bemiparin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
heparin derivatives including low molecular mass heparins	4840	9041-08-1

Description:

Molecule	Description
Synonyms: tinzaparin ardeparin sodium dalteparin sodium tinzaparin sodium bemiparin bemiparin sodium	A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed) Molecular weight: Formula: None CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

tinzaparin
ardeparin sodium
dalteparin sodium
tinzaparin sodium
bemiparin
bemiparin sodium

A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)

Molecular weight:
Formula: None
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
3.50	TU	P
2.50	TU	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 22, 1994	FDA	PFIZER INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pulmonary embolism	242.57	12.91	269	25966	116415	63346372
Thrombocytopenia	191.48	12.91	272	25963	150885	63311902
Drug ineffective	158.67	12.91	121	26114	1044644	62418143
Hepatocellular injury	153.97	12.91	111	26124	27270	63435517
Acute kidney injury	143.57	12.91	328	25907	263087	63199700
Toxic epidermal necrolysis	138.57	12.91	101	26134	25233	63437554
Anaemia	104.83	12.91	312	25923	293118	63169669
Heparin-induced thrombocytopenia	102.68	12.91	46	26189	4536	63458251
Needle issue	100.03	12.91	59	26176	10317	63452470
General physical health deterioration	100.02	12.91	242	25993	201160	63261627
Drug intolerance	87.44	12.91	12	26223	308649	63154138
Arthralgia	77.45	12.91	73	26162	569637	62893150
Cholestasis	77.34	12.91	77	26158	29357	63433430
Arthropathy	74.48	12.91	6	26229	234786	63228001
Deep vein thrombosis	74.14	12.91	128	26107	83672	63379115
Febrile neutropenia	73.99	12.91	156	26079	118293	63344494
Rheumatoid arthritis	69.25	12.91	11	26224	253808	63208979
Neutropenic sepsis	64.79	12.91	54	26181	16384	63446403
Therapeutic product effect decreased	63.96	12.91	4	26231	193183	63269604
Product dose omission issue	62.04	12.91	11	26224	234302	63228485
Glossodynia	61.40	12.91	3	26232	178873	63283914
Abdominal discomfort	59.72	12.91	29	26206	320856	63141931
Neutropenia	59.46	12.91	183	26052	174822	63287965
Cytokine release syndrome	58.45	12.91	48	26187	14266	63448521
Systemic lupus erythematosus	57.10	12.91	9	26226	208909	63253878
Drug reaction with eosinophilia and systemic symptoms	56.79	12.91	70	26165	33766	63429021
Pancytopenia	55.18	12.91	123	26112	96810	63365977
Sinusitis	55.11	12.91	13	26222	226640	63236147
Blue toe syndrome	52.53	12.91	15	26220	392	63462395
Joint swelling	51.90	12.91	36	26199	327630	63135157
Blood creatine increased	51.77	12.91	31	26204	5570	63457217
Biliary sepsis	51.61	12.91	18	26217	913	63461874
Jaundice	51.50	12.91	62	26173	29189	63433598
Rash maculo-papular	50.36	12.91	64	26171	31832	63430955
Gamma-glutamyltransferase increased	50.16	12.91	66	26169	33965	63428822
Headache	49.29	12.91	119	26116	633122	62829665
Arteriovenous fistula occlusion	49.06	12.91	14	26221	365	63462422
Discomfort	48.57	12.91	6	26229	167368	63295419
Alopecia	47.25	12.91	42	26193	337494	63125293
Treatment failure	47.25	12.91	12	26223	199031	63263756
Venous pressure jugular decreased	46.86	12.91	9	26226	35	63462752
Sepsis	46.41	12.91	154	26081	152969	63309818
Thrombosis	46.00	12.91	90	26145	64665	63398122
Activated partial thromboplastin time prolonged	45.87	12.91	31	26204	6862	63455925
Haemoglobin decreased	45.60	12.91	148	26087	145337	63317450
Melaena	44.92	12.91	59	26176	30306	63432481
Dermatitis exfoliative	44.79	12.91	28	26207	5431	63457356
Haematoma	44.47	12.91	63	26172	34757	63428030
Hyperkalaemia	44.31	12.91	80	26155	54123	63408664
Agranulocytosis	43.80	12.91	53	26182	25081	63437706
Premature delivery	43.51	12.91	58	26177	30223	63432564
Hyperthyroidism	43.45	12.91	41	26194	14632	63448155
Drug hypersensitivity	43.07	12.91	39	26196	310648	63152139
Normal newborn	42.77	12.91	32	26203	8309	63454478
Pericarditis	42.73	12.91	3	26232	131576	63331211
Vessel puncture site bruise	42.40	12.91	13	26222	437	63462350
Blood creatinine increased	40.81	12.91	103	26132	87741	63375046
Adrenal suppression	40.45	12.91	15	26220	909	63461878
Wound	40.40	12.91	9	26226	163254	63299533
Pain	40.12	12.91	164	26071	740464	62722323
Pituitary tumour	40.07	12.91	15	26220	933	63461854
Premature baby	39.90	12.91	46	26189	20689	63442098
Abdominal wall haematoma	39.31	12.91	21	26214	3034	63459753
Ascites	37.03	12.91	63	26172	40665	63422122
Body dysmorphic disorder	36.98	12.91	11	26224	333	63462454
Musculoskeletal stiffness	36.96	12.91	15	26220	184603	63278184
Ovarian hyperstimulation syndrome	36.54	12.91	22	26213	3992	63458795
Gastrointestinal haemorrhage	36.48	12.91	94	26141	81082	63381705
Blood loss anaemia	36.36	12.91	30	26205	8971	63453816
Diarrhoea haemorrhagic	36.24	12.91	30	26205	9012	63453775
Hypothalamo-pituitary disorder	35.84	12.91	13	26222	740	63462047
Malignant neoplasm progression	35.78	12.91	94	26141	82027	63380760
Epistaxis	35.59	12.91	87	26148	72638	63390149
Abdominal wall haemorrhage	35.18	12.91	9	26226	153	63462634
Constipation	34.07	12.91	183	26052	224760	63238027
Contraindicated product administered	33.01	12.91	25	26210	217623	63245164
Pyrexia	32.20	12.91	316	25919	470162	62992625
Depression	31.87	12.91	21	26214	196471	63266316
Cardiac failure	30.96	12.91	94	26141	89048	63373739
Haematoma muscle	30.64	12.91	13	26222	1124	63461663
