skin indentation 13.97 10.36 4 76393 26 50528701
Intestinal adhesion lysis 13.96 10.36 3 76394 4 50528723
Salpingo-oophorectomy bilateral 13.89 10.36 6 76391 144 50528583
Anxiety disorder 13.87 10.36 22 76375 3651 50525076
Limb injury 13.86 10.36 64 76333 20186 50508541
Liver function test increased 13.84 10.36 11 76386 25595 50503132
Vertigo 13.76 10.36 129 76268 51703 50477024
Malabsorption 13.72 10.36 22 76375 3684 50525043
Periodontal disease 13.69 10.36 14 76383 1496 50527231
Vision blurred 13.65 10.36 180 76217 78467 50450260
Bone marrow failure 13.56 10.36 13 76384 27611 50501116
Oestrogen deficiency 13.55 10.36 6 76391 153 50528574
Oedema mouth 13.54 10.36 17 76380 2273 50526454
Kyphosis 13.51 10.36 17 76380 2278 50526449
Blood creatinine increased 13.50 10.36 64 76333 76096 50452631
Mixed incontinence 13.50 10.36 5 76392 79 50528648
Intermenstrual bleeding 13.49 10.36 31 76366 6783 50521944
Hypoglycaemia 13.45 10.36 39 76358 53542 50475185
Bone disorder 13.39 10.36 60 76337 18692 50510035
Urge incontinence 13.37 10.36 10 76387 703 50528024
Nerve injury 13.35 10.36 35 76362 8315 50520412
Gamma-glutamyltransferase increased 13.34 10.36 15 76382 29608 50499119
Glucose tolerance impaired 13.28 10.36 26 76371 5092 50523635
Amaurosis fugax 13.26 10.36 8 76389 393 50528334
Neurotoxicity 13.24 10.36 3 76394 14737 50513990
Alanine aminotransferase abnormal 13.15 10.36 23 76374 4133 50524594
Pneumocystis jirovecii pneumonia 13.14 10.36 3 76394 14660 50514067
Gallbladder disorder 13.04 10.36 55 76342 16687 50512040
Aortic stenosis 13.00 10.36 23 76374 4171 50524556
Laryngeal pain 12.98 10.36 23 76374 4176 50524551
Vulvovaginal mycotic infection 12.98 10.36 24 76373 4505 50524222
Fistula discharge 12.95 10.36 11 76386 929 50527798
Erythema 12.92 10.36 150 76247 146264 50382463
Skin abrasion 12.87 10.36 34 76363 8116 50520611
Fatigue 12.84 10.36 908 75489 706693 49822034
Anger 12.83 10.36 42 76355 11291 50517436
Mitral valve calcification 12.74 10.36 11 76386 950 50527777
Back injury 12.69 10.36 31 76366 7054 50521673
Respiratory failure 12.68 10.36 83 76314 91098 50437629
Emotional disorder 12.63 10.36 43 76354 11793 50516934
Foot deformity 12.63 10.36 60 76337 19150 50509577
Transaminases increased 12.63 10.36 14 76383 27810 50500917
Intermittent claudication 12.63 10.36 14 76383 1641 50527086
Barrett's oesophagus 12.47 10.36 9 76388 599 50528128
Osteoma 12.46 10.36 4 76393 40 50528687
Clostridium difficile infection 12.45 10.36 12 76385 25427 50503300
Cholelithiasis 12.43 10.36 99 76298 37874 50490853
Intentional self-injury 12.40 10.36 10 76387 23102 50505625
Influenza like illness 12.37 10.36 137 76260 57322 50471405
Vaginal dysplasia 12.37 10.36 4 76393 41 50528686
Hypersexuality 12.34 10.36 8 76389 446 50528281
Myocardial ischaemia 12.23 10.36 42 76355 11571 50517156
Chromaturia 12.21 10.36 49 76348 14541 50514186
Oxygen saturation decreased 12.15 10.36 63 76334 73185 50455542
Irritability 12.13 10.36 79 76318 28347 50500380
Gallbladder oedema 12.13 10.36 6 76391 198 50528529
Sciatica 12.09 10.36 64 76333 21318 50507409
Red blood cell sedimentation rate increased 12.08 10.36 16 76381 29400 50499327
Feelings of worthlessness 12.08 10.36 7 76390 319 50528408
Cytomegalovirus infection 12.07 10.36 6 76391 17956 50510771
Essential hypertension 12.05 10.36 23 76374 4421 50524306
Cervical radiculopathy 12.05 10.36 10 76387 818 50527909
Limb asymmetry 12.05 10.36 10 76387 818 50527909
Migraine with aura 12 10.36 16 76381 2269 50526458
Deep vein thrombosis 12.00 10.36 166 76231 73138 50455589
Pulpitis dental 11.99 10.36 10 76387 823 50527904
Musculoskeletal stiffness 11.97 10.36 130 76267 128351 50400376
Arterial occlusive disease 11.96 10.36 24 76373 4784 50523943
Endometrial cancer 11.91 10.36 18 76379 2865 50525862
Drug interaction 11.86 10.36 221 76176 199400 50329327
Hyperaesthesia teeth 11.80 10.36 13 76384 1513 50527214
Change of bowel habit 11.77 10.36 14 76383 1770 50526957
Sinus disorder 11.66 10.36 57 76340 18401 50510326
Osteomalacia 11.66 10.36 9 76388 663 50528064
Myelosuppression 11.66 10.36 3 76394 13514 50515213
Postmenopause 11.65 10.36 4 76393 50 50528677
Posterior reversible encephalopathy syndrome 11.62 10.36 4 76393 14924 50513803
Vascular calcification 11.54 10.36 9 76388 673 50528054
