Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin II receptor antagonists, antihypertensive (non-peptidic) | 475 | 145040-37-5 |
Dose | Unit | Route |
---|---|---|
8 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.05 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.61 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
June 4, 1998 | FDA | ASTRAZENECA | |
March 12, 1999 | PMDA | Takeda Pharmaceutical Company Limited |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 413.73 | 10.54 | 898 | 63051 | 227160 | 50314015 |
Hyponatraemia | 306.15 | 10.54 | 483 | 63466 | 95656 | 50445519 |
Hyperkalaemia | 190.79 | 10.54 | 268 | 63681 | 47821 | 50493354 |
General physical health deterioration | 175.48 | 10.54 | 484 | 63465 | 141950 | 50399225 |
Drug ineffective | 170.04 | 10.54 | 505 | 63444 | 818828 | 49722347 |
Completed suicide | 125.96 | 10.54 | 11 | 63938 | 131878 | 50409297 |
Synovitis | 124.91 | 10.54 | 8 | 63941 | 123857 | 50417318 |
Oligohydramnios | 121.62 | 10.54 | 81 | 63868 | 5669 | 50535506 |
Angina pectoris | 117.54 | 10.54 | 155 | 63794 | 26033 | 50515142 |
Product dose omission issue | 117.06 | 10.54 | 43 | 63906 | 183795 | 50357380 |
Hand deformity | 112.51 | 10.54 | 3 | 63946 | 100196 | 50440979 |
Glossodynia | 112.11 | 10.54 | 9 | 63940 | 115560 | 50425615 |
Maternal exposure during pregnancy | 107.56 | 10.54 | 34 | 63915 | 159744 | 50381431 |
Arthropathy | 103.83 | 10.54 | 35 | 63914 | 157871 | 50383304 |
Bradycardia | 102.16 | 10.54 | 241 | 63708 | 64185 | 50476990 |
Alopecia | 95.85 | 10.54 | 101 | 63848 | 244946 | 50296229 |
Swelling | 95.23 | 10.54 | 69 | 63880 | 200803 | 50340372 |
Drug interaction | 92.76 | 10.54 | 497 | 63452 | 199124 | 50342051 |
Renal impairment | 90.96 | 10.54 | 255 | 63694 | 75406 | 50465769 |
Syncope | 84.27 | 10.54 | 304 | 63645 | 102698 | 50438477 |
Cough | 82.24 | 10.54 | 554 | 63395 | 240710 | 50300465 |
Haematochezia | 81.19 | 10.54 | 165 | 63784 | 39717 | 50501458 |
Cardiac failure | 80.58 | 10.54 | 245 | 63704 | 75795 | 50465380 |
Drug hypersensitivity | 79.89 | 10.54 | 121 | 63828 | 250889 | 50290286 |
Systemic lupus erythematosus | 79.71 | 10.54 | 39 | 63910 | 140583 | 50400592 |
Pain | 79.26 | 10.54 | 420 | 63529 | 578483 | 49962692 |
Blood pressure increased | 77.86 | 10.54 | 354 | 63595 | 132778 | 50408397 |
Sputum discoloured | 77.35 | 10.54 | 90 | 63859 | 13305 | 50527870 |
Death | 77.23 | 10.54 | 187 | 63762 | 325192 | 50215983 |
Pericarditis | 76.66 | 10.54 | 6 | 63943 | 78683 | 50462492 |
Fall | 76.55 | 10.54 | 701 | 63248 | 334231 | 50206944 |
Hypotension | 73.35 | 10.54 | 529 | 63420 | 234940 | 50306235 |
Neovascularisation | 72.29 | 10.54 | 32 | 63917 | 981 | 50540194 |
Anuria | 70.77 | 10.54 | 79 | 63870 | 11165 | 50530010 |
Injection site pain | 70.57 | 10.54 | 26 | 63923 | 110998 | 50430177 |
Arterial occlusive disease | 70.07 | 10.54 | 54 | 63895 | 4754 | 50536421 |
Blood creatinine increased | 67.64 | 10.54 | 231 | 63718 | 75929 | 50465246 |
Product use issue | 67.41 | 10.54 | 54 | 63895 | 149421 | 50391754 |
Dizziness | 66.45 | 10.54 | 699 | 63250 | 345670 | 50195505 |
Lactic acidosis | 65.53 | 10.54 | 136 | 63813 | 33219 | 50507956 |
Abdominal discomfort | 65.06 | 10.54 | 121 | 63828 | 231520 | 50309655 |
Hypertensive crisis | 63.93 | 10.54 | 81 | 63868 | 13073 | 50528102 |
Joint swelling | 61.34 | 10.54 | 137 | 63812 | 245149 | 50296026 |
Contraindicated product administered | 60.92 | 10.54 | 59 | 63890 | 148899 | 50392276 |
Product prescribing error | 60.71 | 10.54 | 101 | 63848 | 20860 | 50520315 |
Anaemia | 60.47 | 10.54 | 534 | 63415 | 251922 | 50289253 |
Rubber sensitivity | 60.08 | 10.54 | 34 | 63915 | 1775 | 50539400 |
Product monitoring error | 58.60 | 10.54 | 39 | 63910 | 2725 | 50538450 |
Atrial fibrillation | 55.38 | 10.54 | 265 | 63684 | 101480 | 50439695 |
Orthostatic hypotension | 55.35 | 10.54 | 118 | 63831 | 29363 | 50511812 |
Inappropriate antidiuretic hormone secretion | 54.70 | 10.54 | 75 | 63874 | 13068 | 50528107 |
Dyspnoea | 52.96 | 10.54 | 978 | 62971 | 546630 | 49994545 |
Hypoglycaemia | 52.46 | 10.54 | 168 | 63781 | 53413 | 50487762 |
Drug intolerance | 51.07 | 10.54 | 127 | 63822 | 218977 | 50322198 |
Labile hypertension | 50.89 | 10.54 | 20 | 63929 | 451 | 50540724 |
Wound | 50.53 | 10.54 | 36 | 63913 | 105758 | 50435417 |
Hepatic enzyme increased | 49.96 | 10.54 | 60 | 63889 | 137320 | 50403855 |
Infusion related reaction | 49.89 | 10.54 | 86 | 63863 | 169471 | 50371704 |
Rash | 46.94 | 10.54 | 342 | 63607 | 437129 | 50104046 |
Peripheral swelling | 46.73 | 10.54 | 121 | 63828 | 205815 | 50335360 |
Infection | 46.22 | 10.54 | 93 | 63856 | 172861 | 50368314 |
Sinusitis | 46.19 | 10.54 | 91 | 63858 | 170467 | 50370708 |
Gangrene | 44.22 | 10.54 | 41 | 63908 | 4651 | 50536524 |
Gastrointestinal disorder | 43.99 | 10.54 | 33 | 63916 | 94423 | 50446752 |
Injection site erythema | 42.11 | 10.54 | 21 | 63928 | 74915 | 50466260 |
Discomfort | 41.94 | 10.54 | 45 | 63904 | 108335 | 50432840 |
Basilar artery occlusion | 41.64 | 10.54 | 12 | 63937 | 98 | 50541077 |
Circulatory collapse | 40.99 | 10.54 | 83 | 63866 | 19917 | 50521258 |
Forced expiratory volume decreased | 40.65 | 10.54 | 38 | 63911 | 4356 | 50536819 |
Cerebral infarction | 40.01 | 10.54 | 86 | 63863 | 21518 | 50519657 |
Skin haemorrhage | 39.14 | 10.54 | 46 | 63903 | 6872 | 50534303 |
Helicobacter infection | 38.35 | 10.54 | 8 | 63941 | 49694 | 50491481 |
Androgenetic alopecia | 37.81 | 10.54 | 12 | 63937 | 140 | 50541035 |
Lung opacity | 37.46 | 10.54 | 26 | 63923 | 1947 | 50539228 |
Vertigo | 36.58 | 10.54 | 146 | 63803 | 51686 | 50489489 |
Paradoxical drug reaction | 36.58 | 10.54 | 33 | 63916 | 3614 | 50537561 |
