Stem definition | Drug id | CAS RN |
---|---|---|
nucleosides antiviral or antineoplastic agents, cytarabine or azacitidine derivatives | 480 | 154361-50-9 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 26 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 3 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 171.93 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
April 16, 2003 | PMDA | CHUGAI PHARMACEUTICAL CO., LTD. | |
April 30, 1998 | FDA | HOFFMANN LA ROCHE | |
Nov. 19, 2012 | EMA | medac Gesellschaft für klinische Spezialpräparate mbH |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 8018.66 | 13.54 | 2544 | 110902 | 20471 | 63355105 |
Disease progression | 3732.96 | 13.54 | 2462 | 110984 | 120296 | 63255280 |
Diarrhoea | 2558.45 | 13.54 | 4554 | 108892 | 710812 | 62664764 |
Malignant neoplasm progression | 2393.09 | 13.54 | 1606 | 111840 | 80515 | 63295061 |
Metastases to liver | 1636.21 | 13.54 | 813 | 112633 | 22826 | 63352750 |
Metastases to bone | 1390.06 | 13.54 | 701 | 112745 | 20318 | 63355258 |
Death | 1261.37 | 13.54 | 2332 | 111114 | 372049 | 63003527 |
Mucosal inflammation | 1124.62 | 13.54 | 815 | 112631 | 46113 | 63329463 |
Metastases to central nervous system | 854.34 | 13.54 | 433 | 113013 | 12672 | 63362904 |
Metastases to lung | 815.82 | 13.54 | 416 | 113030 | 12334 | 63363242 |
Breast cancer metastatic | 604.49 | 13.54 | 334 | 113112 | 11684 | 63363892 |
Neoplasm progression | 569.06 | 13.54 | 492 | 112954 | 35936 | 63339640 |
Neuropathy peripheral | 546.06 | 13.54 | 832 | 112614 | 112835 | 63262741 |
Vomiting | 517.32 | 13.54 | 2170 | 111276 | 557447 | 62818129 |
Neutropenia | 510.39 | 13.54 | 1028 | 112418 | 173977 | 63201599 |
Dehydration | 459.31 | 13.54 | 979 | 112467 | 172375 | 63203201 |
Rheumatoid arthritis | 436.38 | 13.54 | 3 | 113443 | 253816 | 63121760 |
Metastases to lymph nodes | 427.57 | 13.54 | 233 | 113213 | 7925 | 63367651 |
Drug ineffective | 411.41 | 13.54 | 780 | 112666 | 1043985 | 62331591 |
Myelosuppression | 375.91 | 13.54 | 323 | 113123 | 23380 | 63352196 |
Joint swelling | 365.87 | 13.54 | 71 | 113375 | 327595 | 63047981 |
Nausea | 355.49 | 13.54 | 2671 | 110775 | 851800 | 62523776 |
Skin exfoliation | 354.76 | 13.54 | 411 | 113035 | 42691 | 63332885 |
Contraindicated product administered | 350.48 | 13.54 | 8 | 113438 | 217640 | 63157936 |
Systemic lupus erythematosus | 335.15 | 13.54 | 8 | 113438 | 208910 | 63166666 |
Neurotoxicity | 331.12 | 13.54 | 261 | 113185 | 16729 | 63358847 |
Stomatitis | 329.34 | 13.54 | 750 | 112696 | 137975 | 63237601 |
Bone marrow failure | 328.49 | 13.54 | 329 | 113117 | 28961 | 63346615 |
Arteriospasm coronary | 321.09 | 13.54 | 152 | 113294 | 3816 | 63371760 |
Maternal exposure during pregnancy | 314.26 | 13.54 | 20 | 113426 | 220042 | 63155534 |
Arthropathy | 311.07 | 13.54 | 30 | 113416 | 234762 | 63140814 |
Skin fissures | 300.67 | 13.54 | 210 | 113236 | 11178 | 63364398 |
Metastases to skin | 293.89 | 13.54 | 111 | 113335 | 1552 | 63374024 |
Condition aggravated | 293.57 | 13.54 | 178 | 113268 | 402039 | 62973537 |
Gastrointestinal toxicity | 288.15 | 13.54 | 177 | 113269 | 7564 | 63368012 |
Arthralgia | 285.70 | 13.54 | 360 | 113086 | 569350 | 62806226 |
Skin toxicity | 284.71 | 13.54 | 148 | 113298 | 4566 | 63371010 |
Paronychia | 275.26 | 13.54 | 153 | 113293 | 5412 | 63370164 |
Thrombocytopenia | 273.87 | 13.54 | 737 | 112709 | 150420 | 63225156 |
Metastasis | 262.86 | 13.54 | 145 | 113301 | 5052 | 63370524 |
Decreased appetite | 254.00 | 13.54 | 1003 | 112443 | 250049 | 63125527 |
Glossodynia | 244.59 | 13.54 | 20 | 113426 | 178856 | 63196720 |
Osteonecrosis of jaw | 243.40 | 13.54 | 307 | 113139 | 34816 | 63340760 |
Breast cancer | 236.05 | 13.54 | 357 | 113089 | 48026 | 63327550 |
Completed suicide | 235.82 | 13.54 | 5 | 113441 | 145668 | 63229908 |
Drug hypersensitivity | 235.78 | 13.54 | 131 | 113315 | 310556 | 63065020 |
Therapeutic product effect decreased | 232.82 | 13.54 | 34 | 113412 | 193153 | 63182423 |
Tumour marker increased | 231.87 | 13.54 | 131 | 113315 | 4784 | 63370792 |
Cardiotoxicity | 230.73 | 13.54 | 159 | 113287 | 8279 | 63367297 |
Haematotoxicity | 229.26 | 13.54 | 165 | 113281 | 9211 | 63366365 |
Enteritis | 219.21 | 13.54 | 153 | 113293 | 8133 | 63367443 |
Dry skin | 215.20 | 13.54 | 374 | 113072 | 56513 | 63319063 |
Exposure during pregnancy | 210.97 | 13.54 | 18 | 113428 | 155529 | 63220047 |
Product use issue | 200.11 | 13.54 | 72 | 113374 | 220448 | 63155128 |
Ascites | 199.35 | 13.54 | 301 | 113145 | 40427 | 63335149 |
Sinusitis | 198.99 | 13.54 | 78 | 113368 | 226575 | 63149001 |
Treatment failure | 196.54 | 13.54 | 56 | 113390 | 198987 | 63176589 |
Asthenia | 193.38 | 13.54 | 1259 | 112187 | 382345 | 62993231 |
Dihydropyrimidine dehydrogenase deficiency | 188.21 | 13.54 | 41 | 113405 | 45 | 63375531 |
Skin discolouration | 187.18 | 13.54 | 281 | 113165 | 37547 | 63338029 |
PIK3CA-activated mutation | 184.66 | 13.54 | 70 | 113376 | 989 | 63374587 |
Wound | 182.80 | 13.54 | 35 | 113411 | 163228 | 63212348 |
Laryngospasm | 182.67 | 13.54 | 95 | 113351 | 2933 | 63372643 |
Pleural effusion | 179.37 | 13.54 | 465 | 112981 | 92745 | 63282831 |
Metastases to peritoneum | 176.73 | 13.54 | 97 | 113349 | 3345 | 63372231 |
Therapy cessation | 175.18 | 13.54 | 243 | 113203 | 30214 | 63345362 |
Metastases to pleura | 170.32 | 13.54 | 74 | 113372 | 1511 | 63374065 |
Hospice care | 170.12 | 13.54 | 129 | 113317 | 7803 | 63367773 |
Swelling | 165.58 | 13.54 | 149 | 113297 | 275229 | 63100347 |
Musculoskeletal stiffness | 159.61 | 13.54 | 65 | 113381 | 184553 | 63191023 |
Fall | 159.39 | 13.54 | 286 | 113160 | 392048 | 62983528 |
Pericarditis | 158.85 | 13.54 | 23 | 113423 | 131556 | 63244020 |
Infusion related reaction | 152.24 | 13.54 | 129 | 113317 | 245392 | 63130184 |
Pseudocirrhosis | 150.06 | 13.54 | 54 | 113392 | 653 | 63374923 |
Metastatic neoplasm | 149.21 | 13.54 | 94 | 113352 | 4201 | 63371375 |
Osteonecrosis | 147.53 | 13.54 | 200 | 113246 | 24330 | 63351246 |
Abdominal discomfort | 144.15 | 13.54 | 219 | 113227 | 320666 | 63054910 |
Nail disorder | 141.87 | 13.54 | 144 | 113302 | 12871 | 63362705 |
Metastases to spine | 140.96 | 13.54 | 82 | 113364 | 3167 | 63372409 |
Hepatic function abnormal | 140.19 | 13.54 | 244 | 113202 | 36898 | 63338678 |
Psoriasis | 136.84 | 13.54 | 4 | 113442 | 86953 | 63288623 |
Weight increased | 134.30 | 13.54 | 161 | 113285 | 260631 | 63114945 |
Pain | 133.43 | 13.54 | 778 | 112668 | 739850 | 62635726 |
Discomfort | 132.08 | 13.54 | 67 | 113379 | 167307 | 63208269 |
Duodenal ulcer perforation | 130.39 | 13.54 | 6 | 113440 | 87203 | 63288373 |
Hyperbilirubinaemia | 128.50 | 13.54 | 128 | 113318 | 11186 | 63364390 |
Lymphangiosis carcinomatosa | 128.21 | 13.54 | 59 | 113387 | 1386 | 63374190 |
Headache | 126.74 | 13.54 | 642 | 112804 | 632599 | 62742977 |
Ejection fraction decreased | 126.66 | 13.54 | 177 | 113269 | 22155 | 63353421 |
Irritable bowel syndrome | 125.43 | 13.54 | 5 | 113441 | 82407 | 63293169 |
Breast cancer recurrent | 123.89 | 13.54 | 84 | 113362 | 4257 | 63371319 |
Carcinoembryonic antigen increased | 122.87 | 13.54 | 61 | 113385 | 1704 | 63373872 |
Hepatic lesion | 122.76 | 13.54 | 87 | 113359 | 4738 | 63370838 |
Arthritis | 121.26 | 13.54 | 29 | 113417 | 115892 | 63259684 |
Onycholysis | 121.22 | 13.54 | 59 | 113387 | 1577 | 63373999 |
Pruritus | 119.46 | 13.54 | 296 | 113150 | 361157 | 63014419 |
Fibromyalgia | 118.73 | 13.54 | 6 | 113440 | 80414 | 63295162 |
Enterocolitis | 118.33 | 13.54 | 104 | 113342 | 7754 | 63367822 |
Carbohydrate antigen 15-3 increased | 115.72 | 13.54 | 55 | 113391 | 1393 | 63374183 |
Blood bilirubin increased | 114.97 | 13.54 | 224 | 113222 | 36916 | 63338660 |
Lower respiratory tract infection | 112.04 | 13.54 | 48 | 113398 | 132259 | 63243317 |
Jaundice | 106.29 | 13.54 | 189 | 113257 | 29062 | 63346514 |
Non-cirrhotic portal hypertension | 102.01 | 13.54 | 31 | 113415 | 210 | 63375366 |
Intestinal obstruction | 96.42 | 13.54 | 187 | 113259 | 30712 | 63344864 |
Asthma | 96.30 | 13.54 | 54 | 113392 | 127507 | 63248069 |
Urticaria | 95.69 | 13.54 | 93 | 113353 | 165709 | 63209867 |
Polyneuropathy | 95.50 | 13.54 | 124 | 113322 | 14465 | 63361111 |
Pneumonia | 94.71 | 13.54 | 457 | 112989 | 456310 | 62919266 |
Bone lesion | 92.92 | 13.54 | 80 | 113366 | 5801 | 63369775 |
Bronchitis | 92.73 | 13.54 | 54 | 113392 | 124881 | 63250695 |
Nasopharyngitis | 92.17 | 13.54 | 198 | 113248 | 254059 | 63121517 |
Osteoarthritis | 91.89 | 13.54 | 28 | 113418 | 95315 | 63280261 |
Therapeutic product effect incomplete | 91.48 | 13.54 | 55 | 113391 | 125001 | 63250575 |
Influenza | 91.16 | 13.54 | 40 | 113406 | 108682 | 63266894 |
Depression | 90.18 | 13.54 | 132 | 113314 | 196360 | 63179216 |
Drug interaction | 89.38 | 13.54 | 171 | 113275 | 228960 | 63146616 |
Overdose | 89.37 | 13.54 | 47 | 113399 | 115031 | 63260545 |
Hypokalaemia | 89.27 | 13.54 | 395 | 113051 | 103409 | 63272167 |
Mobility decreased | 87.63 | 13.54 | 54 | 113392 | 121105 | 63254471 |
Intentional overdose | 87.10 | 13.54 | 14 | 113432 | 74138 | 63301438 |
Paraesthesia | 86.76 | 13.54 | 528 | 112918 | 156438 | 63219138 |
Injection site pain | 85.65 | 13.54 | 64 | 113382 | 129736 | 63245840 |
Leukopenia | 85.47 | 13.54 | 318 | 113128 | 76972 | 63298604 |
Hypersensitivity | 84.42 | 13.54 | 256 | 113190 | 292429 | 63083147 |
Dysaesthesia pharynx | 82.91 | 13.54 | 24 | 113422 | 134 | 63375442 |
Hepatic enzyme increased | 82.45 | 13.54 | 147 | 113299 | 202181 | 63173395 |
Metastases to chest wall | 81.54 | 13.54 | 33 | 113413 | 560 | 63375016 |
Bradycardia | 81.28 | 13.54 | 16 | 113430 | 73211 | 63302365 |
Folliculitis | 80.98 | 13.54 | 14 | 113432 | 70303 | 63305273 |
Metastases to meninges | 80.64 | 13.54 | 53 | 113393 | 2549 | 63373027 |
Product use in unapproved indication | 78.61 | 13.54 | 124 | 113322 | 178956 | 63196620 |
Bone pain | 78.14 | 13.54 | 245 | 113201 | 54396 | 63321180 |
Hepatic failure | 78.13 | 13.54 | 187 | 113259 | 35469 | 63340107 |
Alopecia | 75.06 | 13.54 | 329 | 113117 | 337207 | 63038369 |
Colitis | 74.43 | 13.54 | 223 | 113223 | 48305 | 63327271 |
Abdominal lymphadenopathy | 74.28 | 13.54 | 33 | 113413 | 712 | 63374864 |
Ileus | 73.70 | 13.54 | 110 | 113336 | 14615 | 63360961 |
Blood cholesterol increased | 73.61 | 13.54 | 38 | 113408 | 93994 | 63281582 |
Loss of personal independence in daily activities | 72.26 | 13.54 | 42 | 113404 | 97248 | 63278328 |
Infusion site coldness | 71.40 | 13.54 | 23 | 113423 | 193 | 63375383 |
Febrile neutropenia | 70.29 | 13.54 | 406 | 113040 | 118043 | 63257533 |
Platelet count decreased | 68.89 | 13.54 | 398 | 113048 | 115724 | 63259852 |
Fingerprint loss | 68.14 | 13.54 | 15 | 113431 | 18 | 63375558 |
Therapy change | 67.58 | 13.54 | 68 | 113378 | 6013 | 63369563 |
Metastases to the mediastinum | 66.56 | 13.54 | 27 | 113419 | 461 | 63375115 |
Suicidal ideation | 66.48 | 13.54 | 15 | 113431 | 62406 | 63313170 |
Suicide attempt | 66.18 | 13.54 | 14 | 113432 | 60904 | 63314672 |
Gastrointestinal perforation | 64.52 | 13.54 | 52 | 113394 | 3439 | 63372137 |
Gamma-glutamyltransferase decreased | 62.55 | 13.54 | 23 | 113423 | 297 | 63375279 |
Abortion spontaneous | 62.50 | 13.54 | 6 | 113440 | 47189 | 63328387 |
Bone disorder | 61.63 | 13.54 | 125 | 113321 | 21201 | 63354375 |
Wheezing | 60.69 | 13.54 | 49 | 113397 | 95546 | 63280030 |
Tooth extraction | 60.67 | 13.54 | 83 | 113363 | 10181 | 63365395 |
Product dose omission issue | 60.58 | 13.54 | 215 | 113231 | 234098 | 63141478 |
Portal hypertension | 60.43 | 13.54 | 52 | 113394 | 3767 | 63371809 |
Nail discolouration | 59.58 | 13.54 | 45 | 113401 | 2705 | 63372871 |
Migraine | 59.57 | 13.54 | 58 | 113388 | 103288 | 63272288 |
Drug intolerance | 58.12 | 13.54 | 319 | 113127 | 308342 | 63067234 |
Device related thrombosis | 56.88 | 13.54 | 37 | 113409 | 1748 | 63373828 |
Skin hyperpigmentation | 56.46 | 13.54 | 61 | 113385 | 5860 | 63369716 |
Neoplasm malignant | 56.39 | 13.54 | 148 | 113298 | 29713 | 63345863 |
Peripheral sensory neuropathy | 56.22 | 13.54 | 68 | 113378 | 7383 | 63368193 |
Hypoalbuminaemia | 55.97 | 13.54 | 86 | 113360 | 11719 | 63363857 |
Pericardial effusion | 55.77 | 13.54 | 148 | 113298 | 29910 | 63345666 |
Pulmonary embolism | 54.93 | 13.54 | 377 | 113069 | 116307 | 63259269 |
Feeling abnormal | 54.19 | 13.54 | 115 | 113331 | 148277 | 63227299 |
Intestinal perforation | 53.73 | 13.54 | 85 | 113361 | 11878 | 63363698 |
Nasal congestion | 53.71 | 13.54 | 25 | 113421 | 65635 | 63309941 |
Injection site erythema | 53.59 | 13.54 | 42 | 113404 | 83132 | 63292444 |
Adverse event | 53.32 | 13.54 | 27 | 113419 | 67532 | 63308044 |
Recurrent cancer | 53.28 | 13.54 | 37 | 113409 | 1950 | 63373626 |
Chronic obstructive pulmonary disease | 52.64 | 13.54 | 23 | 113423 | 62663 | 63312913 |
Plasma cell myeloma | 51.99 | 13.54 | 3 | 113443 | 35902 | 63339674 |
Metastases to adrenals | 51.95 | 13.54 | 26 | 113420 | 739 | 63374837 |
Blood pressure fluctuation | 51.65 | 13.54 | 10 | 113436 | 46307 | 63329269 |
Type 2 diabetes mellitus | 51.20 | 13.54 | 25 | 113421 | 63843 | 63311733 |
Superior vena cava syndrome | 51.17 | 13.54 | 25 | 113421 | 674 | 63374902 |
Lymphoedema | 49.67 | 13.54 | 81 | 113365 | 11611 | 63363965 |
Jaw operation | 49.31 | 13.54 | 26 | 113420 | 826 | 63374750 |
Erythema | 49.09 | 13.54 | 505 | 112941 | 175246 | 63200330 |
Prescribed overdose | 49.00 | 13.54 | 3 | 113443 | 34150 | 63341426 |
Intentional product misuse | 48.60 | 13.54 | 24 | 113422 | 60893 | 63314683 |
Leukoencephalopathy | 48.41 | 13.54 | 49 | 113397 | 4364 | 63371212 |
Mucosal toxicity | 48.39 | 13.54 | 20 | 113426 | 359 | 63375217 |
Debridement | 48.28 | 13.54 | 29 | 113417 | 1189 | 63374387 |
Lacrimation increased | 48.24 | 13.54 | 111 | 113335 | 20520 | 63355056 |
Chronic kidney disease | 48.16 | 13.54 | 11 | 113435 | 45387 | 63330189 |
Hyperhidrosis | 47.93 | 13.54 | 74 | 113372 | 107762 | 63267814 |
Therapy interrupted | 47.76 | 13.54 | 147 | 113299 | 32308 | 63343268 |
Insomnia | 47.68 | 13.54 | 210 | 113236 | 215042 | 63160534 |
Disseminated intravascular coagulation | 47.33 | 13.54 | 105 | 113341 | 18946 | 63356630 |
Injury | 47.18 | 13.54 | 37 | 113409 | 73210 | 63302366 |
Anastomotic leak | 47.14 | 13.54 | 21 | 113425 | 456 | 63375120 |
Abdominal pain | 47.04 | 13.54 | 761 | 112685 | 292695 | 63082881 |
Neoplasm | 45.86 | 13.54 | 61 | 113385 | 7284 | 63368292 |
Nail infection | 45.40 | 13.54 | 37 | 113409 | 2486 | 63373090 |