Hysterectomy 11.54 10.36 32 76365 7858 50520869
Endometrial cancer stage I 11.52 10.36 6 76391 221 50528506
Keratoconus 11.49 10.36 3 76394 13 50528714
Ascites 11.46 10.36 23 76374 35838 50492889
Restless legs syndrome 11.45 10.36 51 76346 15846 50512881
Breast reconstruction 11.45 10.36 6 76391 224 50528503
Bladder disorder 11.44 10.36 31 76366 7512 50521215
Defaecation urgency 11.22 10.36 18 76379 3015 50525712
Procedural pain 11.22 10.36 46 76351 13786 50514941
Nipple pain 11.20 10.36 6 76391 234 50528493
Rib fracture 11.19 10.36 58 76339 19163 50509564
Otitis media 11.17 10.36 22 76375 4327 50524400
Urethral disorder 11.17 10.36 5 76392 131 50528596
Jaw fracture 11.15 10.36 16 76381 2430 50526297
Right ventricular failure 11.15 10.36 5 76392 15888 50512839
Lymphocyte count decreased 11.12 10.36 14 76383 26293 50502434
Skin laceration 11.07 10.36 57 76340 18785 50509942
Stress 11.01 10.36 127 76270 53666 50475061
Platelet aggregation increased 10.83 10.36 3 76394 17 50528710
Mood altered 10.77 10.36 43 76354 12730 50515997
Angiopathy 10.77 10.36 21 76376 4101 50524626
Multiple injuries 10.75 10.36 13 76384 1673 50527054
Progressive multiple sclerosis 10.74 10.36 9 76388 746 50527981
Night sweats 10.70 10.36 87 76310 33487 50495240
Multiple sclerosis 10.69 10.36 60 76337 20433 50508294
Breast fibrosis 10.68 10.36 3 76394 18 50528709
Pulmonary arterial hypertension 10.64 10.36 9 76388 20310 50508417
Meralgia paraesthetica 10.61 10.36 5 76392 148 50528579
Neck pain 10.49 10.36 132 76265 56935 50471792
Rash maculo-papular 10.43 10.36 15 76382 26626 50502101
Metastases to liver 10.41 10.36 9 76388 20095 50508632
Post procedural cellulitis 10.37 10.36 4 76393 71 50528656

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hot flush 219.31 10.56 238 57718 45997 64394779
Vulvovaginal burning sensation 207.80 10.56 66 57890 1113 64439663
Depression 191.53 10.56 473 57483 182818 64257958
Coronary artery disease 184.83 10.56 249 57707 60184 64380592
Cerebrovascular accident 172.03 10.56 381 57575 137202 64303574
Death 155.30 10.56 124 57832 482581 63958195
Toxicity to various agents 150.94 10.56 69 57887 363444 64077332
Acute kidney injury 150.10 10.56 111 57845 449129 63991647
Hyperlipidaemia 143.03 10.56 137 57819 22839 64417937
Vulvovaginal discomfort 141.12 10.56 53 57903 1502 64439274
Osteoarthritis 118.69 10.56 208 57748 63128 64377648
Carpal tunnel syndrome 109.32 10.56 100 57856 15728 64425048
Anxiety 105.32 10.56 410 57546 202239 64238537
Neutropenia 104.93 10.56 42 57914 239582 64201194
Vulvovaginal dryness 104.37 10.56 43 57913 1565 64439211
Blood cholesterol increased 103.80 10.56 172 57784 49894 64390882
Oestrogen receptor assay positive 103.61 10.56 28 57928 258 64440518
Gastrooesophageal reflux disease 102.42 10.56 229 57727 82914 64357862
Chest pain 101.14 10.56 450 57506 235530 64205246
Febrile neutropenia 99.99 10.56 23 57933 187634 64253142
Hypertension 96.16 10.56 474 57482 258787 64181989
Drug abuse 95.14 10.56 6 57950 132368 64308408
Fibrocystic breast disease 95.05 10.56 31 57925 571 64440205
Breast cancer in situ 94.98 10.56 34 57922 838 64439938
Intervertebral disc degeneration 94.75 10.56 85 57871 13035 64427741
Transient ischaemic attack 94.58 10.56 154 57802 44028 64396748
Osteopenia 93.59 10.56 91 57865 15449 64425327
Breast cancer 93.52 10.56 123 57833 29025 64411751
Vulvovaginal pain 85.20 10.56 38 57918 1684 64439092
Mitral valve incompetence 82.29 10.56 108 57848 25430 64415346
Drug interaction 82.09 10.56 124 57832 361959 64078817
Spinal osteoarthritis 80.83 10.56 81 57875 14260 64426516
Completed suicide 78.02 10.56 53 57903 224361 64216415
Pyrexia 77.56 10.56 251 57705 558393 63882383
Progesterone receptor assay positive 75.63 10.56 21 57935 216 64440560
Meniscus injury 74.29 10.56 53 57903 5854 64434922
Breast cancer female 74.06 10.56 50 57906 5053 64435723
Rotator cuff syndrome 73.10 10.56 71 57885 12036 64428740
Spinal stenosis 71.83 10.56 75 57881 13856 64426920
Low turnover osteopathy 69.89 10.56 34 57922 1839 64438937
Thrombocytopenia 68.70 10.56 60 57896 223741 64217035
Fibromyalgia 67.76 10.56 118 57838 35613 64405163
Migraine 65.58 10.56 162 57794 62515 64378261
Myocardial infarction 64.15 10.56 307 57649 165514 64275262
