sodium picosulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4779	10040-45-6

Description:

Molecule	Description
Synonyms: sodium picosulfate picosulfate sodium picosulfol rapilax picolax	contains two active ingredients, sodium picosulfate and magnesium citrate, which are both laxatives; structure Molecular weight: 481.40 Formula: C18H13NNa2O8S2 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 145.75 ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium picosulfate
picosulfate sodium
picosulfol
rapilax
picolax

contains two active ingredients, sodium picosulfate and magnesium citrate, which are both laxatives; structure

Molecular weight: 481.40
Formula: C18H13NNa2O8S2
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 145.75
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
5	mg	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 16, 2012	FDA	FERRING PHARMS AS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urinary retention	91.79	21.08	51	6908	30250	63451813
Reduced facial expression	89.37	21.08	24	6935	1942	63480121
Listless	84.83	21.08	25	6934	2835	63479228
General physical health deterioration	84.48	21.08	107	6852	201295	63280768
Cognitive disorder	81.03	21.08	59	6900	55756	63426307
Ileus	74.38	21.08	35	6924	14690	63467373
Apathy	70.74	21.08	29	6930	8765	63473298
Hyponatraemia	69.74	21.08	73	6886	111827	63370236
Cholestatic liver injury	65.26	21.08	20	6939	2590	63479473
Hypokalaemia	58.12	21.08	64	6895	103740	63378323
Altered state of consciousness	56.68	21.08	35	6924	25195	63456868
Head discomfort	56.03	21.08	28	6931	13387	63468676
Drug ineffective	55.21	21.08	23	6936	1044742	62437321
Delirium	52.83	21.08	44	6915	50497	63431566
Product prescribing error	50.41	21.08	33	6926	26256	63455807
Pyrexia	47.97	21.08	136	6823	470342	63011721
Drug interaction	46.49	21.08	87	6872	229044	63253019
Foreign body	46.32	21.08	15	6944	2323	63479740
Prescription drug used without a prescription	46.02	21.08	15	6944	2371	63479692
Dehydration	45.83	21.08	74	6885	173280	63308783
Immobile	45.76	21.08	19	6940	5924	63476139
Affect lability	42.84	21.08	22	6937	11129	63470934
Creatinine renal clearance decreased	42.78	21.08	25	6934	16283	63465780
Inappropriate antidiuretic hormone secretion	38.71	21.08	23	6936	15439	63466624
Fracture	38.56	21.08	25	6934	19559	63462504
Confusional state	37.46	21.08	81	6878	236299	63245764
Multiple drug therapy	36.20	21.08	14	6945	3632	63478431
Abdominal rigidity	36.12	21.08	12	6947	2012	63480051
Sedation complication	35.75	21.08	21	6938	13801	63468262
Oxygen saturation decreased	35.36	21.08	46	6913	88539	63393524
Restlessness	33.61	21.08	27	6932	29426	63452637
Electrolyte imbalance	33.21	21.08	23	6936	20053	63462010
Vascular device infection	32.72	21.08	16	6943	7296	63474767
Overdose	31.58	21.08	50	6909	115028	63367035
Pelvic fracture	31.20	21.08	19	6940	13329	63468734
Encephalopathy	31.08	21.08	29	6930	38591	63443472
Sedation	30.96	21.08	29	6930	38780	63443283
Orthostatic hypotension	30.75	21.08	28	6931	36132	63445931
Constipation	29.98	21.08	72	6887	224871	63257192
Blood calcium decreased	29.66	21.08	24	6935	26427	63455636
Liver function test increased	29.07	21.08	26	6933	32785	63449278
Fall	28.49	21.08	101	6858	392233	63089830
Vomiting	27.82	21.08	128	6831	559489	62922574
Medication error	27.11	21.08	31	6928	52253	63429810
Product administration error	26.56	21.08	21	6938	22376	63459687
Febrile neutropenia	26.53	21.08	47	6912	118402	63363661
Anaemia	26.15	21.08	81	6878	293349	63188714
Depressed level of consciousness	25.96	21.08	33	6926	62045	63420018
Mobility decreased	25.76	21.08	47	6912	121112	63360951
Vertigo	25.30	21.08	32	6927	59855	63422208
Oliguria	23.99	21.08	14	6945	9087	63472976
Bedridden	23.97	21.08	15	6944	11036	63471027
Drug intolerance	23.63	21.08	3	6956	308658	63173405
Concomitant disease aggravated	21.37	21.08	13	6946	9099	63472964
Pemphigoid	21.24	21.08	12	6947	7332	63474731
Joint swelling	21.13	21.08	5	6954	327661	63154402