Ear infection | 45.35 | 13.54 | 7 | 113439 | 38206 | 63337370 |
Osteoporosis | 45.12 | 13.54 | 23 | 113423 | 57315 | 63318261 |
Pyogenic granuloma | 44.99 | 13.54 | 18 | 113428 | 296 | 63375280 |
Contusion | 44.82 | 13.54 | 129 | 113317 | 149915 | 63225661 |
Central nervous system lesion | 44.26 | 13.54 | 73 | 113373 | 10562 | 63365014 |
Subacute cutaneous lupus erythematosus | 43.89 | 13.54 | 37 | 113409 | 2606 | 63372970 |
Osteolysis | 43.19 | 13.54 | 38 | 113408 | 2836 | 63372740 |
Drug reaction with eosinophilia and systemic symptoms | 43.01 | 13.54 | 5 | 113441 | 33831 | 63341745 |
Somnolence | 42.87 | 13.54 | 169 | 113277 | 178516 | 63197060 |
Angina bullosa haemorrhagica | 42.21 | 13.54 | 14 | 113432 | 130 | 63375446 |
Drug ineffective for unapproved indication | 40.98 | 13.54 | 6 | 113440 | 34057 | 63341519 |
Bone sequestrum | 40.82 | 13.54 | 28 | 113418 | 1446 | 63374130 |
Lymphadenopathy | 40.65 | 13.54 | 156 | 113290 | 38302 | 63337274 |
Gingival bleeding | 40.27 | 13.54 | 77 | 113369 | 12510 | 63363066 |
Therapy partial responder | 40.18 | 13.54 | 70 | 113376 | 10588 | 63364988 |
Mouth ulceration | 40.09 | 13.54 | 140 | 113306 | 32844 | 63342732 |
Pharyngeal inflammation | 40.00 | 13.54 | 21 | 113425 | 661 | 63374915 |
Dysphagia | 39.79 | 13.54 | 283 | 113163 | 88302 | 63287274 |
Plantar erythema | 39.63 | 13.54 | 15 | 113431 | 211 | 63375365 |
Congestive cardiomyopathy | 39.61 | 13.54 | 52 | 113394 | 6130 | 63369446 |
Blood uric acid decreased | 39.55 | 13.54 | 22 | 113424 | 779 | 63374797 |
Wrong technique in product usage process | 39.51 | 13.54 | 32 | 113414 | 62308 | 63313268 |
Colon cancer metastatic | 39.50 | 13.54 | 25 | 113421 | 1126 | 63374450 |
Oxygen saturation decreased | 39.16 | 13.54 | 61 | 113385 | 88524 | 63287052 |
Performance status decreased | 38.82 | 13.54 | 40 | 113406 | 3638 | 63371938 |
Acute coronary syndrome | 38.82 | 13.54 | 67 | 113379 | 10059 | 63365517 |
Neutrophil count decreased | 38.58 | 13.54 | 201 | 113245 | 56205 | 63319371 |
Metastases to ovary | 38.45 | 13.54 | 18 | 113428 | 440 | 63375136 |
Cardiac output decreased | 38.16 | 13.54 | 23 | 113423 | 949 | 63374627 |
Cataract | 37.79 | 13.54 | 28 | 113418 | 57025 | 63318551 |
Hypotension | 37.61 | 13.54 | 309 | 113137 | 272295 | 63103281 |
Confusional state | 37.32 | 13.54 | 258 | 113188 | 236122 | 63139454 |
Dysaesthesia | 37.31 | 13.54 | 43 | 113403 | 4435 | 63371141 |
Cold dysaesthesia | 37.10 | 13.54 | 8 | 113438 | 8 | 63375568 |
Anxiety | 37.09 | 13.54 | 232 | 113214 | 217309 | 63158267 |
Malignant ascites | 37.03 | 13.54 | 22 | 113424 | 884 | 63374692 |
Constipation | 37.02 | 13.54 | 586 | 112860 | 224357 | 63151219 |
Periodontitis | 36.82 | 13.54 | 37 | 113409 | 3266 | 63372310 |
Exposed bone in jaw | 36.79 | 13.54 | 35 | 113411 | 2890 | 63372686 |
Pulmonary sarcoidosis | 36.66 | 13.54 | 23 | 113423 | 1020 | 63374556 |
Hiccups | 36.57 | 13.54 | 31 | 113415 | 2200 | 63373376 |
Sedation | 36.31 | 13.54 | 12 | 113434 | 38797 | 63336779 |
Malignant pleural effusion | 36.28 | 13.54 | 33 | 113413 | 2573 | 63373003 |
Prescribed underdose | 36.25 | 13.54 | 5 | 113441 | 29684 | 63345892 |
Hypovolaemic shock | 36.18 | 13.54 | 50 | 113396 | 6191 | 63369385 |
Blood creatinine decreased | 36.08 | 13.54 | 47 | 113399 | 5498 | 63370078 |
Cardiac failure congestive | 35.98 | 13.54 | 69 | 113377 | 92364 | 63283212 |
Neoplasm recurrence | 35.94 | 13.54 | 33 | 113413 | 2605 | 63372971 |
Human epidermal growth factor receptor negative | 35.53 | 13.54 | 9 | 113437 | 27 | 63375549 |
Peripheral swelling | 35.53 | 13.54 | 304 | 113142 | 265638 | 63109938 |
COVID-19 | 35.44 | 13.54 | 95 | 113351 | 113008 | 63262568 |
Stridor | 34.95 | 13.54 | 37 | 113409 | 3473 | 63372103 |
Premature delivery | 34.92 | 13.54 | 6 | 113440 | 30275 | 63345301 |
Anastomotic fistula | 34.59 | 13.54 | 9 | 113437 | 31 | 63375545 |
Eosinophil percentage increased | 34.44 | 13.54 | 22 | 113424 | 1007 | 63374569 |
Blood pressure systolic increased | 34.43 | 13.54 | 21 | 113425 | 47376 | 63328200 |
Joint range of motion decreased | 34.12 | 13.54 | 8 | 113438 | 32420 | 63343156 |
Hypophagia | 34.02 | 13.54 | 128 | 113318 | 31131 | 63344445 |
White blood cell count decreased | 33.88 | 13.54 | 389 | 113057 | 138715 | 63236861 |
Nodular regenerative hyperplasia | 33.78 | 13.54 | 17 | 113429 | 489 | 63375087 |
Pregnancy | 33.41 | 13.54 | 12 | 113434 | 36824 | 63338752 |
Hypoaesthesia | 33.33 | 13.54 | 453 | 112993 | 167940 | 63207636 |
Proteinuria | 33.24 | 13.54 | 92 | 113354 | 19053 | 63356523 |
Gastric perforation | 33.15 | 13.54 | 26 | 113420 | 1653 | 63373923 |
Granulocyte count decreased | 33.04 | 13.54 | 23 | 113423 | 1217 | 63374359 |
Hyperkalaemia | 32.90 | 13.54 | 29 | 113417 | 54174 | 63321402 |
Accidental exposure to product | 32.57 | 13.54 | 5 | 113441 | 27400 | 63348176 |
Breast neoplasm | 32.29 | 13.54 | 24 | 113422 | 1408 | 63374168 |
Tumour pain | 32.21 | 13.54 | 24 | 113422 | 1413 | 63374163 |
Hyperaesthesia | 32.12 | 13.54 | 59 | 113387 | 9299 | 63366277 |
Oesophagitis | 32.11 | 13.54 | 78 | 113368 | 14930 | 63360646 |
General physical health deterioration | 31.76 | 13.54 | 521 | 112925 | 200881 | 63174695 |
Medication error | 31.71 | 13.54 | 28 | 113418 | 52256 | 63323320 |
Hand-foot-and-mouth disease | 31.50 | 13.54 | 12 | 113434 | 172 | 63375404 |
Foetal exposure during pregnancy | 31.49 | 13.54 | 9 | 113437 | 31953 | 63343623 |
Radiation necrosis | 31.23 | 13.54 | 15 | 113431 | 389 | 63375187 |
Foot deformity | 31.08 | 13.54 | 6 | 113440 | 27847 | 63347729 |
Infusion site induration | 31.01 | 13.54 | 22 | 113424 | 1200 | 63374376 |
Vocal cord paralysis | 30.90 | 13.54 | 28 | 113418 | 2173 | 63373403 |
Colorectal cancer metastatic | 30.71 | 13.54 | 17 | 113429 | 596 | 63374980 |
Brachiocephalic vein thrombosis | 30.33 | 13.54 | 10 | 113436 | 91 | 63375485 |
Thrombosis | 30.32 | 13.54 | 209 | 113237 | 64546 | 63311030 |
Hydronephrosis | 30.22 | 13.54 | 62 | 113384 | 10600 | 63364976 |
Early satiety | 30.17 | 13.54 | 20 | 113426 | 976 | 63374600 |
Toothache | 30.16 | 13.54 | 89 | 113357 | 19110 | 63356466 |
Hormone receptor positive breast cancer | 29.79 | 13.54 | 16 | 113430 | 528 | 63375048 |
Joint injury | 29.75 | 13.54 | 8 | 113438 | 29564 | 63346012 |
Pigmentation disorder | 29.69 | 13.54 | 39 | 113407 | 4600 | 63370976 |
Epistaxis | 29.61 | 13.54 | 227 | 113219 | 72498 | 63303078 |
Breast disorder | 29.42 | 13.54 | 29 | 113417 | 2501 | 63373075 |
Varices oesophageal | 29.26 | 13.54 | 32 | 113414 | 3116 | 63372460 |
Stress cardiomyopathy | 29.24 | 13.54 | 57 | 113389 | 9393 | 63366183 |
Device issue | 29.05 | 13.54 | 4 | 113442 | 23777 | 63351799 |
Biliary sepsis | 28.94 | 13.54 | 19 | 113427 | 912 | 63374664 |
Sopor | 28.87 | 13.54 | 3 | 113443 | 22161 | 63353415 |
Blood glucose increased | 28.84 | 13.54 | 67 | 113379 | 83689 | 63291887 |
Radiation skin injury | 28.72 | 13.54 | 19 | 113427 | 924 | 63374652 |
Mucosal necrosis | 28.54 | 13.54 | 8 | 113438 | 39 | 63375537 |
Agitation | 28.52 | 13.54 | 39 | 113407 | 59718 | 63315858 |
Sequestrectomy | 28.50 | 13.54 | 18 | 113428 | 808 | 63374768 |
Injection site bruising | 28.50 | 13.54 | 20 | 113426 | 41890 | 63333686 |
Obesity | 28.48 | 13.54 | 9 | 113437 | 29943 | 63345633 |
Retroperitoneal neoplasm metastatic | 28.37 | 13.54 | 8 | 113438 | 40 | 63375536 |
Dermatomyositis | 28.32 | 13.54 | 30 | 113416 | 2818 | 63372758 |
Sciatica | 28.18 | 13.54 | 13 | 113433 | 34311 | 63341265 |
Bone debridement | 28.17 | 13.54 | 12 | 113434 | 233 | 63375343 |
Treatment noncompliance | 27.87 | 13.54 | 16 | 113430 | 37309 | 63338267 |
Abnormal behaviour | 27.65 | 13.54 | 3 | 113443 | 21423 | 63354153 |
Cachexia | 27.55 | 13.54 | 42 | 113404 | 5684 | 63369892 |
Pancreatic fistula | 27.35 | 13.54 | 6 | 113440 | 7 | 63375569 |
Rhabdomyolysis | 27.30 | 13.54 | 23 | 113423 | 43928 | 63331648 |
C-reactive protein increased | 27.13 | 13.54 | 83 | 113363 | 94624 | 63280952 |
Recall phenomenon | 27.13 | 13.54 | 16 | 113430 | 634 | 63374942 |
Cheilitis | 26.98 | 13.54 | 35 | 113411 | 4078 | 63371498 |
Onychomadesis | 26.92 | 13.54 | 42 | 113404 | 5798 | 63369778 |
Acute kidney injury | 26.92 | 13.54 | 321 | 113125 | 263094 | 63112482 |
Loss of consciousness | 26.89 | 13.54 | 114 | 113332 | 118007 | 63257569 |
Vascular pain | 26.84 | 13.54 | 17 | 113429 | 767 | 63374809 |
Odynophagia | 26.71 | 13.54 | 48 | 113398 | 7438 | 63368138 |
Pulpitis dental | 26.58 | 13.54 | 18 | 113428 | 910 | 63374666 |
Pneumonitis | 26.54 | 13.54 | 129 | 113317 | 35093 | 63340483 |
Brain oedema | 26.43 | 13.54 | 70 | 113376 | 14125 | 63361451 |
Adnexa uteri mass | 26.29 | 13.54 | 15 | 113431 | 558 | 63375018 |
Tooth erosion | 26.15 | 13.54 | 14 | 113432 | 459 | 63375117 |
Bursitis | 26.09 | 13.54 | 17 | 113429 | 37024 | 63338552 |
Dermatitis acneiform | 25.97 | 13.54 | 38 | 113408 | 4958 | 63370618 |
Incorrect dose administered | 25.84 | 13.54 | 42 | 113404 | 59926 | 63315650 |
Pulmonary mass | 25.82 | 13.54 | 94 | 113352 | 22502 | 63353074 |
Asthenopia | 25.73 | 13.54 | 26 | 113420 | 2311 | 63373265 |
Multiple sclerosis | 25.66 | 13.54 | 6 | 113440 | 24366 | 63351210 |
Arterial thrombosis | 25.62 | 13.54 | 21 | 113425 | 1422 | 63374154 |
Hepatic cancer metastatic | 25.61 | 13.54 | 13 | 113433 | 381 | 63375195 |
Metastases to eye | 25.59 | 13.54 | 10 | 113436 | 154 | 63375422 |
Fluid retention | 25.53 | 13.54 | 42 | 113404 | 59644 | 63315932 |
Brain operation | 25.44 | 13.54 | 15 | 113431 | 594 | 63374982 |
Oral pigmentation | 25.40 | 13.54 | 6 | 113440 | 12 | 63375564 |
Ataxia | 25.38 | 13.54 | 72 | 113374 | 15123 | 63360453 |
Vasodilatation | 25.19 | 13.54 | 26 | 113420 | 2369 | 63373207 |
Limbal stem cell deficiency | 25.08 | 13.54 | 6 | 113440 | 13 | 63375563 |
Gingivitis | 25.06 | 13.54 | 50 | 113396 | 8379 | 63367197 |
Pneumatosis intestinalis | 25.03 | 13.54 | 26 | 113420 | 2387 | 63373189 |
Nervousness | 25.02 | 13.54 | 12 | 113434 | 30967 | 63344609 |
Tumour perforation | 24.85 | 13.54 | 9 | 113437 | 111 | 63375465 |
Respiratory disorder | 24.84 | 13.54 | 20 | 113426 | 39062 | 63336514 |
Failure to anastomose | 24.78 | 13.54 | 6 | 113440 | 14 | 63375562 |
Hand dermatitis | 24.73 | 13.54 | 11 | 113435 | 238 | 63375338 |
Intracranial pressure increased | 24.67 | 13.54 | 38 | 113408 | 5189 | 63370387 |
Fatigue | 24.59 | 13.54 | 1872 | 111574 | 886156 | 62489420 |
Hypervolaemia | 24.53 | 13.54 | 10 | 113436 | 28403 | 63347173 |
Oral pain | 24.34 | 13.54 | 108 | 113338 | 28286 | 63347290 |
Tongue discolouration | 24.23 | 13.54 | 29 | 113417 | 3114 | 63372462 |
Nightmare | 23.99 | 13.54 | 3 | 113443 | 19191 | 63356385 |
Vessel puncture site bruise | 23.98 | 13.54 | 13 | 113433 | 437 | 63375139 |
Bone marrow infiltration | 23.83 | 13.54 | 15 | 113431 | 669 | 63374907 |
Blood lactate dehydrogenase increased | 23.80 | 13.54 | 93 | 113353 | 23023 | 63352553 |
Weight decreased | 23.69 | 13.54 | 655 | 112791 | 276143 | 63099433 |
Nephrolithiasis | 23.68 | 13.54 | 24 | 113422 | 41960 | 63333616 |
Myocardial infarction | 23.61 | 13.54 | 95 | 113351 | 99798 | 63275778 |
Hepatic atrophy | 23.38 | 13.54 | 11 | 113435 | 272 | 63375304 |
Procedural pain | 23.33 | 13.54 | 5 | 113441 | 21564 | 63354012 |
Ejection fraction | 23.31 | 13.54 | 25 | 113421 | 2381 | 63373195 |
Transaminases | 23.24 | 13.54 | 8 | 113438 | 84 | 63375492 |
Product quality issue | 23.24 | 13.54 | 18 | 113428 | 35847 | 63339729 |
Computerised tomogram abnormal | 23.20 | 13.54 | 24 | 113422 | 2193 | 63373383 |
Schistosomiasis | 23.19 | 13.54 | 5 | 113441 | 5 | 63375571 |
Increased liver stiffness | 23.19 | 13.54 | 5 | 113441 | 5 | 63375571 |
Unresponsive to stimuli | 23.17 | 13.54 | 16 | 113430 | 33800 | 63341776 |
Evans syndrome | 23.11 | 13.54 | 10 | 113436 | 202 | 63375374 |
Muscle swelling | 23.05 | 13.54 | 13 | 113433 | 473 | 63375103 |
Neutrophil count abnormal | 22.81 | 13.54 | 27 | 113419 | 2865 | 63372711 |
Acute myeloid leukaemia | 22.79 | 13.54 | 75 | 113371 | 17072 | 63358504 |
Post-traumatic neck syndrome | 22.70 | 13.54 | 23 | 113423 | 2051 | 63373525 |
Disturbance in attention | 22.50 | 13.54 | 21 | 113425 | 38168 | 63337408 |
Metastases to breast | 22.50 | 13.54 | 11 | 113435 | 297 | 63375279 |
Brain neoplasm | 22.40 | 13.54 | 33 | 113413 | 4333 | 63371243 |
Adenocarcinoma | 22.38 | 13.54 | 27 | 113419 | 2923 | 63372653 |
Cytomegalovirus infection | 22.38 | 13.54 | 5 | 113441 | 20947 | 63354629 |
Atrial fibrillation | 22.20 | 13.54 | 120 | 113326 | 116516 | 63259060 |
Steatohepatitis | 22.19 | 13.54 | 14 | 113432 | 627 | 63374949 |
Delirium | 22.15 | 13.54 | 35 | 113411 | 50506 | 63325070 |
Metastases to spleen | 22.01 | 13.54 | 9 | 113437 | 157 | 63375419 |
Macular degeneration | 22.01 | 13.54 | 8 | 113438 | 24368 | 63351208 |
Injection site haemorrhage | 21.92 | 13.54 | 8 | 113438 | 24306 | 63351270 |
Diverticulitis | 21.87 | 13.54 | 23 | 113423 | 39534 | 63336042 |
Urinary tract infection | 21.82 | 13.54 | 337 | 113109 | 264347 | 63111229 |
Device malfunction | 21.82 | 13.54 | 3 | 113443 | 17854 | 63357722 |
Dental care | 21.79 | 13.54 | 17 | 113429 | 1072 | 63374504 |
Blood pressure increased | 21.74 | 13.54 | 185 | 113261 | 161877 | 63213699 |
Respiratory arrest | 21.64 | 13.54 | 16 | 113430 | 32629 | 63342947 |
Inflammation | 21.56 | 13.54 | 75 | 113371 | 82198 | 63293378 |
Lactic acidosis | 21.46 | 13.54 | 22 | 113424 | 38265 | 63337311 |
Hyperglycaemia | 21.33 | 13.54 | 138 | 113308 | 41729 | 63333847 |
Chemotherapy cardiotoxicity attenuation | 21.32 | 13.54 | 4 | 113442 | 0 | 63375576 |
Motion sickness | 21.28 | 13.54 | 16 | 113430 | 955 | 63374621 |
Neuroendocrine breast tumour | 21.28 | 13.54 | 6 | 113440 | 30 | 63375546 |
Ingrowing nail | 21.22 | 13.54 | 24 | 113422 | 2425 | 63373151 |
Pulmonary hypertension | 21.19 | 13.54 | 21 | 113425 | 37102 | 63338474 |
Neutropenic sepsis | 21.05 | 13.54 | 71 | 113375 | 16367 | 63359209 |
ECG signs of myocardial ischaemia | 20.92 | 13.54 | 7 | 113439 | 67 | 63375509 |
Hip arthroplasty | 20.87 | 13.54 | 33 | 113413 | 47613 | 63327963 |
Injection site swelling | 20.79 | 13.54 | 33 | 113413 | 47539 | 63328037 |
Right ventricular failure | 20.74 | 13.54 | 3 | 113443 | 17185 | 63358391 |
Vertebral column mass | 20.70 | 13.54 | 9 | 113437 | 184 | 63375392 |
Pleural neoplasm | 20.56 | 13.54 | 11 | 113435 | 360 | 63375216 |
Infection | 20.55 | 13.54 | 287 | 113159 | 228886 | 63146690 |
Purulent discharge | 20.53 | 13.54 | 33 | 113413 | 4673 | 63370903 |
Caesarean section | 20.49 | 13.54 | 3 | 113443 | 17029 | 63358547 |
HER2 positive breast cancer | 20.42 | 13.54 | 11 | 113435 | 365 | 63375211 |
