sodium nitrite Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
NO2 - derivatives 4797 7632-00-0

Description:

MoleculeDescription

Synonyms:

  • Nitrous acid, sodium salt
  • sodium nitrite
  • nitrite sodium
Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.
  • Molecular weight: 69.00
  • Formula: NNaO2
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 52.49
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 14, 2011 FDA HOPE PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AB08 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
MeSH PA D005503 Food Additives
MeSH PA D005520 Food Preservatives
MeSH PA D007202 Indicators and Reagents
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:64909 poisonous agents
CHEBI has role CHEBI:65256 antimicrobial preservatives
CHEBI has role CHEBI:77962 food antioxidants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Toxic effect of cyanide indication 66207005

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
300MG/10ML(30MG/ML),N/A;N/A,12.5GM/50ML(250MG/ML) NITHIODOTE HOPE PHARMS N201444 Jan. 14, 2011 RX SOLUTION, SOLUTION INTRAVENOUS, INTRAVENOUS 8496973 March 29, 2031 TREATMENT OF ACUTE CYANIDE POISONING THAT IS JUDGED TO BE LIFE THREATENING
300MG/10ML(30MG/ML),N/A;N/A,12.5GM/50ML(250MG/ML) NITHIODOTE HOPE PHARMS N201444 Jan. 14, 2011 RX SOLUTION, SOLUTION INTRAVENOUS, INTRAVENOUS 9345724 March 29, 2031 SODIUM THIOSULFATE INJECTION IS INDICATED FOR SEQUENTIAL USE WITH SODIUM NITRITE FOR THE TREATMENT OF ACUTE CYANIDE POISONING

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 1.20 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 2.08 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 1.90 CHEMBL

External reference:

IDSource
M0KG633D4F UNII
D05865 KEGG_DRUG
4017515 VUID
N0000145900 NUI
4017515 VANDF
C0037532 UMLSCUI
CHEBI:78870 CHEBI
CHEMBL93268 ChEMBL_ID
23668193 PUBCHEM_CID
D012977 MESH_DESCRIPTOR_UI
9894 RXNORM
47919 MMSL
5488 MMSL
d04086 MMSL
000682 NDDF
10377000 SNOMEDCT_US
317873006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sodium Nitrite HUMAN PRESCRIPTION DRUG LABEL 1 60267-311 INJECTION, SOLUTION 30 mg INTRAVENOUS NDA 28 sections