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	325.57	19.98	109	8323	8492	34940007
Appendicitis	274.71	19.98	111	8321	14696	34933803
General physical health deterioration	215.40	19.98	205	8227	128064	34820435
Cardiogenic shock	209.57	19.98	110	8322	26508	34921991
Blood phosphorus increased	208.06	19.98	76	8356	7645	34940854
Abdominal distension	200.97	19.98	142	8290	58350	34890149
Stress	198.76	19.98	111	8321	30236	34918263
Ventricular fibrillation	186.78	19.98	97	8335	22857	34925642
Ascites	169.06	19.98	117	8315	46454	34902045
Hyponatraemia	157.55	19.98	142	8290	82549	34865950
Multiple organ dysfunction syndrome	131.26	19.98	124	8308	76442	34872057
Abdominal pain	130.74	19.98	178	8254	163440	34785059
Dry mouth	114.60	19.98	78	8354	30087	34918412
Constipation	112.32	19.98	151	8281	136831	34811668
Myasthenia gravis	88.71	19.98	40	8392	6900	34941599
Vomiting	84.82	19.98	185	8247	247436	34701063
Blood uric acid increased	82.03	19.98	42	8390	9582	34938917
Sepsis	75.54	19.98	140	8292	166421	34782078
Nausea	74.35	19.98	214	8218	339694	34608805
Somnolence	68.31	19.98	107	8325	111009	34837490
Blood cholesterol increased	50.67	19.98	41	8391	20502	34927997
Incorrect route of product administration	46.16	19.98	34	8398	14811	34933688
Drug therapy	45.26	19.98	15	8417	1126	34947373
Drug ineffective	44.22	19.98	28	8404	456723	34491776
Sleep disorder therapy	42.80	19.98	14	8418	1009	34947490
Hyperphosphataemia	39.65	19.98	20	8412	4417	34944082
Iron deficiency	33.31	19.98	19	8413	5362	34943137
Hypophosphataemia	29.30	19.98	23	8409	11003	34937496
Ileus	28.71	19.98	27	8405	16472	34932027
Abdominal neoplasm	27.42	19.98	8	8424	393	34948106
Faecaloma	25.51	19.98	16	8416	5361	34943138
Cholestatic liver injury	25.14	19.98	12	8420	2352	34946147
Bacterial infection	24.24	19.98	25	8407	17038	34931461
Condition aggravated	23.41	19.98	100	8332	192096	34756403
Neuralgia	23.03	19.98	23	8409	15090	34933409

