ecallantide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
peptides and glycopeptides 4846 460738-38-9

Description:

MoleculeDescription

Synonyms:

  • ecallantide
  • DX-88
  • kalbitor
an NSAID and analgesic
  • Molecular weight: 7053.90
  • Formula: C305H442N88O91S8
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 2912.95
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.18 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Nov. 27, 2009 FDA DYAX CORP.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hereditary angioedema 467.52 34.16 85 1196 9280 90617886
Inappropriate schedule of product administration 74.32 34.16 38 1243 149895 90477271
Anaphylactic reaction 67.22 34.16 30 1251 87494 90539672
Pharyngeal oedema 54.84 34.16 16 1265 13755 90613411
Off label use 40.07 34.16 62 1219 1102190 89524976
Laryngeal oedema 36.47 34.16 10 1271 6871 90620295

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hereditary angioedema 69.46 54.43 10 97 1471 42619757

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hereditary angioedema 301.79 36.61 53 995 7061 110581190
Anaphylactic reaction 91.80 36.61 36 1012 114264 110473987
Inappropriate schedule of product administration 54.62 36.61 30 1018 203607 110384644
Off label use 50.86 36.61 66 982 1500119 109088132
Pharyngeal oedema 49.23 36.61 14 1034 16414 110571837
Therapeutic response decreased 42.79 36.61 20 1028 96479 110491772

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B06AC03 BLOOD AND BLOOD FORMING ORGANS
OTHER HEMATOLOGICAL AGENTS
OTHER HEMATOLOGICAL AGENTS
Drugs used in hereditary angioedema
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
FDA MoA N0000184151 Kallikrein Inhibitors
FDA EPC N0000192750 Plasma Kallikrein Inhibitor

Related Drugs by ATC class:

B06AC Drugs used in hereditary angioedema 7 drugs
berotralstatconestat alfadonidalorsengaradacimabicatibantlanadelumabsebetralstat

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hereditary angioneurotic edema indication 82966003 DOID:14735




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Plasma kallikrein Enzyme INHIBITOR Ki 10.60 DRUG LABEL DRUG LABEL

External reference:

IDSource
5Q6TZN2HNM UNII
D03931 KEGG_DRUG
4029548 VUID
N0000180428 NUI
4029548 VANDF
C1722685 UMLSCUI
CHEBI:749611 CHEBI
CHEMBL1201837 ChEMBL_ID
44152182 PUBCHEM_CID
DB05311 DRUGBANK_ID
8476 INN_ID
C511194 MESH_SUPPLEMENTAL_RECORD_UI
6955 IUPHAR_LIGAND_ID
658708 RXNORM
169356 MMSL
26876 MMSL
d07521 MMSL
013351 NDDF
445564003 SNOMEDCT_US
445569008 SNOMEDCT_US
5Q6TZN2HNM INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Kalbitor HUMAN PRESCRIPTION DRUG LABEL 1 47783-101 INJECTION, SOLUTION 10 mg SUBCUTANEOUS BLA 27 sections