Metastases to spinal cord | 20.37 | 13.54 | 8 | 113438 | 125 | 63375451 |
Hepatic neoplasm | 20.33 | 13.54 | 21 | 113425 | 1915 | 63373661 |
Epilepsy | 20.30 | 13.54 | 99 | 113347 | 26966 | 63348610 |
Cholangitis | 20.28 | 13.54 | 36 | 113410 | 5525 | 63370051 |
Acute respiratory failure | 20.27 | 13.54 | 19 | 113427 | 34466 | 63341110 |
Large intestine perforation | 20.23 | 13.54 | 46 | 113400 | 8436 | 63367140 |
No adverse event | 20.19 | 13.54 | 135 | 113311 | 41270 | 63334306 |
Anaemia | 20.19 | 13.54 | 676 | 112770 | 292754 | 63082822 |
Lymphadenopathy mediastinal | 20.17 | 13.54 | 25 | 113421 | 2783 | 63372793 |
Mucosal disorder | 20.08 | 13.54 | 22 | 113424 | 2147 | 63373429 |
Sinus congestion | 20.02 | 13.54 | 4 | 113442 | 18119 | 63357457 |
Product prescribing error | 20.01 | 13.54 | 11 | 113435 | 26278 | 63349298 |
Oral disorder | 20 | 13.54 | 47 | 113399 | 8807 | 63366769 |
Prinzmetal angina | 19.96 | 13.54 | 14 | 113432 | 750 | 63374826 |
Eosinophilia | 19.66 | 13.54 | 8 | 113438 | 22748 | 63352828 |
Illness | 19.64 | 13.54 | 36 | 113410 | 49023 | 63326553 |
Ankle fracture | 19.60 | 13.54 | 4 | 113442 | 17851 | 63357725 |
Respiratory tract congestion | 19.57 | 13.54 | 4 | 113442 | 17828 | 63357748 |
Metastases to muscle | 19.54 | 13.54 | 8 | 113438 | 140 | 63375436 |
Eye pain | 19.50 | 13.54 | 19 | 113427 | 33835 | 63341741 |
Pulmonary arterial hypertension | 19.40 | 13.54 | 8 | 113438 | 22569 | 63353007 |
Biliary obstruction | 19.38 | 13.54 | 25 | 113421 | 2896 | 63372680 |
Angioedema | 19.37 | 13.54 | 35 | 113411 | 47930 | 63327646 |
Hyperchlorhydria | 19.36 | 13.54 | 20 | 113426 | 1824 | 63373752 |
Folate deficiency | 19.35 | 13.54 | 23 | 113423 | 2452 | 63373124 |
Disease recurrence | 19.24 | 13.54 | 100 | 113346 | 27930 | 63347646 |
Subileus | 19.23 | 13.54 | 26 | 113420 | 3153 | 63372423 |
Invasive ductal breast carcinoma | 19.18 | 13.54 | 40 | 113406 | 6918 | 63368658 |
Metastases to stomach | 19.12 | 13.54 | 9 | 113437 | 223 | 63375353 |
Small intestinal obstruction | 19.06 | 13.54 | 74 | 113372 | 18263 | 63357313 |
Bronchiectasis | 19.06 | 13.54 | 3 | 113443 | 16139 | 63359437 |
Femoral artery embolism | 18.99 | 13.54 | 6 | 113440 | 47 | 63375529 |
Cognitive disorder | 18.93 | 13.54 | 45 | 113401 | 55770 | 63319806 |
Tubulointerstitial nephritis | 18.89 | 13.54 | 6 | 113440 | 19897 | 63355679 |
Weight fluctuation | 18.88 | 13.54 | 49 | 113397 | 9770 | 63365806 |
Excessive granulation tissue | 18.87 | 13.54 | 14 | 113432 | 819 | 63374757 |
Coronary artery disease | 18.85 | 13.54 | 18 | 113428 | 32359 | 63343217 |
Small intestinal perforation | 18.81 | 13.54 | 18 | 113428 | 1497 | 63374079 |
Depressed level of consciousness | 18.80 | 13.54 | 53 | 113393 | 62025 | 63313551 |
Gamma-glutamyltransferase abnormal | 18.65 | 13.54 | 10 | 113436 | 329 | 63375247 |
Metastases to thorax | 18.61 | 13.54 | 9 | 113437 | 237 | 63375339 |
Haematoma | 18.42 | 13.54 | 21 | 113425 | 34799 | 63340777 |
Pericardial effusion malignant | 18.39 | 13.54 | 7 | 113439 | 100 | 63375476 |
Disability | 18.38 | 13.54 | 5 | 113441 | 18342 | 63357234 |
Catheter site inflammation | 18.34 | 13.54 | 14 | 113432 | 855 | 63374721 |
Metastases to abdominal cavity | 18.31 | 13.54 | 11 | 113435 | 451 | 63375125 |
Diarrhoea haemorrhagic | 18.29 | 13.54 | 46 | 113400 | 8996 | 63366580 |
Necrotising oesophagitis | 18.29 | 13.54 | 11 | 113435 | 452 | 63375124 |
Pelvic fluid collection | 18.24 | 13.54 | 14 | 113432 | 862 | 63374714 |
Upper respiratory tract infection | 18.17 | 13.54 | 80 | 113366 | 81967 | 63293609 |
Metastases to pelvis | 18.12 | 13.54 | 11 | 113435 | 460 | 63375116 |
Chemical peritonitis | 18.08 | 13.54 | 7 | 113439 | 105 | 63375471 |
Radiation fibrosis - lung | 18.07 | 13.54 | 5 | 113441 | 23 | 63375553 |
Hyperammonaemia | 17.97 | 13.54 | 33 | 113413 | 5199 | 63370377 |
Carcinoid tumour pulmonary | 17.97 | 13.54 | 11 | 113435 | 467 | 63375109 |
Body temperature decreased | 17.96 | 13.54 | 78 | 113368 | 20241 | 63355335 |
Psychotic disorder | 17.84 | 13.54 | 12 | 113434 | 25700 | 63349876 |
Hypothalamo-pituitary disorder | 17.83 | 13.54 | 13 | 113433 | 740 | 63374836 |
Rhinorrhoea | 17.71 | 13.54 | 59 | 113387 | 65518 | 63310058 |
Blood lactate dehydrogenase abnormal | 17.70 | 13.54 | 10 | 113436 | 365 | 63375211 |
Oral toxicity | 17.66 | 13.54 | 4 | 113442 | 6 | 63375570 |
Calcium ionised increased | 17.62 | 13.54 | 7 | 113439 | 113 | 63375463 |
Radiation injury | 17.61 | 13.54 | 11 | 113435 | 484 | 63375092 |
Myalgia | 17.59 | 13.54 | 172 | 113274 | 146357 | 63229219 |
Botryomycosis | 17.57 | 13.54 | 5 | 113441 | 26 | 63375550 |
Abdominal distension | 17.53 | 13.54 | 234 | 113212 | 86381 | 63289195 |
Sensory disturbance | 17.46 | 13.54 | 59 | 113387 | 13613 | 63361963 |
Blood alkaline phosphatase increased | 17.42 | 13.54 | 134 | 113312 | 42833 | 63332743 |
Enterocolitis haemorrhagic | 17.41 | 13.54 | 17 | 113429 | 1449 | 63374127 |
Artificial menopause | 17.41 | 13.54 | 5 | 113441 | 27 | 63375549 |
Dyschezia | 17.41 | 13.54 | 21 | 113425 | 2273 | 63373303 |
Tumour marker abnormal | 17.41 | 13.54 | 10 | 113436 | 377 | 63375199 |
Paresis | 17.33 | 13.54 | 22 | 113424 | 2508 | 63373068 |
Gallbladder disorder | 17.32 | 13.54 | 6 | 113440 | 18836 | 63356740 |
Pulmonary thrombosis | 17.32 | 13.54 | 44 | 113402 | 8658 | 63366918 |
Ileus paralytic | 17.30 | 13.54 | 30 | 113416 | 4521 | 63371055 |
Hypertriglyceridaemia | 17.27 | 13.54 | 36 | 113410 | 6223 | 63369353 |
Joint dislocation | 17.26 | 13.54 | 6 | 113440 | 18794 | 63356782 |
Herpangina | 17.26 | 13.54 | 5 | 113441 | 28 | 63375548 |
Peripheral motor neuropathy | 17.23 | 13.54 | 18 | 113428 | 1663 | 63373913 |
Bone fistula | 17.18 | 13.54 | 6 | 113440 | 66 | 63375510 |
Colitis ischaemic | 17.17 | 13.54 | 50 | 113396 | 10658 | 63364918 |
Impaired work ability | 17.07 | 13.54 | 5 | 113441 | 17470 | 63358106 |
Oncologic complication | 17.04 | 13.54 | 8 | 113438 | 197 | 63375379 |
Gastroenteropancreatic neuroendocrine tumour disease | 16.97 | 13.54 | 5 | 113441 | 30 | 63375546 |
Sudden death | 16.95 | 13.54 | 49 | 113397 | 10400 | 63365176 |
Wound dehiscence | 16.94 | 13.54 | 31 | 113415 | 4872 | 63370704 |
Anaphylactic reaction | 16.82 | 13.54 | 61 | 113385 | 66039 | 63309537 |
Premature baby | 16.79 | 13.54 | 8 | 113438 | 20727 | 63354849 |
Anal erythema | 16.78 | 13.54 | 8 | 113438 | 204 | 63375372 |
Skin disorder | 16.74 | 13.54 | 100 | 113346 | 29407 | 63346169 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 16.74 | 13.54 | 14 | 113432 | 975 | 63374601 |
Obstructive airways disorder | 16.74 | 13.54 | 8 | 113438 | 20691 | 63354885 |
Autoimmune disorder | 16.62 | 13.54 | 5 | 113441 | 17172 | 63358404 |
Drug level increased | 16.61 | 13.54 | 10 | 113436 | 22726 | 63352850 |
Gait disturbance | 16.56 | 13.54 | 229 | 113217 | 182949 | 63192627 |
Metastases to kidney | 16.53 | 13.54 | 8 | 113438 | 211 | 63375365 |
Blood bilirubin abnormal | 16.52 | 13.54 | 14 | 113432 | 993 | 63374583 |
Anastomotic complication | 16.48 | 13.54 | 7 | 113439 | 135 | 63375441 |
Brachial plexopathy | 16.48 | 13.54 | 7 | 113439 | 135 | 63375441 |
Amnesia | 16.43 | 13.54 | 48 | 113398 | 55537 | 63320039 |
Metastases to bladder | 16.43 | 13.54 | 8 | 113438 | 214 | 63375362 |
Dysgeusia | 16.41 | 13.54 | 141 | 113305 | 46569 | 63329007 |
Gastrointestinal inflammation | 16.34 | 13.54 | 33 | 113413 | 5579 | 63369997 |
Hallucination, visual | 16.32 | 13.54 | 7 | 113439 | 19291 | 63356285 |
Radioisotope scan | 16.32 | 13.54 | 4 | 113442 | 10 | 63375566 |
Incorrect route of product administration | 16.29 | 13.54 | 15 | 113431 | 27437 | 63348139 |
Cytokine release syndrome | 16.15 | 13.54 | 3 | 113443 | 14311 | 63361265 |
Influenza like illness | 16.14 | 13.54 | 63 | 113383 | 66761 | 63308815 |
Malignant peritoneal neoplasm | 16.13 | 13.54 | 12 | 113434 | 705 | 63374871 |
Rectal perforation | 16.11 | 13.54 | 10 | 113436 | 435 | 63375141 |
Hyperbaric oxygen therapy | 16.07 | 13.54 | 5 | 113441 | 37 | 63375539 |
Hypermutation | 16.07 | 13.54 | 5 | 113441 | 37 | 63375539 |
Hospitalisation | 16.05 | 13.54 | 227 | 113219 | 84854 | 63290722 |
Sleep disorder | 16.03 | 13.54 | 83 | 113363 | 81483 | 63294093 |
Tumour invasion | 16.02 | 13.54 | 7 | 113439 | 145 | 63375431 |
Actinomycosis | 16.01 | 13.54 | 14 | 113432 | 1036 | 63374540 |
Dermatoglyphic anomaly | 15.99 | 13.54 | 3 | 113443 | 0 | 63375576 |
Hyperchylomicronaemia | 15.99 | 13.54 | 3 | 113443 | 0 | 63375576 |
Metastases to thyroid | 15.99 | 13.54 | 3 | 113443 | 0 | 63375576 |
Vein disorder | 15.89 | 13.54 | 31 | 113415 | 5110 | 63370466 |
Staphylococcal infection | 15.87 | 13.54 | 31 | 113415 | 41225 | 63334351 |
Gastric varices haemorrhage | 15.84 | 13.54 | 7 | 113439 | 149 | 63375427 |
Kidney infection | 15.83 | 13.54 | 11 | 113435 | 23165 | 63352411 |
Heart rate increased | 15.78 | 13.54 | 101 | 113345 | 94137 | 63281439 |
Hallucination | 15.73 | 13.54 | 48 | 113398 | 54769 | 63320807 |
Dermatitis | 15.69 | 13.54 | 66 | 113380 | 16892 | 63358684 |
Bone erosion | 15.68 | 13.54 | 6 | 113440 | 17711 | 63357865 |
Liver scan abnormal | 15.52 | 13.54 | 5 | 113441 | 42 | 63375534 |
Thyroid disorder | 15.44 | 13.54 | 4 | 113442 | 15158 | 63360418 |
Gram stain positive | 15.41 | 13.54 | 5 | 113441 | 43 | 63375533 |
Sputum discoloured | 15.39 | 13.54 | 5 | 113441 | 16342 | 63359234 |
Memory impairment | 15.36 | 13.54 | 116 | 113330 | 104142 | 63271434 |
Sepsis | 15.32 | 13.54 | 370 | 113076 | 152753 | 63222823 |
Neutropenic colitis | 15.31 | 13.54 | 23 | 113423 | 3072 | 63372504 |
Bone cancer metastatic | 15.31 | 13.54 | 7 | 113439 | 162 | 63375414 |
Restless legs syndrome | 15.24 | 13.54 | 7 | 113439 | 18524 | 63357052 |
Pituitary tumour | 15.19 | 13.54 | 13 | 113433 | 935 | 63374641 |
Blood phosphorus decreased | 15.19 | 13.54 | 28 | 113418 | 4425 | 63371151 |
Carbohydrate antigen 19-9 increased | 15.15 | 13.54 | 8 | 113438 | 255 | 63375321 |
Mediastinal disorder | 15.14 | 13.54 | 9 | 113437 | 362 | 63375214 |
Sinus disorder | 15.06 | 13.54 | 13 | 113433 | 24540 | 63351036 |
Limb injury | 15.02 | 13.54 | 14 | 113432 | 25463 | 63350113 |
Musculoskeletal chest pain | 15.02 | 13.54 | 76 | 113370 | 21007 | 63354569 |
Pleural disorder | 14.94 | 13.54 | 11 | 113435 | 636 | 63374940 |
Keratitis | 14.93 | 13.54 | 24 | 113422 | 3398 | 63372178 |
Paraneoplastic dermatomyositis | 14.91 | 13.54 | 4 | 113442 | 16 | 63375560 |
Musculoskeletal pain | 14.90 | 13.54 | 100 | 113346 | 92177 | 63283399 |
Facial asymmetry | 14.90 | 13.54 | 12 | 113434 | 793 | 63374783 |
Mood swings | 14.84 | 13.54 | 7 | 113439 | 18241 | 63357335 |
Full blood count abnormal | 14.83 | 13.54 | 21 | 113425 | 31696 | 63343880 |
Oestrogen receptor assay positive | 14.83 | 13.54 | 10 | 113436 | 502 | 63375074 |
Renal hydrocele | 14.71 | 13.54 | 4 | 113442 | 17 | 63375559 |
Cancer pain | 14.71 | 13.54 | 23 | 113423 | 3182 | 63372394 |
Left ventricular dysfunction | 14.67 | 13.54 | 51 | 113395 | 11937 | 63363639 |
Pulmonary hilum mass | 14.66 | 13.54 | 6 | 113440 | 105 | 63375471 |
Torsade de pointes | 14.64 | 13.54 | 3 | 113443 | 13348 | 63362228 |
Perforation | 14.58 | 13.54 | 14 | 113432 | 1169 | 63374407 |
Radiotherapy | 14.53 | 13.54 | 9 | 113437 | 390 | 63375186 |
Extrapyramidal disorder | 14.53 | 13.54 | 3 | 113443 | 13281 | 63362295 |
Myopathy toxic | 14.52 | 13.54 | 10 | 113436 | 520 | 63375056 |
Cardiac murmur | 14.52 | 13.54 | 4 | 113442 | 14548 | 63361028 |
Abdominal symptom | 14.51 | 13.54 | 9 | 113437 | 391 | 63375185 |
Renal vein thrombosis | 14.47 | 13.54 | 9 | 113437 | 393 | 63375183 |
Respiratory tract infection | 14.43 | 13.54 | 33 | 113413 | 41450 | 63334126 |
Venous thrombosis limb | 14.38 | 13.54 | 22 | 113424 | 2986 | 63372590 |
Peritoneal fluid analysis abnormal | 14.35 | 13.54 | 4 | 113442 | 19 | 63375557 |
Lip pain | 14.32 | 13.54 | 17 | 113429 | 1809 | 63373767 |
Nail avulsion | 14.28 | 13.54 | 7 | 113439 | 190 | 63375386 |
Hypoglycaemia | 14.27 | 13.54 | 57 | 113389 | 60008 | 63315568 |
Glaucoma | 14.26 | 13.54 | 8 | 113438 | 18897 | 63356679 |
Tumour excision | 14.25 | 13.54 | 9 | 113437 | 404 | 63375172 |
Activated PI3 kinase delta syndrome | 14.19 | 13.54 | 4 | 113442 | 20 | 63375556 |
Wound treatment | 14.18 | 13.54 | 7 | 113439 | 193 | 63375383 |
Tumour haemorrhage | 14.16 | 13.54 | 16 | 113430 | 1615 | 63373961 |
Corneal erosion | 14.09 | 13.54 | 8 | 113438 | 295 | 63375281 |
Obstruction gastric | 14.07 | 13.54 | 13 | 113433 | 1034 | 63374542 |
Vulval disorder | 14.06 | 13.54 | 12 | 113434 | 860 | 63374716 |
Rectal cancer recurrent | 14.02 | 13.54 | 4 | 113442 | 21 | 63375555 |
Ureteric obstruction | 14.00 | 13.54 | 17 | 113429 | 1853 | 63373723 |
Anxiety disorder due to a general medical condition | 13.91 | 13.54 | 3 | 113443 | 3 | 63375573 |
Bile duct stenosis | 13.87 | 13.54 | 14 | 113432 | 1242 | 63374334 |
Skin sensitisation | 13.85 | 13.54 | 12 | 113434 | 877 | 63374699 |
Subclavian vein thrombosis | 13.85 | 13.54 | 17 | 113429 | 1873 | 63373703 |
Electrocardiogram QT prolonged | 13.82 | 13.54 | 57 | 113389 | 59473 | 63316103 |
Hepatic cancer | 13.80 | 13.54 | 27 | 113419 | 4460 | 63371116 |
Protein total decreased | 13.80 | 13.54 | 32 | 113414 | 5945 | 63369631 |
Product complaint | 13.79 | 13.54 | 3 | 113443 | 12806 | 63362770 |
Ocular icterus | 13.76 | 13.54 | 24 | 113422 | 3632 | 63371944 |
Dark circles under eyes | 13.75 | 13.54 | 10 | 113436 | 567 | 63375009 |
Aggression | 13.75 | 13.54 | 13 | 113433 | 23485 | 63352091 |
Faeces soft | 13.72 | 13.54 | 31 | 113415 | 5661 | 63369915 |
Blood phosphorus increased | 13.65 | 13.54 | 22 | 113424 | 3123 | 63372453 |
Lymphangitis | 13.65 | 13.54 | 12 | 113434 | 895 | 63374681 |
Pulmonary fibrosis | 13.58 | 13.54 | 32 | 113414 | 39777 | 63335799 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 2434.82 | 14.46 | 929 | 52707 | 15866 | 34887429 |
Diarrhoea | 1383.32 | 14.46 | 2271 | 51365 | 387641 | 34515654 |
Disease progression | 1220.83 | 14.46 | 1134 | 52502 | 106943 | 34796352 |
Death | 589.70 | 14.46 | 1629 | 52007 | 396420 | 34506875 |
Arteriospasm coronary | 485.22 | 14.46 | 186 | 53450 | 3196 | 34900099 |
Neuropathy peripheral | 398.58 | 14.46 | 561 | 53075 | 82702 | 34820593 |
Mucosal inflammation | 388.22 | 14.46 | 381 | 53255 | 38241 | 34865054 |
Vomiting | 260.38 | 14.46 | 902 | 52734 | 246719 | 34656576 |
Stomatitis | 256.36 | 14.46 | 321 | 53315 | 42193 | 34861102 |
Dehydration | 255.22 | 14.46 | 594 | 53042 | 129375 | 34773920 |
Anastomotic leak | 243.58 | 14.46 | 73 | 53563 | 558 | 34902737 |
