sodium nitrite 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
NO2 - derivatives	4797	7632-00-0

Description:

Molecule	Description
Synonyms: Nitrous acid, sodium salt sodium nitrite nitrite sodium	Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines. Molecular weight: 69.00 Formula: NNaO2 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 52.49 ALOGS: ROTB: None

Molecule

Description

Synonyms:

Nitrous acid, sodium salt
sodium nitrite
nitrite sodium

Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.

Molecular weight: 69.00
Formula: NNaO2
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 52.49
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 14, 2011	FDA	HOPE PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V03AB08	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes
MeSH PA	D005503	Food Additives
MeSH PA	D005520	Food Preservatives
MeSH PA	D007202	Indicators and Reagents
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:64909	poisonous agent
CHEBI has role	CHEBI:65256	antimicrobial food preservatives
CHEBI has role	CHEBI:77962	food antioxidants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Toxic effect of cyanide	indication	66207005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
300MG/10ML(30MG/ML),N/A;N/A,12.5GM/50ML(250MG/ML)	NITHIODOTE	HOPE PHARMS	N201444	Jan. 14, 2011	RX	SOLUTION, SOLUTION	INTRAVENOUS, INTRAVENOUS	9687506	Feb. 10, 2030	SODIUM NITRITE INJECTION IS ADMINISTERED BY INTRAVENOUS INJECTION
300MG/10ML(30MG/ML),N/A;N/A,12.5GM/50ML(250MG/ML)	NITHIODOTE	HOPE PHARMS	N201444	Jan. 14, 2011	RX	SOLUTION, SOLUTION	INTRAVENOUS, INTRAVENOUS	9687506	Feb. 10, 2030	SODIUM NITRITE INJECTION IS INDICATED FOR SEQUENTIAL USE WITH SODIUM THIOSULFATE FOR THE TREATMENT OF ACUTE CYANIDE POISONING
300MG/10ML (30MG/ML)	SODIUM NITRITE	HOPE PHARMS	N203922	Feb. 14, 2012	RX	SOLUTION	INTRAVENOUS	9687506	Feb. 10, 2030	SODIUM NITRITE INJECTION IS ADMINISTERED BY INTRAVENOUS INJECTION
300MG/10ML (30MG/ML)	SODIUM NITRITE	HOPE PHARMS	N203922	Feb. 14, 2012	RX	SOLUTION	INTRAVENOUS	9687506	Feb. 10, 2030	SODIUM NITRITE INJECTION IS INDICATED FOR SEQUENTIAL USE WITH SODIUM THIOSULFATE FOR THE TREATMENT OF ACUTE CYANIDE POISONING
300MG/10ML(30MG/ML),N/A;N/A,12.5GM/50ML(250MG/ML)	NITHIODOTE	HOPE PHARMS	N201444	Jan. 14, 2011	RX	SOLUTION, SOLUTION	INTRAVENOUS, INTRAVENOUS	10479686	July 7, 2030	SODIUM THIOSULFATE INJECTION IS ADMINISTERED BY INTRAVENOUS INJECTION
300MG/10ML(30MG/ML),N/A;N/A,12.5GM/50ML(250MG/ML)	NITHIODOTE	HOPE PHARMS	N201444	Jan. 14, 2011	RX	SOLUTION, SOLUTION	INTRAVENOUS, INTRAVENOUS	9345724	July 7, 2030	SODIUM THIOSULFATE INJECTION IS INDICATED FOR SEQUENTIAL USE WITH SODIUM NITRITE FOR THE TREATMENT OF ACUTE CYANIDE POISONING
300MG/10ML(30MG/ML),N/A;N/A,12.5GM/50ML(250MG/ML)	NITHIODOTE	HOPE PHARMS	N201444	Jan. 14, 2011	RX	SOLUTION, SOLUTION	INTRAVENOUS, INTRAVENOUS	8496973	March 29, 2031	TREATMENT OF ACUTE CYANIDE POISONING THAT IS JUDGED TO BE LIFE THREATENING

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN	Ki	1.20	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN	Ki	2.08	CHEMBL
Carbonic anhydrase 13	Enzyme		CAH13_MOUSE	Ki	1.90	CHEMBL

External reference:

ID	Source
M0KG633D4F	UNII
D05865	KEGG_DRUG
4017515	VUID
N0000145900	NUI
4017515	VANDF
C0037532	UMLSCUI
CHEBI:78870	CHEBI
CHEMBL93268	ChEMBL_ID
23668193	PUBCHEM_CID
D012977	MESH_DESCRIPTOR_UI
9894	RXNORM
47919	MMSL
5488	MMSL
d04086	MMSL
000682	NDDF
10377000	SNOMEDCT_US
317873006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Sodium Nitrite	HUMAN PRESCRIPTION DRUG LABEL	1	60267-311	INJECTION, SOLUTION	30 mg	INTRAVENOUS	NDA	28 sections
Sodium Nitrite	HUMAN PRESCRIPTION DRUG LABEL	1	60267-311	INJECTION, SOLUTION	30 mg	INTRAVENOUS	NDA	28 sections