Vulvovaginal pruritus 63.73 10.56 32 57924 1854 64438922
Product complaint 62.79 10.56 65 57891 11889 64428887
Dental caries 62.71 10.56 62 57894 10738 64430038
Stress urinary incontinence 62.63 10.56 30 57926 1568 64439208
Sepsis 62.34 10.56 69 57887 230272 64210504
Renal impairment 61.84 10.56 22 57934 134995 64305781
Ventricular hypertrophy 60.97 10.56 49 57907 6467 64434309
Body height decreased 60.68 10.56 52 57904 7502 64433274
Breast mass 58.53 10.56 44 57912 5266 64435510
Pancytopenia 58.14 10.56 28 57928 143281 64297495
Feeling abnormal 57.31 10.56 255 57701 133347 64307429
Carotid artery stenosis 56.46 10.56 51 57905 7890 64432886
Temporomandibular joint syndrome 55.98 10.56 36 57920 3352 64437424
Exostosis of jaw 54.79 10.56 25 57931 1169 64439607
Insomnia 54.62 10.56 334 57622 197502 64243274
Stress fracture 54.13 10.56 43 57913 5581 64435195
Nasal turbinate hypertrophy 53.64 10.56 20 57936 555 64440221
Vaginal haemorrhage 53.54 10.56 76 57880 19268 64421508
Femur fracture 51.28 10.56 102 57854 34033 64406743
Bronchial neoplasm 51.01 10.56 18 57938 425 64440351
Lacunar infarction 50.49 10.56 41 57915 5491 64435285
Cystocele 49.57 10.56 20 57936 689 64440087
Malignant neoplasm progression 49.01 10.56 20 57936 112851 64327925
General physical health deterioration 48.23 10.56 68 57888 204357 64236419
Haemorrhoids 47.79 10.56 81 57875 23920 64416856
Disease progression 47.19 10.56 35 57921 141645 64299131
Breast calcifications 47.00 10.56 20 57936 790 64439986
Arteriosclerosis 46.35 10.56 64 57892 15813 64424963
Hypotension 46.21 10.56 181 57775 380793 64059983
Angina unstable 46.14 10.56 63 57893 15404 64425372
Menopausal symptoms 45.14 10.56 24 57932 1566 64439210
Bursitis 44.76 10.56 74 57882 21411 64419365
Exposure during pregnancy 44.50 10.56 8 57948 77667 64363109
Tricuspid valve incompetence 44.42 10.56 65 57891 16938 64423838
Pericarditis 44.41 10.56 3 57953 62513 64378263
Mammogram abnormal 43.89 10.56 16 57940 416 64440360
Maternal exposure during pregnancy 43.26 10.56 16 57940 95868 64344908
Back pain 42.41 10.56 376 57580 249795 64190981
Emotional distress 41.84 10.56 97 57859 35941 64404835
Angina pectoris 41.44 10.56 111 57845 44970 64395806
Cardiac disorder 41.20 10.56 127 57829 55689 64385087
Breast disorder 41.11 10.56 23 57933 1661 64439115
Mitral valve prolapse 40.83 10.56 24 57932 1903 64438873
Endometrial ablation 40.67 10.56 18 57938 783 64439993
Hyperkalaemia 40.64 10.56 20 57936 101109 64339667
Cataract 40.06 10.56 119 57837 51143 64389633
Spondylolisthesis 39.65 10.56 27 57929 2767 64438009
Jaw disorder 39.59 10.56 33 57923 4584 64436192
Breast tenderness 39.47 10.56 24 57932 2025 64438751
Uterine leiomyoma 39.19 10.56 35 57921 5334 64435442
Product prescribing error 38.84 10.56 93 57863 35176 64405600
Platelet count decreased 38.36 10.56 57 57899 167654 64273122
Morton's neuralgia 38.22 10.56 9 57947 44 64440732
Hepatic function abnormal 38.22 10.56 6 57950 64307 64376469
Cardiac failure 37.64 10.56 38 57918 132335 64308441
Osteonecrosis 37.28 10.56 80 57876 28149 64412627
Coma 37.27 10.56 16 57940 87599 64353177
Headache 36.87 10.56 674 57282 528793 63911983
Atrophic vulvovaginitis 36.58 10.56 19 57937 1182 64439594
Back disorder 36.53 10.56 45 57911 9945 64430831
Aortic valve incompetence 36.34 10.56 41 57915 8260 64432516
Rectocele 36.27 10.56 15 57941 551 64440225
Exostosis 36.27 10.56 48 57908 11390 64429386
Nervousness 35.91 10.56 81 57875 29475 64411301
Fracture nonunion 35.72 10.56 20 57936 1446 64439330
Rhinitis allergic 35.54 10.56 40 57916 8038 64432738
Bronchitis 35.48 10.56 192 57764 108551 64332225
Interstitial lung disease 35.40 10.56 22 57934 97710 64343066
Hiatus hernia 35.38 10.56 64 57892 19893 64420883
Breast cyst 35.21 10.56 18 57938 1083 64439693
Septic shock 35.16 10.56 26 57930 105411 64335365
Coronary artery occlusion 34.70 10.56 52 57904 13839 64426937
Oral infection 34.59 10.56 31 57925 4746 64436030
Vaginal disorder 34.52 10.56 14 57942 489 64440287
Diverticulum 33.82 10.56 50 57906 13148 64427628
Vaginal infection 33.80 10.56 31 57925 4889 64435887
Lactic acidosis 33.75 10.56 7 57949 61403 64379373
Bronchial haemorrhage 33.44 10.56 18 57938 1204 64439572
Pain in extremity 33.18 10.56 417 57539 302668 64138108