Disorientation | 36.32 | 10.54 | 113 | 63836 | 35371 | 50505804 |
Oedema peripheral | 35.64 | 10.54 | 330 | 63619 | 157631 | 50383544 |
Fibromyalgia | 35.20 | 10.54 | 7 | 63942 | 44971 | 50496204 |
Cholestatic liver injury | 34.59 | 10.54 | 25 | 63924 | 1996 | 50539179 |
Neurologic neglect syndrome | 34.40 | 10.54 | 22 | 63927 | 1436 | 50539739 |
Renal failure | 33.95 | 10.54 | 241 | 63708 | 106392 | 50434783 |
Gamma-glutamyltransferase increased | 33.78 | 10.54 | 98 | 63851 | 29525 | 50511650 |
Diffuse alopecia | 33.65 | 10.54 | 16 | 63933 | 580 | 50540595 |
Injection site reaction | 33.01 | 10.54 | 11 | 63938 | 50021 | 50491154 |
Pemphigoid | 32.96 | 10.54 | 39 | 63910 | 5868 | 50535307 |
Hypersensitivity | 31.62 | 10.54 | 152 | 63797 | 215009 | 50326166 |
Palpitations | 31.50 | 10.54 | 216 | 63733 | 94290 | 50446885 |
Occupational asthma | 31.48 | 10.54 | 10 | 63939 | 117 | 50541058 |
Carotid artery thrombosis | 31.42 | 10.54 | 21 | 63928 | 1478 | 50539697 |
Productive cough | 31.41 | 10.54 | 141 | 63808 | 52553 | 50488622 |
Haematoma | 31.08 | 10.54 | 97 | 63852 | 30413 | 50510762 |
Non-cardiogenic pulmonary oedema | 30.99 | 10.54 | 15 | 63934 | 566 | 50540609 |
Off label use | 30.67 | 10.54 | 419 | 63530 | 474007 | 50067168 |
Aphasia | 30.33 | 10.54 | 92 | 63857 | 28402 | 50512773 |
Drug ineffective for unapproved indication | 29.87 | 10.54 | 76 | 63873 | 21205 | 50519970 |
Systemic infection | 29.73 | 10.54 | 24 | 63925 | 2259 | 50538916 |
Chromaturia | 29.25 | 10.54 | 60 | 63889 | 14530 | 50526645 |
Arthralgia | 29.23 | 10.54 | 385 | 63564 | 438317 | 50102858 |
Treatment failure | 28.86 | 10.54 | 84 | 63865 | 137553 | 50403622 |
Tubulointerstitial nephritis | 28.68 | 10.54 | 61 | 63888 | 15150 | 50526025 |
Rheumatoid arthritis | 28.66 | 10.54 | 145 | 63804 | 202405 | 50338770 |
Heart rate | 28.47 | 10.54 | 8 | 63941 | 59 | 50541116 |
Ill-defined disorder | 28.26 | 10.54 | 17 | 63932 | 54637 | 50486538 |
Toxicity to various agents | 27.91 | 10.54 | 156 | 63793 | 212343 | 50328832 |
Hypomagnesaemia | 27.75 | 10.54 | 78 | 63871 | 23078 | 50518097 |
Vertigo positional | 27.74 | 10.54 | 24 | 63925 | 2487 | 50538688 |
Hospitalisation | 27.65 | 10.54 | 27 | 63922 | 67910 | 50473265 |
Mobility decreased | 26.90 | 10.54 | 37 | 63912 | 79911 | 50461264 |
Vestibular migraine | 26.24 | 10.54 | 10 | 63939 | 207 | 50540968 |
Therapy non-responder | 26.20 | 10.54 | 16 | 63933 | 51006 | 50490169 |
Lichen planus | 26.19 | 10.54 | 21 | 63928 | 1958 | 50539217 |
Sensitivity to weather change | 26.12 | 10.54 | 35 | 63914 | 5966 | 50535209 |
Dehydration | 26.06 | 10.54 | 301 | 63648 | 152148 | 50389027 |
Arrhythmia | 25.55 | 10.54 | 96 | 63853 | 33036 | 50508139 |
Gastrointestinal tract adenoma | 25.55 | 10.54 | 11 | 63938 | 315 | 50540860 |
Therapeutic product effect incomplete | 25.47 | 10.54 | 48 | 63901 | 91467 | 50449708 |
Oesophageal dilatation | 25.32 | 10.54 | 11 | 63938 | 322 | 50540853 |
Intraventricular haemorrhage | 25.08 | 10.54 | 20 | 63929 | 1850 | 50539325 |
Blood hyposmosis | 25.05 | 10.54 | 6 | 63943 | 21 | 50541154 |
Therapeutic product effect decreased | 25.04 | 10.54 | 88 | 63861 | 135962 | 50405213 |
Haematoma muscle | 25.04 | 10.54 | 14 | 63935 | 714 | 50540461 |
Confusional state | 24.95 | 10.54 | 351 | 63598 | 185577 | 50355598 |
Blood pressure measurement | 24.90 | 10.54 | 10 | 63939 | 239 | 50540936 |
C-reactive protein abnormal | 24.77 | 10.54 | 3 | 63946 | 27806 | 50513369 |
Hemiplegia | 24.71 | 10.54 | 38 | 63911 | 7343 | 50533832 |
International normalised ratio increased | 24.63 | 10.54 | 114 | 63835 | 43038 | 50498137 |
Total lung capacity decreased | 24.48 | 10.54 | 17 | 63932 | 1274 | 50539901 |
Rhabdomyolysis | 24.45 | 10.54 | 106 | 63843 | 38921 | 50502254 |
Malaise | 24.34 | 10.54 | 575 | 63374 | 334957 | 50206218 |
Barotrauma | 24.00 | 10.54 | 9 | 63940 | 178 | 50540997 |
Irritable bowel syndrome | 23.91 | 10.54 | 18 | 63931 | 51423 | 50489752 |
Mental status changes | 23.88 | 10.54 | 8 | 63941 | 36264 | 50504911 |
Pulmonary hypoplasia | 23.43 | 10.54 | 10 | 63939 | 280 | 50540895 |
Purpura senile | 23.32 | 10.54 | 12 | 63937 | 517 | 50540658 |
Obstructive airways disorder | 23.12 | 10.54 | 57 | 63892 | 15595 | 50525580 |
Extrapyramidal disorder | 23.12 | 10.54 | 48 | 63901 | 11722 | 50529453 |
Respiratory tract inflammation | 23.09 | 10.54 | 12 | 63937 | 528 | 50540647 |
Intentional overdose | 23.02 | 10.54 | 27 | 63922 | 62477 | 50478698 |
Myalgia | 22.85 | 10.54 | 249 | 63700 | 124070 | 50417105 |
No adverse event | 22.83 | 10.54 | 7 | 63942 | 33571 | 50507604 |
Internal haemorrhage | 22.74 | 10.54 | 28 | 63921 | 4389 | 50536786 |
Transaminases increased | 22.62 | 10.54 | 82 | 63867 | 27742 | 50513433 |
Osteochondrosis | 22.15 | 10.54 | 15 | 63934 | 1079 | 50540096 |
Disturbance in attention | 22.12 | 10.54 | 88 | 63861 | 31098 | 50510077 |
Cerebellar syndrome | 22.11 | 10.54 | 24 | 63925 | 3287 | 50537888 |
Tinnitus | 22.10 | 10.54 | 82 | 63867 | 28050 | 50513125 |
Vasoplegia syndrome | 21.90 | 10.54 | 15 | 63934 | 1099 | 50540076 |
Exposure during pregnancy | 21.79 | 10.54 | 79 | 63870 | 120936 | 50420239 |
Altered state of consciousness | 21.71 | 10.54 | 69 | 63880 | 21841 | 50519334 |
Adjustment disorder | 21.70 | 10.54 | 19 | 63930 | 2000 | 50539175 |
Hemiparesis | 21.59 | 10.54 | 65 | 63884 | 19983 | 50521192 |
Acute myocardial infarction | 21.08 | 10.54 | 83 | 63866 | 29190 | 50511985 |
Impaired healing | 20.87 | 10.54 | 35 | 63914 | 69751 | 50471424 |
Melaena | 20.85 | 10.54 | 78 | 63871 | 26786 | 50514389 |
Occult blood | 20.82 | 10.54 | 15 | 63934 | 1192 | 50539983 |
Mental status changes postoperative | 20.58 | 10.54 | 8 | 63941 | 175 | 50541000 |