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	346.49	16.89	108	15152	8443	79720685
Appendicitis	282.99	16.89	117	15143	20677	79708451
General physical health deterioration	274.86	16.89	299	14961	274939	79454189
Blood phosphorus increased	207.04	16.89	77	15183	10270	79718858
Hyponatraemia	201.73	16.89	207	15053	177641	79551487
Cardiogenic shock	186.39	16.89	110	15150	41804	79687324
Ventricular fibrillation	180.35	16.89	98	15162	31828	79697300
Ascites	166.01	16.89	128	15132	75434	79653694
Abdominal distension	164.90	16.89	155	15105	119495	79609633
Constipation	137.81	16.89	216	15044	282834	79446294
Stress	124.98	16.89	111	15149	79501	79649627
Multiple organ dysfunction syndrome	115.03	16.89	128	15132	120118	79609010
Abdominal pain	110.21	16.89	235	15025	389334	79339794
Drug ineffective	89.56	16.89	48	15212	1080865	78648263
Ileus	89.08	16.89	58	15202	26153	79702975
Vomiting	88.80	16.89	304	14956	665524	79063604
Blood uric acid increased	83.82	16.89	44	15216	13316	79715812
Myasthenia gravis	82.07	16.89	40	15220	10359	79718769
Sepsis	73.14	16.89	160	15100	269268	79459860
Cholestatic liver injury	71.25	16.89	29	15231	4912	79724216
Urinary retention	69.68	16.89	69	15191	56561	79672567
Nausea	65.41	16.89	357	14903	956839	78772289
Somnolence	63.79	16.89	141	15119	238840	79490288
Reduced facial expression	60.55	16.89	22	15238	2743	79726385
Listless	60.29	16.89	24	15236	3837	79725291
Dry mouth	60.06	16.89	79	15181	87940	79641188
Altered state of consciousness	53.17	16.89	53	15207	43769	79685359
Drug therapy	52.13	16.89	16	15244	1185	79727943
Sleep disorder therapy	45.97	16.89	14	15246	1010	79728118
Apathy	42.34	16.89	28	15232	12949	79716179
Delirium	41.61	16.89	65	15195	84562	79644566
Faecaloma	40.29	16.89	26	15234	11538	79717590
Hyperphosphataemia	39.99	16.89	21	15239	6355	79722773
Hypokalaemia	39.53	16.89	86	15174	143954	79585174
Anaemia	39.42	16.89	179	15081	444836	79284292
Joint swelling	38.31	16.89	5	15255	288641	79440487
Pyrexia	37.65	16.89	240	15020	678469	79050659
Fatigue	36.76	16.89	77	15183	929650	78799478
Inappropriate antidiuretic hormone secretion	36.00	16.89	34	15226	26279	79702849
Immobile	35.49	16.89	20	15240	6953	79722175
Head discomfort	34.97	16.89	26	15234	14476	79714652
Cognitive disorder	34.77	16.89	54	15206	69872	79659256
Hypophosphataemia	33.69	16.89	29	15231	19884	79709244
Foreign body	31.78	16.89	14	15246	2880	79726248
Product prescribing error	30.21	16.89	40	15220	44773	79684355
Incorrect route of product administration	29.66	16.89	35	15225	34894	79694234
Product dose omission issue	29.03	16.89	6	15254	247531	79481597
Hepatic function abnormal	29.00	16.89	51	15209	73056	79656072
Affect lability	28.98	16.89	21	15239	11238	79717890
Dehydration	28.34	16.89	108	15152	248079	79481049
Abdominal rigidity	27.78	16.89	13	15247	3075	79726053
Iron deficiency	27.72	16.89	20	15240	10634	79718494
Arthralgia	27.35	16.89	42	15218	571761	79157367
Multiple drug therapy	27.21	16.89	14	15246	4064	79725064
Prescription drug used without a prescription	27.18	16.89	14	15246	4071	79725057
Sinusitis	26.88	16.89	3	15257	195498	79533630
Creatinine renal clearance decreased	26.85	16.89	25	15235	18977	79710151
Electrolyte imbalance	26.31	16.89	31	15229	30850	79698278
Headache	25.90	16.89	54	15206	653718	79075410
Pneumonia aspiration	25.64	16.89	46	15214	66921	79662207
Peripheral swelling	25.24	16.89	10	15250	269607	79459521
Systemic infection	24.67	16.89	18	15242	9734	79719394
Fracture	23.95	16.89	25	15235	21776	79707352
Vascular device infection	23.83	16.89	18	15242	10258	79718870
pH body fluid increased	23.78	16.89	5	15255	78	79729050
Drug interaction	23.05	16.89	147	15113	415036	79314092
Sedation complication	22.88	16.89	21	15239	15648	79713480
Rheumatoid arthritis	22.56	16.89	6	15254	208464	79520664
Diabetes mellitus	21.71	16.89	47	15213	78343	79650785
Therapeutic product effect decreased	21.34	16.89	3	15257	163860	79565268
Pelvic fracture	21.10	16.89	18	15242	12186	79716942
Ileus paralytic	20.45	16.89	16	15244	9604	79719524
Fall	20.28	16.89	161	15099	487468	79241660
Treatment failure	20.26	16.89	4	15256	170482	79558646
Neutrophil count decreased	20.19	16.89	51	15209	93908	79635220
Liver function test increased	20.17	16.89	31	15229	39742	79689386
Bacterial infection	19.67	16.89	27	15233	31253	79697875
Decreased appetite	19.46	16.89	122	15138	342296	79386832
Upper respiratory tract inflammation	19.00	16.89	11	15249	4024	79725104
Hypersensitivity	18.35	16.89	14	15246	262225	79466903
Orthostatic hypotension	18.29	16.89	36	15224	56128	79673000
Depressed level of consciousness	18.25	16.89	50	15210	96602	79632526
Contraindicated product administered	18.09	16.89	4	15256	157534	79571594
Abdominal discomfort	18.04	16.89	13	15247	250714	79478414
Restlessness	17.88	16.89	32	15228	46460	79682668
Blood calcium decreased	17.84	16.89	26	15234	31793	79697335
Infusion related reaction	17.83	16.89	11	15249	230226	79498902
Anti factor X activity increased	17.72	16.89	4	15256	88	79729040
Medication error	17.70	16.89	40	15220	68602	79660526
Pemphigoid	17.61	16.89	18	15242	15297	79713831
Paraesthesia	17.41	16.89	6	15254	176317	79552811
Chronotropic incompetence	17.39	16.89	4	15256	96	79729032