Intentional overdose 32.92 10.56 20 57936 89924 64350852
Treatment failure 32.68 10.56 34 57922 116782 64323994
Cardiac failure congestive 32.62 10.56 215 57741 130365 64310411
Anaemia postoperative 32.35 10.56 20 57936 1738 64439038
Expired product administered 32.24 10.56 33 57923 5954 64434822
Urinary incontinence 32.21 10.56 88 57868 36063 64404713
Seborrhoeic keratosis 32.05 10.56 21 57935 2019 64438757
Peripheral vascular disorder 32.02 10.56 36 57920 7225 64433551
Ventricular dysfunction 31.99 10.56 31 57925 5239 64435537
Uterine disorder 31.75 10.56 20 57936 1797 64438979
Multiple organ dysfunction syndrome 31.32 10.56 27 57929 101386 64339390
Respiratory failure 31.15 10.56 61 57895 161122 64279654
Vaginal discharge 31.06 10.56 27 57929 3970 64436806
Bone density abnormal 30.82 10.56 23 57933 2722 64438054
Decreased appetite 30.75 10.56 139 57817 281150 64159626
Postmenopausal haemorrhage 30.74 10.56 18 57938 1417 64439359
Cervicobrachial syndrome 30.69 10.56 16 57940 1003 64439773
Tooth fracture 30.47 10.56 41 57915 9886 64430890
Scoliosis 30.03 10.56 32 57924 6050 64434726
Leukopenia 30.01 10.56 28 57928 101214 64339562
Pneumonia 30.01 10.56 340 57616 559236 63881540
Muscle spasms 29.28 10.56 222 57734 140801 64299975
Product quality issue 29.04 10.56 75 57881 29724 64411052
Resorption bone increased 28.64 10.56 16 57940 1152 64439624
Cardiovascular disorder 28.24 10.56 51 57905 15830 64424946
Wound 28.00 10.56 17 57939 76460 64364316
Vaginal prolapse 27.95 10.56 10 57946 246 64440530
Peptic ulcer 27.87 10.56 29 57927 5334 64435442
Intervertebral disc protrusion 27.56 10.56 58 57898 20133 64420643
Road traffic accident 27.55 10.56 75 57881 30670 64410106
Haemoglobin decreased 27.40 10.56 87 57869 194976 64245800
Product dispensing error 27.38 10.56 42 57914 11408 64429368
Arthritis 26.67 10.56 147 57809 83667 64357109
Vulvovaginal erythema 26.49 10.56 9 57947 189 64440587
Vulval oedema 26.46 10.56 6 57950 24 64440752
Vaginal cyst 26.30 10.56 8 57948 116 64440660
Infusion related reaction 26.28 10.56 69 57887 164398 64276378
Encephalopathy 26.22 10.56 10 57946 58809 64381967
Hypoacusis 26.14 10.56 66 57890 25801 64414975
Memory impairment 25.76 10.56 148 57808 85534 64355242
Metabolic acidosis 25.66 10.56 16 57940 70942 64369834
Breast hyperplasia 25.63 10.56 8 57948 127 64440649
Vulvovaginal swelling 25.63 10.56 10 57946 315 64440461
Sleep disorder 25.60 10.56 114 57842 59595 64381181
Sinusitis 25.56 10.56 221 57735 145707 64295069
Urinary tract infection 25.47 10.56 319 57637 231277 64209499
Palpitations 25.46 10.56 171 57785 104317 64336459
Breast cancer stage II 25.41 10.56 16 57940 1436 64439340
Hormone level abnormal 25.34 10.56 17 57939 1700 64439076
Aortic arteriosclerosis 24.68 10.56 32 57924 7444 64433332
Therapeutic response unexpected 24.57 10.56 50 57906 16951 64423825
Hospitalisation 24.49 10.56 19 57937 75188 64365588
Bronchial disorder 24.37 10.56 18 57938 2097 64438679
Contraindicated product administered 24.30 10.56 37 57919 107792 64332984
Uterine polyp 24.23 10.56 15 57941 1307 64439469
Mucosal inflammation 24.21 10.56 13 57943 62571 64378205
Hypoglycaemia 24.21 10.56 27 57929 89865 64350911
Agranulocytosis 24.05 10.56 3 57953 38226 64402550
Arteriosclerosis coronary artery 24.04 10.56 47 57909 15482 64425294
Cardio-respiratory arrest 23.92 10.56 32 57924 98361 64342415
Muscle strain 23.87 10.56 33 57923 8161 64432615
Altered state of consciousness 23.78 10.56 3 57953 37899 64402877
Cardiac arrest 23.59 10.56 66 57890 153998 64286778
Tooth disorder 23.52 10.56 58 57898 22344 64418432
Ligament sprain 23.45 10.56 38 57918 10814 64429962
Osteoporosis 23.33 10.56 87 57869 41993 64398783
Injury 23.33 10.56 106 57850 55886 64384890
Cardiac valve disease 23.32 10.56 26 57930 5169 64435607
Chronic disease 23.31 10.56 7 57949 97 64440679
Cytomegalovirus infection 23.20 10.56 3 57953 37196 64403580
Subclavian artery embolism 23.16 10.56 5 57951 15 64440761
Anaemia 23.16 10.56 223 57733 378457 64062319
Rhabdomyolysis 23.15 10.56 29 57927 91697 64349079
Peripheral swelling 23.06 10.56 103 57853 209050 64231726
Breast pain 22.96 10.56 30 57926 7031 64433745
Varicose vein 22.87 10.56 22 57934 3685 64437091
Thyroid disorder 22.67 10.56 39 57917 11653 64429123