Intravascular haemolysis | 20.39 | 10.54 | 9 | 63940 | 274 | 50540901 |
Sinus arrest | 20.33 | 10.54 | 17 | 63932 | 1681 | 50539494 |
Injection site swelling | 20.22 | 10.54 | 14 | 63935 | 41759 | 50499416 |
Adverse drug reaction | 20.18 | 10.54 | 24 | 63925 | 55198 | 50485977 |
Sinonasal obstruction | 20.09 | 10.54 | 8 | 63941 | 187 | 50540988 |
Multiple sclerosis relapse | 20.01 | 10.54 | 15 | 63934 | 42949 | 50498226 |
Cornea verticillata | 19.92 | 10.54 | 6 | 63943 | 58 | 50541117 |
Drug abuse | 19.82 | 10.54 | 28 | 63921 | 59818 | 50481357 |
Pneumobilia | 19.81 | 10.54 | 7 | 63942 | 116 | 50541059 |
Confusion postoperative | 19.78 | 10.54 | 8 | 63941 | 195 | 50540980 |
Cerebral haemorrhage | 19.72 | 10.54 | 77 | 63872 | 26975 | 50514200 |
Blood uric acid increased | 19.25 | 10.54 | 24 | 63925 | 3810 | 50537365 |
Painful respiration | 19.07 | 10.54 | 19 | 63930 | 2356 | 50538819 |
Glomerular filtration rate decreased | 18.90 | 10.54 | 44 | 63905 | 11608 | 50529567 |
Nausea | 18.76 | 10.54 | 1079 | 62870 | 704319 | 49836856 |
Bronchopulmonary aspergillosis allergic | 18.73 | 10.54 | 14 | 63935 | 1177 | 50539998 |
Blister | 18.73 | 10.54 | 51 | 63898 | 85367 | 50455808 |
Renal tubular disorder | 18.66 | 10.54 | 19 | 63930 | 2418 | 50538757 |
Decreased appetite | 18.65 | 10.54 | 357 | 63592 | 200566 | 50340609 |
Gastrointestinal haemorrhage | 18.48 | 10.54 | 157 | 63792 | 73164 | 50468011 |
Therapeutic response changed | 18.26 | 10.54 | 12 | 63937 | 821 | 50540354 |
Blood pressure inadequately controlled | 18.23 | 10.54 | 25 | 63924 | 4355 | 50536820 |
Injection site bruising | 18.23 | 10.54 | 12 | 63937 | 36756 | 50504419 |
Dermatosis | 18.17 | 10.54 | 8 | 63941 | 242 | 50540933 |
Female sterilisation | 17.96 | 10.54 | 10 | 63939 | 506 | 50540669 |
Renal impairment neonatal | 17.90 | 10.54 | 5 | 63944 | 36 | 50541139 |
Hepatic function abnormal | 17.67 | 10.54 | 85 | 63864 | 32596 | 50508579 |
Psoriatic arthropathy | 17.66 | 10.54 | 20 | 63929 | 47012 | 50494163 |
Iron deficiency anaemia | 17.59 | 10.54 | 54 | 63895 | 16780 | 50524395 |
Gastroenteritis | 17.57 | 10.54 | 67 | 63882 | 23214 | 50517961 |
Tarsal tunnel syndrome | 17.55 | 10.54 | 10 | 63939 | 529 | 50540646 |
Cystitis | 17.38 | 10.54 | 106 | 63843 | 44458 | 50496717 |
Vomiting | 17.05 | 10.54 | 728 | 63221 | 460030 | 50081145 |
Histamine intolerance | 17.02 | 10.54 | 5 | 63944 | 44 | 50541131 |
Dyspnoea at rest | 17.00 | 10.54 | 22 | 63927 | 3625 | 50537550 |
Wrong strength | 16.92 | 10.54 | 5 | 63944 | 45 | 50541130 |
Putamen haemorrhage | 16.88 | 10.54 | 7 | 63942 | 182 | 50540993 |
Neuropathy peripheral | 16.87 | 10.54 | 64 | 63885 | 96693 | 50444482 |
Blood creatine phosphokinase increased | 16.81 | 10.54 | 72 | 63877 | 26295 | 50514880 |
Product quality issue | 16.81 | 10.54 | 9 | 63940 | 30849 | 50510326 |
Subarachnoid haemorrhage | 16.72 | 10.54 | 40 | 63909 | 10736 | 50530439 |
Iron deficiency | 16.64 | 10.54 | 28 | 63921 | 5834 | 50535341 |
Psoas abscess | 16.61 | 10.54 | 9 | 63940 | 431 | 50540744 |
Prothrombin time shortened | 16.55 | 10.54 | 15 | 63934 | 1652 | 50539523 |
Diabetic ketoacidosis | 16.55 | 10.54 | 55 | 63894 | 17817 | 50523358 |
Hypokalaemia | 16.51 | 10.54 | 177 | 63772 | 87815 | 50453360 |
Injection site pruritus | 16.51 | 10.54 | 16 | 63933 | 40395 | 50500780 |
Spider naevus | 16.42 | 10.54 | 6 | 63943 | 110 | 50541065 |
Asthenia | 16.38 | 10.54 | 523 | 63426 | 318519 | 50222656 |
Interstitial lung disease | 16.23 | 10.54 | 119 | 63830 | 53057 | 50488118 |
Potentiating drug interaction | 16.22 | 10.54 | 22 | 63927 | 3794 | 50537381 |
Knee arthroplasty | 16.08 | 10.54 | 13 | 63936 | 35833 | 50505342 |
Cor pulmonale acute | 16.05 | 10.54 | 8 | 63941 | 322 | 50540853 |
Eosinophilia | 16.04 | 10.54 | 56 | 63893 | 18596 | 50522579 |
Vestibular disorder | 15.81 | 10.54 | 13 | 63936 | 1256 | 50539919 |
Hypoventilation | 15.75 | 10.54 | 22 | 63927 | 3899 | 50537276 |
Disease progression | 15.70 | 10.54 | 65 | 63884 | 95801 | 50445374 |
Blepharospasm | 15.68 | 10.54 | 19 | 63930 | 2929 | 50538246 |
Agranulocytosis | 15.64 | 10.54 | 61 | 63888 | 21360 | 50519815 |
Glossitis | 15.60 | 10.54 | 18 | 63931 | 2637 | 50538538 |
Walking disability | 15.57 | 10.54 | 13 | 63936 | 1283 | 50539892 |
Chest wall mass | 15.48 | 10.54 | 5 | 63944 | 62 | 50541113 |
Abortion spontaneous | 15.43 | 10.54 | 18 | 63931 | 41754 | 50499421 |
Musculoskeletal stiffness | 15.43 | 10.54 | 97 | 63852 | 128384 | 50412791 |
Renal aplasia | 15.42 | 10.54 | 7 | 63942 | 228 | 50540947 |
Accidental exposure to product | 15.33 | 10.54 | 5 | 63944 | 23052 | 50518123 |
Labelled drug-drug interaction medication error | 15.31 | 10.54 | 38 | 63911 | 10439 | 50530736 |
Urogenital haemorrhage | 15.17 | 10.54 | 7 | 63942 | 237 | 50540938 |
Brain stem stroke | 15.11 | 10.54 | 7 | 63942 | 239 | 50540936 |
Microcytic anaemia | 15.00 | 10.54 | 19 | 63930 | 3065 | 50538110 |
Visual acuity reduced transiently | 14.96 | 10.54 | 6 | 63943 | 143 | 50541032 |
Haematemesis | 14.91 | 10.54 | 72 | 63877 | 27653 | 50513522 |
Pain in jaw | 14.81 | 10.54 | 16 | 63933 | 38412 | 50502763 |
Atrioventricular block complete | 14.74 | 10.54 | 30 | 63919 | 7225 | 50533950 |
Full blood count decreased | 14.59 | 10.54 | 5 | 63944 | 22341 | 50518834 |
Lip infection | 14.55 | 10.54 | 5 | 63944 | 76 | 50541099 |
Upper gastrointestinal haemorrhage | 14.54 | 10.54 | 49 | 63900 | 15986 | 50525189 |
C-reactive protein increased | 14.53 | 10.54 | 138 | 63811 | 66336 | 50474839 |
Skin texture abnormal | 14.51 | 10.54 | 8 | 63941 | 397 | 50540778 |
Intentional product misuse | 14.38 | 10.54 | 23 | 63926 | 46711 | 50494464 |