Pneumothorax traumatic	30.14	12.91	8	26227	158	63462629
Perforation	30.14	12.91	13	26222	1170	63461617
Electrolyte imbalance	29.68	12.91	39	26196	20037	63442750
Infusion related reaction	29.29	12.91	35	26200	245486	63217301
Acute generalised exanthematous pustulosis	29.08	12.91	29	26206	11070	63451717
Intra-abdominal haemorrhage	29.07	12.91	16	26219	2453	63460334
Impaired healing	28.96	12.91	4	26231	102538	63360249
Fatigue	28.93	12.91	232	26003	887796	62574991
Cerebral haemorrhage	28.55	12.91	48	26187	30681	63432106
Drug interaction	28.55	12.91	177	26058	228954	63233833
Joint ankylosis	28.32	12.91	12	26223	1034	63461753
Hypersensitivity	27.77	12.91	49	26186	292636	63170151
Gastric antral vascular ectasia	26.79	12.91	10	26225	617	63462170
Exposure during pregnancy	26.64	12.91	131	26104	155416	63307371
Cardiomyopathy acute	26.50	12.91	8	26227	255	63462532
Neoplasm progression	26.31	12.91	51	26184	36377	63426410
Cholecystitis	26.10	12.91	32	26203	15345	63447442
Eosinophilia	25.90	12.91	39	26196	22717	63440070
Leukopenia	25.44	12.91	80	26155	77210	63385577
Muscle haemorrhage	25.31	12.91	16	26219	3163	63459624
Catheter site thrombosis	25.12	12.91	7	26228	167	63462620
Blood alkaline phosphatase increased	24.97	12.91	55	26180	42912	63419875
Psychiatric decompensation	24.96	12.91	12	26223	1389	63461398
Fracture blisters	24.81	12.91	6	26229	80	63462707
Multiple organ dysfunction syndrome	24.75	12.91	65	26170	56687	63406100
International normalised ratio increased	24.28	12.91	57	26178	46368	63416419
Pleural effusion	24.11	12.91	89	26146	93121	63369666
Bone marrow eosinophilic leukocyte count increased	23.97	12.91	5	26230	32	63462755
Feeling abnormal	23.86	12.91	16	26219	148376	63314411
Diarrhoea	23.78	12.91	421	25814	714945	62747842
Femoral neck fracture	23.69	12.91	23	26212	8500	63454287
Blood cholesterol increased	23.63	12.91	5	26230	94027	63368760
Ill-defined disorder	23.54	12.91	3	26232	81752	63381035
Caesarean section	23.51	12.91	32	26203	17000	63445787
Hypokalaemia	23.49	12.91	95	26140	103709	63359078
Cerebellar haematoma	23.30	12.91	8	26227	387	63462400
Embolism	23.23	12.91	22	26213	7884	63454903
Cerebral infarction	23.10	12.91	38	26197	23855	63438932
Allergic hepatitis	23.10	12.91	5	26230	39	63462748
Haemoptysis	22.96	12.91	42	26193	28684	63434103
Renal tubular acidosis	22.82	12.91	12	26223	1680	63461107
Bronchopulmonary dysplasia	22.58	12.91	8	26227	425	63462362
Pneumobilia	22.35	12.91	6	26229	124	63462663
Foetal growth restriction	22.16	12.91	21	26214	7532	63455255
Retroperitoneal haemorrhage	22.08	12.91	14	26221	2783	63460004
Erythema	22.02	12.91	136	26099	175615	63287172
Haemorrhagic erosive gastritis	21.89	12.91	8	26227	465	63462322
Hepatitis cholestatic	21.87	12.91	20	26215	6858	63455929
Skin warm	21.60	12.91	18	26217	5458	63457329
Granulomatous liver disease	21.31	12.91	9	26226	769	63462018
Gastrointestinal disorder	21.30	12.91	14	26221	131225	63331562
Therapeutic product effect incomplete	20.76	12.91	13	26222	125043	63337744
Haemorrhagic thyroid cyst	20.74	12.91	4	26231	16	63462771
Thrombophlebitis	20.72	12.91	16	26219	4352	63458435
Rash	20.35	12.91	142	26093	560729	62902058
Phlebitis	20.31	12.91	19	26216	6705	63456082
Limbal swelling	20.18	12.91	4	26231	19	63462768
Hypoaesthesia	20.08	12.91	24	26211	168369	63294418
Disease progression	20.03	12.91	102	26133	122656	63340131
Product use issue	19.94	12.91	38	26197	220482	63242305
Subcutaneous haematoma	19.86	12.91	11	26224	1707	63461080
Swelling	19.61	12.91	54	26181	275324	63187463
Gastric ulcer	19.03	12.91	35	26200	24002	63438785
Anaemia folate deficiency	18.97	12.91	6	26229	224	63462563
Toxicity to various agents	18.73	12.91	47	26188	247203	63215584
Hyperlipasaemia	18.71	12.91	8	26227	705	63462082
Restlessness	18.60	12.91	39	26196	29414	63433373
Haemangioma congenital	18.55	12.91	7	26228	445	63462342
Gestational diabetes	18.51	12.91	20	26215	8376	63454411
Protein S decreased	18.39	12.91	4	26231	32	63462755
Autoimmune heparin-induced thrombocytopenia	18.30	12.91	3	26232	3	63462784
Mobility decreased	18.25	12.91	14	26221	121145	63341642
Maternal drugs affecting foetus	18.16	12.91	16	26219	5226	63457561
Haemorrhage	18.13	12.91	61	26174	60961	63401826
Pericardial effusion	18.06	12.91	39	26196	30019	63432768
Abdominal pain	18.06	12.91	193	26042	293263	63169524
Cell death	18.03	12.91	12	26223	2589	63460198
Cholestatic liver injury	17.99	12.91	12	26223	2598	63460189
Protein C decreased	17.78	12.91	4	26231	38	63462749
Mucosal inflammation	17.73	12.91	51	26184	46877	63415910
Faecaloma	17.65	12.91	19	26216	7922	63454865
Chemotherapeutic drug level increased	17.32	12.91	5	26230	136	63462651
Rectal haemorrhage	17.29	12.91	52	26183	48978	63413809
Respiratory disorder	17.28	12.91	45	26190	39037	63423750
Subcutaneous abscess	17.27	12.91	16	26219	5580	63457207
Lordosis	17.15	12.91	6	26229	307	63462480
Insomnia	17.03	12.91	40	26195	215212	63247575
Acidosis	16.88	12.91	22	26213	11211	63451576
Alanine aminotransferase increased	16.77	12.91	86	26149	103684	63359103
Intra-abdominal haematoma	16.71	12.91	10	26225	1795	63460992
Gastrointestinal tract adenoma	16.70	12.91	6	26229	332	63462455
Hepatic function abnormal	16.66	12.91	43	26192	37099	63425688
Sudden death	16.54	12.91	21	26214	10428	63452359
Asthma	16.50	12.91	17	26218	127544	63335243
Haemolysis	16.48	12.91	17	26218	6751	63456036
