peramivir Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antivirals neuraminidase inhibitors	4823	330600-85-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

rapivab
peramivir hydrate
RWJ-270201
peramivir
BCX-1812
rapiacta

Peramivir is an inhibitor of influenza virus neuraminidase, an enzyme that releases viral particles from the plasma membrane of infected cells.

Molecular weight: 328.41
Formula: C15H28N4O4
CLOGP: -1.31
LIPINSKI: 1
HAC: 8
HDO: 6
TPSA: 148.53
ALOGS: -2.94
ROTB: 7

Status: ONP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.60	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Hosey CM, Chan R, Benet LZ

Approvals:

Date	Agency	Company	Orphan
April 13, 2018	EMA	BIOCRYST UK LIMITED
Dec. 19, 2014	FDA	BIOCRYST

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

Source	Code	Description
ATC	J05AH03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Neuraminidase inhibitors
FDA MoA	N0000175436	Neuraminidase Inhibitors
FDA EPC	N0000175524	Neuraminidase Inhibitor
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000998	Antiviral Agents
MeSH PA	D004791	Enzyme Inhibitors
CHEBI has role	CHEBI:36044	anti-virus drug
CHEBI has role	CHEBI:52425	sialidase inhibitor

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Influenza	indication	6142004	DOID:8469

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.6	acidic
pKa2	12.05	acidic
pKa3	13.73	acidic
pKa4	10.07	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Neuraminidase	Enzyme		NRAM_I34A1	INHIBITOR	IC50	8.85		CHEMBL	DRUG LABEL
Neuraminidase	Enzyme		NRAM_INBLE	INHIBITOR	IC50	8.30		CHEMBL	DRUG LABEL
Neuraminidase	Enzyme		NRAM_I18A0	INHIBITOR	Ki	9.08		CHEMBL	DRUG LABEL
Neuraminidase	Enzyme		B4URF0_9INFA		IC50	10.15		CHEMBL

External reference:

ID	Source
D03829	KEGG_DRUG
1041434-82-5	SECONDARY_CAS_RN
4034033	VANDF
C0961216	UMLSCUI
CHEBI:85202	CHEBI
BCZ	PDB_CHEM_ID
CHEMBL3989402	ChEMBL_ID
CHEMBL139367	ChEMBL_ID
DB06614	DRUGBANK_ID
C414210	MESH_SUPPLEMENTAL_RECORD_UI
154234	PUBCHEM_CID
QW7Y7ZR15U	UNII
1598078	RXNORM
231961	MMSL
30814	MMSL
d08335	MMSL
013296	NDDF
716121006	SNOMEDCT_US
763542005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Rapivab	HUMAN PRESCRIPTION DRUG LABEL	1	61364-181	SOLUTION	600 mg	INTRAVENOUS	NDA	27 sections
Rapivab	HUMAN PRESCRIPTION DRUG LABEL	1	72769-181	SOLUTION	600 mg	INTRAVENOUS	NDA	26 sections