acemetacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory, indometacin derivatives	47	53164-05-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

Bay f 4975
TVX 1322
acemetacin
acemet
acemethacin
acemethazine
rantudil

Molecular weight: 415.83
Formula: C21H18ClNO6
CLOGP: 4.20
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 94.83
ALOGS: -5.26
ROTB: 7

Drug dosage:

Dose	Unit	Route
0.12	g	O

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.06 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Axial spondyloarthritis	55.06	53.36	8	495	376	63488143

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ankylosing spondylitis	63.32	53.32	12	135	5592	34951192
Uveitis	53.80	53.32	11	136	7524	34949260

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Axial spondyloarthritis	75.49	42.02	11	571	575	79743231
Residual urine volume increased	42.85	42.02	5	577	43	79743763

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01AB11	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Acetic acid derivatives and related substances
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35544	cyclooxygenase inhibitors
CHEBI has role	CHEBI:50266	Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatism	indication	396332003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.15	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR				KEGG DRUG	KEGG DRUG
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR				KEGG DRUG	KEGG DRUG
Lactoylglutathione lyase	Enzyme	Q04760	LGUL_HUMAN		Ki	4.89		CHEMBL

External reference:

ID	Source
D01582	KEGG_DRUG
16695	RXNORM
C0050409	UMLSCUI
CHEBI:31162	CHEBI
CHEMBL189171	ChEMBL_ID
DB13783	DRUGBANK_ID
C026784	MESH_SUPPLEMENTAL_RECORD_UI
1981	PUBCHEM_CID
C519896	MESH_SUPPLEMENTAL_RECORD_UI
3664	INN_ID
5V141XK28X	UNII
329906008	SNOMEDCT_US
391704009	SNOMEDCT_US
003916	NDDF

Pharmaceutical products:

None