Enteritis | 233.01 | 14.46 | 149 | 53487 | 7993 | 34895302 |
Nausea | 232.88 | 14.46 | 1083 | 52553 | 338825 | 34564470 |
Myelosuppression | 217.98 | 14.46 | 203 | 53433 | 19062 | 34884233 |
Malignant neoplasm progression | 208.44 | 14.46 | 434 | 53202 | 87612 | 34815683 |
Neurotoxicity | 198.43 | 14.46 | 187 | 53449 | 17823 | 34885472 |
Metastases to liver | 192.46 | 14.46 | 163 | 53473 | 13500 | 34889795 |
Gastrointestinal perforation | 182.94 | 14.46 | 98 | 53538 | 3765 | 34899530 |
Dihydropyrimidine dehydrogenase deficiency | 171.69 | 14.46 | 37 | 53599 | 49 | 34903246 |
Intestinal obstruction | 166.57 | 14.46 | 190 | 53446 | 22632 | 34880663 |
Decreased appetite | 164.82 | 14.46 | 595 | 53041 | 165797 | 34737498 |
Metastases to lung | 162.59 | 14.46 | 126 | 53510 | 9194 | 34894101 |
Gastrointestinal toxicity | 160.52 | 14.46 | 80 | 53556 | 2639 | 34900656 |
Skin toxicity | 153.10 | 14.46 | 94 | 53542 | 4690 | 34898605 |
Bone marrow failure | 146.96 | 14.46 | 202 | 53434 | 29051 | 34874244 |
Enterocolitis | 143.27 | 14.46 | 110 | 53526 | 7916 | 34895379 |
Drug ineffective | 136.13 | 14.46 | 314 | 53322 | 456437 | 34446858 |
Completed suicide | 136.08 | 14.46 | 3 | 53633 | 98165 | 34805130 |
Anastomotic complication | 123.07 | 14.46 | 39 | 53597 | 366 | 34902929 |
Neutropenia | 104.09 | 14.46 | 496 | 53140 | 156282 | 34747013 |
Colon cancer metastatic | 101.80 | 14.46 | 50 | 53586 | 1597 | 34901698 |
Tumour perforation | 101.29 | 14.46 | 32 | 53604 | 297 | 34902998 |
Abdominal pain | 98.90 | 14.46 | 504 | 53132 | 163114 | 34740181 |
Ileus | 98.43 | 14.46 | 124 | 53512 | 16375 | 34886920 |
Arthralgia | 97.84 | 14.46 | 71 | 53565 | 169970 | 34733325 |
Condition aggravated | 96.12 | 14.46 | 92 | 53544 | 192104 | 34711191 |
Headache | 95.81 | 14.46 | 100 | 53536 | 200535 | 34702760 |
Therapy cessation | 95.64 | 14.46 | 124 | 53512 | 16849 | 34886446 |
Cardiotoxicity | 87.04 | 14.46 | 71 | 53565 | 5577 | 34897718 |
Stomal varices | 85.12 | 14.46 | 21 | 53615 | 67 | 34903228 |
Metastases to peritoneum | 85.12 | 14.46 | 46 | 53590 | 1798 | 34901497 |
Pneumonia | 81.43 | 14.46 | 285 | 53351 | 362342 | 34540953 |
Thrombocytopenia | 76.72 | 14.46 | 455 | 53181 | 155792 | 34747503 |
Carcinoembryonic antigen increased | 74.11 | 14.46 | 31 | 53605 | 674 | 34902621 |
Overdose | 73.56 | 14.46 | 24 | 53612 | 91035 | 34812260 |
Gastrointestinal anastomotic leak | 73.04 | 14.46 | 27 | 53609 | 417 | 34902878 |
Wound dehiscence | 71.73 | 14.46 | 51 | 53585 | 3260 | 34900035 |
Cardiac failure congestive | 68.95 | 14.46 | 21 | 53615 | 83249 | 34820046 |
Intestinal perforation | 68.75 | 14.46 | 77 | 53559 | 8983 | 34894312 |
Drug interaction | 66.45 | 14.46 | 156 | 53480 | 225790 | 34677505 |
Fall | 66.35 | 14.46 | 132 | 53504 | 202753 | 34700542 |
Neoplasm progression | 66.05 | 14.46 | 124 | 53512 | 23176 | 34880119 |
Portal hypertension | 64.57 | 14.46 | 52 | 53584 | 4010 | 34899285 |
Skin exfoliation | 64.51 | 14.46 | 135 | 53501 | 27297 | 34875998 |
Necrotising fasciitis | 64.21 | 14.46 | 50 | 53586 | 3672 | 34899623 |
Dysphagia | 64.05 | 14.46 | 226 | 53410 | 62155 | 34841140 |
Proteus infection | 60.76 | 14.46 | 31 | 53605 | 1075 | 34902220 |
Product dose omission issue | 60.13 | 14.46 | 57 | 53579 | 119654 | 34783641 |
Haematotoxicity | 59.39 | 14.46 | 68 | 53568 | 8126 | 34895169 |
Depression | 59.18 | 14.46 | 38 | 53598 | 97060 | 34806235 |
Anxiety | 57.80 | 14.46 | 41 | 53595 | 99387 | 34803908 |
Gastric perforation | 57.34 | 14.46 | 40 | 53596 | 2480 | 34900815 |
Toxic leukoencephalopathy | 57.04 | 14.46 | 22 | 53614 | 384 | 34902911 |
Terminal ileitis | 56.85 | 14.46 | 19 | 53617 | 214 | 34903081 |
Proteinuria | 56.34 | 14.46 | 102 | 53534 | 18540 | 34884755 |
Recall phenomenon | 56.33 | 14.46 | 24 | 53612 | 547 | 34902748 |
Hyperammonaemic encephalopathy | 55.49 | 14.46 | 38 | 53598 | 2286 | 34901009 |
Fingerprint loss | 55.45 | 14.46 | 13 | 53623 | 31 | 34903264 |
Colitis | 54.60 | 14.46 | 154 | 53482 | 37596 | 34865699 |
Non-cirrhotic portal hypertension | 53.70 | 14.46 | 19 | 53617 | 257 | 34903038 |
Rectal perforation | 53.47 | 14.46 | 22 | 53614 | 458 | 34902837 |
Metastases to lymph nodes | 51.87 | 14.46 | 49 | 53587 | 4679 | 34898616 |
Focal nodular hyperplasia | 50.79 | 14.46 | 16 | 53620 | 147 | 34903148 |
COVID-19 | 50.56 | 14.46 | 28 | 53608 | 77522 | 34825773 |
Peritonitis | 50.04 | 14.46 | 90 | 53546 | 16275 | 34887020 |
Hiccups | 49.67 | 14.46 | 69 | 53567 | 10013 | 34893282 |
Paraesthesia | 49.17 | 14.46 | 212 | 53424 | 63960 | 34839335 |
Subileus | 48.79 | 14.46 | 40 | 53596 | 3163 | 34900132 |
Splenorenal shunt | 47.90 | 14.46 | 10 | 53626 | 10 | 34903285 |
Intentional product misuse | 46.90 | 14.46 | 7 | 53629 | 45604 | 34857691 |
Induration | 46.90 | 14.46 | 25 | 53611 | 950 | 34902345 |
Cough | 46.24 | 14.46 | 101 | 53535 | 150039 | 34753256 |
Dermatitis acneiform | 45.93 | 14.46 | 52 | 53584 | 6137 | 34897158 |
Faecal volume decreased | 45.72 | 14.46 | 14 | 53622 | 116 | 34903179 |
Pulmonary embolism | 45.68 | 14.46 | 264 | 53372 | 89482 | 34813813 |
Hepatic lesion | 45.64 | 14.46 | 41 | 53595 | 3671 | 34899624 |
Hallucination | 44.44 | 14.46 | 12 | 53624 | 51486 | 34851809 |
Therapy interrupted | 44.03 | 14.46 | 77 | 53559 | 13620 | 34889675 |
Influenza | 43.95 | 14.46 | 11 | 53625 | 49655 | 34853640 |
Weight increased | 43.62 | 14.46 | 47 | 53589 | 92986 | 34810309 |
Hypovolaemic shock | 43.45 | 14.46 | 54 | 53582 | 7031 | 34896264 |
Obstruction gastric | 43.25 | 14.46 | 24 | 53612 | 989 | 34902306 |
Metastases to central nervous system | 43.21 | 14.46 | 58 | 53578 | 8147 | 34895148 |
Pruritus | 42.50 | 14.46 | 97 | 53539 | 141884 | 34761411 |
Vascular pain | 42.02 | 14.46 | 14 | 53622 | 156 | 34903139 |
Confusional state | 41.15 | 14.46 | 101 | 53535 | 144059 | 34759236 |
Prothrombin level decreased | 40.84 | 14.46 | 24 | 53612 | 1104 | 34902191 |
Dizziness | 40.49 | 14.46 | 185 | 53451 | 218336 | 34684959 |
Pancreatic neuroendocrine tumour metastatic | 40.23 | 14.46 | 12 | 53624 | 90 | 34903205 |
Portal shunt | 40.05 | 14.46 | 10 | 53626 | 34 | 34903261 |
Aggression | 40.02 | 14.46 | 6 | 53630 | 38958 | 34864337 |
Oesophageal haemorrhage | 39.89 | 14.46 | 25 | 53611 | 1293 | 34902002 |
Oesophagitis | 39.36 | 14.46 | 72 | 53564 | 13189 | 34890106 |
Electrocardiogram ST segment elevation | 38.86 | 14.46 | 44 | 53592 | 5194 | 34898101 |
Foetal exposure during pregnancy | 38.83 | 14.46 | 6 | 53630 | 38095 | 34865200 |
Large intestinal obstruction | 38.80 | 14.46 | 26 | 53610 | 1509 | 34901786 |
Device occlusion | 38.72 | 14.46 | 49 | 53587 | 6496 | 34896799 |
Diaphragmatic spasm | 38.71 | 14.46 | 12 | 53624 | 104 | 34903191 |
No adverse event | 38.65 | 14.46 | 99 | 53537 | 22828 | 34880467 |
Joint swelling | 38.49 | 14.46 | 22 | 53614 | 59868 | 34843427 |
Agitation | 38.47 | 14.46 | 20 | 53616 | 57379 | 34845916 |
Mucosal disorder | 38.35 | 14.46 | 27 | 53609 | 1699 | 34901596 |
Musculoskeletal stiffness | 38.22 | 14.46 | 12 | 53624 | 46668 | 34856627 |
Hospice care | 37.99 | 14.46 | 50 | 53586 | 6890 | 34896405 |
Metastatic gastric cancer | 37.85 | 14.46 | 13 | 53623 | 160 | 34903135 |
Tumour marker increased | 37.75 | 14.46 | 19 | 53617 | 640 | 34902655 |
Hypokalaemia | 37.66 | 14.46 | 183 | 53453 | 58031 | 34845264 |
Suicidal ideation | 37.62 | 14.46 | 8 | 53628 | 40380 | 34862915 |
Rhabdomyolysis | 37.17 | 14.46 | 30 | 53606 | 68133 | 34835162 |
Small intestinal obstruction | 37.11 | 14.46 | 75 | 53561 | 14791 | 34888504 |
Clostridial infection | 36.79 | 14.46 | 36 | 53600 | 3591 | 34899704 |
Laryngospasm | 36.62 | 14.46 | 25 | 53611 | 1496 | 34901799 |
Gastrointestinal disorder | 36.56 | 14.46 | 125 | 53511 | 33823 | 34869472 |
Anal erythema | 36.26 | 14.46 | 11 | 53625 | 88 | 34903207 |
Insomnia | 36.19 | 14.46 | 65 | 53571 | 103842 | 34799453 |
Inappropriate schedule of product administration | 35.78 | 14.46 | 26 | 53610 | 62270 | 34841025 |
Stoma site haemorrhage | 35.05 | 14.46 | 20 | 53616 | 870 | 34902425 |
Prostate cancer | 34.66 | 14.46 | 9 | 53627 | 39640 | 34863655 |
Polyneuropathy | 34.65 | 14.46 | 73 | 53563 | 14823 | 34888472 |
Metastasis | 34.53 | 14.46 | 37 | 53599 | 4107 | 34899188 |
Large intestine perforation | 34.36 | 14.46 | 53 | 53583 | 8450 | 34894845 |
Protein urine | 34.35 | 14.46 | 20 | 53616 | 904 | 34902391 |
Venoocclusive liver disease | 34.09 | 14.46 | 51 | 53585 | 7915 | 34895380 |
Colon cancer recurrent | 33.91 | 14.46 | 11 | 53625 | 112 | 34903183 |
Skin fissures | 33.73 | 14.46 | 41 | 53595 | 5218 | 34898077 |
Psoriasis | 33.57 | 14.46 | 9 | 53627 | 38803 | 34864492 |
Bradycardia | 33.28 | 14.46 | 40 | 53596 | 75378 | 34827917 |
Sinusitis | 33.26 | 14.46 | 11 | 53625 | 41391 | 34861904 |
Rectal tenesmus | 33.16 | 14.46 | 19 | 53617 | 833 | 34902462 |
Biliary obstruction | 33.12 | 14.46 | 30 | 53606 | 2715 | 34900580 |
Anal prolapse | 32.89 | 14.46 | 6 | 53630 | 0 | 34903295 |
Asthenia | 32.69 | 14.46 | 543 | 53093 | 244708 | 34658587 |
Electrocardiogram QT prolonged | 32.69 | 14.46 | 11 | 53625 | 40941 | 34862354 |
Dysaesthesia pharynx | 32.19 | 14.46 | 9 | 53627 | 52 | 34903243 |
Asthma | 31.46 | 14.46 | 13 | 53623 | 42643 | 34860652 |
Intestinal dilatation | 31.03 | 14.46 | 21 | 53615 | 1239 | 34902056 |
Hypoaesthesia | 30.76 | 14.46 | 180 | 53456 | 61264 | 34842031 |
Skin discolouration | 30.02 | 14.46 | 77 | 53559 | 17768 | 34885527 |
Peripheral ischaemia | 29.64 | 14.46 | 40 | 53596 | 5647 | 34897648 |
Therapy partial responder | 29.54 | 14.46 | 53 | 53583 | 9563 | 34893732 |
Neutropenic sepsis | 29.20 | 14.46 | 65 | 53571 | 13702 | 34889593 |
Ascites | 29.12 | 14.46 | 145 | 53491 | 46426 | 34856869 |
Chronic obstructive pulmonary disease | 28.64 | 14.46 | 20 | 53616 | 48898 | 34854397 |
Injection site pain | 28.59 | 14.46 | 12 | 53624 | 38993 | 34864302 |
Wound infection | 28.43 | 14.46 | 44 | 53592 | 7035 | 34896260 |
Therapy change | 28.37 | 14.46 | 29 | 53607 | 3048 | 34900247 |
Rectal cancer metastatic | 28.01 | 14.46 | 11 | 53625 | 202 | 34903093 |
Nasopharyngitis | 27.91 | 14.46 | 40 | 53596 | 69928 | 34833367 |
Neutrophil count decreased | 27.74 | 14.46 | 153 | 53483 | 50951 | 34852344 |
Disseminated intravascular coagulation | 27.71 | 14.46 | 85 | 53551 | 21731 | 34881564 |
Abnormal behaviour | 27.68 | 14.46 | 3 | 53633 | 24966 | 34878329 |
Hyperbilirubinaemia | 27.64 | 14.46 | 72 | 53564 | 16771 | 34886524 |
Leukopenia | 27.59 | 14.46 | 178 | 53458 | 62678 | 34840617 |
Arterial thrombosis | 27.55 | 14.46 | 21 | 53615 | 1494 | 34901801 |
Pneumatosis intestinalis | 27.49 | 14.46 | 32 | 53604 | 3891 | 34899404 |
Leukoencephalopathy | 27.26 | 14.46 | 33 | 53603 | 4182 | 34899113 |
Wheezing | 26.90 | 14.46 | 15 | 53621 | 41387 | 34861908 |
Cellulitis | 26.81 | 14.46 | 25 | 53611 | 52926 | 34850369 |
Erythema | 26.78 | 14.46 | 230 | 53406 | 88550 | 34814745 |
Cheilitis | 26.65 | 14.46 | 25 | 53611 | 2366 | 34900929 |
Fatigue | 26.55 | 14.46 | 750 | 52886 | 369903 | 34533392 |
Gastroenteritis radiation | 26.49 | 14.46 | 12 | 53624 | 318 | 34902977 |
Proctalgia | 26.46 | 14.46 | 38 | 53598 | 5685 | 34897610 |
Pelvic abscess | 26.40 | 14.46 | 17 | 53619 | 922 | 34902373 |
Feeling abnormal | 26.37 | 14.46 | 35 | 53601 | 63200 | 34840095 |
Product use issue | 26.36 | 14.46 | 35 | 53601 | 63181 | 34840114 |
Myalgia | 26.35 | 14.46 | 56 | 53580 | 84054 | 34819241 |
Bronchitis | 26.13 | 14.46 | 16 | 53620 | 41947 | 34861348 |
Drug reaction with eosinophilia and systemic symptoms | 26.12 | 14.46 | 9 | 53627 | 33003 | 34870292 |
Pigmentation disorder | 25.97 | 14.46 | 25 | 53611 | 2444 | 34900851 |
Blood pressure fluctuation | 25.67 | 14.46 | 4 | 53632 | 25245 | 34878050 |
Gastrointestinal mucosal necrosis | 25.54 | 14.46 | 10 | 53626 | 182 | 34903113 |
Dysaesthesia | 25.50 | 14.46 | 24 | 53612 | 2281 | 34901014 |
Hypertriglyceridaemia | 25.24 | 14.46 | 46 | 53590 | 8402 | 34894893 |
Ileus paralytic | 25.10 | 14.46 | 38 | 53598 | 5959 | 34897336 |
Seizure | 25.05 | 14.46 | 80 | 53556 | 104777 | 34798518 |
Nasal congestion | 24.99 | 14.46 | 3 | 53633 | 23054 | 34880241 |
Therapeutic product effect decreased | 24.96 | 14.46 | 11 | 53625 | 34732 | 34868563 |
Tenderness | 24.96 | 14.46 | 41 | 53595 | 6893 | 34896402 |
Gastric dilatation | 24.95 | 14.46 | 15 | 53621 | 720 | 34902575 |
Peripheral sensorimotor neuropathy | 24.61 | 14.46 | 20 | 53616 | 1562 | 34901733 |
Gastrointestinal stoma necrosis | 24.60 | 14.46 | 6 | 53630 | 18 | 34903277 |
Somnolence | 24.36 | 14.46 | 88 | 53548 | 111028 | 34792267 |
Hyperfibrinolysis | 24.35 | 14.46 | 6 | 53630 | 19 | 34903276 |
Cognitive disorder | 24.17 | 14.46 | 7 | 53629 | 28686 | 34874609 |
Aortic thrombosis | 24.16 | 14.46 | 15 | 53621 | 763 | 34902532 |
Pancreatitis viral | 23.95 | 14.46 | 5 | 53631 | 5 | 34903290 |
Chronic kidney disease | 23.92 | 14.46 | 17 | 53619 | 41193 | 34862102 |
Arthropathy | 23.72 | 14.46 | 6 | 53630 | 26901 | 34876394 |
Lactic acidosis | 23.46 | 14.46 | 12 | 53624 | 34760 | 34868535 |
Treatment noncompliance | 23.40 | 14.46 | 7 | 53629 | 28093 | 34875202 |
Gastrointestinal stoma complication | 23.33 | 14.46 | 18 | 53618 | 1304 | 34901991 |
Performance status decreased | 22.95 | 14.46 | 30 | 53606 | 4107 | 34899188 |
Heart rate decreased | 22.89 | 14.46 | 10 | 53626 | 31735 | 34871560 |
Eosinophilia | 22.83 | 14.46 | 6 | 53630 | 26216 | 34877079 |
Irritability | 22.77 | 14.46 | 5 | 53631 | 24685 | 34878610 |
Alanine aminotransferase increased | 22.74 | 14.46 | 57 | 53579 | 80758 | 34822537 |
Mucosal toxicity | 22.58 | 14.46 | 10 | 53626 | 251 | 34903044 |
Temperature intolerance | 22.47 | 14.46 | 27 | 53609 | 3395 | 34899900 |
Colorectal cancer metastatic | 22.31 | 14.46 | 14 | 53622 | 726 | 34902569 |
Ectropion | 22.04 | 14.46 | 8 | 53628 | 117 | 34903178 |
Varices oesophageal | 22.03 | 14.46 | 28 | 53608 | 3727 | 34899568 |
Pharyngeal ulceration | 22.01 | 14.46 | 11 | 53625 | 365 | 34902930 |
Dyspnoea | 21.95 | 14.46 | 427 | 53209 | 376355 | 34526940 |
Cholangitis | 21.88 | 14.46 | 44 | 53592 | 8645 | 34894650 |
Urticaria | 21.73 | 14.46 | 39 | 53597 | 62338 | 34840957 |
Acute promyelocytic leukaemia | 21.66 | 14.46 | 12 | 53624 | 493 | 34902802 |
Erectile dysfunction | 21.60 | 14.46 | 3 | 53633 | 20634 | 34882661 |
Tumour necrosis | 21.56 | 14.46 | 17 | 53619 | 1271 | 34902024 |
Colostomy | 21.48 | 14.46 | 12 | 53624 | 501 | 34902794 |
Failure to anastomose | 21.09 | 14.46 | 9 | 53627 | 206 | 34903089 |
Hepatic infarction | 20.93 | 14.46 | 9 | 53627 | 210 | 34903085 |