Visual acuity reduced transiently	16.43	12.91	5	26230	164	63462623
Anterior segment ischaemia	16.43	12.91	4	26231	55	63462732
Cerebral haematoma	16.41	12.91	13	26222	3670	63459117
Liver iron concentration abnormal	16.23	12.91	4	26231	58	63462729
Antibiotic level above therapeutic	16.11	12.91	6	26229	368	63462419
Pharyngeal haematoma	16.04	12.91	4	26231	61	63462726
Therapeutic response decreased	16.02	12.91	3	26232	61522	63401265
Chest X-ray abnormal	15.99	12.91	14	26221	4535	63458252
Varices oesophageal	15.97	12.91	12	26223	3136	63459651
Respiratory distress	15.95	12.91	40	26195	33911	63428876
Interstitial lung disease	15.91	12.91	59	26176	61849	63400938
Cholelithiasis	15.88	12.91	47	26188	43878	63418909
Cardiac hypertrophy	15.79	12.91	8	26227	1037	63461750
Magnetic resonance imaging head abnormal	15.70	12.91	10	26225	2003	63460784
Upper gastrointestinal haemorrhage	15.62	12.91	28	26207	18824	63443963
Hepatic cytolysis	15.57	12.91	25	26210	15382	63447405
Migraine	15.49	12.91	12	26223	103334	63359453
Therapy non-responder	15.45	12.91	6	26229	75895	63386892
Gait disturbance	15.33	12.91	33	26202	183145	63279642
Infantile haemangioma	15.22	12.91	4	26231	76	63462711
Adverse drug reaction	15.11	12.91	7	26228	79707	63383080
Thyroid haemorrhage	15.07	12.91	4	26231	79	63462708
Persecutory delusion	14.97	12.91	11	26224	2779	63460008
Peritonitis	14.89	12.91	26	26209	17128	63445659
Type 2 diabetes mellitus	14.85	12.91	4	26231	63864	63398923
Cardiac failure congestive	14.81	12.91	10	26225	92423	63370364
Hydronephrosis	14.67	12.91	20	26215	10642	63452145
Stevens-Johnson syndrome	14.56	12.91	32	26203	24918	63437869
Upper respiratory tract infection	14.36	12.91	8	26227	82039	63380748
Intracranial pressure increased	14.33	12.91	14	26221	5213	63457574
Adverse event	14.33	12.91	5	26230	67554	63395233
Shock haemorrhagic	14.28	12.91	19	26216	9876	63452911
Arteriovenous fistula site complication	14.27	12.91	6	26229	507	63462280
Peripheral swelling	14.25	12.91	59	26176	265883	63196904
Humerus fracture	14.24	12.91	18	26217	8898	63453889
Post procedural haematoma	14.23	12.91	8	26227	1277	63461510
Catheter site injury	14.18	12.91	5	26230	262	63462525
CSF white blood cell count decreased	14.15	12.91	3	26232	21	63462766
Thrombosis prophylaxis	14.02	12.91	3	26232	22	63462765
Clostridium difficile colitis	13.89	12.91	28	26207	20541	63442246
Polyneuropathy	13.83	12.91	23	26212	14566	63448221
Right ventricular dilatation	13.72	12.91	8	26227	1368	63461419
Loss of personal independence in daily activities	13.71	12.91	12	26223	97278	63365509
Muscle strain	13.69	12.91	17	26218	8257	63454530
Nasal congestion	13.69	12.91	5	26230	65655	63397132
Purulent discharge	13.65	12.91	13	26222	4693	63458094
Dizziness	13.61	12.91	113	26122	429812	63032975
Vascular occlusion	13.51	12.91	7	26228	950	63461837
Reticulocyte count increased	13.42	12.91	7	26228	963	63461824
Injection site erythema	13.32	12.91	9	26226	83165	63379622
Thrombotic microangiopathy	13.32	12.91	19	26216	10542	63452245
Anxiety disorder	13.32	12.91	12	26223	4038	63458749
Renal pain	13.30	12.91	15	26220	6584	63456203
Strabismus	13.26	12.91	9	26226	2005	63460782
Cardiac arrest	13.12	12.91	74	26161	92471	63370316
Rectosigmoid cancer metastatic	13.11	12.91	3	26232	31	63462756
Varicophlebitis	13.11	12.91	3	26232	31	63462756
Thrombocytosis	13.07	12.91	14	26221	5804	63456983
Malnutrition	13.03	12.91	23	26212	15275	63447512
Injury	13.03	12.91	7	26228	73240	63389547
Anaphylactic reaction	13.01	12.91	58	26177	66042	63396745
Mucosal erosion	13.01	12.91	8	26227	1508	63461279
Disseminated intravascular coagulation	12.94	12.91	26	26209	19025	63443762
Congenital genitourinary abnormality	12.94	12.91	3	26232	33	63462754
Gastrointestinal stoma output increased	12.92	12.91	5	26230	341	63462446

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	319.90	13.87	147	25976	8454	34922354
Appendicitis	252.46	13.87	150	25973	14657	34916151
General physical health deterioration	233.89	13.87	375	25748	127894	34802914
Cardiogenic shock	204.38	13.87	165	25958	26453	34904355
Stress	156.38	13.87	150	25973	30197	34900611
Ascites	139.59	13.87	173	25950	46398	34884410
Multiple organ dysfunction syndrome	134.02	13.87	220	25903	76346	34854462
Ventricular fibrillation	132.75	13.87	121	26002	22833	34907975
Drug ineffective	131.24	13.87	91	26032	456660	34474148
Blood phosphorus increased	128.39	13.87	77	26046	7644	34923164
Hyponatraemia	122.91	13.87	221	25902	82470	34848338
Abdominal distension	118.83	13.87	180	25943	58312	34872496
Pulmonary embolism	112.47	13.87	223	25900	89523	34841285
Sepsis	107.37	13.87	320	25803	166241	34764567
Abdominal pain	94.87	13.87	303	25820	163315	34767493
Toxic epidermal necrolysis	77.33	13.87	88	26035	21558	34909250
Hepatocellular injury	73.82	13.87	87	26036	22124	34908684
Dry mouth	70.15	13.87	99	26024	30066	34900742
Thrombocytopenia	65.30	13.87	260	25863	155987	34774821
Heparin-induced thrombocytopenia	59.11	13.87	42	26081	5553	34925255
Toxicity to various agents	58.50	13.87	39	26084	200323	34730485
Drug abuse	58.47	13.87	4	26119	99092	34831716
Lymph node calcification	57.79	13.87	15	26108	143	34930665
Acute kidney injury	49.01	13.87	392	25731	304596	34626212
Constipation	48.66	13.87	217	25906	136765	34794043
Blood uric acid increased	46.58	13.87	46	26077	9578	34921230
Myasthenia gravis	44.89	13.87	39	26084	6901	34923907