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A06AB08	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives
ATC	A06AB58	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives
MeSH PA	D002400	Cathartics
MeSH PA	D005765	Gastrointestinal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Colonoscopy	indication	73761001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
12GM/BOT;3.5GM/BOT;10MG/BOT	CLENPIQ	FERRING PHARMS INC	N209589	Nov. 28, 2017	RX	SOLUTION	ORAL	11191753	June 23, 2034	FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY
12GM/BOT;3.5GM/BOT;10MG/BOT	CLENPIQ	FERRING PHARMS INC	N209589	Nov. 28, 2017	RX	SOLUTION	ORAL	9827231	June 26, 2034	FOR CLEANSING THE LARGE INTESTINE AS A PREPARATION FOR COLONOSCOPY

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
LR57574HN8	UNII
4032318	VUID
N0000186955	NUI
4032318	VANDF
C0071042	UMLSCUI
CHEBI:32147	CHEBI
CHEMBL1697768	ChEMBL_ID
68654	PUBCHEM_CID
C005701	MESH_SUPPLEMENTAL_RECORD_UI
DB14232	DRUGBANK_ID
1872905	RXNORM
18056	MMSL
d04939	MMSL
003762	NDDF
317558003	SNOMEDCT_US
395881001	SNOMEDCT_US
C0058139	UMLSCUI
1307301-38-7	SECONDARY_CAS_RN
69046	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
SODIUM PICOSULFATE, MAGNESIUM OXIDE AND ANHYDROUS CITRIC ACID	HUMAN PRESCRIPTION DRUG LABEL	3	31722-874	POWDER, METERED	10 mg	ORAL	ANDA	25 sections
CLENPIQ	HUMAN PRESCRIPTION DRUG LABEL	3	55566-6700	LIQUID	10 mg	ORAL	NDA	32 sections
CLENPIQ	HUMAN PRESCRIPTION DRUG LABEL	3	55566-6800	LIQUID	10 mg	ORAL	NDA	31 sections