ecallantide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
peptides and glycopeptides	4846	460738-38-9

Description:

Molecule	Description
Synonyms: ecallantide DX-88 kalbitor	an NSAID and analgesic Molecular weight: 7053.90 Formula: C305H442N88O91S8 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2912.95 ALOGS: ROTB: None

Molecule

Description

Synonyms:

ecallantide
DX-88
kalbitor

an NSAID and analgesic

Molecular weight: 7053.90
Formula: C305H442N88O91S8
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 2912.95
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

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Property	Value	Reference
t_half (Half-life)	1.80 hours	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.60 mL/min/kg	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	0.18 L/kg	Lombardo F, Berellini G, Obach RS

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Approvals:

Date	Agency	Company	Orphan
Nov. 27, 2009	FDA	DYAX CORP.

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hereditary angioedema	535.21	33.71	98	1239	7464	63480221
Inappropriate schedule of product administration	76.02	33.71	39	1298	103926	63383759
Anaphylactic reaction	63.82	33.71	30	1307	66070	63421615
Pharyngeal oedema	52.66	33.71	17	1320	13704	63473981
Off label use	50.62	33.71	66	1271	674396	62813289
Prescribed overdose	37.59	33.71	17	1320	34136	63453549
Laryngeal oedema	34.35	33.71	10	1327	5708	63481977

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hereditary angioedema	63.21	57.32	9	94	1038	34955790

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hereditary angioedema	364.96	35.97	63	1026	5272	79738027
Anaphylactic reaction	89.88	35.97	36	1053	83707	79659592
Off label use	65.18	35.97	70	1019	907145	78836154
Inappropriate schedule of product administration	59.03	35.97	31	1058	133597	79609702
Pharyngeal oedema	48.51	35.97	15	1074	16257	79727042
Therapeutic response decreased	42.82	35.97	20	1069	66833	79676466

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	B06AC03	BLOOD AND BLOOD FORMING ORGANS OTHER HEMATOLOGICAL AGENTS OTHER HEMATOLOGICAL AGENTS Drugs used in hereditary angioedema
FDA EPC	N0000192750	Plasma Kallikrein Inhibitor
FDA MoA	N0000184151	Kallikrein Inhibitors
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018373	Peripheral Nervous System Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hereditary angioneurotic edema	indication	82966003	DOID:14735

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Plasma kallikrein	Enzyme	P03952	KLKB1_HUMAN	INHIBITOR	Ki	10.60		DRUG LABEL	DRUG LABEL

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External reference:

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ID	Source
013351	NDDF
118984459	PUBCHEM_CID
169356	MMSL
26876	MMSL
4029548	VUID
4029548	VANDF
445564003	SNOMEDCT_US
445569008	SNOMEDCT_US
5Q6TZN2HNM	UNII
658708	RXNORM

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Kalbitor	HUMAN PRESCRIPTION DRUG LABEL	1	47783-101	INJECTION, SOLUTION	10 mg	SUBCUTANEOUS	BLA	27 sections
Kalbitor	HUMAN PRESCRIPTION DRUG LABEL	1	47783-101	INJECTION, SOLUTION	10 mg	SUBCUTANEOUS	BLA	27 sections

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