Gingivitis 22.54 10.56 31 57925 7628 64433148
Hyponatraemia 22.38 10.56 64 57892 148275 64292501
Rhonchi 22.21 10.56 21 57935 3442 64437334
Panic disorder 22.19 10.56 19 57937 2738 64438038
Lumbar spinal stenosis 22.14 10.56 24 57932 4626 64436150
Neutrophil count decreased 22.12 10.56 22 57934 77174 64363602
Vaginal odour 22.09 10.56 9 57947 318 64440458
Hypercholesterolaemia 21.97 10.56 45 57911 15328 64425448
Cerebrovascular disorder 21.95 10.56 21 57935 3494 64437282
Vertigo 21.88 10.56 108 57848 58903 64381873
Modified radical mastectomy 21.83 10.56 4 57952 3 64440773
Cardiac murmur 21.67 10.56 38 57918 11525 64429251
Blood creatinine increased 21.67 10.56 57 57899 135725 64305051
Blood oestrogen decreased 21.66 10.56 7 57949 125 64440651
Nerve compression 21.66 10.56 30 57926 7431 64433345
Eosinophilia 21.64 10.56 4 57952 38072 64402704
Joint injury 21.59 10.56 57 57899 22890 64417886
Drug resistance 21.49 10.56 3 57953 35099 64405677
Rheumatoid factor positive 21.36 10.56 3 57953 34935 64405841
Granuloma 21.26 10.56 28 57928 6613 64434163
Cholelithiasis 21.13 10.56 89 57867 45417 64395359
Cholestasis 21.07 10.56 7 57949 44865 64395911
Bladder prolapse 21.05 10.56 13 57943 1128 64439648
Toxic epidermal necrolysis 20.92 10.56 4 57952 37162 64403614
Vulvovaginal rash 20.85 10.56 6 57950 71 64440705
Stevens-Johnson syndrome 20.80 10.56 3 57953 34246 64406530
Hypertonic bladder 20.55 10.56 20 57936 3398 64437378
Vulvovaginal injury 20.41 10.56 8 57948 255 64440521
Lumbar radiculopathy 20.35 10.56 15 57941 1742 64439034
Blood pressure abnormal 20.33 10.56 42 57914 14393 64426383
Hypothyroidism 20.27 10.56 81 57875 40376 64400400
Chronic obstructive pulmonary disease 20.24 10.56 121 57835 70927 64369849
Epilepsy 20.22 10.56 3 57953 33528 64407248
Dyspareunia 20.20 10.56 15 57941 1762 64439014
Foot fracture 20.12 10.56 48 57908 18109 64422667
Nocturia 20.04 10.56 36 57920 11129 64429647
Affective disorder 19.92 10.56 27 57929 6553 64434223
Multiple sclerosis 19.84 10.56 49 57907 18892 64421884
Sciatica 19.75 10.56 51 57905 20213 64420563
Blood pressure increased 19.53 10.56 239 57717 172313 64268463
Melaena 19.46 10.56 12 57944 53536 64387240
Cardiolipin antibody positive 19.46 10.56 7 57949 175 64440601
Dizziness 19.46 10.56 515 57441 429648 64011128
Drug abuser 19.39 10.56 25 57931 5783 64434993
Bone disorder 19.33 10.56 45 57911 16714 64424062
Lung neoplasm 19.29 10.56 26 57930 6279 64434497
Mixed incontinence 19.24 10.56 5 57951 39 64440737
Stomatitis 19.06 10.56 44 57912 109561 64331215
Crying 19.00 10.56 50 57906 20040 64420736
Confusional state 18.97 10.56 147 57809 260997 64179779
Bone marrow failure 18.49 10.56 10 57946 47942 64392834
Drug-induced liver injury 18.28 10.56 10 57946 47633 64393143
Non-cardiac chest pain 18.22 10.56 30 57926 8650 64432126
Neoplasm progression 18.20 10.56 7 57949 40957 64399819
Suspected counterfeit product 18.19 10.56 9 57947 505 64440271
Drug intolerance 18.16 10.56 97 57859 187895 64252881
Vaginal cancer metastatic 18.05 10.56 3 57953 0 64440776
Tooth abscess 18.05 10.56 39 57917 13787 64426989
Blood triglycerides increased 17.89 10.56 47 57909 18819 64421957
Eye disorder 17.88 10.56 47 57909 18822 64421954
Intervertebral disc disorder 17.81 10.56 21 57935 4436 64436340
Gallbladder disorder 17.78 10.56 44 57912 16986 64423790
Pain 17.66 10.56 635 57321 552876 63887900
Oedema mouth 17.63 10.56 17 57939 2856 64437920
Breast disorder female 17.62 10.56 5 57951 56 64440720
Carotid artery disease 17.60 10.56 15 57941 2148 64438628
Seasonal allergy 17.56 10.56 35 57921 11691 64429085
Hepatotoxicity 17.47 10.56 7 57949 39955 64400821
Skin indentation 17.45 10.56 4 57952 17 64440759
Drug effective for unapproved indication 17.41 10.56 19 57937 3689 64437087
Large intestine polyp 17.02 10.56 33 57923 10804 64429972
Amnesia 16.95 10.56 87 57869 48182 64392594
Musculoskeletal discomfort 16.94 10.56 42 57914 16235 64424541
Sinus disorder 16.94 10.56 43 57913 16865 64423911
Thyroid neoplasm 16.83 10.56 16 57940 2641 64438135
Spinal disorder 16.79 10.56 29 57927 8693 64432083
Dilatation atrial 16.76 10.56 18 57938 3432 64437344
Radiculopathy 16.74 10.56 23 57933 5655 64435121
Device failure 16.70 10.56 23 57933 5669 64435107