Respiratory tract infection bacterial	43.87	13.87	23	26100	1759	34929049
Respiratory tract infection viral	39.00	13.87	24	26099	2493	34928315
Pulmonary sarcoidosis	34.72	13.87	14	26109	582	34930226
Haemorrhage	34.20	13.87	100	26023	51270	34879538
Shock haemorrhagic	33.68	13.87	42	26081	11312	34919496
Feeling abnormal	33.41	13.87	4	26119	63231	34867577
Vomiting	33.24	13.87	306	25817	247315	34683493
Haematemesis	32.42	13.87	67	26056	27644	34903164
Aplasia	32.16	13.87	27	26096	4561	34926247
Drug therapy	31.77	13.87	16	26107	1125	34929683
Respiratory tract infection	30.91	13.87	54	26069	19658	34911150
Dizziness	30.88	13.87	74	26049	218447	34712361
Cardiac failure congestive	30.53	13.87	12	26111	83258	34847550
Suspected product quality issue	29.85	13.87	9	26114	154	34930654
Splenic vein thrombosis	29.64	13.87	12	26111	504	34930304
Depression	29.53	13.87	18	26105	97080	34833728
Bronchial obstruction	29.17	13.87	17	26106	1599	34929209
Hepatic haematoma	28.70	13.87	11	26112	399	34930409
Neutropenia	28.14	13.87	207	25916	156571	34774237
Metastatic malignant melanoma	27.85	13.87	18	26105	2037	34928771
Analgesic therapy	27.80	13.87	14	26109	984	34929824
Peritoneal haematoma	27.43	13.87	7	26116	62	34930746
Hyperkalaemia	26.95	13.87	113	26010	69276	34861532
Lower respiratory tract infection	26.47	13.87	67	26056	31570	34899238
Bronchial disorder	25.96	13.87	15	26108	1388	34929420
Death	25.81	13.87	183	25940	397866	34532942
Hyperphosphataemia	24.87	13.87	23	26100	4414	34926394
Product dose omission issue	24.63	13.87	32	26091	119679	34811129
Sleep disorder therapy	24.60	13.87	13	26110	1010	34929798
Cholestasis	24.59	13.87	59	26064	26889	34903919
Insomnia	24.37	13.87	25	26098	103882	34826926
Portal vein thrombosis	23.92	13.87	21	26102	3767	34927041
Anastomotic infection	23.54	13.87	7	26116	114	34930694
Floppy infant	23.54	13.87	7	26116	114	34930694
Pancytopenia	23.38	13.87	136	25987	95021	34835787
Genitalia external ambiguous	22.86	13.87	8	26115	223	34930585
Therapeutic product effect incomplete	22.68	13.87	5	26118	50536	34880272
Rash maculo-papular	22.51	13.87	59	26064	28392	34902416
Febrile neutropenia	22.47	13.87	177	25946	136672	34794136
Muscle haemorrhage	22.26	13.87	20	26103	3698	34927110
Haematoma	22.23	13.87	55	26068	25550	34905258
Arthralgia	22.13	13.87	60	26063	169981	34760827
Mucosal inflammation	21.81	13.87	71	26052	38551	34892257
Anaemia	21.73	13.87	268	25855	233067	34697741
Embolism	21.70	13.87	28	26095	7801	34923007
Oesophagitis	21.67	13.87	37	26086	13224	34917584
Chondrocalcinosis	21.56	13.87	9	26114	409	34930399
Hypertrophic osteoarthropathy	21.35	13.87	6	26117	79	34930729
Congenital bladder anomaly	21.28	13.87	8	26115	275	34930533
Myalgia	21.16	13.87	19	26104	84091	34846717
Iron deficiency	21.14	13.87	23	26100	5358	34925450
Lung cancer metastatic	20.78	13.87	17	26106	2770	34928038
Drug reaction with eosinophilia and systemic symptoms	20.76	13.87	63	26060	32949	34897859
Mucosal disorder	20.68	13.87	14	26109	1712	34929096
Hepatic cytolysis	20.54	13.87	38	26085	14458	34916350
Haemorrhagic disorder	20.18	13.87	10	26113	679	34930129
Eosinophil percentage decreased	20.16	13.87	6	26117	98	34930710
Neutropenic infection	20	13.87	13	26110	1485	34929323
Diastasis recti abdominis	19.93	13.87	5	26118	41	34930767
Fall	19.93	13.87	81	26042	202804	34728004
Incorrect route of product administration	19.89	13.87	38	26085	14807	34916001
Septic shock	19.18	13.87	105	26018	71729	34859079
Coagulation factor VII level decreased	19.07	13.87	6	26117	119	34930689
Respiratory disorder neonatal	19	13.87	13	26110	1617	34929191
Epistaxis	18.94	13.87	90	26033	58161	34872647
Foetal hypokinesia	18.91	13.87	8	26115	376	34930432
Blood cholesterol increased	18.76	13.87	45	26078	20498	34910310
Vascular device infection	18.41	13.87	19	26104	4166	34926642
Treatment failure	18.35	13.87	6	26117	46691	34884117
Pulmonary infarction	18.26	13.87	12	26111	1396	34929412
Therapeutic product effect prolonged	18.26	13.87	7	26116	254	34930554
Neonatal respiratory depression	18.13	13.87	8	26115	417	34930391
Anxiety	18.06	13.87	29	26094	99399	34831409
Prothrombin time shortened	17.84	13.87	12	26111	1452	34929356
Gamma-glutamyltransferase increased	17.65	13.87	55	26068	29176	34901632
Headache	17.35	13.87	84	26039	200551	34730257
Suicide attempt	17.29	13.87	4	26119	39112	34891696
Myocardial infarction	17.08	13.87	41	26082	121044	34809764
Abdominal discomfort	16.95	13.87	12	26111	59823	34870985
Klebsiella infection	16.93	13.87	26	26097	8505	34922303
Pulmonary artery thrombosis	16.57	13.87	9	26114	739	34930069
Therapeutic product effect decreased	16.50	13.87	3	26120	34740	34896068
Thrombosis	16.43	13.87	78	26045	50380	34880428
Abdominal sepsis	16.37	13.87	10	26113	1025	34929783
Jaundice cholestatic	16.29	13.87	19	26104	4775	34926033
Bladder tamponade	16.27	13.87	8	26115	534	34930274
Butterfly rash	15.71	13.87	5	26118	103	34930705
Compartment syndrome	15.68	13.87	15	26108	3003	34927805
Wrong strength	15.67	13.87	5	26118	104	34930704
Blood pressure diastolic increased	15.57	13.87	19	26104	5006	34925802
Foetal exposure during delivery	15.53	13.87	5	26118	107	34930701
Haemolytic anaemia	15.51	13.87	28	26095	10451	34920357
Needle issue	15.47	13.87	21	26102	6144	34924664
Cardiac flutter	15.30	13.87	12	26111	1841	34928967
Bacterial infection	15.18	13.87	37	26086	17026	34913782