Breast discomfort | 14.36 | 10.54 | 8 | 63941 | 405 | 50540770 |
Cardiorenal syndrome | 14.32 | 10.54 | 9 | 63940 | 570 | 50540605 |
Binocular eye movement disorder | 14.18 | 10.54 | 4 | 63945 | 30 | 50541145 |
Hyperuricaemia | 14.15 | 10.54 | 23 | 63926 | 4657 | 50536518 |
Lower respiratory tract infection | 14.11 | 10.54 | 67 | 63882 | 95134 | 50446041 |
Retroperitoneal fibrosis | 13.95 | 10.54 | 7 | 63942 | 286 | 50540889 |
Device issue | 13.87 | 10.54 | 4 | 63945 | 19968 | 50521207 |
Epilepsy | 13.83 | 10.54 | 59 | 63890 | 21508 | 50519667 |
Ultrasound kidney abnormal | 13.74 | 10.54 | 4 | 63945 | 34 | 50541141 |
Laryngeal papilloma | 13.74 | 10.54 | 3 | 63946 | 6 | 50541169 |
Spinal osteoarthritis | 13.61 | 10.54 | 44 | 63905 | 14048 | 50527127 |
Haemorrhagic cyst | 13.61 | 10.54 | 6 | 63943 | 182 | 50540993 |
Anaemia folate deficiency | 13.58 | 10.54 | 6 | 63943 | 183 | 50540992 |
Coronavirus test positive | 13.55 | 10.54 | 9 | 63940 | 627 | 50540548 |
Respiratory tract congestion | 13.42 | 10.54 | 44 | 63905 | 14155 | 50527020 |
Flatulence | 13.40 | 10.54 | 73 | 63876 | 29385 | 50511790 |
Urinary retention | 13.36 | 10.54 | 67 | 63882 | 26123 | 50515052 |
Fluid intake reduced | 13.27 | 10.54 | 18 | 63931 | 3104 | 50538071 |
Sputum retention | 13.26 | 10.54 | 8 | 63941 | 471 | 50540704 |
Nasal congestion | 13.20 | 10.54 | 28 | 63921 | 51092 | 50490083 |
Aortic dissection | 13.19 | 10.54 | 13 | 63936 | 1590 | 50539585 |
Cardiac murmur functional | 13.16 | 10.54 | 4 | 63945 | 40 | 50541135 |
Metastases to fallopian tube | 13.16 | 10.54 | 4 | 63945 | 40 | 50541135 |
Laryngeal dysplasia | 13.14 | 10.54 | 3 | 63946 | 8 | 50541167 |
Abdominal pain | 13.11 | 10.54 | 391 | 63558 | 235837 | 50305338 |
Wrong technique in product usage process | 13.04 | 10.54 | 32 | 63917 | 55478 | 50485697 |
Adverse event | 13.03 | 10.54 | 22 | 63927 | 43741 | 50497434 |
Cholestasis | 12.97 | 10.54 | 65 | 63884 | 25336 | 50515839 |
Therapeutic response decreased | 12.94 | 10.54 | 25 | 63924 | 47206 | 50493969 |
Hypochloraemia | 12.90 | 10.54 | 13 | 63936 | 1634 | 50539541 |
Thirst | 12.88 | 10.54 | 36 | 63913 | 10614 | 50530561 |
Decreased ventricular preload | 12.88 | 10.54 | 3 | 63946 | 9 | 50541166 |
Endometrial cancer | 12.83 | 10.54 | 17 | 63932 | 2866 | 50538309 |
Suicide attempt | 12.81 | 10.54 | 29 | 63920 | 51703 | 50489472 |
Sneezing | 12.81 | 10.54 | 43 | 63906 | 14001 | 50527174 |
Transient ischaemic attack | 12.80 | 10.54 | 77 | 63872 | 32133 | 50509042 |
Polyneuropathy | 12.75 | 10.54 | 39 | 63910 | 12092 | 50529083 |
Personality disorder | 12.74 | 10.54 | 21 | 63928 | 4303 | 50536872 |
Multiple sclerosis | 12.68 | 10.54 | 5 | 63944 | 20488 | 50520687 |
Eczema nummular | 12.63 | 10.54 | 6 | 63943 | 217 | 50540958 |
Gastroenteritis viral | 12.62 | 10.54 | 4 | 63945 | 18782 | 50522393 |
Neonatal hypotension | 12.55 | 10.54 | 5 | 63944 | 117 | 50541058 |
Cystitis escherichia | 12.52 | 10.54 | 7 | 63942 | 357 | 50540818 |
Drug therapeutic incompatibility | 12.50 | 10.54 | 4 | 63945 | 48 | 50541127 |
Staphylococcal infection | 12.47 | 10.54 | 16 | 63933 | 35600 | 50505575 |
Vital capacity decreased | 12.34 | 10.54 | 10 | 63939 | 946 | 50540229 |
Treatment noncompliance | 12.24 | 10.54 | 12 | 63937 | 30138 | 50511037 |
Hallucinations, mixed | 12.19 | 10.54 | 20 | 63929 | 4083 | 50537092 |
Ear infection | 12.18 | 10.54 | 9 | 63940 | 25961 | 50515214 |
Body temperature increased | 12.13 | 10.54 | 13 | 63936 | 31328 | 50509847 |
Urticaria | 12.11 | 10.54 | 105 | 63844 | 129456 | 50411719 |
Paresis | 12.10 | 10.54 | 14 | 63935 | 2057 | 50539118 |
Hepatitis cholestatic | 12.08 | 10.54 | 25 | 63924 | 6092 | 50535083 |
Pharyngeal enanthema | 12.07 | 10.54 | 4 | 63945 | 54 | 50541121 |
Drug metabolising enzyme decreased | 12.02 | 10.54 | 3 | 63946 | 13 | 50541162 |
Taste disorder | 11.96 | 10.54 | 30 | 63919 | 8294 | 50532881 |
Cold sweat | 11.93 | 10.54 | 35 | 63914 | 10609 | 50530566 |
Resorption bone increased | 11.85 | 10.54 | 10 | 63939 | 1001 | 50540174 |
Chemotherapeutic drug level increased | 11.85 | 10.54 | 5 | 63944 | 136 | 50541039 |
Flail chest | 11.81 | 10.54 | 4 | 63945 | 58 | 50541117 |
Muscular weakness | 11.79 | 10.54 | 177 | 63772 | 94836 | 50446339 |
Leiomyoma | 11.77 | 10.54 | 7 | 63942 | 401 | 50540774 |
Injection site rash | 11.69 | 10.54 | 3 | 63946 | 16174 | 50525001 |
COVID-19 | 11.68 | 10.54 | 26 | 63923 | 46636 | 50494539 |
White blood cell count decreased | 11.63 | 10.54 | 93 | 63856 | 116629 | 50424546 |
Nocturia | 11.56 | 10.54 | 26 | 63923 | 6704 | 50534471 |
Pancreatitis acute | 11.51 | 10.54 | 60 | 63889 | 23752 | 50517423 |
Thalamus haemorrhage | 11.49 | 10.54 | 8 | 63941 | 602 | 50540573 |
Intentional product use issue | 11.47 | 10.54 | 54 | 63895 | 76864 | 50464311 |
Cerebral haematoma | 11.41 | 10.54 | 17 | 63932 | 3194 | 50537981 |
Depression | 11.40 | 10.54 | 144 | 63805 | 165279 | 50375896 |
Lordosis | 11.40 | 10.54 | 6 | 63943 | 271 | 50540904 |
Rales | 11.36 | 10.54 | 33 | 63916 | 9945 | 50531230 |
Weight increased | 11.36 | 10.54 | 183 | 63766 | 201708 | 50339467 |
Lung perforation | 11.34 | 10.54 | 4 | 63945 | 66 | 50541109 |
Ischaemic stroke | 11.31 | 10.54 | 45 | 63904 | 15903 | 50525272 |
Stasis dermatitis | 11.27 | 10.54 | 8 | 63941 | 621 | 50540554 |
Wheezing | 11.26 | 10.54 | 124 | 63825 | 61923 | 50479252 |
Subdural haematoma | 11.24 | 10.54 | 39 | 63910 | 12908 | 50528267 |
Ventricular extrasystoles | 11.23 | 10.54 | 34 | 63915 | 10482 | 50530693 |
Sinus congestion | 11.20 | 10.54 | 41 | 63908 | 13930 | 50527245 |
Proteinuria | 11.11 | 10.54 | 46 | 63903 | 16551 | 50524624 |
Gastritis bacterial | 11.07 | 10.54 | 4 | 63945 | 71 | 50541104 |
