ridaforolimus 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
immunosuppressants, rapamycin derivatives 4778 572924-54-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • deforolimus
  • ridaforolimus
  • AP23573
  • MK-8669
  • jenzyl
an mTOR inhibitor for the treatment of cancer
  • Molecular weight: 990.22
  • Formula: C53H84NO14P
  • CLOGP: 7.20
  • LIPINSKI: 3
  • HAC: 15
  • HDO: 2
  • TPSA: 201.50
  • ALOGS: -6.09
  • ROTB: 8

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 3.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 46.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01EG03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PROTEIN KINASE INHIBITORS
Mammalian target of rapamycin (mTOR) kinase inhibitors
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:68481 mTOR inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Serine/threonine-protein kinase mTOR Kinase INHIBITOR IC50 9.70 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Kd 5.90 CHEMBL

External reference:

IDSource
D08900 KEGG_DRUG
CHEBI:82677 CHEBI
CHEMBL2103839 ChEMBL_ID
C515074 MESH_SUPPLEMENTAL_RECORD_UI
7884 IUPHAR_LIGAND_ID
8822 INN_ID
DB06233 DRUGBANK_ID
48Z35KB15K UNII
11520894 PUBCHEM_CID
C2713007 UMLSCUI

Pharmaceutical products:

None