Thrombocytosis	15.16	13.87	17	26106	4095	34926713
Nausea	15.11	13.87	346	25777	339562	34591246
Mental status changes	14.77	13.87	5	26118	38078	34892730
Hypophosphataemia	14.50	13.87	28	26095	10998	34919810
Hospitalisation	14.13	13.87	13	26110	56889	34873919
Penile necrosis	14.08	13.87	4	26119	55	34930753
Pyrexia	13.88	13.87	336	25787	332677	34598131

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	345.10	11.79	146	48766	8405	79687071
General physical health deterioration	322.69	11.79	593	48319	274645	79420831
Pulmonary embolism	313.09	11.79	452	48460	171202	79524274
Drug ineffective	242.93	11.79	186	48726	1080727	78614749
Appendicitis	235.13	11.79	151	48761	20643	79674833
Thrombocytopenia	222.97	11.79	498	48414	264761	79430715
Cardiogenic shock	204.10	11.79	184	48728	41730	79653746
Hepatocellular injury	201.01	11.79	193	48719	47400	79648076
Toxic epidermal necrolysis	190.57	11.79	182	48730	44399	79651077
Ascites	170.86	11.79	221	48691	75341	79620135
Acute kidney injury	158.59	11.79	684	48228	518720	79176756
Multiple organ dysfunction syndrome	158.45	11.79	273	48639	119973	79575503
Sepsis	157.90	11.79	441	48471	268987	79426489
Heparin-induced thrombocytopenia	144.55	11.79	84	48828	9598	79685878
Blood phosphorus increased	126.60	11.79	79	48833	10268	79685208
Ventricular fibrillation	120.88	11.79	122	48790	31804	79663672
Anaemia	108.38	11.79	549	48363	444466	79251010
Arthralgia	98.33	11.79	124	48788	571679	79123797
Abdominal distension	97.35	11.79	222	48690	119428	79576048
Hyponatraemia	97.14	11.79	284	48628	177564	79517912
Toxicity to various agents	94.87	11.79	72	48840	421468	79274008
Constipation	91.72	11.79	380	48532	282670	79412806
Cholestasis	91.57	11.79	135	48777	51974	79643502
Abdominal pain	86.09	11.79	468	48444	389101	79306375
Drug abuse	79.91	11.79	5	48907	162686	79532790
Arthropathy	79.87	11.79	8	48904	177103	79518373
Therapeutic product effect decreased	77.69	11.79	6	48906	163857	79531619
Stress	70.68	11.79	153	48759	79459	79616017
Febrile neutropenia	69.27	11.79	303	48609	230696	79464780
Headache	68.05	11.79	192	48720	653580	79041896
Pancytopenia	68.02	11.79	240	48672	165505	79529971
Neutropenia	67.84	11.79	352	48560	287358	79408118
Hyperkalaemia	67.60	11.79	188	48724	114210	79581266
Drug reaction with eosinophilia and systemic symptoms	64.66	11.79	130	48782	64114	79631362
Abdominal discomfort	64.21	11.79	37	48875	250690	79444786
Sinusitis	64.19	11.79	20	48892	195481	79499995
Joint swelling	63.99	11.79	50	48862	288596	79406880
Drug intolerance	63.45	11.79	42	48870	264077	79431399
Neutropenic sepsis	62.45	11.79	80	48832	26984	79668492
Rash maculo-papular	61.93	11.79	118	48794	55960	79639516
Blood uric acid increased	61.78	11.79	57	48855	13303	79682173
Gamma-glutamyltransferase increased	60.31	11.79	115	48797	54565	79640911
Haematoma	59.09	11.79	111	48801	52084	79643392
Product dose omission issue	58.60	11.79	40	48872	247497	79447979
Deep vein thrombosis	57.48	11.79	184	48728	120735	79574741
Treatment failure	56.77	11.79	17	48895	170469	79525007
Rheumatoid arthritis	55.94	11.79	29	48883	208441	79487035
Thrombosis	54.48	11.79	143	48769	83957	79611519
Discomfort	53.31	11.79	7	48905	125610	79569866
Epistaxis	53.28	11.79	170	48742	111345	79584131
Depression	52.70	11.79	34	48878	216756	79478720
Systemic lupus erythematosus	50.82	11.79	7	48905	121142	79574334
Malignant neoplasm progression	50.77	11.79	191	48721	135799	79559677
Lymph node calcification	50.51	11.79	16	48896	399	79695077
Pemphigus	49.07	11.79	3	48909	99579	79595897
Shock haemorrhagic	48.99	11.79	61	48851	19999	79675477
Musculoskeletal stiffness	48.98	11.79	23	48889	174985	79520491
Glossodynia	48.37	11.79	4	48908	103333	79592143
Respiratory tract infection bacterial	47.74	11.79	24	48888	2053	79693423
Feeling abnormal	47.61	11.79	19	48893	159180	79536296
Cytokine release syndrome	46.40	11.79	81	48831	35917	79659559
Embolism	44.99	11.79	49	48863	13933	79681543
Haemoglobin decreased	44.43	11.79	260	48652	221859	79473617
Blood loss anaemia	42.53	11.79	50	48862	15448	79680028
Aplasia	41.37	11.79	36	48876	7784	79687692
Blue toe syndrome	41.21	11.79	15	48897	576	79694900
Jaundice	41.17	11.79	97	48815	53252	79642224
Respiratory tract infection viral	41.03	11.79	28	48884	4231	79691245
Cardiac failure congestive	40.96	11.79	18	48894	142384	79553092
Haemorrhage	40.90	11.79	136	48776	90982	79604494
Therapeutic product effect incomplete	40.59	11.79	18	48894	141627	79553849
Agranulocytosis	40.48	11.79	87	48825	44943	79650533
Alopecia	39.83	11.79	50	48862	231305	79464171
Myasthenia gravis	39.83	11.79	40	48872	10359	79685117
Muscle haemorrhage	39.52	11.79	32	48880	6268	79689208
Cerebral haemorrhage	39.34	11.79	100	48812	57573	79637903
Arteriovenous fistula occlusion	38.45	11.79	14	48898	538	79694938
Infusion related reaction	38.36	11.79	51	48861	230186	79465290
Hyperthyroidism	38.23	11.79	57	48855	22152	79673324
Biliary sepsis	38.10	11.79	19	48893	1598	79693878
Hypersensitivity	37.96	11.79	64	48848	262175	79433301
Melaena	37.87	11.79	102	48810	60788	79634688
Hepatic cytolysis	37.50	11.79	63	48849	27088	79668388
Blood creatine increased	37.38	11.79	37	48875	9418	79686058
Venous pressure jugular decreased	36.80	11.79	9	48903	82	79695394
Dizziness	36.76	11.79	182	48730	526259	79169217
Pyrexia	36.71	11.79	602	48310	678107	79017369
Insomnia	36.26	11.79	59	48853	245111	79450365