Foetal malformation | 11.04 | 10.54 | 5 | 63944 | 162 | 50541013 |
Electrolyte imbalance | 11.03 | 10.54 | 47 | 63902 | 17122 | 50524053 |
Jaundice | 11.03 | 10.54 | 64 | 63885 | 26365 | 50514810 |
Vertebrobasilar insufficiency | 11.01 | 10.54 | 4 | 63945 | 72 | 50541103 |
Dysarthria | 11.01 | 10.54 | 83 | 63866 | 37320 | 50503855 |
Therapy cessation | 10.97 | 10.54 | 10 | 63939 | 26001 | 50515174 |
Joint injury | 10.95 | 10.54 | 7 | 63942 | 21782 | 50519393 |
Laboratory test abnormal | 10.94 | 10.54 | 8 | 63941 | 23200 | 50517975 |
Base excess decreased | 10.91 | 10.54 | 4 | 63945 | 74 | 50541101 |
Microangiopathy | 10.91 | 10.54 | 9 | 63940 | 874 | 50540301 |
Phlebitis | 10.85 | 10.54 | 23 | 63926 | 5697 | 50535478 |
Uterine dilation and evacuation | 10.81 | 10.54 | 3 | 63946 | 21 | 50541154 |
Musculoskeletal pain | 10.79 | 10.54 | 139 | 63810 | 72038 | 50469137 |
Drug monitoring procedure not performed | 10.74 | 10.54 | 7 | 63942 | 472 | 50540703 |
Device dislocation | 10.72 | 10.54 | 7 | 63942 | 21539 | 50519636 |
Blood sodium decreased | 10.72 | 10.54 | 54 | 63895 | 21093 | 50520082 |
Delayed fontanelle closure | 10.69 | 10.54 | 3 | 63946 | 22 | 50541153 |
Incarcerated incisional hernia | 10.69 | 10.54 | 3 | 63946 | 22 | 50541153 |
Joint range of motion decreased | 10.68 | 10.54 | 5 | 63944 | 18507 | 50522668 |
Pregnancy | 10.65 | 10.54 | 13 | 63936 | 29564 | 50511611 |
Hypoosmolar state | 10.60 | 10.54 | 5 | 63944 | 178 | 50540997 |
Motor dysfunction | 10.57 | 10.54 | 28 | 63921 | 8003 | 50533172 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 192.77 | 10.18 | 486 | 48820 | 102371 | 29422850 |
Hyperkalaemia | 165.12 | 10.18 | 335 | 48971 | 61057 | 29464164 |
Acute kidney injury | 159.38 | 10.18 | 865 | 48441 | 264402 | 29260819 |
Death | 149.83 | 10.18 | 212 | 49094 | 341872 | 29183349 |
Product monitoring error | 125.22 | 10.18 | 69 | 49237 | 2576 | 29522645 |
Completed suicide | 116.31 | 10.18 | 9 | 49297 | 90237 | 29434984 |
Toxicity to various agents | 91.30 | 10.18 | 93 | 49213 | 173568 | 29351653 |
Product prescribing error | 85.01 | 10.18 | 126 | 49180 | 17850 | 29507371 |
Product dose omission issue | 80.51 | 10.18 | 30 | 49276 | 96353 | 29428868 |
Haematochezia | 78.99 | 10.18 | 184 | 49122 | 36799 | 29488422 |
Bradycardia | 73.82 | 10.18 | 259 | 49047 | 65370 | 29459851 |
Drug abuse | 73.52 | 10.18 | 21 | 49285 | 79862 | 29445359 |
Drug ineffective | 69.41 | 10.18 | 341 | 48965 | 362829 | 29162392 |
Angina pectoris | 56.67 | 10.18 | 136 | 49170 | 27714 | 29497507 |
Neutropenia | 56.03 | 10.18 | 83 | 49223 | 131628 | 29393593 |
Blood cholesterol | 55.23 | 10.18 | 18 | 49288 | 170 | 29525051 |
Renal impairment | 51.05 | 10.18 | 269 | 49037 | 81064 | 29444157 |
Labelled drug-drug interaction medication error | 48.77 | 10.18 | 79 | 49227 | 12080 | 29513141 |
Dizziness | 48.45 | 10.18 | 506 | 48800 | 189178 | 29336043 |
Pulmonary hypoplasia | 47.47 | 10.18 | 20 | 49286 | 406 | 29524815 |
Renal artery stenosis | 46.57 | 10.18 | 33 | 49273 | 1928 | 29523293 |
Cardiac failure | 44.89 | 10.18 | 255 | 49051 | 79032 | 29446189 |
Off label use | 44.22 | 10.18 | 307 | 48999 | 300493 | 29224728 |
Myalgia | 42.52 | 10.18 | 239 | 49067 | 73780 | 29451441 |
Gastrointestinal angiodysplasia | 42.12 | 10.18 | 20 | 49286 | 543 | 29524678 |
Lymphocyte count abnormal | 40.08 | 10.18 | 20 | 49286 | 607 | 29524614 |
Presyncope | 39.90 | 10.18 | 85 | 49221 | 16004 | 29509217 |
Blood creatinine increased | 39.50 | 10.18 | 260 | 49046 | 84842 | 29440379 |
Dyspnoea | 39.33 | 10.18 | 763 | 48543 | 325969 | 29199252 |
Drug hypersensitivity | 36.60 | 10.18 | 36 | 49270 | 68370 | 29456851 |
Oedema peripheral | 35.84 | 10.18 | 295 | 49011 | 103262 | 29421959 |
Interstitial lung disease | 35.58 | 10.18 | 190 | 49116 | 57528 | 29467693 |
Disease progression | 34.43 | 10.18 | 52 | 49254 | 81864 | 29443357 |
Multiple drug therapy | 33.60 | 10.18 | 15 | 49291 | 352 | 29524869 |
Renal artery thrombosis | 33.38 | 10.18 | 14 | 49292 | 281 | 29524940 |
Sepsis | 33.23 | 10.18 | 124 | 49182 | 142558 | 29382663 |
Neuropathy peripheral | 31.91 | 10.18 | 43 | 49263 | 70984 | 29454237 |
Anencephaly | 31.69 | 10.18 | 11 | 49295 | 128 | 29525093 |
Febrile neutropenia | 31.34 | 10.18 | 90 | 49216 | 112150 | 29413071 |
Hospitalisation | 31.20 | 10.18 | 19 | 49287 | 45969 | 29479252 |
Electrolyte imbalance | 30.81 | 10.18 | 62 | 49244 | 11212 | 29514009 |
Jaundice | 30.67 | 10.18 | 113 | 49193 | 29183 | 29496038 |
Agitation | 29.82 | 10.18 | 25 | 49281 | 51279 | 29473942 |
Renal cyst haemorrhage | 29.12 | 10.18 | 14 | 49292 | 391 | 29524830 |
Cerebral infarction | 29.11 | 10.18 | 99 | 49207 | 24576 | 29500645 |
Adrenal insufficiency | 29.05 | 10.18 | 60 | 49246 | 11054 | 29514167 |
Patient dissatisfaction with treatment | 28.93 | 10.18 | 9 | 49297 | 72 | 29525149 |
Blood pressure inadequately controlled | 28.69 | 10.18 | 27 | 49279 | 2359 | 29522862 |
Pemphigoid | 27.38 | 10.18 | 47 | 49259 | 7534 | 29517687 |
Arrhythmia | 27.28 | 10.18 | 114 | 49192 | 31199 | 29494022 |
Seizure | 27.24 | 10.18 | 73 | 49233 | 93050 | 29432171 |
Vena cava injury | 26.88 | 10.18 | 11 | 49295 | 207 | 29525014 |
Hypoxia | 25.26 | 10.18 | 25 | 49281 | 47354 | 29477867 |
Intraductal papillary mucinous neoplasm | 25.20 | 10.18 | 12 | 49294 | 328 | 29524893 |
Cardiac arrest | 25.10 | 10.18 | 67 | 49239 | 85524 | 29439697 |
Aortic valve incompetence | 24.94 | 10.18 | 36 | 49270 | 4977 | 29520244 |
Pneumonia | 24.90 | 10.18 | 380 | 48926 | 319792 | 29205429 |
Glycosylated haemoglobin increased | 24.77 | 10.18 | 51 | 49255 | 9375 | 29515846 |
Lactic acidosis | 24.71 | 10.18 | 108 | 49198 | 30139 | 29495082 |
Peripheral arterial occlusive disease | 24.59 | 10.18 | 36 | 49270 | 5040 | 29520181 |