Palmar erythema | 20.90 | 14.46 | 10 | 53626 | 301 | 34902994 |
Nephrotic syndrome | 20.85 | 14.46 | 39 | 53597 | 7264 | 34896031 |
Wrong technique in product usage process | 20.68 | 14.46 | 15 | 53621 | 35971 | 34867324 |
Oxygen saturation decreased | 20.26 | 14.46 | 32 | 53604 | 53786 | 34849509 |
Basal cell carcinoma | 20.25 | 14.46 | 3 | 53633 | 19655 | 34883640 |
Change of bowel habit | 20.17 | 14.46 | 15 | 53621 | 1028 | 34902267 |
Interstitial lung disease | 20.14 | 14.46 | 170 | 53466 | 65112 | 34838183 |
Scleroderma-like reaction | 20.12 | 14.46 | 6 | 53630 | 45 | 34903250 |
Electrolyte imbalance | 20.05 | 14.46 | 58 | 53578 | 14354 | 34888941 |
Upper respiratory tract infection | 20.04 | 14.46 | 13 | 53623 | 33046 | 34870249 |
Coronary artery disease | 19.87 | 14.46 | 27 | 53609 | 48278 | 34855017 |
Pulmonary hypertension | 19.78 | 14.46 | 4 | 53632 | 20920 | 34882375 |
Tremor | 19.73 | 14.46 | 63 | 53573 | 82524 | 34820771 |
Back pain | 19.71 | 14.46 | 108 | 53528 | 121681 | 34781614 |
Perforation | 19.58 | 14.46 | 9 | 53627 | 247 | 34903048 |
Idiosyncratic drug reaction | 19.57 | 14.46 | 11 | 53625 | 465 | 34902830 |
Therapeutic product effect prolonged | 19.41 | 14.46 | 9 | 53627 | 252 | 34903043 |
Gastrointestinal wall thickening | 19.32 | 14.46 | 17 | 53619 | 1481 | 34901814 |
Nail bed inflammation | 19.29 | 14.46 | 8 | 53628 | 170 | 34903125 |
Cataract | 19.28 | 14.46 | 8 | 53628 | 26178 | 34877117 |
Hepatic atrophy | 19.08 | 14.46 | 8 | 53628 | 175 | 34903120 |
Gastrointestinal mucosal disorder | 19.01 | 14.46 | 10 | 53626 | 370 | 34902925 |
Incisional hernia | 18.99 | 14.46 | 16 | 53620 | 1314 | 34901981 |
Drug hypersensitivity | 18.84 | 14.46 | 62 | 53574 | 80467 | 34822828 |
Blood glucose increased | 18.81 | 14.46 | 47 | 53589 | 66671 | 34836624 |
Psychotic disorder | 18.77 | 14.46 | 7 | 53629 | 24445 | 34878850 |
Gastrointestinal inflammation | 18.76 | 14.46 | 25 | 53611 | 3486 | 34899809 |
Haematemesis | 18.55 | 14.46 | 88 | 53548 | 27623 | 34875672 |
Balance disorder | 18.53 | 14.46 | 21 | 53615 | 40633 | 34862662 |
Eczema impetiginous | 18.49 | 14.46 | 5 | 53631 | 25 | 34903270 |
Metastases to the mediastinum | 18.48 | 14.46 | 9 | 53627 | 282 | 34903013 |
Eosinophilic pneumonia chronic | 18.36 | 14.46 | 9 | 53627 | 286 | 34903009 |
Anterior spinal artery syndrome | 18.27 | 14.46 | 4 | 53632 | 6 | 34903289 |
Blood lactic acid increased | 18.06 | 14.46 | 35 | 53601 | 6693 | 34896602 |
Hot flush | 18.06 | 14.46 | 3 | 53633 | 18063 | 34885232 |
Memory impairment | 18.04 | 14.46 | 24 | 53612 | 43294 | 34860001 |
Feeling cold | 17.99 | 14.46 | 46 | 53590 | 10593 | 34892702 |
Laryngeal discomfort | 17.98 | 14.46 | 8 | 53628 | 203 | 34903092 |
Peripheral sensory neuropathy | 17.95 | 14.46 | 35 | 53601 | 6725 | 34896570 |
Sedation | 17.92 | 14.46 | 5 | 53631 | 21001 | 34882294 |
Peripheral embolism | 17.91 | 14.46 | 14 | 53622 | 1034 | 34902261 |
Metastases to pelvis | 17.75 | 14.46 | 9 | 53627 | 308 | 34902987 |
Contusion | 17.45 | 14.46 | 18 | 53618 | 36346 | 34866949 |
Disturbance in attention | 17.44 | 14.46 | 9 | 53627 | 25936 | 34877359 |
Treatment failure | 17.36 | 14.46 | 28 | 53608 | 46669 | 34856626 |
Metastases to eye | 17.31 | 14.46 | 6 | 53630 | 76 | 34903219 |
Gastrointestinal injury | 17.20 | 14.46 | 10 | 53626 | 451 | 34902844 |
Muscular weakness | 17.14 | 14.46 | 56 | 53580 | 72841 | 34830454 |
Hyperammonaemia | 16.94 | 14.46 | 33 | 53603 | 6334 | 34896961 |
Ventricular fibrillation | 16.93 | 14.46 | 75 | 53561 | 22879 | 34880416 |
Pallor | 16.89 | 14.46 | 9 | 53627 | 25471 | 34877824 |
Arthritis | 16.83 | 14.46 | 14 | 53622 | 31332 | 34871963 |
Scrotal ulcer | 16.76 | 14.46 | 10 | 53626 | 473 | 34902822 |
Neck pain | 16.73 | 14.46 | 9 | 53627 | 25340 | 34877955 |
Hand-foot-genital syndrome | 16.66 | 14.46 | 4 | 53632 | 11 | 34903284 |
Hypoglycaemia | 16.59 | 14.46 | 37 | 53599 | 54603 | 34848692 |
Adenocarcinoma metastatic | 16.59 | 14.46 | 5 | 53631 | 39 | 34903256 |
Depressed level of consciousness | 16.58 | 14.46 | 25 | 53611 | 42816 | 34860479 |
Vasospasm | 16.53 | 14.46 | 9 | 53627 | 357 | 34902938 |
Acute coronary syndrome | 16.48 | 14.46 | 52 | 53584 | 13493 | 34889802 |
Urethral ulcer | 16.44 | 14.46 | 3 | 53633 | 0 | 34903295 |
Faeces pale | 16.27 | 14.46 | 15 | 53621 | 1388 | 34901907 |
Pelvic fluid collection | 16.17 | 14.46 | 7 | 53629 | 166 | 34903129 |
Cardiac failure | 15.83 | 14.46 | 79 | 53557 | 91169 | 34812126 |
Metastases to meninges | 15.82 | 14.46 | 15 | 53621 | 1439 | 34901856 |
Phimosis | 15.71 | 14.46 | 12 | 53624 | 856 | 34902439 |
Intestinal ischaemia | 15.64 | 14.46 | 36 | 53600 | 7758 | 34895537 |
Neutrophilia | 15.62 | 14.46 | 25 | 53611 | 4112 | 34899183 |
Peritoneal disorder | 15.59 | 14.46 | 8 | 53628 | 281 | 34903014 |
Duodenal perforation | 15.48 | 14.46 | 14 | 53622 | 1264 | 34902031 |
Metastatic neoplasm | 15.48 | 14.46 | 21 | 53615 | 2979 | 34900316 |
Acral peeling skin syndrome | 15.41 | 14.46 | 5 | 53631 | 51 | 34903244 |
Liver injury | 15.33 | 14.46 | 54 | 53582 | 14824 | 34888471 |
False negative investigation result | 15.17 | 14.46 | 7 | 53629 | 194 | 34903101 |
Perineal ulceration | 15.13 | 14.46 | 4 | 53632 | 18 | 34903277 |
Swelling of eyelid | 15.12 | 14.46 | 13 | 53623 | 1098 | 34902197 |
Accidental overdose | 15.07 | 14.46 | 6 | 53630 | 20134 | 34883161 |
Urinary tract infection | 15.05 | 14.46 | 72 | 53564 | 84009 | 34819286 |
Electromyogram abnormal | 14.99 | 14.46 | 5 | 53631 | 56 | 34903239 |
Prostatic calcification | 14.94 | 14.46 | 6 | 53630 | 117 | 34903178 |
Phrenic nerve paralysis | 14.90 | 14.46 | 6 | 53630 | 118 | 34903177 |
Blood pressure increased | 14.88 | 14.46 | 77 | 53559 | 88025 | 34815270 |
Biliary fistula | 14.83 | 14.46 | 5 | 53631 | 58 | 34903237 |
Hypotension | 14.83 | 14.46 | 245 | 53391 | 221404 | 34681891 |
Malignant ascites | 14.80 | 14.46 | 9 | 53627 | 441 | 34902854 |
Mouth ulceration | 14.75 | 14.46 | 46 | 53590 | 11864 | 34891431 |
Respiratory arrest | 14.48 | 14.46 | 13 | 53623 | 28030 | 34875265 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 7642.36 | 12.86 | 2609 | 124613 | 30525 | 79586641 |
Disease progression | 3274.06 | 12.86 | 2551 | 124671 | 181811 | 79435355 |
Diarrhoea | 2852.81 | 12.86 | 5037 | 122185 | 875452 | 78741714 |
Malignant neoplasm progression | 1258.15 | 12.86 | 1305 | 125917 | 134685 | 79482481 |
Mucosal inflammation | 1132.18 | 12.86 | 949 | 126273 | 74631 | 79542535 |
Metastases to liver | 1055.66 | 12.86 | 622 | 126600 | 27692 | 79589474 |
Neuropathy peripheral | 884.76 | 12.86 | 1108 | 126114 | 140197 | 79476969 |
Metastases to bone | 818.27 | 12.86 | 501 | 126721 | 23926 | 79593240 |
Arteriospasm coronary | 757.70 | 12.86 | 314 | 126908 | 6402 | 79610764 |
Metastases to lung | 703.26 | 12.86 | 409 | 126813 | 17754 | 79599412 |
Death | 671.21 | 12.86 | 2204 | 125018 | 564310 | 79052856 |
Myelosuppression | 572.25 | 12.86 | 491 | 126731 | 39805 | 79577361 |
Vomiting | 545.15 | 12.86 | 2300 | 124922 | 663528 | 78953638 |
Metastases to central nervous system | 513.23 | 12.86 | 322 | 126900 | 16053 | 79601113 |
Neurotoxicity | 449.05 | 12.86 | 390 | 126832 | 32128 | 79585038 |
Nausea | 444.73 | 12.86 | 2822 | 124400 | 954374 | 78662792 |
Stomatitis | 435.76 | 12.86 | 814 | 126408 | 145943 | 79471223 |
Dehydration | 417.76 | 12.86 | 1096 | 126126 | 247091 | 79370075 |
Breast cancer metastatic | 407.07 | 12.86 | 221 | 127001 | 8381 | 79608785 |
Neutropenia | 402.85 | 12.86 | 1188 | 126034 | 286522 | 79330644 |
Bone marrow failure | 402.48 | 12.86 | 451 | 126771 | 50656 | 79566510 |
Gastrointestinal toxicity | 382.80 | 12.86 | 208 | 127014 | 7901 | 79609265 |
Completed suicide | 375.07 | 12.86 | 3 | 127219 | 245764 | 79371402 |
Metastases to lymph nodes | 355.14 | 12.86 | 216 | 127006 | 10181 | 79606985 |
Enteritis | 341.20 | 12.86 | 239 | 126983 | 14344 | 79602822 |
Skin toxicity | 339.86 | 12.86 | 194 | 127028 | 8120 | 79609046 |
Neoplasm progression | 338.55 | 12.86 | 415 | 126807 | 51267 | 79565899 |
Drug ineffective | 325.18 | 12.86 | 785 | 126437 | 1080128 | 78537038 |
Rheumatoid arthritis | 315.89 | 12.86 | 3 | 127219 | 208467 | 79408699 |
Arthralgia | 293.73 | 12.86 | 288 | 126934 | 571515 | 79045651 |
Condition aggravated | 282.96 | 12.86 | 231 | 126991 | 500893 | 79116273 |
Dihydropyrimidine dehydrogenase deficiency | 282.80 | 12.86 | 62 | 127160 | 88 | 79617078 |
Decreased appetite | 281.29 | 12.86 | 1186 | 126036 | 341232 | 79275934 |
Thrombocytopenia | 276.70 | 12.86 | 991 | 126231 | 264268 | 79352898 |
Cardiotoxicity | 271.09 | 12.86 | 194 | 127028 | 12045 | 79605121 |
Joint swelling | 255.49 | 12.86 | 72 | 127150 | 288574 | 79328592 |
Skin exfoliation | 245.69 | 12.86 | 367 | 126855 | 54733 | 79562433 |
Enterocolitis | 235.31 | 12.86 | 191 | 127031 | 14321 | 79602845 |
Skin fissures | 231.07 | 12.86 | 181 | 127041 | 12892 | 79604274 |
Anastomotic leak | 226.03 | 12.86 | 79 | 127143 | 986 | 79616180 |
Gastrointestinal perforation | 205.75 | 12.86 | 126 | 127096 | 6011 | 79611155 |
Metastases to skin | 201.87 | 12.86 | 83 | 127139 | 1656 | 79615510 |
Haematotoxicity | 197.98 | 12.86 | 178 | 127044 | 15341 | 79601825 |
Asthenia | 187.24 | 12.86 | 1426 | 125796 | 510263 | 79106903 |
Tumour marker increased | 183.55 | 12.86 | 103 | 127119 | 4169 | 79612997 |
Arthropathy | 181.10 | 12.86 | 32 | 127190 | 177079 | 79440087 |
Fall | 179.01 | 12.86 | 315 | 126907 | 487314 | 79129852 |
Contraindicated product administered | 173.54 | 12.86 | 23 | 127199 | 157515 | 79459651 |
Laryngospasm | 173.45 | 12.86 | 97 | 127125 | 3900 | 79613266 |
Hospice care | 171.87 | 12.86 | 138 | 127084 | 10186 | 79606980 |
Therapy cessation | 170.03 | 12.86 | 252 | 126970 | 37310 | 79579856 |
Paronychia | 166.60 | 12.86 | 121 | 127101 | 7687 | 79609479 |
Systemic lupus erythematosus | 163.19 | 12.86 | 7 | 127215 | 121142 | 79496024 |
Therapeutic product effect decreased | 162.42 | 12.86 | 32 | 127190 | 163831 | 79453335 |
Metastases to peritoneum | 160.10 | 12.86 | 95 | 127127 | 4277 | 79612889 |
Non-cirrhotic portal hypertension | 159.01 | 12.86 | 50 | 127172 | 437 | 79616729 |
Skin discolouration | 155.98 | 12.86 | 254 | 126968 | 40780 | 79576386 |
Maternal exposure during pregnancy | 155.11 | 12.86 | 18 | 127204 | 136520 | 79480646 |
Intestinal obstruction | 152.41 | 12.86 | 258 | 126964 | 42762 | 79574404 |
Carcinoembryonic antigen increased | 151.79 | 12.86 | 73 | 127149 | 2136 | 79615030 |
Osteonecrosis of jaw | 151.51 | 12.86 | 258 | 126964 | 42968 | 79574198 |
Drug interaction | 146.22 | 12.86 | 275 | 126947 | 414908 | 79202258 |
Dry skin | 145.81 | 12.86 | 330 | 126892 | 67665 | 79549501 |
Treatment failure | 144.44 | 12.86 | 46 | 127176 | 170440 | 79446726 |
Overdose | 143.61 | 12.86 | 57 | 127165 | 184149 | 79433017 |
Pseudocirrhosis | 142.62 | 12.86 | 50 | 127172 | 630 | 79616536 |
Sinusitis | 137.54 | 12.86 | 70 | 127152 | 195431 | 79421735 |
Pneumonia | 136.72 | 12.86 | 566 | 126656 | 659680 | 78957486 |
Musculoskeletal stiffness | 136.68 | 12.86 | 54 | 127168 | 174954 | 79442212 |
Drug hypersensitivity | 136.09 | 12.86 | 166 | 127056 | 298750 | 79318416 |
Paraesthesia | 135.45 | 12.86 | 599 | 126623 | 175724 | 79441442 |
Metastasis | 134.17 | 12.86 | 101 | 127121 | 6779 | 79610387 |
Product use issue | 133.48 | 12.86 | 85 | 127137 | 209737 | 79407429 |
Headache | 126.47 | 12.86 | 575 | 126647 | 653197 | 78963969 |
Intentional overdose | 125.40 | 12.86 | 12 | 127210 | 105948 | 79511218 |
Portal hypertension | 124.72 | 12.86 | 98 | 127124 | 7010 | 79610156 |
Weight increased | 120.07 | 12.86 | 160 | 127062 | 277226 | 79339940 |
Depression | 119.55 | 12.86 | 102 | 127120 | 216688 | 79400478 |
Exposure during pregnancy | 118.25 | 12.86 | 12 | 127210 | 101120 | 79516046 |
Breast cancer | 114.93 | 12.86 | 199 | 127023 | 33582 | 79583584 |
PIK3CA-activated mutation | 113.81 | 12.86 | 41 | 127181 | 562 | 79616604 |
Hepatic lesion | 113.68 | 12.86 | 92 | 127130 | 6867 | 79610299 |
Hyperbilirubinaemia | 113.13 | 12.86 | 166 | 127056 | 24352 | 79592814 |
Nail disorder | 111.56 | 12.86 | 115 | 127107 | 11737 | 79605429 |
Breast cancer recurrent | 109.83 | 12.86 | 65 | 127157 | 2912 | 79614254 |
Lymphangiosis carcinomatosa | 109.36 | 12.86 | 58 | 127164 | 2096 | 79615070 |
Anastomotic complication | 108.01 | 12.86 | 37 | 127185 | 433 | 79616733 |
Psoriasis | 106.40 | 12.86 | 10 | 127212 | 89577 | 79527589 |
Influenza | 106.22 | 12.86 | 37 | 127185 | 129569 | 79487597 |
Colitis | 105.41 | 12.86 | 306 | 126916 | 73001 | 79544165 |
Dysaesthesia pharynx | 104.21 | 12.86 | 30 | 127192 | 187 | 79616979 |
Tumour perforation | 104.04 | 12.86 | 35 | 127187 | 386 | 79616780 |
Glossodynia | 102.76 | 12.86 | 20 | 127202 | 103317 | 79513849 |
Onycholysis | 99.89 | 12.86 | 54 | 127168 | 2029 | 79615137 |
Polyneuropathy | 99.34 | 12.86 | 155 | 127067 | 23996 | 79593170 |
Ascites | 98.80 | 12.86 | 305 | 126917 | 75257 | 79541909 |
Pruritus | 97.55 | 12.86 | 314 | 126908 | 394334 | 79222832 |
Cardiac failure congestive | 97.16 | 12.86 | 53 | 127169 | 142349 | 79474817 |
Abdominal pain | 96.73 | 12.86 | 998 | 126224 | 388571 | 79228595 |
Suicide attempt | 96.54 | 12.86 | 10 | 127212 | 82922 | 79534244 |
Fingerprint loss | 95.30 | 12.86 | 22 | 127200 | 45 | 79617121 |
Hypokalaemia | 94.18 | 12.86 | 467 | 126755 | 143573 | 79473593 |
Metastases to pleura | 93.77 | 12.86 | 47 | 127175 | 1507 | 79615659 |
Arthritis | 92.09 | 12.86 | 34 | 127188 | 114846 | 79502320 |
Bradycardia | 90.26 | 12.86 | 52 | 127170 | 135505 | 79481661 |
Ileus | 89.94 | 12.86 | 155 | 127067 | 26056 | 79591110 |
Wound | 88.82 | 12.86 | 37 | 127185 | 116142 | 79501024 |
Carbohydrate antigen 15-3 increased | 87.24 | 12.86 | 41 | 127181 | 1138 | 79616028 |
Asthma | 84.15 | 12.86 | 56 | 127166 | 135039 | 79482127 |
Leukopenia | 82.83 | 12.86 | 387 | 126835 | 116126 | 79501040 |
Urticaria | 81.98 | 12.86 | 105 | 127117 | 185096 | 79432070 |
Intentional product misuse | 81.79 | 12.86 | 25 | 127197 | 95140 | 79522026 |
Stomal varices | 81.64 | 12.86 | 21 | 127201 | 79 | 79617087 |
Pericarditis | 81.63 | 12.86 | 32 | 127190 | 104204 | 79512962 |
Bronchitis | 80.25 | 12.86 | 55 | 127167 | 130589 | 79486577 |
Product dose omission issue | 80.15 | 12.86 | 172 | 127050 | 247365 | 79369801 |
Fibromyalgia | 79.65 | 12.86 | 6 | 127216 | 64334 | 79552832 |
Swelling | 78.44 | 12.86 | 141 | 127081 | 216570 | 79400596 |
Osteoarthritis | 76.74 | 12.86 | 22 | 127200 | 87287 | 79529879 |
Irritable bowel syndrome | 76.49 | 12.86 | 6 | 127216 | 62235 | 79554931 |
