All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

gramicidin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
naturally occurring antibiotics (undefined group)	4794	1405-97-6

Description:

Molecule	Description
Synonyms: gramicidin gramicidins gramoderm gramicidin D gramicidine gramicidin Dubos	A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN. Molecular weight: 9354.60 Formula: C491H701N97O87 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 548.99 ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 3, 1968	FDA	MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	625.39	153.20	124	707	24252	63463939
Drug ineffective	173.22	153.20	125	706	1044640	62443551

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	155.92	143.86	32	622	11264	79732470
Chronic sinusitis	151.37	143.86	32	622	12994	79730740

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R02AB30	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antibiotics
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Blepharoconjunctivitis	indication	68659002	DOID:2456
Bacterial conjunctivitis	indication	128350005	DOID:9700
Infective blepharitis	indication	312219000
Bacterial keratitis	indication	314557000
Superficial Ocular Infection	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Endothelin-1 receptor	GPCR	P25101	EDNRA_HUMAN		Ki	5.74		DRUG MATRIX
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN		IC50	5.96		DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN		IC50	5.48		DRUG MATRIX
Thromboxane-A synthase	Enzyme	P24557	THAS_HUMAN		IC50	6.11		DRUG MATRIX
Substance-K receptor	GPCR	P21452	NK2R_HUMAN		Ki	5.82		DRUG MATRIX
Melanocortin receptor 4	GPCR	P32245	MC4R_HUMAN		Ki	5.50		DRUG MATRIX
Melanocortin receptor 5	GPCR	P33032	MC5R_HUMAN		Ki	5.72		DRUG MATRIX
Sodium/potassium-transporting ATPase subunit alpha-2	Ion channel		AT1A2_PIG		IC50	5.29		DRUG MATRIX

External reference:

ID	Source
5IE62321P4	UNII
D04369	KEGG_DRUG
4018774	VUID
N0000147077	NUI
113-73-5	SECONDARY_CAS_RN
4018774	VANDF
C0018165	UMLSCUI
CHEBI:5530	CHEBI
CHEMBL1201469	ChEMBL_ID
16132269	PUBCHEM_CID
DB00027	DRUGBANK_ID
CHEMBL373496	ChEMBL_ID
D006096	MESH_DESCRIPTOR_UI
2025	INN_ID
5011	RXNORM
4800	MMSL
002801	NDDF
004423	NDDF
387524003	SNOMEDCT_US
91479004	SNOMEDCT_US
CHEMBL557217	ChEMBL_ID
3052	INN_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Neomycin and Polymyxin B Sulfates and Gramicidin	HUMAN PRESCRIPTION DRUG LABEL	3	21695-528	SOLUTION/ DROPS	0.03 mg	OPHTHALMIC	ANDA	19 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN	HUMAN PRESCRIPTION DRUG LABEL	3	24208-790	SOLUTION/ DROPS	0.03 mg	OPHTHALMIC	ANDA	19 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN	HUMAN PRESCRIPTION DRUG LABEL	3	24208-790	SOLUTION/ DROPS	0.03 mg	OPHTHALMIC	ANDA	19 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN	HUMAN PRESCRIPTION DRUG LABEL	3	50090-0247	SOLUTION/ DROPS	0.03 mg	OPHTHALMIC	ANDA	18 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN	HUMAN PRESCRIPTION DRUG LABEL	3	50090-0247	SOLUTION/ DROPS	0.03 mg	OPHTHALMIC	ANDA	18 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN	HUMAN PRESCRIPTION DRUG LABEL	3	54868-6253	SOLUTION/ DROPS	0.03 mg	OPHTHALMIC	ANDA	18 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN	HUMAN PRESCRIPTION DRUG LABEL	3	55045-1194	SOLUTION/ DROPS	0.03 mg	OPHTHALMIC	ANDA	18 sections