Rectal prolapse | 24.57 | 10.18 | 11 | 49295 | 260 | 29524961 |
Hypotension | 23.66 | 10.18 | 455 | 48851 | 193899 | 29331322 |
Actinic keratosis | 23.08 | 10.18 | 30 | 49276 | 3756 | 29521465 |
Mental status changes | 22.90 | 10.18 | 15 | 49291 | 34912 | 29490309 |
SARS-CoV-2 antibody test positive | 22.87 | 10.18 | 10 | 49296 | 223 | 29524998 |
Joint contracture | 22.86 | 10.18 | 21 | 49285 | 1779 | 29523442 |
Treatment failure | 22.72 | 10.18 | 17 | 49289 | 36922 | 29488299 |
Hypertensive crisis | 22.46 | 10.18 | 44 | 49262 | 7804 | 29517417 |
Gastrointestinal ischaemia | 22.41 | 10.18 | 9 | 49297 | 161 | 29525060 |
Lung hernia | 21.88 | 10.18 | 7 | 49299 | 62 | 29525159 |
Respiratory arrest | 21.61 | 10.18 | 8 | 49298 | 25825 | 29499396 |
Diverticulum intestinal | 21.52 | 10.18 | 27 | 49279 | 3263 | 29521958 |
Post concussion syndrome | 21.52 | 10.18 | 8 | 49298 | 115 | 29525106 |
Renal artery angioplasty | 21.52 | 10.18 | 5 | 49301 | 10 | 29525211 |
Renal artery stent placement | 21.52 | 10.18 | 5 | 49301 | 10 | 29525211 |
Hyperuricaemia | 21.41 | 10.18 | 40 | 49266 | 6849 | 29518372 |
Blood creatine phosphokinase increased | 20.58 | 10.18 | 127 | 49179 | 40517 | 29484704 |
Acute cutaneous lupus erythematosus | 20.36 | 10.18 | 7 | 49299 | 79 | 29525142 |
Nervous system neoplasm | 19.62 | 10.18 | 8 | 49298 | 149 | 29525072 |
Costovertebral angle tenderness | 19.54 | 10.18 | 7 | 49299 | 90 | 29525131 |
Hemiataxia | 19.51 | 10.18 | 6 | 49300 | 46 | 29525175 |
Anxiety disorder due to a general medical condition | 19.36 | 10.18 | 4 | 49302 | 3 | 29525218 |
Vasculitic rash | 19.32 | 10.18 | 14 | 49292 | 847 | 29524374 |
Rhabdomyolysis | 19.31 | 10.18 | 170 | 49136 | 60638 | 29464583 |
Sedation | 19.22 | 10.18 | 3 | 49303 | 17402 | 29507819 |
Urinary hesitation | 19.21 | 10.18 | 21 | 49285 | 2192 | 29523029 |
Atrioventricular block second degree | 19.15 | 10.18 | 25 | 49281 | 3143 | 29522078 |
Food aversion | 19.05 | 10.18 | 10 | 49296 | 338 | 29524883 |
White blood cell count decreased | 19.02 | 10.18 | 73 | 49233 | 83289 | 29441932 |
Tonsillar ulcer | 19.01 | 10.18 | 8 | 49298 | 162 | 29525059 |
Oral lichen planus | 18.96 | 10.18 | 8 | 49298 | 163 | 29525058 |
Total cholesterol/HDL ratio increased | 18.96 | 10.18 | 8 | 49298 | 163 | 29525058 |
Intentional product misuse | 18.81 | 10.18 | 18 | 49288 | 34643 | 29490578 |
Abdominal pain lower | 18.45 | 10.18 | 43 | 49263 | 8595 | 29516626 |
Hyperparathyroidism secondary | 18.42 | 10.18 | 16 | 49290 | 1259 | 29523962 |
Drug dependence | 18.41 | 10.18 | 6 | 49300 | 20975 | 29504246 |
Acute right ventricular failure | 18.03 | 10.18 | 7 | 49299 | 114 | 29525107 |
Product use in unapproved indication | 17.99 | 10.18 | 79 | 49227 | 86796 | 29438425 |
Blood growth hormone increased | 17.86 | 10.18 | 9 | 49297 | 279 | 29524942 |
Gamma-glutamyltransferase increased | 17.83 | 10.18 | 90 | 49216 | 26647 | 29498574 |
Ventricular extrasystoles | 17.70 | 10.18 | 48 | 49258 | 10534 | 29514687 |
Congenital renal disorder | 17.59 | 10.18 | 6 | 49300 | 66 | 29525155 |
Drug resistance | 17.47 | 10.18 | 7 | 49299 | 21533 | 29503688 |
pH body fluid increased | 17.35 | 10.18 | 6 | 49300 | 69 | 29525152 |
Macular ischaemia | 17.35 | 10.18 | 6 | 49300 | 69 | 29525152 |
Sinusitis | 17.32 | 10.18 | 19 | 49287 | 34331 | 29490890 |
Drug interaction | 17.31 | 10.18 | 441 | 48865 | 196944 | 29328277 |
Paresis cranial nerve | 17.27 | 10.18 | 6 | 49300 | 70 | 29525151 |
Eczema eyelids | 17.17 | 10.18 | 5 | 49301 | 31 | 29525190 |
Full blood count decreased | 17.11 | 10.18 | 3 | 49303 | 15989 | 29509232 |
Haematuria | 17.03 | 10.18 | 129 | 49177 | 44010 | 29481211 |
Coronavirus infection | 16.93 | 10.18 | 24 | 49282 | 3264 | 29521957 |
Vertebral artery stenosis | 16.80 | 10.18 | 7 | 49299 | 138 | 29525083 |
Xanthopsia | 16.48 | 10.18 | 7 | 49299 | 145 | 29525076 |
Diabetic nephropathy | 16.48 | 10.18 | 18 | 49288 | 1877 | 29523344 |
Incarcerated inguinal hernia | 16.41 | 10.18 | 6 | 49300 | 82 | 29525139 |
Device lead damage | 16.20 | 10.18 | 3 | 49303 | 0 | 29525221 |
Hypochromic anaemia | 16.19 | 10.18 | 12 | 49294 | 752 | 29524469 |
Congenital muscle absence | 16.18 | 10.18 | 5 | 49301 | 39 | 29525182 |
Congenital vas deferens absence | 16.18 | 10.18 | 5 | 49301 | 39 | 29525182 |
Plasma cell myeloma | 16.13 | 10.18 | 23 | 49283 | 37092 | 29488129 |
Mucosal haemorrhage | 16.01 | 10.18 | 16 | 49290 | 1505 | 29523716 |
Respiratory symptom | 16 | 10.18 | 13 | 49293 | 933 | 29524288 |
Abdominal wall haemorrhage | 15.87 | 10.18 | 8 | 49298 | 248 | 29524973 |
Choroidal detachment | 15.81 | 10.18 | 9 | 49297 | 358 | 29524863 |
Muscle rupture | 15.71 | 10.18 | 18 | 49288 | 1979 | 29523242 |
Unevaluable event | 15.62 | 10.18 | 16 | 49290 | 29835 | 29495386 |
Renovascular hypertension | 15.60 | 10.18 | 4 | 49302 | 14 | 29525207 |
Shock hypoglycaemic | 15.55 | 10.18 | 6 | 49300 | 96 | 29525125 |
Pancreatitis acute | 15.51 | 10.18 | 81 | 49225 | 24304 | 29500917 |
Hallucination | 15.50 | 10.18 | 32 | 49274 | 44680 | 29480541 |
Coronary artery stenosis | 15.47 | 10.18 | 40 | 49266 | 8533 | 29516688 |
Basilar artery thrombosis | 15.42 | 10.18 | 7 | 49299 | 171 | 29525050 |
Hepatic ischaemia | 15.37 | 10.18 | 9 | 49297 | 378 | 29524843 |
Bronchopulmonary aspergillosis allergic | 15.36 | 10.18 | 10 | 49296 | 508 | 29524713 |
No adverse event | 15.33 | 10.18 | 5 | 49301 | 17473 | 29507748 |
Mixed liver injury | 15.32 | 10.18 | 18 | 49288 | 2033 | 29523188 |
Cardiovascular insufficiency | 15.31 | 10.18 | 15 | 49291 | 1378 | 29523843 |
Neuroleptic malignant syndrome | 15.30 | 10.18 | 4 | 49302 | 16144 | 29509077 |
Respiratory failure | 15.27 | 10.18 | 97 | 49209 | 97034 | 29428187 |