Intentional self-injury 16.61 10.56 3 57953 29041 64411735
Endometrial cancer stage I 16.53 10.56 6 57950 154 64440622
Upper respiratory tract infection 16.48 10.56 117 57839 72668 64368108
Cystitis 16.46 10.56 79 57877 42596 64398180
Cervical spinal stenosis 16.36 10.56 14 57942 2015 64438761
Vaginal dysplasia 16.30 10.56 4 57952 24 64440752
Ascites 16.28 10.56 19 57937 61982 64378794
Wrong strength 16.25 10.56 6 57950 162 64440614
Procedural pain 16.12 10.56 40 57916 15468 64425308
Osteomyelitis 16.10 10.56 58 57898 27529 64413247
Oestrogen deficiency 16.10 10.56 5 57951 78 64440698
Gastritis 15.80 10.56 78 57878 42540 64398236
Vomiting 15.79 10.56 376 57580 550741 63890035
Carotid bruit 15.78 10.56 9 57947 674 64440102
Melanocytic naevus 15.78 10.56 19 57937 4101 64436675
Tendonitis 15.76 10.56 47 57909 20235 64420541
Phyllodes tumour 15.65 10.56 4 57952 29 64440747
Urge incontinence 15.60 10.56 10 57946 926 64439850
Foot deformity 15.53 10.56 41 57915 16463 64424313
Endometrial hyperplasia 15.43 10.56 8 57948 496 64440280
Electrocardiogram QT prolonged 15.40 10.56 30 57926 79418 64361358
Dyspepsia 15.31 10.56 124 57832 80188 64360588
Neurotoxicity 15.31 10.56 3 57953 27401 64413375
Tension headache 15.31 10.56 17 57939 3366 64437410
Stress 15.30 10.56 100 57856 60434 64380342
Essential hypertension 15.25 10.56 21 57935 5173 64435603
Post procedural complication 15.21 10.56 48 57908 21305 64419471
Rash maculo-papular 15.16 10.56 12 57944 47014 64393762
Uterine prolapse 15.12 10.56 9 57947 730 64440046
Radicular pain 14.90 10.56 7 57949 350 64440426
Migraine with aura 14.79 10.56 14 57942 2298 64438478
Rhinitis 14.78 10.56 31 57925 10734 64430042
Glossodynia 14.77 10.56 22 57934 64674 64376102
Plague 14.76 10.56 3 57953 6 64440770
Contusion 14.74 10.56 162 57794 113803 64326973
Blood bilirubin increased 14.73 10.56 18 57938 57535 64383241
Diarrhoea 14.67 10.56 517 57439 722187 63718589
Defaecation urgency 14.63 10.56 18 57938 3971 64436805
Dyslexia 14.57 10.56 6 57950 218 64440558
Asthma 14.52 10.56 140 57816 95085 64345691
Progressive multiple sclerosis 14.51 10.56 9 57947 787 64439989
Ankle fracture 14.31 10.56 37 57919 14673 64426103
Arthralgia 14.24 10.56 508 57448 441752 63999024
Plantar fasciitis 14.21 10.56 15 57941 2805 64437971
Mitral valve calcification 14.14 10.56 11 57945 1385 64439391
Cerebral haemorrhage 14.14 10.56 15 57941 51075 64389701
Lower respiratory tract infection 14.13 10.56 41 57915 94573 64346203
Pollakiuria 14.12 10.56 61 57895 31469 64409307
Hyperhidrosis 14.12 10.56 173 57783 124747 64316029
Gingival recession 14.11 10.56 10 57946 1093 64439683
Nerve injury 14.07 10.56 25 57931 7660 64433116
Diabetes mellitus 13.98 10.56 105 57851 66369 64374407
Overdose 13.97 10.56 85 57871 159481 64281295
Infection 13.93 10.56 103 57853 184777 64255999
Depressed level of consciousness 13.91 10.56 33 57923 81403 64359373
Back injury 13.90 10.56 25 57931 7732 64433044
Bone fragmentation 13.83 10.56 8 57948 616 64440160
Gingival disorder 13.76 10.56 16 57940 3328 64437448
Gamma-glutamyltransferase increased 13.70 10.56 14 57942 48496 64392280
Biopsy breast abnormal 13.66 10.56 3 57953 10 64440766
Illness 13.56 10.56 47 57909 21891 64418885
Urethral disorder 13.50 10.56 5 57951 136 64440640
Agitation 13.41 10.56 38 57918 88329 64352447
Chronic fatigue syndrome 13.39 10.56 10 57946 1185 64439591
Night sweats 13.38 10.56 66 57890 35980 64404796
White blood cell count decreased 13.34 10.56 85 57871 157752 64283024
Clostridium difficile infection 13.29 10.56 8 57948 36155 64404621
Micturition urgency 13.27 10.56 29 57927 10330 64430446
Glucose tolerance impaired 13.16 10.56 22 57934 6421 64434355
Bradycardia 13.15 10.56 58 57898 118161 64322615
Skin laceration 13.13 10.56 50 57906 24367 64416409
Hyperaesthesia teeth 13.08 10.56 11 57945 1546 64439230
Endometrial cancer 13.05 10.56 12 57944 1898 64438878
Gastrointestinal haemorrhage 12.92 10.56 68 57888 132244 64308532
Vision blurred 12.90 10.56 131 57825 90185 64350591
Vaginal erosion 12.86 10.56 3 57953 14 64440762
Neck pain 12.83 10.56 97 57859 61436 64379340
International normalised ratio increased 12.80 10.56 33 57923 79134 64361642
Erythema 12.80 10.56 107 57849 186963 64253813
Suicide attempt 12.75 10.56 28 57928 70979 64369797