Wound	36.18	11.79	13	48899	116166	79579310
Haematemesis	36.04	11.79	91	48821	52173	79643303
Vessel puncture site bruise	35.72	11.79	13	48899	499	79694977
Pain	34.31	11.79	272	48640	703530	78991946
Normal newborn	34.31	11.79	31	48881	7041	79688435
Drug therapy	33.99	11.79	16	48896	1185	79694291
Psoriatic arthropathy	33.94	11.79	4	48908	77995	79617481
Body dysmorphic disorder	33.32	11.79	11	48901	314	79695162
Fatigue	33.19	11.79	388	48524	929339	78766137
Premature delivery	33.14	11.79	55	48857	23412	79672064
Gastrointestinal haemorrhage	32.88	11.79	178	48734	147541	79547935
Activated partial thromboplastin time prolonged	32.73	11.79	42	48870	14186	79681290
Phlebitis	32.06	11.79	33	48879	8797	79686679
Hepatitis cholestatic	32.04	11.79	41	48871	13811	79681665
Blood alkaline phosphatase increased	31.26	11.79	98	48814	63566	79631910
Ovarian hyperstimulation syndrome	30.95	11.79	22	48890	3549	79691927
Nasal congestion	30.77	11.79	5	48907	76547	79618929
Needle issue	30.73	11.79	39	48873	13029	79682447
Pituitary tumour	30.70	11.79	15	48897	1207	79694269
Gait disturbance	30.62	11.79	50	48862	207456	79488020
Mucosal inflammation	30.59	11.79	109	48803	75471	79620005
Analgesic therapy	30.29	11.79	14	48898	995	79694481
Therapeutic response decreased	30.17	11.79	3	48909	66850	79628626
Duodenal ulcer perforation	29.81	11.79	3	48909	66208	79629268
Ill-defined disorder	29.62	11.79	3	48909	65872	79629604
Haematoma muscle	29.58	11.79	19	48893	2596	79692880
Hyperphosphataemia	29.08	11.79	27	48885	6349	79689127
Pulmonary sarcoidosis	29.00	11.79	15	48897	1362	79694114
Abdominal wall haematoma	28.99	11.79	24	48888	4849	79690627
Adrenal suppression	28.78	11.79	15	48897	1384	79694092
Neoplasm progression	28.62	11.79	83	48829	51599	79643877
Intra-abdominal haemorrhage	28.35	11.79	23	48889	4517	79690959
Vomiting	28.04	11.79	568	48344	665260	79030216
Asthma	27.94	11.79	25	48887	135070	79560406
Mobility decreased	27.25	11.79	21	48891	122154	79573322
Pericarditis	27.21	11.79	15	48897	104221	79591255
Sleep disorder therapy	27.02	11.79	13	48899	1011	79694465
Splenic vein thrombosis	26.71	11.79	12	48900	798	79694678
Intentional overdose	26.59	11.79	16	48896	105944	79589532
Dermatitis exfoliative	26.55	11.79	33	48879	10796	79684680
Bronchial obstruction	26.20	11.79	18	48894	2750	79692726
Peritonitis	26.16	11.79	55	48857	27981	79667495
Hepatic haematoma	26.01	11.79	12	48900	849	79694627
Peripheral swelling	25.92	11.79	82	48830	269535	79425941
Hypokalaemia	25.85	11.79	164	48748	143876	79551600
Lung cancer metastatic	25.80	11.79	20	48892	3679	79691797
Suspected product quality issue	25.71	11.79	9	48903	308	79695168
Diarrhoea	25.44	11.79	713	48199	879776	78815700
Thrombophlebitis	25.43	11.79	25	48887	6310	79689166
Septic shock	25.34	11.79	145	48767	122656	79572820
Portal vein thrombosis	25.28	11.79	24	48888	5803	79689673
Dry mouth	25.23	11.79	114	48798	87905	79607571
Hypothalamo-pituitary disorder	25.13	11.79	13	48899	1181	79694295
Limbal swelling	24.16	11.79	5	48907	19	79695457
Haemolytic anaemia	24.14	11.79	41	48871	17779	79677697
Nasopharyngitis	23.86	11.79	78	48834	253803	79441673
Subcutaneous haematoma	23.82	11.79	17	48895	2760	79692716
Migraine	23.71	11.79	12	48900	87481	79607995
Anastomotic infection	23.70	11.79	7	48905	137	79695339
Cell death	23.59	11.79	21	48891	4678	79690798
Rash	23.53	11.79	234	48678	578124	79117352
Rectal haemorrhage	23.52	11.79	101	48811	76199	79619277
Metastatic malignant melanoma	23.35	11.79	17	48895	2846	79692630
Pneumothorax traumatic	23.25	11.79	8	48904	260	79695216
Adverse drug reaction	23.24	11.79	6	48906	66386	79629090
Bronchial disorder	23.12	11.79	16	48896	2473	79693003
Oesophagitis	23.07	11.79	48	48864	24241	79671235
Pulmonary infarction	22.99	11.79	19	48893	3830	79691646
Retroperitoneal haemorrhage	22.73	11.79	22	48890	5448	79690028
Acute generalised exanthematous pustulosis	22.46	11.79	39	48873	17215	79678261
Fracture blisters	22.46	11.79	6	48906	80	79695396
Loss of personal independence in daily activities	22.41	11.79	18	48894	102562	79592914
Catheter site thrombosis	22.34	11.79	8	48904	293	79695183
Drug hypersensitivity	22.19	11.79	101	48811	298815	79396661
Clostridium difficile colitis	22.03	11.79	56	48856	32227	79663249
Myalgia	21.94	11.79	51	48861	185590	79509886
Bone marrow eosinophilic leukocyte count increased	21.87	11.79	5	48907	33	79695443
Gastric antral vascular ectasia	21.81	11.79	11	48901	947	79694529
Cardiomyopathy acute	21.79	11.79	8	48904	315	79695161
Leukopenia	21.74	11.79	134	48778	116379	79579097
Folliculitis	21.42	11.79	4	48908	55376	79640100
Neutropenic infection	21.14	11.79	15	48897	2412	79693064
Klebsiella infection	21.08	11.79	36	48876	15684	79679792
Peritoneal haematoma	21.06	11.79	7	48905	204	79695272
Allergic hepatitis	20.81	11.79	5	48907	42	79695434
Haemolysis	20.80	11.79	32	48880	12780	79682696
Iron deficiency	20.76	11.79	29	48883	10625	79684851
Injury	20.45	11.79	11	48901	77485	79617991
Gastrointestinal disorder	20.41	11.79	27	48885	122178	79573298
Perforation	20.30	11.79	12	48900	1414	79694062
Compartment syndrome	20.30	11.79	20	48892	5062	79690414
Hypertrophic osteoarthropathy	20.10	11.79	6	48906	122	79695354
Hyperthermia	19.96	11.79	38	48874	17999	79677477
Gastrointestinal stoma output increased	19.91	11.79	8	48904	403	79695073
Hypoaesthesia	19.84	11.79	51	48861	179301	79516175
