canrenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists	478	976-71-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

canrenone
aldadiene
phanurane

A synthetic pregnadiene compound with anti-aldosterone activity.

Molecular weight: 340.46
Formula: C22H28O3
CLOGP: 2.91
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 43.37
ALOGS: -4.91
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	148.12	51.11	72	948	229059	63258943
Hyperkalaemia	110.87	51.11	39	981	54164	63433838
Sopor	103.81	51.11	30	990	22134	63465868

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	118.29	49.19	32	833	12104	34943962
Hyperkalaemia	88.51	49.19	40	825	69349	34886717
Drug interaction	53.24	49.19	44	821	225902	34730164

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	202.54	37.07	61	1955	32949	79709423
Hyperkalaemia	186.64	37.07	79	1937	114319	79628053
Drug interaction	173.57	37.07	115	1901	415068	79327304
Hyponatraemia	47.88	37.07	38	1978	177810	79564562
Syncope	45.45	37.07	37	1979	179412	79562960
Bradycardia	45.39	37.07	33	1983	135524	79606848
Melaena	43.59	37.07	24	1992	60866	79681506
Acute kidney injury	43.31	37.07	59	1957	519345	79223027
Anaemia	42.41	37.07	54	1962	444961	79297411

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C03DA03	CARDIOVASCULAR SYSTEM DIURETICS ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS Aldosterone antagonists
MeSH PA	D004232	Diuretics
MeSH PA	D006727	Hormone Antagonists
MeSH PA	D000451	Mineralocorticoid Receptor Antagonists
MeSH PA	D045283	Natriuretic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN	ANTAGONIST	IC50	6.52		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
N0000167426	NUI
D03363	KEGG_DRUG
1982	RXNORM
C0006882	UMLSCUI
CHEBI:135445	CHEBI
CHEMBL1463345	ChEMBL_ID
DB12221	DRUGBANK_ID
D002192	MESH_DESCRIPTOR_UI
13789	PUBCHEM_CID
2445	INN_ID
78O20X9J0U	UNII
96291007	SNOMEDCT_US
005943	NDDF

Pharmaceutical products:

None