Therapy partial responder | 76.26 | 12.86 | 115 | 127107 | 17282 | 79599884 |
Anxiety | 76.11 | 12.86 | 178 | 127044 | 248334 | 79368832 |
Suicidal ideation | 75.42 | 12.86 | 15 | 127207 | 76325 | 79540841 |
Pain | 75.28 | 12.86 | 739 | 126483 | 703063 | 78914103 |
Metastatic neoplasm | 74.72 | 12.86 | 63 | 127159 | 4979 | 79612187 |
Hypovolaemic shock | 74.62 | 12.86 | 95 | 127127 | 12181 | 79604985 |
Duodenal ulcer perforation | 74.50 | 12.86 | 9 | 127213 | 66202 | 79550964 |
Hepatic function abnormal | 74.20 | 12.86 | 271 | 126951 | 72836 | 79544330 |
Recall phenomenon | 73.39 | 12.86 | 36 | 127186 | 1101 | 79616065 |
Chronic obstructive pulmonary disease | 72.40 | 12.86 | 23 | 127199 | 85396 | 79531770 |
Metastases to spine | 72.40 | 12.86 | 58 | 127164 | 4266 | 79612900 |
Ejection fraction decreased | 72.09 | 12.86 | 166 | 127056 | 34411 | 79582755 |
Plasma cell myeloma | 71.96 | 12.86 | 3 | 127219 | 53256 | 79563910 |
Infusion site coldness | 71.68 | 12.86 | 23 | 127199 | 216 | 79616950 |
Gastric perforation | 71.56 | 12.86 | 56 | 127166 | 3981 | 79613185 |
Blood pressure fluctuation | 71.12 | 12.86 | 11 | 127211 | 67134 | 79550032 |
Proteinuria | 68.83 | 12.86 | 157 | 127065 | 32345 | 79584821 |
Colon cancer metastatic | 68.60 | 12.86 | 43 | 127179 | 2138 | 79615028 |
Infusion related reaction | 68.05 | 12.86 | 168 | 127054 | 230069 | 79387097 |
Nasal congestion | 67.82 | 12.86 | 19 | 127203 | 76533 | 79540633 |
Pulmonary embolism | 67.39 | 12.86 | 487 | 126735 | 171167 | 79445999 |
Dysaesthesia | 66.67 | 12.86 | 63 | 127159 | 5785 | 79611381 |
COVID-19 | 66.11 | 12.86 | 93 | 127129 | 157581 | 79459585 |
Bone lesion | 66.02 | 12.86 | 63 | 127159 | 5856 | 79611310 |
Mobility decreased | 65.48 | 12.86 | 59 | 127163 | 122116 | 79495050 |
Platelet count decreased | 65.11 | 12.86 | 532 | 126690 | 194132 | 79423034 |
Intestinal perforation | 65.04 | 12.86 | 107 | 127115 | 17319 | 79599847 |
Oesophagitis | 64.93 | 12.86 | 129 | 127093 | 24160 | 79593006 |
Muscle injury | 64.74 | 12.86 | 3 | 127219 | 48558 | 79568608 |
Confusional state | 64.13 | 12.86 | 275 | 126947 | 317722 | 79299444 |
Wound dehiscence | 63.90 | 12.86 | 65 | 127157 | 6530 | 79610636 |
Feeling abnormal | 63.71 | 12.86 | 97 | 127125 | 159102 | 79458064 |
Discomfort | 63.43 | 12.86 | 64 | 127158 | 125553 | 79491613 |
Wheezing | 62.93 | 12.86 | 56 | 127166 | 116608 | 79500558 |
Fatigue | 62.72 | 12.86 | 1932 | 125290 | 927795 | 78689371 |
Drug reaction with eosinophilia and systemic symptoms | 62.68 | 12.86 | 13 | 127209 | 64231 | 79552935 |
Electrocardiogram QT prolonged | 62.58 | 12.86 | 33 | 127189 | 90353 | 79526813 |
Hepatic enzyme increased | 62.38 | 12.86 | 123 | 127099 | 182487 | 79434679 |
Neutrophil count decreased | 62.36 | 12.86 | 306 | 126916 | 93653 | 79523513 |
Subacute cutaneous lupus erythematosus | 62.27 | 12.86 | 49 | 127173 | 3512 | 79613654 |
Dermatitis acneiform | 61.80 | 12.86 | 78 | 127144 | 9915 | 79607251 |
Hepatic failure | 61.35 | 12.86 | 226 | 126996 | 60986 | 79556180 |
Rhabdomyolysis | 61.25 | 12.86 | 45 | 127177 | 103086 | 79514080 |
Osteonecrosis | 61.25 | 12.86 | 146 | 127076 | 30949 | 79586217 |
Gamma-glutamyltransferase decreased | 61.00 | 12.86 | 23 | 127199 | 361 | 79616805 |
Mucosal toxicity | 60.81 | 12.86 | 26 | 127196 | 574 | 79616592 |
Device related thrombosis | 60.49 | 12.86 | 43 | 127179 | 2640 | 79614526 |
Nail discolouration | 60.22 | 12.86 | 45 | 127177 | 2986 | 79614180 |
Nasopharyngitis | 59.92 | 12.86 | 206 | 127016 | 253675 | 79363491 |
Metastases to chest wall | 59.84 | 12.86 | 25 | 127197 | 520 | 79616646 |
Skin hyperpigmentation | 58.40 | 12.86 | 65 | 127157 | 7238 | 79609928 |
Hypoaesthesia | 58.28 | 12.86 | 487 | 126735 | 178865 | 79438301 |
Abdominal discomfort | 58.12 | 12.86 | 205 | 127017 | 250522 | 79366644 |
Injection site pain | 58.08 | 12.86 | 73 | 127149 | 129765 | 79487401 |
Insomnia | 57.81 | 12.86 | 199 | 127023 | 244971 | 79372195 |
Hypotension | 57.37 | 12.86 | 439 | 126783 | 439878 | 79177288 |
Peripheral sensory neuropathy | 56.91 | 12.86 | 86 | 127136 | 12947 | 79604219 |
Gastrointestinal anastomotic leak | 56.29 | 12.86 | 24 | 127198 | 526 | 79616640 |
Therapy change | 56.00 | 12.86 | 64 | 127158 | 7335 | 79609831 |
Recurrent cancer | 55.79 | 12.86 | 41 | 127181 | 2652 | 79614514 |
Loss of personal independence in daily activities | 55.61 | 12.86 | 49 | 127173 | 102531 | 79514635 |
Toxic leukoencephalopathy | 55.57 | 12.86 | 30 | 127192 | 1124 | 79616042 |
Metastases to meninges | 55.45 | 12.86 | 46 | 127176 | 3555 | 79613611 |
Varices oesophageal | 54.35 | 12.86 | 57 | 127165 | 5934 | 79611232 |
Disseminated intravascular coagulation | 53.82 | 12.86 | 152 | 127070 | 35690 | 79581476 |
Acute coronary syndrome | 53.82 | 12.86 | 110 | 127112 | 21023 | 79596143 |
Dysphagia | 53.51 | 12.86 | 356 | 126866 | 121780 | 79495386 |
Terminal ileitis | 53.18 | 12.86 | 27 | 127195 | 890 | 79616276 |
Blood bilirubin increased | 53.07 | 12.86 | 228 | 126994 | 66004 | 79551162 |
Electrocardiogram ST segment elevation | 52.66 | 12.86 | 66 | 127156 | 8331 | 79608835 |
Injury | 52.62 | 12.86 | 29 | 127193 | 77467 | 79539699 |
Chronic kidney disease | 52.30 | 12.86 | 20 | 127202 | 66134 | 79551032 |
Subileus | 51.66 | 12.86 | 54 | 127168 | 5600 | 79611566 |
Hiccups | 50.80 | 12.86 | 71 | 127151 | 9960 | 79607206 |
Vascular pain | 50.34 | 12.86 | 26 | 127196 | 889 | 79616277 |
Lacrimation increased | 50.30 | 12.86 | 111 | 127111 | 22366 | 79594800 |
Neutropenic sepsis | 50.02 | 12.86 | 124 | 127098 | 26940 | 79590226 |
Cytomegalovirus infection | 50.00 | 12.86 | 5 | 127217 | 42639 | 79574527 |
Performance status decreased | 49.90 | 12.86 | 55 | 127167 | 6058 | 79611108 |
Wrong technique in product usage process | 49.65 | 12.86 | 28 | 127194 | 73847 | 79543319 |
Lower respiratory tract infection | 49.55 | 12.86 | 81 | 127141 | 129139 | 79488027 |
Leukoencephalopathy | 49.21 | 12.86 | 62 | 127160 | 7867 | 79609299 |
Venoocclusive liver disease | 49.04 | 12.86 | 76 | 127146 | 11695 | 79605471 |
Oxygen saturation decreased | 48.45 | 12.86 | 82 | 127140 | 128965 | 79488201 |
Prescribed overdose | 48.44 | 12.86 | 3 | 127219 | 37880 | 79579286 |
Agitation | 47.87 | 12.86 | 53 | 127169 | 99662 | 79517504 |
Metastases to the mediastinum | 47.58 | 12.86 | 22 | 127200 | 588 | 79616578 |
Acute kidney injury | 47.16 | 12.86 | 566 | 126656 | 518838 | 79098328 |
Somnolence | 46.74 | 12.86 | 209 | 127013 | 238772 | 79378394 |
Abdominal lymphadenopathy | 46.28 | 12.86 | 28 | 127194 | 1306 | 79615860 |
Splenorenal shunt | 45.69 | 12.86 | 10 | 127212 | 14 | 79617152 |
Hyperkalaemia | 45.48 | 12.86 | 70 | 127152 | 114328 | 79502838 |
Peritonitis | 44.17 | 12.86 | 121 | 127101 | 27915 | 79589251 |
Mucosal disorder | 44.08 | 12.86 | 40 | 127182 | 3488 | 79613678 |
Jaw operation | 44.01 | 12.86 | 23 | 127199 | 806 | 79616360 |
Coronary artery disease | 43.73 | 12.86 | 25 | 127197 | 65449 | 79551717 |
Sleep apnoea syndrome | 43.50 | 12.86 | 4 | 127218 | 36474 | 79580692 |
Hypertriglyceridaemia | 43.26 | 12.86 | 75 | 127147 | 12665 | 79604501 |
Anastomotic fistula | 43.21 | 12.86 | 14 | 127208 | 136 | 79617030 |
Drug level increased | 43.14 | 12.86 | 6 | 127216 | 39645 | 79577521 |
Erythema | 43.11 | 12.86 | 545 | 126677 | 222745 | 79394421 |
Pneumatosis intestinalis | 42.88 | 12.86 | 52 | 127170 | 6345 | 79610821 |
Myalgia | 42.86 | 12.86 | 152 | 127070 | 185489 | 79431677 |
Cytokine release syndrome | 42.78 | 12.86 | 4 | 127218 | 35994 | 79581172 |
Lactic acidosis | 42.69 | 12.86 | 30 | 127192 | 70329 | 79546837 |
Aggression | 42.69 | 12.86 | 14 | 127208 | 50944 | 79566222 |
Basal cell carcinoma | 42.25 | 12.86 | 5 | 127217 | 37370 | 79579796 |
Sedation | 42.19 | 12.86 | 15 | 127207 | 51880 | 79565286 |
Lymphoedema | 42.05 | 12.86 | 73 | 127149 | 12340 | 79604826 |
Pyogenic granuloma | 41.50 | 12.86 | 19 | 127203 | 496 | 79616670 |
Obstruction gastric | 41.37 | 12.86 | 29 | 127193 | 1741 | 79615425 |
Abnormal behaviour | 40.85 | 12.86 | 5 | 127217 | 36416 | 79580750 |
Arterial thrombosis | 40.84 | 12.86 | 34 | 127188 | 2640 | 79614526 |
Blood cholesterol increased | 40.74 | 12.86 | 44 | 127178 | 83676 | 79533490 |
Medication error | 40.69 | 12.86 | 30 | 127192 | 68612 | 79548554 |
Eosinophilia | 40.64 | 12.86 | 11 | 127211 | 45334 | 79571832 |
Delirium | 40.60 | 12.86 | 45 | 127177 | 84582 | 79532584 |
Focal nodular hyperplasia | 40.58 | 12.86 | 21 | 127201 | 721 | 79616445 |
Device occlusion | 40.48 | 12.86 | 70 | 127152 | 11796 | 79605370 |
Therapy interrupted | 40.48 | 12.86 | 126 | 127096 | 31215 | 79585951 |
Pleural effusion | 40.25 | 12.86 | 381 | 126841 | 144881 | 79472285 |
Biliary obstruction | 39.80 | 12.86 | 43 | 127179 | 4631 | 79612535 |
Hallucination | 39.62 | 12.86 | 47 | 127175 | 85698 | 79531468 |
Mouth ulceration | 39.52 | 12.86 | 143 | 127079 | 38251 | 79578915 |
Treatment noncompliance | 39.37 | 12.86 | 17 | 127205 | 52251 | 79564915 |
Injection site erythema | 39.28 | 12.86 | 40 | 127182 | 78157 | 79539009 |
Pulmonary hypertension | 38.91 | 12.86 | 14 | 127208 | 48066 | 79569100 |
Portal shunt | 38.71 | 12.86 | 11 | 127211 | 65 | 79617101 |
Folliculitis | 38.66 | 12.86 | 20 | 127202 | 55360 | 79561806 |
Prothrombin level decreased | 38.58 | 12.86 | 27 | 127195 | 1617 | 79615549 |
Granulocyte count decreased | 38.53 | 12.86 | 28 | 127194 | 1780 | 79615386 |
Rectal tenesmus | 38.12 | 12.86 | 27 | 127195 | 1648 | 79615518 |
Drug ineffective for unapproved indication | 38.06 | 12.86 | 17 | 127205 | 51221 | 79565945 |
Cold dysaesthesia | 38.01 | 12.86 | 8 | 127214 | 8 | 79617158 |
Unresponsive to stimuli | 37.69 | 12.86 | 21 | 127201 | 55767 | 79561399 |
Tooth extraction | 37.69 | 12.86 | 65 | 127157 | 10930 | 79606236 |
Therapeutic product effect incomplete | 37.56 | 12.86 | 109 | 127113 | 141536 | 79475630 |
Diaphragmatic spasm | 37.56 | 12.86 | 12 | 127210 | 111 | 79617055 |
Prinzmetal angina | 37.48 | 12.86 | 27 | 127195 | 1693 | 79615473 |
Thrombosis | 37.35 | 12.86 | 246 | 126976 | 83854 | 79533312 |
Large intestine perforation | 37.30 | 12.86 | 76 | 127146 | 14491 | 79602675 |
Infusion site induration | 37.27 | 12.86 | 23 | 127199 | 1112 | 79616054 |
Hyperammonaemic encephalopathy | 37.27 | 12.86 | 42 | 127180 | 4740 | 79612426 |
Necrotising fasciitis | 37.06 | 12.86 | 47 | 127175 | 6003 | 79611163 |
Jaundice | 37.01 | 12.86 | 176 | 127046 | 53173 | 79563993 |
Dizziness | 36.97 | 12.86 | 604 | 126618 | 525837 | 79091329 |
Proteus infection | 36.72 | 12.86 | 29 | 127193 | 2089 | 79615077 |
Pharyngeal inflammation | 36.72 | 12.86 | 22 | 127200 | 1008 | 79616158 |
Biliary sepsis | 36.65 | 12.86 | 26 | 127196 | 1591 | 79615575 |
Blood pressure systolic increased | 36.30 | 12.86 | 32 | 127190 | 66954 | 79550212 |
Hypophagia | 36.21 | 12.86 | 156 | 127066 | 45211 | 79571955 |
Product use in unapproved indication | 35.76 | 12.86 | 243 | 126979 | 250116 | 79367050 |
Depressed level of consciousness | 35.74 | 12.86 | 62 | 127160 | 96590 | 79520576 |
Cataract | 35.73 | 12.86 | 28 | 127194 | 62092 | 79555074 |
Contusion | 35.56 | 12.86 | 120 | 127102 | 148656 | 79468510 |
Aortic thrombosis | 35.55 | 12.86 | 26 | 127196 | 1669 | 79615497 |
Ectropion | 35.15 | 12.86 | 16 | 127206 | 412 | 79616754 |
Pigmentation disorder | 34.98 | 12.86 | 44 | 127178 | 5574 | 79611592 |
Adverse event | 34.82 | 12.86 | 27 | 127195 | 60187 | 79556979 |
Hepatic atrophy | 34.69 | 12.86 | 16 | 127206 | 425 | 79616741 |
Metastases to ovary | 34.64 | 12.86 | 15 | 127207 | 342 | 79616824 |
Congestive cardiomyopathy | 34.46 | 12.86 | 65 | 127157 | 11715 | 79605451 |
Cholangitis | 34.32 | 12.86 | 68 | 127154 | 12708 | 79604458 |
Nervousness | 34.21 | 12.86 | 6 | 127216 | 33409 | 79583757 |
Joint range of motion decreased | 34.02 | 12.86 | 6 | 127216 | 33276 | 79583890 |
Hypoalbuminaemia | 33.63 | 12.86 | 92 | 127130 | 21205 | 79595961 |
Cachexia | 33.48 | 12.86 | 62 | 127160 | 11021 | 79606145 |
Nodular regenerative hyperplasia | 33.46 | 12.86 | 23 | 127199 | 1338 | 79615828 |
Abortion spontaneous | 33.22 | 12.86 | 4 | 127218 | 29503 | 79587663 |
Adnexa uteri mass | 33.22 | 12.86 | 15 | 127207 | 379 | 79616787 |
Pulmonary sarcoidosis | 33.21 | 12.86 | 23 | 127199 | 1354 | 79615812 |
Bone pain | 33.10 | 12.86 | 176 | 127046 | 55566 | 79561600 |
Small intestinal obstruction | 32.81 | 12.86 | 107 | 127115 | 27165 | 79590001 |
Bone disorder | 32.64 | 12.86 | 85 | 127137 | 19028 | 79598138 |
Obesity | 32.47 | 12.86 | 8 | 127214 | 35117 | 79582049 |
Migraine | 32.47 | 12.86 | 56 | 127166 | 87437 | 79529729 |
Hyperhidrosis | 32.38 | 12.86 | 128 | 127094 | 151364 | 79465802 |
Induration | 32.29 | 12.86 | 26 | 127196 | 1926 | 79615240 |
COVID-19 pneumonia | 32.26 | 12.86 | 4 | 127218 | 28845 | 79588321 |
Blood uric acid decreased | 32.22 | 12.86 | 22 | 127200 | 1266 | 79615900 |
Hand-foot-and-mouth disease | 32.13 | 12.86 | 14 | 127208 | 324 | 79616842 |
Faecal volume decreased | 32.08 | 12.86 | 12 | 127210 | 184 | 79616982 |
Myocardial infarction | 31.94 | 12.86 | 168 | 127054 | 183961 | 79433205 |
Metastases to eye | 31.87 | 12.86 | 13 | 127209 | 254 | 79616912 |
Osteoporosis | 31.62 | 12.86 | 24 | 127198 | 54088 | 79563078 |
Hypermutation | 31.41 | 12.86 | 9 | 127213 | 55 | 79617111 |
Type 2 diabetes mellitus | 31.30 | 12.86 | 27 | 127195 | 57095 | 79560071 |
White blood cell count decreased | 31.15 | 12.86 | 447 | 126775 | 187841 | 79429325 |
Hyperammonaemia | 30.96 | 12.86 | 60 | 127162 | 11033 | 79606133 |
Prescribed underdose | 30.88 | 12.86 | 5 | 127217 | 29509 | 79587657 |
Ejection fraction | 30.88 | 12.86 | 27 | 127195 | 2242 | 79614924 |
Protein urine | 30.87 | 12.86 | 23 | 127199 | 1519 | 79615647 |
Constipation | 30.81 | 12.86 | 628 | 126594 | 282422 | 79334744 |
Colorectal cancer metastatic | 30.62 | 12.86 | 21 | 127201 | 1217 | 79615949 |
Stoma site haemorrhage | 30.60 | 12.86 | 25 | 127197 | 1891 | 79615275 |
Respiratory arrest | 30.58 | 12.86 | 28 | 127194 | 57522 | 79559644 |
Pelvic fluid collection | 30.52 | 12.86 | 18 | 127204 | 801 | 79616365 |
Debridement | 30.49 | 12.86 | 24 | 127198 | 1721 | 79615445 |
Cheilitis | 30.38 | 12.86 | 40 | 127182 | 5301 | 79611865 |
Psychotic disorder | 30.34 | 12.86 | 14 | 127208 | 41388 | 79575778 |
Oesophageal haemorrhage | 30.22 | 12.86 | 24 | 127198 | 1743 | 79615423 |
Weight decreased | 30.20 | 12.86 | 761 | 126461 | 354437 | 79262729 |
Prostate cancer | 29.95 | 12.86 | 8 | 127214 | 33260 | 79583906 |
Sciatica | 29.88 | 12.86 | 8 | 127214 | 33214 | 79583952 |
Loss of consciousness | 29.82 | 12.86 | 152 | 127070 | 167791 | 79449375 |
