potassium canrenoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
477 2181-04-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • potassium canrenoate
  • aldadiene kalium
  • aldadiene potassium
  • canrenoate potassium
  • canrenoate
  • kanrenol
  • canrenoic acid
  • canrenoic acid potassium
  • canrenoic acid potassium salt
A synthetic pregnadiene derivative with anti-aldosterone activity.
  • Molecular weight: 358.48
  • Formula: C22H30O4
  • CLOGP: 3.16
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: -3.91
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.40 g P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,PDK1,PDK2,PDK4,PRKDC 11
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6,MAP3K14,TGFBR1 5
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 153.56 27.85 50 3166 24594 90600637
Hyperkalaemia 144.96 27.85 62 3154 64902 90560329
Drug interaction 127.07 27.85 93 3123 276360 90348871
Lactic acidosis 102.17 27.85 45 3171 50418 90574813
Acute kidney injury 100.26 27.85 86 3130 320301 90304930
Hyponatraemia 94.99 27.85 59 3157 133479 90491752
Melaena 76.82 27.85 33 3183 34764 90590467
Syncope 73.17 27.85 50 3166 132613 90492618
Toxic epidermal necrolysis 72.30 27.85 31 3185 32497 90592734
Bradycardia 69.75 27.85 41 3175 83806 90541425
International normalised ratio increased 67.12 27.85 33 3183 47283 90577948
Metabolic acidosis 48.32 27.85 28 3188 55648 90569583
Dehydration 46.51 27.85 45 3171 194402 90430829
Anaemia 43.77 27.85 58 3158 352744 90272487
Hyponatraemic syndrome 39.82 27.85 8 3208 566 90624665
Hyponatraemic encephalopathy 38.30 27.85 7 3209 299 90624932
Necrotising colitis 38.26 27.85 9 3207 1329 90623902
Oliguria 37.01 27.85 14 3202 10610 90614621
Polyglandular disorder 33.51 27.85 6 3210 228 90625003
Hypoglycaemia 33.04 27.85 24 3192 69824 90555407
Electrocardiogram QT prolonged 32.25 27.85 24 3192 72432 90552799
Drug ineffective 30.80 27.85 6 3210 1384292 89240939
Asthenia 30.75 27.85 62 3154 533689 90091542
Vascular parkinsonism 30.07 27.85 5 3211 122 90625109
Hypokalaemia 28.81 27.85 29 3187 131087 90494144
Anaemia folate deficiency 28.44 27.85 6 3210 540 90624691

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 178.93 30.66 90 2486 80368 42538391
Sopor 94.59 30.66 34 2542 13168 42605591
Hypotension 86.35 30.66 91 2485 257540 42361219
Melaena 84.81 30.66 43 2533 38703 42580056
Anaemia 83.45 30.66 93 2483 280185 42338574
Drug interaction 80.15 30.66 89 2487 266910 42351849
Metabolic acidosis 65.26 30.66 40 2536 51818 42566941
Toxic epidermal necrolysis 62.35 30.66 31 2545 26719 42592040
Asthenia 57.13 30.66 77 2499 280716 42338043
Presyncope 52.32 30.66 26 2550 22361 42596398
Renal ischaemia 40.73 30.66 11 2565 1659 42617100
Acute kidney injury 39.05 30.66 75 2501 367262 42251497
Hyponatraemia 35.82 30.66 37 2539 101425 42517334
Oliguria 31.59 30.66 14 2562 9299 42609460

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 314.64 25.42 151 5829 135645 110447674
Sopor 226.01 25.42 82 5898 36464 110546855
Drug interaction 188.28 25.42 179 5801 500004 110083315
Melaena 157.49 25.42 76 5904 68681 110514638
Toxic epidermal necrolysis 127.75 25.42 62 5918 56665 110526654
Acute kidney injury 123.38 25.42 161 5819 635269 109948050
Anaemia 117.80 25.42 146 5834 546940 110036379
Metabolic acidosis 110.06 25.42 68 5912 99676 110483643
Hyponatraemia 107.43 25.42 91 5889 217562 110365757
Lactic acidosis 104.24 25.42 64 5916 92747 110490572
Syncope 88.44 25.42 79 5901 202457 110380862
Hypotension 80.82 25.42 119 5861 523730 110059589
Asthenia 80.82 25.42 138 5842 688861 109894458
Bradycardia 78.67 25.42 66 5914 155451 110427868
International normalised ratio increased 73.17 25.42 50 5930 86722 110496597
Oliguria 62.82 25.42 27 5953 18630 110564689
Presyncope 58.15 25.42 35 5945 48852 110534467
Dehydration 51.13 25.42 69 5911 279442 110303877
Haematuria 43.52 25.42 36 5944 82969 110500350
Electrocardiogram QT prolonged 40.69 25.42 39 5941 108921 110474398
Renal ischaemia 38.33 25.42 11 5969 2312 110581007
Hypokalaemia 36.35 25.42 47 5933 182401 110400918
Hypoglycaemia 34.99 25.42 37 5943 116067 110467252
Hyponatraemic syndrome 33.84 25.42 8 5972 789 110582530
Hyponatraemic encephalopathy 33.52 25.42 7 5973 391 110582928
Necrotising colitis 32.02 25.42 9 5971 1756 110581563
Polyglandular disorder 30.69 25.42 6 5974 240 110583079
Ascites 30.52 25.42 31 5949 92777 110490542
Loss of consciousness 29.27 25.42 44 5936 196262 110387057
Vascular parkinsonism 28.08 25.42 5 5975 119 110583200
Renal failure 27.20 25.42 46 5934 226528 110356791
Shock haemorrhagic 26.07 25.42 17 5963 27230 110556089
Rectal haemorrhage 25.64 25.42 32 5948 119801 110463518

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03DA02 CARDIOVASCULAR SYSTEM
DIURETICS
ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Aldosterone antagonists
MeSH PA D000451 Mineralocorticoid Receptor Antagonists
MeSH PA D004232 Diuretics
MeSH PA D006727 Hormone Antagonists
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:50113 androgen

Related Drugs by ATC class:

C03DA Aldosterone antagonists 5 drugs
canrenonedapagliflozineplerenonefinerenonespironolactone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.78 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01943 KEGG_DRUG
1981 RXNORM
CHEBI:749783 CHEBI
CHEMBL1371200 ChEMBL_ID
CHEMBL1616951 ChEMBL_ID
4138-96-9 SECONDARY_CAS_RN
DB09015 DRUGBANK_ID
318053000 SNOMEDCT_US
419615001 SNOMEDCT_US
C0006881 UMLSCUI
D002191 MESH_DESCRIPTOR_UI
23671691 PUBCHEM_CID
2448 INN_ID
2571 INN_ID
M671F9NLEA UNII
003944 NDDF
003945 NDDF
M671F9NLEA INXIGHT DRUGS

Pharmaceutical products:

None