Treatment noncompliance	19.74	11.79	4	48908	52264	79643212
Retroperitoneal haematoma	19.60	11.79	20	48892	5277	79690199
Thrombocytosis	19.35	11.79	25	48887	8501	79686975
Weight increased	19.26	11.79	96	48816	277290	79418186
Haemorrhagic thyroid cyst	19.16	11.79	4	48908	16	79695460
Blood creatinine increased	18.90	11.79	161	48751	154896	79540580
Abdominal wall haemorrhage	18.89	11.79	9	48903	685	79694791
Suicide attempt	18.82	11.79	14	48898	82918	79612558
Diarrhoea haemorrhagic	18.66	11.79	31	48881	13203	79682273
Reading disorder	18.51	11.79	10	48902	992	79694484
Balance disorder	18.47	11.79	20	48892	98837	79596639
Eosinophil percentage decreased	18.39	11.79	7	48905	305	79695171
Pleural effusion	18.33	11.79	152	48760	145110	79550366
Chondrocalcinosis	18.02	11.79	10	48902	1046	79694430
Livedo reticularis	17.99	11.79	17	48895	4086	79691390
Pulmonary artery thrombosis	17.97	11.79	11	48901	1381	79694095
Upper gastrointestinal haemorrhage	17.88	11.79	61	48851	41319	79654157
Respiratory distress	17.81	11.79	77	48835	58262	79637214
Hospitalisation	17.68	11.79	19	48893	94217	79601259
Basilar artery occlusion	17.26	11.79	6	48906	201	79695275
Impaired healing	17.20	11.79	17	48895	87638	79607838
Bladder tamponade	17.10	11.79	8	48904	584	79694892
International normalised ratio increased	16.80	11.79	99	48813	84622	79610854
Injection site erythema	16.74	11.79	14	48898	78183	79617293
Adverse event	16.70	11.79	8	48904	60206	79635270
Influenza	16.64	11.79	34	48878	129572	79565904
Coagulation factor VII level decreased	16.59	11.79	6	48906	226	79695250
Cerebellar haematoma	16.56	11.79	8	48904	628	79694848
Drug resistance	16.43	11.79	3	48909	42210	79653266
Pneumobilia	16.42	11.79	6	48906	233	79695243
Dysgraphia	16.35	11.79	16	48896	4016	79691460
Transaminases increased	16.34	11.79	69	48843	51674	79643802
Pain in extremity	16.30	11.79	144	48768	364394	79331082
Femoral neck fracture	16.30	11.79	25	48887	9959	79685517
Erysipelas	16.09	11.79	26	48886	10824	79684652
Cerebral haematoma	16.04	11.79	22	48890	7920	79687556
Suicidal ideation	15.93	11.79	14	48898	76326	79619150
Alanine aminotransferase increased	15.89	11.79	161	48751	162409	79533067
International normalised ratio decreased	15.77	11.79	22	48890	8048	79687428
Throat irritation	15.75	11.79	3	48909	40943	79654533
Joint ankylosis	15.67	11.79	12	48900	2168	79693308
Drug dependence	15.65	11.79	3	48909	40766	79654710
Disseminated intravascular coagulation	15.63	11.79	53	48859	35789	79659687
Fall	15.63	11.79	208	48704	487421	79208055
Renal failure	15.52	11.79	190	48722	200778	79494698
Haemorrhagic erosive gastritis	15.42	11.79	8	48904	731	79694745
Adenocarcinoma of colon	15.41	11.79	18	48894	5523	79689953
Engraftment syndrome	15.35	11.79	10	48902	1399	79694077
Acute polyneuropathy	15.34	11.79	7	48905	483	79694993
Intracranial pressure increased	15.25	11.79	22	48890	8300	79687176
Hepatic enzyme increased	15.22	11.79	59	48853	182551	79512925
Penile necrosis	15.21	11.79	4	48908	50	79695426
Influenza like illness	15.15	11.79	13	48899	71694	79623782
Gestational diabetes	15.15	11.79	19	48893	6274	79689202
Febrile bone marrow aplasia	15.12	11.79	28	48884	12992	79682484
Injection site pain	15.07	11.79	36	48876	129802	79565674
Overdose	15.04	11.79	60	48852	184146	79511330
Beta-2 glycoprotein antibody positive	15.04	11.79	3	48909	9	79695467
Platelet count decreased	15.02	11.79	184	48728	194480	79500996
Knee arthroplasty	14.96	11.79	4	48908	43244	79652232
Bone marrow disorder	14.95	11.79	14	48898	3329	79692147
Anaemia folate deficiency	14.92	11.79	6	48906	303	79695173
Product use issue	14.91	11.79	72	48840	209750	79485726
Decubitus ulcer	14.90	11.79	31	48881	15656	79679820
Anterior segment ischaemia	14.86	11.79	4	48908	55	79695421
Viral infection	14.84	11.79	4	48908	43012	79652464
Liver iron concentration abnormal	14.66	11.79	4	48908	58	79695418
Pain in jaw	14.64	11.79	5	48907	46146	79649330
Cholecystitis	14.61	11.79	38	48874	22174	79673302
Burning sensation	14.50	11.79	9	48903	58623	79636853
Vascular device infection	14.40	11.79	24	48888	10252	79685224
Haemorrhagic disorder	14.32	11.79	10	48902	1568	79693908
Mental status changes	14.31	11.79	12	48900	66947	79628529
Varices oesophageal	14.28	11.79	18	48894	5973	79689503
Malaise	14.26	11.79	213	48699	489656	79205820
Sedation	14.24	11.79	7	48905	51888	79643588
Therapeutic product effect prolonged	14.22	11.79	7	48905	572	79694904
Chemotherapeutic drug level increased	14.08	11.79	6	48906	351	79695125
C-reactive protein abnormal	14.08	11.79	6	48906	48361	79647115
Arthritis	14.03	11.79	31	48881	114849	79580627
Superior vena cava syndrome	13.94	11.79	9	48903	1240	79694236
Wrong strength	13.94	11.79	5	48907	184	79695292
Therapy cessation	13.93	11.79	3	48909	37559	79657917
Cardiolipin antibody positive	13.89	11.79	5	48907	186	79695290
Therapy non-responder	13.83	11.79	22	48890	92283	79603193
Wheezing	13.82	11.79	32	48880	116632	79578844
Type 2 diabetes mellitus	13.81	11.79	9	48903	57113	79638363
Hypovolaemic shock	13.75	11.79	26	48886	12250	79683226
Haemoperitoneum	13.59	11.79	15	48897	4328	79691148
Device related thrombosis	13.49	11.79	12	48900	2671	79692805
Injection site swelling	13.48	11.79	6	48906	47126	79648350
Protein C decreased	13.46	11.79	4	48908	80	79695396
Magnetic resonance imaging head abnormal	13.32	11.79	12	48900	2714	79692762