Angioedema | 29.76 | 12.86 | 47 | 127175 | 75988 | 79541178 |
Ear infection | 29.66 | 12.86 | 9 | 127213 | 34423 | 79582743 |
Plantar erythema | 29.60 | 12.86 | 13 | 127209 | 307 | 79616859 |
Nail infection | 29.58 | 12.86 | 27 | 127195 | 2372 | 79614794 |
Stress cardiomyopathy | 29.48 | 12.86 | 59 | 127163 | 11107 | 79606059 |
Fluid retention | 29.42 | 12.86 | 41 | 127181 | 69768 | 79547398 |
Disturbance in attention | 29.09 | 12.86 | 23 | 127199 | 50778 | 79566388 |
Eosinophil percentage increased | 28.97 | 12.86 | 22 | 127200 | 1496 | 79615670 |
Hypervolaemia | 28.94 | 12.86 | 16 | 127206 | 42674 | 79574492 |
Pancreatic neuroendocrine tumour metastatic | 28.89 | 12.86 | 10 | 127212 | 121 | 79617045 |
Odynophagia | 28.89 | 12.86 | 59 | 127163 | 11268 | 79605898 |
Rectal perforation | 28.86 | 12.86 | 18 | 127204 | 887 | 79616279 |
Blood glucose increased | 28.67 | 12.86 | 91 | 127131 | 114884 | 79502282 |
Tumour pain | 28.59 | 12.86 | 26 | 127196 | 2273 | 79614893 |
Emotional distress | 28.55 | 12.86 | 14 | 127208 | 39955 | 79577211 |
Metastases to pelvis | 28.55 | 12.86 | 16 | 127206 | 646 | 79616520 |
Clostridial infection | 28.27 | 12.86 | 40 | 127182 | 5674 | 79611492 |
C-reactive protein increased | 28.22 | 12.86 | 108 | 127114 | 128919 | 79488247 |
Respiratory depression | 28.20 | 12.86 | 5 | 127217 | 27625 | 79589541 |
Upper respiratory tract infection | 28.12 | 12.86 | 65 | 127157 | 91103 | 79526063 |
Hypoglycaemia | 27.80 | 12.86 | 77 | 127145 | 101517 | 79515649 |
Acute myeloid leukaemia | 27.63 | 12.86 | 110 | 127112 | 30775 | 79586391 |
Anal erythema | 27.59 | 12.86 | 11 | 127211 | 202 | 79616964 |
Cognitive disorder | 27.58 | 12.86 | 43 | 127179 | 69883 | 79547283 |
Device issue | 27.47 | 12.86 | 5 | 127217 | 27103 | 79590063 |
Asthenopia | 27.39 | 12.86 | 26 | 127196 | 2401 | 79614765 |
Angina bullosa haemorrhagica | 27.20 | 12.86 | 11 | 127211 | 210 | 79616956 |
General physical health deterioration | 27.15 | 12.86 | 602 | 126620 | 274636 | 79342530 |
Acute promyelocytic leukaemia | 27.12 | 12.86 | 21 | 127201 | 1470 | 79615696 |
Withdrawal syndrome | 27.11 | 12.86 | 5 | 127217 | 26849 | 79590317 |
Skin reaction | 26.97 | 12.86 | 71 | 127151 | 15997 | 79601169 |
Gastrointestinal mucosal necrosis | 26.77 | 12.86 | 11 | 127211 | 219 | 79616947 |
Hyperfibrinolysis | 26.68 | 12.86 | 7 | 127215 | 29 | 79617137 |
Malignant ascites | 26.64 | 12.86 | 19 | 127203 | 1173 | 79615993 |
Tooth erosion | 26.58 | 12.86 | 13 | 127209 | 395 | 79616771 |
Blood creatinine decreased | 26.48 | 12.86 | 46 | 127176 | 7779 | 79609387 |
Pulmonary mass | 26.45 | 12.86 | 104 | 127118 | 28930 | 79588236 |
Tumour necrosis | 26.41 | 12.86 | 23 | 127199 | 1899 | 79615267 |
Gastrointestinal inflammation | 26.39 | 12.86 | 45 | 127177 | 7499 | 79609667 |
Neoplasm recurrence | 26.23 | 12.86 | 33 | 127189 | 4181 | 79612985 |
Bone sequestrum | 26.11 | 12.86 | 19 | 127203 | 1210 | 79615956 |
Acute respiratory failure | 26.07 | 12.86 | 34 | 127188 | 59507 | 79557659 |
Haematoma | 25.87 | 12.86 | 27 | 127195 | 52168 | 79564998 |
Small intestinal perforation | 25.77 | 12.86 | 29 | 127193 | 3268 | 79613898 |
Extrapyramidal disorder | 25.72 | 12.86 | 3 | 127219 | 22676 | 79594490 |
Lymphadenopathy | 25.64 | 12.86 | 159 | 127063 | 53088 | 79564078 |
Joint injury | 25.57 | 12.86 | 9 | 127213 | 31326 | 79585840 |
Accidental exposure to product | 25.55 | 12.86 | 9 | 127213 | 31313 | 79585853 |
Illness | 25.47 | 12.86 | 22 | 127200 | 46489 | 79570677 |
Foot deformity | 25.36 | 12.86 | 4 | 127218 | 24070 | 79593096 |
Disease recurrence | 25.33 | 12.86 | 138 | 127084 | 43971 | 79573195 |
Rhinorrhoea | 25.31 | 12.86 | 52 | 127170 | 76022 | 79541144 |
Accidental overdose | 25.19 | 12.86 | 16 | 127206 | 39565 | 79577601 |
Mucosal necrosis | 25.07 | 12.86 | 9 | 127213 | 122 | 79617044 |
Tendonitis | 25.02 | 12.86 | 4 | 127218 | 23826 | 79593340 |
Carbohydrate antigen 19-9 increased | 24.97 | 12.86 | 13 | 127209 | 452 | 79616714 |
Hormone receptor positive breast cancer | 24.83 | 12.86 | 12 | 127210 | 355 | 79616811 |
Vasodilatation | 24.83 | 12.86 | 28 | 127194 | 3163 | 79614003 |
Memory impairment | 24.78 | 12.86 | 93 | 127129 | 111641 | 79505525 |
Post-traumatic neck syndrome | 24.72 | 12.86 | 23 | 127199 | 2071 | 79615095 |
Haemophagocytic lymphohistiocytosis | 24.49 | 12.86 | 3 | 127219 | 21834 | 79595332 |
Peripheral sensorimotor neuropathy | 24.43 | 12.86 | 27 | 127195 | 2983 | 79614183 |
Neoplasm malignant | 24.33 | 12.86 | 108 | 127114 | 31702 | 79585464 |
Restlessness | 24.25 | 12.86 | 23 | 127199 | 46469 | 79570697 |
Eye pain | 24.18 | 12.86 | 15 | 127207 | 37563 | 79579603 |
Hospitalisation | 24.05 | 12.86 | 243 | 126979 | 93993 | 79523173 |
Dysgeusia | 24.03 | 12.86 | 165 | 127057 | 57012 | 79560154 |
Device malfunction | 23.92 | 12.86 | 3 | 127219 | 21445 | 79595721 |
Vessel puncture site bruise | 23.79 | 12.86 | 13 | 127209 | 499 | 79616667 |
Drug eruption | 23.79 | 12.86 | 21 | 127201 | 43914 | 79573252 |
Human epidermal growth factor receptor negative | 23.75 | 12.86 | 5 | 127217 | 5 | 79617161 |
Xeroderma | 23.55 | 12.86 | 11 | 127211 | 301 | 79616865 |
Malignant pleural effusion | 23.52 | 12.86 | 28 | 127194 | 3352 | 79613814 |
Coma | 23.49 | 12.86 | 82 | 127140 | 100567 | 79516599 |
Early satiety | 23.45 | 12.86 | 19 | 127203 | 1420 | 79615746 |
Urinary tract infection | 23.41 | 12.86 | 303 | 126919 | 274209 | 79342957 |
Pulmonary arterial hypertension | 23.40 | 12.86 | 8 | 127214 | 28358 | 79588808 |
Incorrect dose administered | 23.34 | 12.86 | 55 | 127167 | 76575 | 79540591 |
Cardiac output decreased | 23.28 | 12.86 | 21 | 127201 | 1817 | 79615349 |
Necrotising oesophagitis | 23.18 | 12.86 | 17 | 127205 | 1096 | 79616070 |
Failure to anastomose | 23.17 | 12.86 | 10 | 127212 | 226 | 79616940 |
Pregnancy | 23.16 | 12.86 | 7 | 127215 | 26844 | 79590322 |
Oral pigmentation | 23.04 | 12.86 | 6 | 127216 | 24 | 79617142 |
Ileal ulcer | 22.95 | 12.86 | 17 | 127205 | 1113 | 79616053 |
Poisoning | 22.89 | 12.86 | 6 | 127216 | 25266 | 79591900 |
Pericardial effusion | 22.85 | 12.86 | 139 | 127083 | 46098 | 79571068 |
Renal hydrocele | 22.84 | 12.86 | 6 | 127216 | 25 | 79617141 |
Gastrointestinal stoma necrosis | 22.84 | 12.86 | 6 | 127216 | 25 | 79617141 |
Hallucination, auditory | 22.82 | 12.86 | 3 | 127219 | 20690 | 79596476 |
Injection site haemorrhage | 22.75 | 12.86 | 8 | 127214 | 27862 | 79589304 |
HER2 positive breast cancer | 22.71 | 12.86 | 11 | 127211 | 327 | 79616839 |
Peripheral ischaemia | 22.64 | 12.86 | 48 | 127174 | 9409 | 79607757 |
Steatohepatitis | 22.63 | 12.86 | 16 | 127206 | 974 | 79616192 |
Obstructive airways disorder | 22.50 | 12.86 | 11 | 127211 | 31448 | 79585718 |
Product prescribing error | 22.42 | 12.86 | 23 | 127199 | 44790 | 79572376 |
Right ventricular failure | 22.42 | 12.86 | 5 | 127217 | 23492 | 79593674 |
Large intestinal obstruction | 22.41 | 12.86 | 27 | 127195 | 3272 | 79613894 |
Vocal cord paralysis | 22.38 | 12.86 | 24 | 127198 | 2563 | 79614603 |
Vein disorder | 22.35 | 12.86 | 34 | 127188 | 5148 | 79612018 |
Haemorrhage intracranial | 22.29 | 12.86 | 7 | 127215 | 26186 | 79590980 |
Oral pain | 22.12 | 12.86 | 105 | 127117 | 31693 | 79585473 |
Lymphadenopathy mediastinal | 22.09 | 12.86 | 31 | 127191 | 4365 | 79612801 |
Productive cough | 21.96 | 12.86 | 70 | 127152 | 88261 | 79528905 |
Dermatomyositis | 21.96 | 12.86 | 28 | 127194 | 3595 | 79613571 |
Neuroendocrine breast tumour | 21.95 | 12.86 | 6 | 127216 | 30 | 79617136 |
ECG signs of myocardial ischaemia | 21.88 | 12.86 | 11 | 127211 | 355 | 79616811 |
Temperature intolerance | 21.80 | 12.86 | 48 | 127174 | 9657 | 79607509 |
Abdominal distension | 21.79 | 12.86 | 289 | 126933 | 119361 | 79497805 |
Brachiocephalic vein thrombosis | 21.77 | 12.86 | 10 | 127212 | 263 | 79616903 |
Dermatoglyphic anomaly | 21.77 | 12.86 | 4 | 127218 | 0 | 79617166 |
Metastatic gastric cancer | 21.71 | 12.86 | 11 | 127211 | 361 | 79616805 |
Bone marrow infiltration | 21.70 | 12.86 | 14 | 127208 | 732 | 79616434 |
Blood lactate dehydrogenase abnormal | 21.67 | 12.86 | 10 | 127212 | 266 | 79616900 |
Viral infection | 21.61 | 12.86 | 22 | 127200 | 42994 | 79574172 |
Toxicity to various agents | 21.55 | 12.86 | 510 | 126712 | 421030 | 79196136 |
Gingival bleeding | 21.54 | 12.86 | 66 | 127156 | 16210 | 79600956 |
Superior vena cava syndrome | 21.44 | 12.86 | 17 | 127205 | 1232 | 79615934 |
Exposed bone in jaw | 21.38 | 12.86 | 28 | 127194 | 3692 | 79613474 |
Dental care | 21.36 | 12.86 | 15 | 127207 | 903 | 79616263 |
Intestinal metastasis | 21.33 | 12.86 | 11 | 127211 | 375 | 79616791 |
Anal prolapse | 21.25 | 12.86 | 7 | 127215 | 72 | 79617094 |
Metastases to breast | 21.23 | 12.86 | 10 | 127212 | 279 | 79616887 |
Blood pressure increased | 21.22 | 12.86 | 225 | 126997 | 211135 | 79406031 |
Hallucination, visual | 21.15 | 12.86 | 13 | 127209 | 32716 | 79584450 |
Colon cancer recurrent | 21.13 | 12.86 | 8 | 127214 | 127 | 79617039 |
Amnesia | 21.07 | 12.86 | 43 | 127179 | 63014 | 79554152 |
Limbal stem cell deficiency | 21.04 | 12.86 | 6 | 127216 | 36 | 79617130 |
Heart rate increased | 21.01 | 12.86 | 110 | 127112 | 120614 | 79496552 |
Epistaxis | 20.99 | 12.86 | 271 | 126951 | 111244 | 79505922 |
Atrial fibrillation | 20.96 | 12.86 | 208 | 127014 | 197678 | 79419488 |
Transaminases | 20.91 | 12.86 | 7 | 127215 | 76 | 79617090 |
Pneumocystis jirovecii pneumonia | 20.88 | 12.86 | 13 | 127209 | 32495 | 79584671 |
Bursitis | 20.81 | 12.86 | 16 | 127206 | 35828 | 79581338 |
Portal vein thrombosis | 20.70 | 12.86 | 35 | 127187 | 5792 | 79611374 |
Injection site bruising | 20.56 | 12.86 | 21 | 127201 | 40981 | 79576185 |
Hyperaesthesia | 20.51 | 12.86 | 54 | 127168 | 12168 | 79604998 |
Premature delivery | 20.46 | 12.86 | 6 | 127216 | 23461 | 79593705 |
Inappropriate schedule of product administration | 20.43 | 12.86 | 127 | 127095 | 133501 | 79483665 |
Hepatitis | 20.37 | 12.86 | 36 | 127186 | 55691 | 79561475 |
Device dislocation | 20.28 | 12.86 | 8 | 127214 | 25962 | 79591204 |
Tenderness | 20.19 | 12.86 | 83 | 127139 | 23559 | 79593607 |
Computerised tomogram abnormal | 20.10 | 12.86 | 26 | 127196 | 3387 | 79613779 |
Sputum discoloured | 20.01 | 12.86 | 5 | 127217 | 21738 | 79595428 |
Stress | 19.86 | 12.86 | 63 | 127159 | 79549 | 79537617 |
Ileus paralytic | 19.85 | 12.86 | 46 | 127176 | 9574 | 79607592 |
Pancreatitis viral | 19.83 | 12.86 | 5 | 127217 | 17 | 79617149 |
Incorrect route of product administration | 19.77 | 12.86 | 16 | 127206 | 34913 | 79582253 |
Panic attack | 19.68 | 12.86 | 7 | 127215 | 24209 | 79592957 |
Bone debridement | 19.63 | 12.86 | 11 | 127211 | 444 | 79616722 |
Respiratory tract congestion | 19.54 | 12.86 | 4 | 127218 | 19950 | 79597216 |
Perforation | 19.47 | 12.86 | 17 | 127205 | 1409 | 79615757 |
Gastrointestinal disorder | 19.36 | 12.86 | 288 | 126934 | 121917 | 79495249 |
Phimosis | 19.36 | 12.86 | 12 | 127210 | 585 | 79616581 |
Sinus bradycardia | 19.35 | 12.86 | 8 | 127214 | 25239 | 79591927 |
Onychomadesis | 19.31 | 12.86 | 32 | 127190 | 5210 | 79611956 |
Breast disorder | 19.24 | 12.86 | 20 | 127202 | 2061 | 79615105 |
Dyskinesia | 19.16 | 12.86 | 26 | 127196 | 44747 | 79572419 |
Hepatic infarction | 19.11 | 12.86 | 14 | 127208 | 901 | 79616265 |
Bronchiectasis | 19.02 | 12.86 | 6 | 127216 | 22380 | 79594786 |
Brain neoplasm | 18.86 | 12.86 | 33 | 127189 | 5613 | 79611553 |
Cardio-respiratory arrest | 18.81 | 12.86 | 99 | 127123 | 108411 | 79508755 |
Aplastic anaemia | 18.81 | 12.86 | 3 | 127219 | 17902 | 79599264 |
Neck pain | 18.59 | 12.86 | 60 | 127162 | 75357 | 79541809 |
Sleep disorder | 18.55 | 12.86 | 72 | 127150 | 85605 | 79531561 |
Metastases to adrenals | 18.45 | 12.86 | 16 | 127206 | 1314 | 79615852 |
Adenocarcinoma metastatic | 18.45 | 12.86 | 8 | 127214 | 183 | 79616983 |
Back pain | 18.44 | 12.86 | 358 | 126864 | 303822 | 79313344 |
Mydriasis | 18.43 | 12.86 | 3 | 127219 | 17640 | 79599526 |
Enterocolitis haemorrhagic | 18.36 | 12.86 | 20 | 127202 | 2174 | 79614992 |
Eosinophilic pneumonia chronic | 18.30 | 12.86 | 11 | 127211 | 507 | 79616659 |
Oropharyngeal pain | 18.28 | 12.86 | 101 | 127121 | 109252 | 79507914 |
Colitis ischaemic | 18.24 | 12.86 | 60 | 127162 | 15299 | 79601867 |
Intestinal dilatation | 18.18 | 12.86 | 22 | 127200 | 2678 | 79614488 |
Metastases to stomach | 18.12 | 12.86 | 9 | 127213 | 283 | 79616883 |
Diabetes mellitus inadequate control | 18.10 | 12.86 | 8 | 127214 | 24256 | 79592910 |
Syncope | 18.02 | 12.86 | 191 | 127031 | 179258 | 79437908 |
Toxic epidermal necrolysis | 17.98 | 12.86 | 27 | 127195 | 44554 | 79572612 |
Retroperitoneal neoplasm metastatic | 17.97 | 12.86 | 5 | 127217 | 27 | 79617139 |
Cryptitis | 17.94 | 12.86 | 9 | 127213 | 289 | 79616877 |
Hypercalcaemia of malignancy | 17.88 | 12.86 | 10 | 127212 | 402 | 79616764 |
No adverse event | 17.87 | 12.86 | 111 | 127111 | 37081 | 79580085 |
Perineal ulceration | 17.85 | 12.86 | 6 | 127216 | 66 | 79617100 |
Metastases to thorax | 17.83 | 12.86 | 8 | 127214 | 199 | 79616967 |
Head injury | 17.78 | 12.86 | 20 | 127202 | 37349 | 79579817 |
Restless legs syndrome | 17.77 | 12.86 | 5 | 127217 | 20087 | 79597079 |
Toothache | 17.76 | 12.86 | 71 | 127151 | 19899 | 79597267 |
Gastric dilatation | 17.72 | 12.86 | 16 | 127206 | 1386 | 79615780 |
Peripheral swelling | 17.69 | 12.86 | 313 | 126909 | 269304 | 79347862 |
Eczema impetiginous | 17.67 | 12.86 | 5 | 127217 | 29 | 79617137 |
Herpangina | 17.67 | 12.86 | 5 | 127217 | 29 | 79617137 |
Fistula | 17.62 | 12.86 | 53 | 127169 | 12887 | 79604279 |
Pneumonitis | 17.53 | 12.86 | 161 | 127061 | 60699 | 79556467 |
Product administration error | 17.51 | 12.86 | 15 | 127207 | 31831 | 79585335 |
Nail avulsion | 17.49 | 12.86 | 7 | 127215 | 130 | 79617036 |
Joint dislocation | 17.43 | 12.86 | 3 | 127219 | 16936 | 79600230 |
Generalised tonic-clonic seizure | 17.32 | 12.86 | 27 | 127195 | 43883 | 79573283 |
Renal vein thrombosis | 17.31 | 12.86 | 11 | 127211 | 560 | 79616606 |
Peripheral motor neuropathy | 17.30 | 12.86 | 24 | 127198 | 3343 | 79613823 |
Gastric varices haemorrhage | 17.18 | 12.86 | 10 | 127212 | 434 | 79616732 |
Multiple sclerosis | 17.18 | 12.86 | 7 | 127215 | 22275 | 79594891 |
Dysphonia | 17.17 | 12.86 | 152 | 127070 | 56720 | 79560446 |
Gastroenteritis radiation | 17.16 | 12.86 | 12 | 127210 | 718 | 79616448 |
Vertebral column mass | 17.12 | 12.86 | 8 | 127214 | 219 | 79616947 |
Stridor | 17.09 | 12.86 | 31 | 127191 | 5422 | 79611744 |
Peritoneal disorder | 17.08 | 12.86 | 12 | 127210 | 723 | 79616443 |