Therapeutic product effect decreased | 15.17 | 10.18 | 16 | 49290 | 29435 | 29495786 |
Retinal artery occlusion | 15.14 | 10.18 | 16 | 49290 | 1607 | 29523614 |
Neurotoxicity | 15.08 | 10.18 | 3 | 49303 | 14610 | 29510611 |
Carotid arteriosclerosis | 14.90 | 10.18 | 15 | 49291 | 1423 | 29523798 |
Blood pressure increased | 14.78 | 10.18 | 188 | 49118 | 73615 | 29451606 |
Mesenteric artery thrombosis | 14.70 | 10.18 | 9 | 49297 | 410 | 29524811 |
Idiopathic pulmonary fibrosis | 14.67 | 10.18 | 22 | 49284 | 3146 | 29522075 |
Therapy non-responder | 14.61 | 10.18 | 18 | 49288 | 30893 | 29494328 |
Metabolic acidosis | 14.49 | 10.18 | 110 | 49196 | 37552 | 29487669 |
Supine hypertension | 14.39 | 10.18 | 8 | 49298 | 304 | 29524917 |
Oligohydramnios | 14.36 | 10.18 | 8 | 49298 | 305 | 29524916 |
Bronchiectasis | 14.30 | 10.18 | 33 | 49273 | 6552 | 29518669 |
Generalised tonic-clonic seizure | 14.30 | 10.18 | 7 | 49299 | 19132 | 29506089 |
Anti-erythropoietin antibody negative | 14.29 | 10.18 | 7 | 49299 | 204 | 29525017 |
Basal cell carcinoma | 14.29 | 10.18 | 61 | 49245 | 16849 | 29508372 |
Hepatic steatosis | 14.28 | 10.18 | 56 | 49250 | 14890 | 29510331 |
Aortic valve stenosis | 14.25 | 10.18 | 18 | 49288 | 2190 | 29523031 |
Peritoneal adhesions | 14.14 | 10.18 | 6 | 49300 | 124 | 29525097 |
Syncope | 14.12 | 10.18 | 202 | 49104 | 81169 | 29444052 |
Cytomegalovirus infection | 13.87 | 10.18 | 11 | 49295 | 23204 | 29502017 |
Pterygium | 13.84 | 10.18 | 6 | 49300 | 131 | 29525090 |
Lymphocyte count | 13.77 | 10.18 | 5 | 49301 | 67 | 29525154 |
Bacteraemia | 13.75 | 10.18 | 5 | 49301 | 16318 | 29508903 |
Desmoplastic melanoma | 13.71 | 10.18 | 4 | 49302 | 25 | 29525196 |
Obstructive airways disorder | 13.70 | 10.18 | 45 | 49261 | 10971 | 29514250 |
Basal ganglia haemorrhage | 13.59 | 10.18 | 11 | 49295 | 785 | 29524436 |
Papillary renal cell carcinoma | 13.59 | 10.18 | 6 | 49300 | 137 | 29525084 |
Adverse drug reaction | 13.59 | 10.18 | 12 | 49294 | 24008 | 29501213 |
Duodenal ulcer | 13.58 | 10.18 | 40 | 49266 | 9198 | 29516023 |
Subileus | 13.50 | 10.18 | 20 | 49286 | 2830 | 29522391 |
Pallor | 13.48 | 10.18 | 70 | 49236 | 20954 | 29504267 |
Alopecia universalis | 13.44 | 10.18 | 5 | 49301 | 72 | 29525149 |
Prothrombin time shortened | 13.43 | 10.18 | 14 | 49292 | 1384 | 29523837 |
Cerebral haematoma | 13.42 | 10.18 | 25 | 49281 | 4271 | 29520950 |
Urogenital haemorrhage | 13.41 | 10.18 | 9 | 49297 | 481 | 29524740 |
Vascular stent thrombosis | 13.36 | 10.18 | 19 | 49287 | 2591 | 29522630 |
Hypozincaemia | 13.26 | 10.18 | 3 | 49303 | 5 | 29525216 |
Pseudarthrosis | 13.25 | 10.18 | 5 | 49301 | 75 | 29525146 |
Cardiac valve sclerosis | 13.25 | 10.18 | 5 | 49301 | 75 | 29525146 |
Product use issue | 13.10 | 10.18 | 43 | 49263 | 51401 | 29473820 |
Stomal hernia | 13.09 | 10.18 | 6 | 49300 | 150 | 29525071 |
Pain | 13.09 | 10.18 | 204 | 49102 | 171228 | 29353993 |
Neurologic neglect syndrome | 13.02 | 10.18 | 6 | 49300 | 152 | 29525069 |
Anaemia | 12.95 | 10.18 | 432 | 48874 | 200519 | 29324702 |
Rhinalgia | 12.92 | 10.18 | 8 | 49298 | 372 | 29524849 |
Respiratory distress | 12.89 | 10.18 | 21 | 49285 | 32085 | 29493136 |
Periorbital discomfort | 12.86 | 10.18 | 4 | 49302 | 32 | 29525189 |
Cranial sutures widening | 12.79 | 10.18 | 5 | 49301 | 83 | 29525138 |
Oliguria | 12.77 | 10.18 | 34 | 49272 | 7378 | 29517843 |
Mechanical urticaria | 12.74 | 10.18 | 5 | 49301 | 84 | 29525137 |
Renal ischaemia | 12.67 | 10.18 | 9 | 49297 | 528 | 29524693 |
Aortic valve disease mixed | 12.63 | 10.18 | 5 | 49301 | 86 | 29525135 |
Renal-limited thrombotic microangiopathy | 12.60 | 10.18 | 3 | 49303 | 7 | 29525214 |
Tumour marker increased | 12.56 | 10.18 | 9 | 49297 | 535 | 29524686 |
Unresponsive to stimuli | 12.55 | 10.18 | 14 | 49292 | 25112 | 29500109 |
Lip ulceration | 12.40 | 10.18 | 10 | 49296 | 710 | 29524511 |
Hyperthyroidism | 12.40 | 10.18 | 37 | 49269 | 8571 | 29516650 |
Orthostatic hypotension | 12.27 | 10.18 | 72 | 49234 | 22557 | 29502664 |
Hypervolaemia | 12.25 | 10.18 | 7 | 49299 | 17538 | 29507683 |
Renin increased | 12.22 | 10.18 | 5 | 49301 | 94 | 29525127 |
Eosinophilic pneumonia | 12.11 | 10.18 | 19 | 49287 | 2827 | 29522394 |
Brain stem infarction | 12.10 | 10.18 | 12 | 49294 | 1118 | 29524103 |
Atrial fibrillation | 12.04 | 10.18 | 245 | 49061 | 105401 | 29419820 |
Acute on chronic liver failure | 11.94 | 10.18 | 5 | 49301 | 100 | 29525121 |
Coronary artery bypass | 11.90 | 10.18 | 25 | 49281 | 4660 | 29520561 |
Infusion site thrombosis | 11.89 | 10.18 | 5 | 49301 | 101 | 29525120 |
Conduction disorder | 11.88 | 10.18 | 15 | 49291 | 1825 | 29523396 |
Hepatocellular carcinoma | 11.84 | 10.18 | 32 | 49274 | 7006 | 29518215 |
Cholecystitis | 11.83 | 10.18 | 38 | 49268 | 9159 | 29516062 |
Apnoeic attack | 11.72 | 10.18 | 7 | 49299 | 305 | 29524916 |
Fracture | 11.71 | 10.18 | 29 | 49277 | 6024 | 29519197 |
Laboratory test abnormal | 11.66 | 10.18 | 8 | 49298 | 18177 | 29507044 |
Respiratory depression | 11.63 | 10.18 | 4 | 49302 | 13519 | 29511702 |
Product quality issue | 11.59 | 10.18 | 6 | 49300 | 15889 | 29509332 |
Hepatic function abnormal | 11.56 | 10.18 | 108 | 49198 | 39151 | 29486070 |
Hepatitis acute | 11.50 | 10.18 | 30 | 49276 | 6432 | 29518789 |
Wrong dose | 11.50 | 10.18 | 8 | 49298 | 454 | 29524767 |
Thrombocytopenia | 11.48 | 10.18 | 157 | 49149 | 134666 | 29390555 |
Aortic dilatation | 11.43 | 10.18 | 11 | 49295 | 988 | 29524233 |
Atypical fibroxanthoma | 11.40 | 10.18 | 6 | 49300 | 204 | 29525017 |
Cough | 11.34 | 10.18 | 284 | 49022 | 126443 | 29398778 |
Gastrointestinal submucosal tumour | 11.29 | 10.18 | 5 | 49301 | 115 | 29525106 |