Venous thrombosis	13.31	11.79	19	48893	7097	79688379
Malnutrition	13.29	11.79	37	48875	22465	79673011
Venous thrombosis limb	13.27	11.79	15	48897	4442	79691034
Emotional distress	13.27	11.79	4	48908	39965	79655511
Staphylococcal scalded skin syndrome	13.24	11.79	6	48906	407	79695069
Antinuclear antibody positive	13.22	11.79	20	48892	7870	79687606
Eosinophilia	13.19	11.79	59	48853	45286	79650190
Illness	13.18	11.79	6	48906	46505	79648971
Fluid retention	13.18	11.79	14	48898	69795	79625681
Lymphopenia	13.16	11.79	45	48867	30512	79664964
Cardiac failure	13.11	11.79	149	48763	154693	79540783
Hypophosphataemia	13.03	11.79	34	48878	19879	79675597
Hip arthroplasty	12.97	11.79	3	48909	35753	79659723
Injection site haemorrhage	12.86	11.79	42	48870	27828	79667648
Varicophlebitis	12.84	11.79	3	48909	22	79695454
Skin warm	12.84	11.79	18	48894	6614	79688862
Myositis	12.82	11.79	33	48879	19135	79676341
Haemoptysis	12.80	11.79	68	48844	55931	79639545
Lordosis	12.74	11.79	6	48906	445	79695031
Intra-abdominal haematoma	12.72	11.79	12	48900	2879	79692597
Device related infection	12.64	11.79	48	48864	34246	79661230
CSF white blood cell count decreased	12.62	11.79	3	48909	24	79695452
Antibiotic level above therapeutic	12.61	11.79	7	48905	733	79694743
Palpitations	12.51	11.79	38	48874	126572	79568904
Prostatitis Escherichia coli	12.51	11.79	3	48909	25	79695451
Mucosal disorder	12.47	11.79	13	48899	3515	79691961
Thyroid haemorrhage	12.47	11.79	4	48908	104	79695372
Death	12.45	11.79	259	48653	566255	79129221
Drug withdrawal syndrome	12.42	11.79	3	48909	34715	79660761
Faecaloma	12.35	11.79	24	48888	11540	79683936
Sudden hearing loss	12.35	11.79	10	48902	1959	79693517
Hypercoagulation	12.34	11.79	12	48900	2988	79692488
Exposure during pregnancy	12.32	11.79	105	48807	101027	79594449
Catheter site injury	12.31	11.79	5	48907	259	79695217
Autoimmune heparin-induced thrombocytopenia	12.30	11.79	3	48909	27	79695449
Mean cell volume increased	12.15	11.79	17	48895	6236	79689240
Gastrointestinal tract adenoma	12.14	11.79	6	48906	495	79694981
Somnolence	12.12	11.79	210	48702	238771	79456705
Haematuria	12.11	11.79	78	48834	68758	79626718
Visual acuity reduced transiently	12.10	11.79	5	48907	271	79695205
Protein S decreased	12.09	11.79	4	48908	115	79695361
IIIrd nerve disorder	12.09	11.79	4	48908	115	79695361
Electrolyte imbalance	12.03	11.79	44	48868	30837	79664639
Osteoarthritis	11.99	11.79	22	48890	87287	79608189
Abdominal sepsis	11.94	11.79	10	48902	2052	79693424
Post procedural pulmonary embolism	11.91	11.79	5	48907	282	79695194
Peripheral ischaemia	11.82	11.79	21	48891	9436	79686040
Large intestine perforation	11.80	11.79	27	48885	14540	79680936

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AB10	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	B01AB12	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
FDA CS	M0010191	Heparin, Low-Molecular-Weight
FDA EPC	N0000175586	Low Molecular Weight Heparin
MeSH PA	D000925	Anticoagulants
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents
CHEBI has role	CHEBI:50249	anticoagulants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pulmonary embolism	indication	59282003	DOID:9477
Deep venous thrombosis	indication	128053003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
PUE0TO3XDR	UNII
4020894	VANDF
4021054	VANDF
4021237	VANDF
4024199	VANDF
C0916062	UMLSCUI
CHEBI:28304	CHEBI
CHEMBL3707365	ChEMBL_ID
772	PUBCHEM_CID
DB09258	DRUGBANK_ID
CHEMBL1201414	ChEMBL_ID
CHEMBL1201448	ChEMBL_ID
CHEMBL1201460	ChEMBL_ID
CHEMBL2108806	ChEMBL_ID
C411345	MESH_SUPPLEMENTAL_RECORD_UI
C093450	MESH_SUPPLEMENTAL_RECORD_UI
6846	IUPHAR_LIGAND_ID
DB06822	DRUGBANK_ID
104466	RXNORM
15471	MMSL
4531	MMSL
d04659	MMSL
005078	NDDF
007911	NDDF
008338	NDDF
108987000	SNOMEDCT_US
108990006	SNOMEDCT_US
350469004	SNOMEDCT_US
395908006	SNOMEDCT_US
410964003	SNOMEDCT_US
410965002	SNOMEDCT_US
410967005	SNOMEDCT_US
412608008	SNOMEDCT_US
D000078222	MESH_DESCRIPTOR_UI
D017985	MESH_DESCRIPTOR_UI
6985	INN_ID
5688	INN_ID
6764	INN_ID
7501	INN_ID
9005-49-6	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0195	INJECTION	2500 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0195	INJECTION	2500 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0196	INJECTION	5000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0196	INJECTION	5000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0206	INJECTION	7500 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0206	INJECTION	7500 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0217	INJECTION	10000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0217	INJECTION	10000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0220	INJECTION	12500 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0220	INJECTION	12500 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0223	INJECTION	15000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0223	INJECTION	15000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0228	INJECTION	18000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0228	INJECTION	18000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0232	INJECTION	25000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0232	INJECTION	25000 [iU]	SUBCUTANEOUS	NDA	28 sections
Fragmin	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0253	INJECTION	2500 [iU]	SUBCUTANEOUS	NDA	28 sections