Vulval disorder 12.69 10.56 7 57949 492 64440284
Cervical radiculopathy 12.68 10.56 9 57947 986 64439790
Palmar-plantar erythrodysaesthesia syndrome 12.68 10.56 5 57951 28814 64411962
Jaw fracture 12.65 10.56 14 57942 2760 64438016
Tonsillar disorder 12.63 10.56 9 57947 992 64439784
Frustration tolerance decreased 12.63 10.56 21 57935 6104 64434672
Bladder disorder 12.63 10.56 24 57932 7743 64433033
Poor quality product administered 12.60 10.56 15 57941 3200 64437576
Calcium deficiency 12.59 10.56 8 57948 730 64440046
Kyphosis 12.54 10.56 13 57943 2380 64438396
Limb injury 12.53 10.56 48 57908 23457 64417319
Major depression 12.52 10.56 24 57932 7792 64432984
Post procedural cellulitis 12.45 10.56 4 57952 70 64440706
Transaminases increased 12.44 10.56 13 57943 44581 64396195
Benign breast neoplasm 12.41 10.56 8 57948 748 64440028
Lymphocyte count decreased 12.36 10.56 11 57945 40688 64400088
Visual impairment 12.34 10.56 111 57845 73966 64366810
Change of bowel habit 12.34 10.56 13 57943 2425 64438351
Blood creatine phosphokinase increased 12.34 10.56 21 57935 58537 64382239
Cardiomegaly 12.33 10.56 48 57908 23636 64417140
Aggression 12.32 10.56 14 57942 46218 64394558
Periodontal disease 12.30 10.56 11 57945 1680 64439096
Labile hypertension 12.24 10.56 7 57949 527 64440249
Barrett's oesophagus 12.23 10.56 8 57948 767 64440009
Ischaemic cardiomyopathy 12.21 10.56 22 57934 6816 64433960
Menopause 12.20 10.56 11 57945 1697 64439079
Alanine aminotransferase abnormal 12.09 10.56 22 57934 6866 64433910
Shock 12.02 10.56 10 57946 38230 64402546
Folliculitis 12 10.56 6 57950 30071 64410705
Gastric disorder 11.96 10.56 55 57901 29142 64411634
Postmenopause 11.95 10.56 3 57953 20 64440756
Burning sensation 11.92 10.56 81 57875 49583 64391193
Intentional product misuse 11.88 10.56 108 57848 72187 64368589
Posterior reversible encephalopathy syndrome 11.84 10.56 3 57953 22943 64417833
Therapy non-responder 11.82 10.56 26 57930 65873 64374903
Pneumonia aspiration 11.82 10.56 22 57934 59249 64381527
Bone density decreased 11.78 10.56 27 57929 9925 64430851
Breast reconstruction 11.69 10.56 4 57952 86 64440690
Coronary artery stenosis 11.68 10.56 29 57927 11219 64429557
Product use in unapproved indication 11.64 10.56 102 57854 176516 64264260
Intermittent claudication 11.56 10.56 14 57942 3040 64437736
Goitre 11.55 10.56 18 57938 4955 64435821
COVID-19 11.44 10.56 26 57930 65114 64375662
Drug withdrawal syndrome 11.41 10.56 57 57899 31234 64409542
Face injury 11.37 10.56 14 57942 3091 64437685
Salpingo-oophorectomy bilateral 11.37 10.56 3 57953 25 64440751
Withdrawal bleed 11.37 10.56 3 57953 25 64440751
Somatic symptom disorder 11.36 10.56 11 57945 1857 64438919
Oedema peripheral 11.34 10.56 258 57698 210059 64230717
Marital problem 11.33 10.56 5 57951 216 64440560
Thyrotoxic periodic paralysis 11.23 10.56 4 57952 97 64440679
Intermenstrual bleeding 11.14 10.56 18 57938 5107 64435669
Nasal septum deviation 11.12 10.56 10 57946 1538 64439238
Laryngeal pain 11.11 10.56 19 57937 5649 64435127
Adverse event 11.08 10.56 67 57889 39422 64401354
Skin abrasion 11.03 10.56 29 57927 11616 64429160
Poisoning 11.02 10.56 3 57953 21876 64418900
Epistaxis 11 10.56 48 57908 98083 64342693
Laryngitis 10.99 10.56 28 57928 11003 64429773
Gait disturbance 10.84 10.56 216 57740 171939 64268837
Drug hypersensitivity 10.80 10.56 285 57671 237530 64203246
Tibia fracture 10.78 10.56 17 57939 4728 64436048
Heart rate irregular 10.75 10.56 51 57905 27362 64413414
Gastroenteritis 10.74 10.56 54 57902 29657 64411119
Piriformis syndrome 10.69 10.56 4 57952 112 64440664
Pneumonitis 10.67 10.56 18 57938 50347 64390429
Anxiety disorder 10.60 10.56 15 57941 3790 64436986

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03CA57 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ESTROGENS
Natural and semisynthetic estrogens, plain
ATC G03CC07 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ESTROGENS
Estrogens, combinations with other drugs
FDA CS M0007792 Estrogens, Conjugated (USP)
FDA MoA N0000000100 Estrogen Receptor Agonists
MeSH PA D004967 Estrogens
MeSH PA D006728 Hormones
FDA EPC N0000175825 Estrogen

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dyspareunia indication 71315007
Menopausal flushing indication 198436008