Hepatic cyst | 17.07 | 12.86 | 33 | 127189 | 6056 | 79611110 |
Hypersplenism | 17.02 | 12.86 | 11 | 127211 | 577 | 79616589 |
Parkinsonism | 16.93 | 12.86 | 3 | 127219 | 16581 | 79600585 |
Paranoia | 16.88 | 12.86 | 5 | 127217 | 19427 | 79597739 |
Breast necrosis | 16.87 | 12.86 | 6 | 127216 | 79 | 79617087 |
Infusion site hypoaesthesia | 16.87 | 12.86 | 5 | 127217 | 35 | 79617131 |
Mechanical ileus | 16.84 | 12.86 | 13 | 127209 | 906 | 79616260 |
Dermatitis | 16.77 | 12.86 | 73 | 127149 | 21248 | 79595918 |
Motion sickness | 16.76 | 12.86 | 13 | 127209 | 912 | 79616254 |
Gallbladder disorder | 16.76 | 12.86 | 5 | 127217 | 19335 | 79597831 |
Injection site swelling | 16.73 | 12.86 | 31 | 127191 | 47101 | 79570065 |
Prostatic calcification | 16.54 | 12.86 | 6 | 127216 | 84 | 79617082 |
Myoclonus | 16.51 | 12.86 | 12 | 127210 | 27648 | 79589518 |
Febrile neutropenia | 16.50 | 12.86 | 484 | 126738 | 230515 | 79386651 |
Hand-foot-genital syndrome | 16.50 | 12.86 | 4 | 127218 | 11 | 79617155 |
Vasospasm | 16.46 | 12.86 | 14 | 127208 | 1120 | 79616046 |
Delusion | 16.43 | 12.86 | 6 | 127216 | 20417 | 79596749 |
Respiratory disorder | 16.37 | 12.86 | 29 | 127193 | 44827 | 79572339 |
Hypoxia | 16.37 | 12.86 | 97 | 127125 | 103146 | 79514020 |
Urethral ulcer | 16.33 | 12.86 | 3 | 127219 | 0 | 79617166 |
Dark circles under eyes | 16.33 | 12.86 | 10 | 127212 | 477 | 79616689 |
Splenomegaly | 16.28 | 12.86 | 71 | 127151 | 20683 | 79596483 |
Venous thrombosis limb | 16.14 | 12.86 | 27 | 127195 | 4430 | 79612736 |
Metastases to spleen | 16.11 | 12.86 | 11 | 127211 | 633 | 79616533 |
Hypersensitivity | 16.09 | 12.86 | 308 | 126914 | 261931 | 79355235 |
Weight fluctuation | 16.07 | 12.86 | 48 | 127174 | 11627 | 79605539 |
Dystonia | 16.05 | 12.86 | 7 | 127215 | 21392 | 79595774 |
Lymphocyte count decreased | 16.01 | 12.86 | 32 | 127190 | 47257 | 79569909 |
Radiation myelopathy | 16.00 | 12.86 | 4 | 127218 | 13 | 79617153 |
Ischaemia | 15.99 | 12.86 | 38 | 127184 | 8037 | 79609129 |
Gastroenteropancreatic neuroendocrine tumour disease | 15.97 | 12.86 | 5 | 127217 | 43 | 79617123 |
Periodontitis | 15.96 | 12.86 | 27 | 127195 | 4469 | 79612697 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 15.89 | 12.86 | 19 | 127203 | 2284 | 79614882 |
Subdural haematoma | 15.88 | 12.86 | 16 | 127206 | 31418 | 79585748 |
Acute generalised exanthematous pustulosis | 15.81 | 12.86 | 4 | 127218 | 17250 | 79599916 |
Brain operation | 15.79 | 12.86 | 11 | 127211 | 654 | 79616512 |
Hand dermatitis | 15.78 | 12.86 | 9 | 127213 | 376 | 79616790 |
Hyperchlorhydria | 15.76 | 12.86 | 18 | 127204 | 2061 | 79615105 |
Sinus congestion | 15.75 | 12.86 | 6 | 127216 | 19890 | 79597276 |
Mood swings | 15.73 | 12.86 | 6 | 127216 | 19874 | 79597292 |
Biliary fistula | 15.64 | 12.86 | 6 | 127216 | 99 | 79617067 |
Bronchopulmonary aspergillosis | 15.63 | 12.86 | 8 | 127214 | 22286 | 79594880 |
Hypoacusis | 15.63 | 12.86 | 15 | 127207 | 30135 | 79587031 |
Diverticulitis | 15.62 | 12.86 | 31 | 127191 | 45905 | 79571261 |
Pancreatic fistula | 15.58 | 12.86 | 6 | 127216 | 100 | 79617066 |
Irritability | 15.57 | 12.86 | 26 | 127196 | 41118 | 79576048 |
Tumour invasion | 15.46 | 12.86 | 9 | 127213 | 391 | 79616775 |
International normalised ratio increased | 15.42 | 12.86 | 76 | 127146 | 84645 | 79532521 |
Lung neoplasm malignant | 15.39 | 12.86 | 13 | 127209 | 27779 | 79589387 |
Liver scan abnormal | 15.39 | 12.86 | 5 | 127217 | 49 | 79617117 |
Drug intolerance | 15.36 | 12.86 | 313 | 126909 | 263806 | 79353360 |
Metastases to bladder | 15.34 | 12.86 | 8 | 127214 | 279 | 79616887 |
Cough | 15.26 | 12.86 | 457 | 126765 | 366332 | 79250834 |
Acral peeling skin syndrome | 15.21 | 12.86 | 5 | 127217 | 51 | 79617115 |
Nail bed inflammation | 15.21 | 12.86 | 10 | 127212 | 540 | 79616626 |
Peripheral coldness | 15.19 | 12.86 | 58 | 127164 | 15912 | 79601254 |
Ventricular fibrillation | 15.16 | 12.86 | 95 | 127127 | 31831 | 79585335 |
Procedural pain | 15.15 | 12.86 | 9 | 127213 | 23075 | 79594091 |
Kidney infection | 15.09 | 12.86 | 8 | 127214 | 21843 | 79595323 |
Malignant peritoneal neoplasm | 15.08 | 12.86 | 11 | 127211 | 703 | 79616463 |
Therapy non-responder | 15.02 | 12.86 | 86 | 127136 | 92219 | 79524947 |
Torsade de pointes | 15.00 | 12.86 | 6 | 127216 | 19306 | 79597860 |
Chemical peritonitis | 14.98 | 12.86 | 8 | 127214 | 293 | 79616873 |
Appendicitis noninfective | 14.98 | 12.86 | 4 | 127218 | 18 | 79617148 |
Femoral artery embolism | 14.96 | 12.86 | 5 | 127217 | 54 | 79617112 |
Limb injury | 14.95 | 12.86 | 15 | 127207 | 29513 | 79587653 |
Radiation fibrosis - lung | 14.88 | 12.86 | 5 | 127217 | 55 | 79617111 |
Peritoneal fluid analysis abnormal | 14.88 | 12.86 | 5 | 127217 | 55 | 79617111 |
Ataxia | 14.82 | 12.86 | 79 | 127143 | 24960 | 79592206 |
Liver abscess | 14.81 | 12.86 | 31 | 127191 | 6023 | 79611143 |
Cerebral infarction | 14.80 | 12.86 | 124 | 127098 | 45552 | 79571614 |
Schistosomiasis | 14.79 | 12.86 | 5 | 127217 | 56 | 79617110 |
Blood alkaline phosphatase increased | 14.75 | 12.86 | 161 | 127061 | 63503 | 79553663 |
Electrolyte imbalance | 14.73 | 12.86 | 92 | 127130 | 30789 | 79586377 |
Hyperbaric oxygen therapy | 14.71 | 12.86 | 5 | 127217 | 57 | 79617109 |
Adenocarcinoma | 14.69 | 12.86 | 24 | 127198 | 3862 | 79613304 |
Blood creatine phosphokinase increased | 14.66 | 12.86 | 55 | 127167 | 66035 | 79551131 |
Osteolysis | 14.65 | 12.86 | 26 | 127196 | 4472 | 79612694 |
Rectal neoplasm | 14.64 | 12.86 | 5 | 127217 | 58 | 79617108 |
Chemotherapy cardiotoxicity attenuation | 14.63 | 12.86 | 4 | 127218 | 20 | 79617146 |
Proctalgia | 14.61 | 12.86 | 42 | 127180 | 9959 | 79607207 |
Pharyngeal ulceration | 14.60 | 12.86 | 13 | 127209 | 1106 | 79616060 |
Actinomycosis | 14.60 | 12.86 | 13 | 127209 | 1106 | 79616060 |
Anhedonia | 14.56 | 12.86 | 3 | 127219 | 14895 | 79602271 |
Botryomycosis | 14.56 | 12.86 | 5 | 127217 | 59 | 79617107 |
Breast neoplasm | 14.55 | 12.86 | 12 | 127210 | 920 | 79616246 |
Axonal and demyelinating polyneuropathy | 14.47 | 12.86 | 4 | 127218 | 21 | 79617145 |
Angina pectoris | 14.47 | 12.86 | 136 | 127086 | 51596 | 79565570 |
Oesophageal varices haemorrhage | 14.46 | 12.86 | 25 | 127197 | 4211 | 79612955 |
Folate deficiency | 14.43 | 12.86 | 22 | 127200 | 3338 | 79613828 |
Laryngeal discomfort | 14.42 | 12.86 | 10 | 127212 | 590 | 79616576 |
Insulinoma | 14.31 | 12.86 | 6 | 127216 | 126 | 79617040 |
Metaplastic breast carcinoma | 14.25 | 12.86 | 3 | 127219 | 3 | 79617163 |
Increased liver stiffness | 14.25 | 12.86 | 3 | 127219 | 3 | 79617163 |
Abdominal fat apron | 14.25 | 12.86 | 3 | 127219 | 3 | 79617163 |
Calcium ionised increased | 14.24 | 12.86 | 7 | 127215 | 215 | 79616951 |
Vulval disorder | 14.15 | 12.86 | 10 | 127212 | 608 | 79616558 |
Nephrolithiasis | 14.13 | 12.86 | 41 | 127181 | 53250 | 79563916 |
Pleural disorder | 14.10 | 12.86 | 12 | 127210 | 961 | 79616205 |
Head discomfort | 14.01 | 12.86 | 3 | 127219 | 14499 | 79602667 |
Haemolytic anaemia | 14.00 | 12.86 | 61 | 127161 | 17759 | 79599407 |
Respiratory tract infection | 14.00 | 12.86 | 36 | 127186 | 48653 | 79568513 |
Gastrointestinal injury | 13.99 | 12.86 | 12 | 127210 | 971 | 79616195 |
Tongue discolouration | 13.99 | 12.86 | 23 | 127199 | 3720 | 79613446 |
Enterovesical fistula | 13.98 | 12.86 | 13 | 127209 | 1169 | 79615997 |
Gastrointestinal oedema | 13.96 | 12.86 | 19 | 127203 | 2599 | 79614567 |
Herpes zoster | 13.95 | 12.86 | 89 | 127133 | 92994 | 79524172 |
Haematemesis | 13.93 | 12.86 | 136 | 127086 | 52128 | 79565038 |
Scleroderma-like reaction | 13.93 | 12.86 | 6 | 127216 | 135 | 79617031 |
Hydronephrosis | 13.91 | 12.86 | 60 | 127162 | 17394 | 79599772 |
Rectal cancer recurrent | 13.89 | 12.86 | 4 | 127218 | 25 | 79617141 |
Hypothalamo-pituitary disorder | 13.87 | 12.86 | 13 | 127209 | 1181 | 79615985 |
Skin sensitisation | 13.86 | 12.86 | 12 | 127210 | 983 | 79616183 |
Colorectal cancer recurrent | 13.85 | 12.86 | 5 | 127217 | 69 | 79617097 |
Miosis | 13.83 | 12.86 | 4 | 127218 | 15785 | 79601381 |
Formication | 13.81 | 12.86 | 27 | 127195 | 4996 | 79612170 |
Radioisotope scan | 13.79 | 12.86 | 3 | 127219 | 4 | 79617162 |
Hyperchylomicronaemia | 13.79 | 12.86 | 3 | 127219 | 4 | 79617162 |
Gastrointestinal wall thickening | 13.74 | 12.86 | 19 | 127203 | 2638 | 79614528 |
Cytomegalovirus enterocolitis | 13.70 | 12.86 | 15 | 127207 | 1640 | 79615526 |
Pallor | 13.65 | 12.86 | 38 | 127184 | 50024 | 79567142 |
Metastases to muscle | 13.65 | 12.86 | 8 | 127214 | 352 | 79616814 |
Orthostatic hypotension | 13.62 | 12.86 | 45 | 127177 | 56119 | 79561047 |
Pituitary tumour | 13.62 | 12.86 | 13 | 127209 | 1209 | 79615957 |
Vasculitis | 13.59 | 12.86 | 12 | 127210 | 25090 | 79592076 |
Blood lactate dehydrogenase increased | 13.59 | 12.86 | 108 | 127114 | 39062 | 79578104 |
Nail toxicity | 13.59 | 12.86 | 8 | 127214 | 355 | 79616811 |
Haemodialysis | 13.54 | 12.86 | 6 | 127216 | 18162 | 79599004 |
Periportal sinus dilatation | 13.53 | 12.86 | 6 | 127216 | 145 | 79617021 |
Duodenal perforation | 13.50 | 12.86 | 17 | 127205 | 2155 | 79615011 |
Fungal infection | 13.50 | 12.86 | 29 | 127193 | 41719 | 79575447 |
Paraneoplastic dermatomyositis | 13.47 | 12.86 | 5 | 127217 | 75 | 79617091 |
Radiation injury | 13.46 | 12.86 | 11 | 127211 | 832 | 79616334 |
Coagulopathy | 13.45 | 12.86 | 101 | 127121 | 35905 | 79581261 |
Muscle swelling | 13.44 | 12.86 | 11 | 127211 | 834 | 79616332 |
Ureteric obstruction | 13.42 | 12.86 | 19 | 127203 | 2697 | 79614469 |
Abdominal wall oedema | 13.39 | 12.86 | 3 | 127219 | 5 | 79617161 |
Acute hepatic failure | 13.39 | 12.86 | 17 | 127205 | 30096 | 79587070 |
Post procedural diarrhoea | 13.38 | 12.86 | 10 | 127212 | 664 | 79616502 |
Squamous cell carcinoma of skin | 13.36 | 12.86 | 3 | 127219 | 14030 | 79603136 |
Subclavian vein thrombosis | 13.36 | 12.86 | 18 | 127204 | 2439 | 79614727 |
Staphylococcal infection | 13.26 | 12.86 | 48 | 127174 | 58247 | 79558919 |
Sequestrectomy | 13.25 | 12.86 | 11 | 127211 | 851 | 79616315 |
Influenza like illness | 13.24 | 12.86 | 64 | 127158 | 71643 | 79545523 |
Urinary tract stoma complication | 13.17 | 12.86 | 5 | 127217 | 80 | 79617086 |
Hemianopia | 13.17 | 12.86 | 15 | 127207 | 1713 | 79615453 |
Night sweats | 13.15 | 12.86 | 41 | 127181 | 52054 | 79565112 |
Skin disorder | 13.12 | 12.86 | 96 | 127126 | 33847 | 79583319 |
Hepatitis cholestatic | 13.11 | 12.86 | 3 | 127219 | 13849 | 79603317 |
Seizure | 13.10 | 12.86 | 217 | 127005 | 188617 | 79428549 |
Onychoclasis | 13.00 | 12.86 | 28 | 127194 | 5550 | 79611616 |
Gastric disorder | 12.96 | 12.86 | 25 | 127197 | 37408 | 79579758 |
None
Source | Code | Description |
---|---|---|
ATC | L01BC06 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
FDA MoA | N0000000233 | Nucleic Acid Synthesis Inhibitors |
FDA EPC | N0000175595 | Nucleoside Metabolic Inhibitor |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000964 | Antimetabolites, Antineoplastic |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D009676 | Noxae |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:50266 | Prodrugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Metastasis from malignant tumor of colon | indication | 314998002 | |
Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
Metastatic Breast Carcinoma | indication | ||
Lymph Node Positive Colorectal Carcinoma | indication | ||
Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
Adenocarcinoma of pancreas | off-label use | 700423003 | DOID:4074 |
Pancreatic Neuroendocrine Tumor | off-label use | 717919005 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Infectious disease | contraindication | 40733004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Acute nephropathy | contraindication | 58574008 | |
Stomatitis | contraindication | 61170000 | DOID:9637 |
Dihydrouracil dehydrogenase (NADP^+^) deficiency | contraindication | 77365006 | DOID:14218 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Severe diarrhea | contraindication | 409587002 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Palmar-Plantar Erythrodysesthesia | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.3 | acidic |
pKa2 | 12.91 | acidic |
pKa3 | 13.46 | acidic |
pKa4 | 0.75 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thymidylate synthase | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4021099 | VUID |
N0000148555 | NUI |
D01223 | KEGG_DRUG |
194000 | RXNORM |
C0671970 | UMLSCUI |
CHEBI:31348 | CHEBI |
CHEMBL1773 | ChEMBL_ID |
DB01101 | DRUGBANK_ID |
D000069287 | MESH_DESCRIPTOR_UI |
60953 | PUBCHEM_CID |
6799 | IUPHAR_LIGAND_ID |
7317 | INN_ID |
6804DJ8Z9U | UNII |
11693 | MMSL |
210675 | MMSL |
4344 | MMSL |
d04311 | MMSL |
108761006 | SNOMEDCT_US |
386906001 | SNOMEDCT_US |
4021099 | VANDF |
007533 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-1100 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 36 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-1100 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 36 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-1101 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 36 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-1101 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 36 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7473 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7473 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7474 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7474 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2511 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2512 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-467 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 27 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-468 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 27 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-072 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-072 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-073 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-073 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-154 | TABLET | 500 mg | ORAL | ANDA | 21 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51079-510 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-095 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-095 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-095 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-096 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 31 sections |