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 20MG BASE;0.45MG DUAVEE WYETH PHARMS N022247 Oct. 3, 2013 RX TABLET ORAL 6479535 May 6, 2024 PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS
EQ 20MG BASE;0.45MG DUAVEE WYETH PHARMS N022247 Oct. 3, 2013 RX TABLET ORAL 6479535 May 6, 2024 TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
EQ 20MG BASE;0.45MG DUAVEE WYETH PHARMS N022247 Oct. 3, 2013 RX TABLET ORAL 7683051 March 10, 2027 PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS
EQ 20MG BASE;0.45MG DUAVEE WYETH PHARMS N022247 Oct. 3, 2013 RX TABLET ORAL 7683051 March 10, 2027 TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL
Estrogen receptor beta Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D04070 KEGG_DRUG
4018403 VUID
N0000167510 NUI
4018403 VANDF
CHEBI:8389 CHEBI
CHEMBL1201649 ChEMBL_ID
DB00286 DRUGBANK_ID
23667301 PUBCHEM_CID
202896 RXNORM
307 MMSL
4500 MMSL
d00541 MMSL
001272 NDDF
126098001 SNOMEDCT_US
16832004 SNOMEDCT_US
D004966 MESH_DESCRIPTOR_UI
C0014938 UMLSCUI
IU5QR144QX UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Duavee HUMAN PRESCRIPTION DRUG LABEL 2 0008-1123 TABLET, FILM COATED 0.45 mg ORAL NDA 32 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 0046-0749 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 25 mg INTRAVENOUS NDA 26 sections
Premarin Vaginal HUMAN PRESCRIPTION DRUG LABEL 1 0046-0872 CREAM 0.63 mg VAGINAL NDA 32 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 0046-1100 TABLET, FILM COATED 0.30 mg ORAL NDA 32 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 0046-1101 TABLET, FILM COATED 0.45 mg ORAL NDA 32 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 0046-1102 TABLET, FILM COATED 0.63 mg ORAL NDA 32 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 0046-1103 TABLET, FILM COATED 0.90 mg ORAL NDA 32 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 0046-1104 TABLET, FILM COATED 1.25 mg ORAL NDA 32 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1105 TABLET, SUGAR COATED 0.30 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1106 TABLET, SUGAR COATED 0.45 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1107 TABLET, SUGAR COATED 0.63 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1108 TABLET, SUGAR COATED 0.63 mg ORAL NDA 30 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 43353-687 TABLET, FILM COATED 0.30 mg ORAL NDA 25 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 43353-688 TABLET, FILM COATED 0.63 mg ORAL NDA 25 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 50090-0167 TABLET, FILM COATED 0.63 mg ORAL NDA 31 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 50090-0167 TABLET, FILM COATED 0.63 mg ORAL NDA 31 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 50090-0573 TABLET, SUGAR COATED 0.63 mg ORAL NDA 30 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 50090-1853 TABLET, FILM COATED 0.30 mg ORAL NDA 31 sections
Esterified Estrogens and Methyltestosterone HUMAN PRESCRIPTION DRUG LABEL 2 51293-639 TABLET 0.63 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Esterified Estrogens and Methyltestosterone HUMAN PRESCRIPTION DRUG LABEL 2 51293-640 TABLET 1.25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 53808-0770 TABLET, FILM COATED 0.63 mg ORAL NDA 25 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 54868-0365 TABLET, FILM COATED 0.90 mg ORAL NDA 14 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 54868-0451 TABLET, FILM COATED 0.63 mg ORAL NDA 14 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 54868-0453 TABLET, FILM COATED 1.25 mg ORAL NDA 14 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 54868-2702 TABLET, FILM COATED 0.30 mg ORAL NDA 14 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 54868-3799 TABLET, SUGAR COATED 0.63 mg ORAL NDA 29 sections
Premarin HUMAN PRESCRIPTION DRUG LABEL 1 54868-4865 TABLET, FILM COATED 0.45 mg ORAL NDA 14 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 54868-4866 TABLET, SUGAR COATED 0.45 mg ORAL NDA 29 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 54868-5047 TABLET, SUGAR COATED 0.30 mg ORAL NDA 29 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 54868-5540 TABLET, SUGAR COATED 0.63 mg ORAL NDA 29 sections