Tongue haematoma | 11.25 | 10.18 | 5 | 49301 | 116 | 29525105 |
Stoma complication | 11.24 | 10.18 | 6 | 49300 | 210 | 29525011 |
Eczema | 11.01 | 10.18 | 49 | 49257 | 13777 | 29511444 |
Tetany | 10.99 | 10.18 | 9 | 49297 | 653 | 29524568 |
Urinary tract infection | 10.99 | 10.18 | 73 | 49233 | 72281 | 29452940 |
Vasoplegia syndrome | 10.88 | 10.18 | 13 | 49293 | 1495 | 29523726 |
Catheter site cellulitis | 10.87 | 10.18 | 5 | 49301 | 126 | 29525095 |
Prostatomegaly | 10.84 | 10.18 | 24 | 49282 | 4637 | 29520584 |
Candida infection | 10.73 | 10.18 | 6 | 49300 | 15219 | 29510002 |
Nephritic syndrome | 10.73 | 10.18 | 4 | 49302 | 58 | 29525163 |
Pancreatic disorder | 10.64 | 10.18 | 13 | 49293 | 1530 | 29523691 |
Pyoderma gangrenosum | 10.63 | 10.18 | 11 | 49295 | 1078 | 29524143 |
Albumin urine present | 10.57 | 10.18 | 7 | 49299 | 366 | 29524855 |
Musculoskeletal stiffness | 10.47 | 10.18 | 30 | 49276 | 37428 | 29487793 |
Feeling abnormal | 10.38 | 10.18 | 51 | 49255 | 54394 | 29470827 |
B-cell lymphoma stage IV | 10.37 | 10.18 | 4 | 49302 | 64 | 29525157 |
Blood parathyroid hormone increased | 10.30 | 10.18 | 12 | 49294 | 1343 | 29523878 |
Aortic dissection | 10.26 | 10.18 | 16 | 49290 | 2368 | 29522853 |
Aortic arteriosclerosis | 10.21 | 10.18 | 21 | 49285 | 3855 | 29521366 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 482.35 | 10.11 | 1655 | 97951 | 447585 | 63951541 |
General physical health deterioration | 355.02 | 10.11 | 895 | 98711 | 203530 | 64195596 |
Hyperkalaemia | 309.54 | 10.11 | 558 | 99048 | 100571 | 64298555 |
Completed suicide | 267.22 | 10.11 | 21 | 99585 | 224393 | 64174733 |
Hyponatraemia | 196.01 | 10.11 | 588 | 99018 | 147751 | 64251375 |
Product monitoring error | 176.00 | 10.11 | 108 | 99498 | 5346 | 64393780 |
Death | 160.04 | 10.11 | 315 | 99291 | 482390 | 63916736 |
Haematochezia | 156.27 | 10.11 | 328 | 99278 | 66045 | 64333081 |
Drug ineffective | 149.90 | 10.11 | 729 | 98877 | 839518 | 63559608 |
Bradycardia | 148.05 | 10.11 | 460 | 99146 | 117759 | 64281367 |
Product prescribing error | 147.36 | 10.11 | 224 | 99382 | 35045 | 64364081 |
Angina pectoris | 145.84 | 10.11 | 255 | 99351 | 44826 | 64354300 |
Product dose omission issue | 142.72 | 10.11 | 61 | 99545 | 194686 | 64204440 |
Toxicity to various agents | 129.41 | 10.11 | 227 | 99379 | 363286 | 64035840 |
Synovitis | 127.70 | 10.11 | 6 | 99600 | 99084 | 64300042 |
Dizziness | 113.49 | 10.11 | 1087 | 98519 | 429076 | 63970050 |
Renal impairment | 112.01 | 10.11 | 459 | 99147 | 134558 | 64264568 |
Drug hypersensitivity | 99.45 | 10.11 | 133 | 99473 | 237682 | 64161444 |
Drug abuse | 92.97 | 10.11 | 44 | 99562 | 132330 | 64266796 |
Cough | 89.95 | 10.11 | 784 | 98822 | 301364 | 64097762 |
Cardiac failure | 88.53 | 10.11 | 422 | 99184 | 131951 | 64267175 |
Maternal exposure during pregnancy | 84.21 | 10.11 | 22 | 99584 | 95862 | 64303264 |
Dyspnoea | 78.92 | 10.11 | 1551 | 98055 | 717123 | 63682003 |
Lactic acidosis | 76.85 | 10.11 | 239 | 99367 | 61171 | 64337955 |
Oligohydramnios | 76.47 | 10.11 | 52 | 99554 | 3072 | 64396054 |
Hypotension | 74 | 10.11 | 906 | 98700 | 380068 | 64019058 |
Arthropathy | 73.68 | 10.11 | 48 | 99558 | 120919 | 64278207 |
Drug interaction | 72.90 | 10.11 | 867 | 98739 | 361216 | 64037910 |
Blood creatinine increased | 72.80 | 10.11 | 407 | 99199 | 135375 | 64263751 |
Pemphigus | 71.29 | 10.11 | 6 | 99600 | 60695 | 64338431 |
Syncope | 70.74 | 10.11 | 451 | 99155 | 157184 | 64241942 |
Fall | 69.53 | 10.11 | 964 | 98642 | 415862 | 63983264 |
Blood pressure increased | 69.19 | 10.11 | 480 | 99126 | 172072 | 64227054 |
Alopecia | 66.88 | 10.11 | 95 | 99511 | 165595 | 64233531 |
Pain | 66.82 | 10.11 | 541 | 99065 | 552970 | 63846156 |
Injection site pain | 64.14 | 10.11 | 47 | 99559 | 111361 | 64287765 |
Off label use | 63.98 | 10.11 | 647 | 98959 | 632159 | 63766967 |
Neovascularisation | 63.57 | 10.11 | 32 | 99574 | 1071 | 64398055 |
Rubber sensitivity | 63.44 | 10.11 | 34 | 99572 | 1298 | 64397828 |
Myalgia | 61.10 | 10.11 | 437 | 99169 | 158180 | 64240946 |
Labelled drug-drug interaction medication error | 60.22 | 10.11 | 116 | 99490 | 21946 | 64377180 |
Oedema peripheral | 58.53 | 10.11 | 538 | 99068 | 209779 | 64189347 |
Neutropenia | 58.37 | 10.11 | 183 | 99423 | 239441 | 64159685 |
Anaemia | 56.85 | 10.11 | 860 | 98746 | 377820 | 64021306 |
Product use issue | 56.40 | 10.11 | 92 | 99514 | 151623 | 64247503 |
Pemphigoid | 54.97 | 10.11 | 83 | 99523 | 12903 | 64386223 |
Glossodynia | 54.64 | 10.11 | 16 | 99590 | 64680 | 64334446 |
Sputum discoloured | 51.35 | 10.11 | 96 | 99510 | 17760 | 64381366 |
Orthostatic hypotension | 51.34 | 10.11 | 174 | 99432 | 46564 | 64352562 |
Hypertensive crisis | 51.10 | 10.11 | 97 | 99509 | 18151 | 64380975 |
Cerebral infarction | 49.74 | 10.11 | 158 | 99448 | 40886 | 64358240 |
Hypoglycaemia | 48.52 | 10.11 | 270 | 99336 | 89622 | 64309504 |
Swelling | 47.54 | 10.11 | 111 | 99495 | 160107 | 64239019 |
Sinusitis | 45.83 | 10.11 | 98 | 99508 | 145830 | 64253296 |
Joint swelling | 44.72 | 10.11 | 176 | 99430 | 215206 | 64183920 |
Arrhythmia | 44.65 | 10.11 | 181 | 99425 | 52763 | 64346363 |
Therapeutic product effect decreased | 43.75 | 10.11 | 69 | 99537 | 115282 | 64283844 |
Pericarditis | 43.54 | 10.11 | 21 | 99585 | 62495 | 64336631 |
Arterial occlusive disease | 43.48 | 10.11 | 54 | 99552 | 6979 | 64392147 |
Mental status changes | 43.43 | 10.11 | 20 | 99586 | 61142 | 64337984 |
Atrial fibrillation | 43.29 | 10.11 | 429 | 99177 | 170660 | 64228466 |
Renal artery stenosis | 42.78 | 10.11 | 36 | 99570 | 2933 | 64396193 |
Presyncope | 42.45 | 10.11 | 135 | 99471 | 34954 | 64364172 |
Infusion related reaction | 41.89 | 10.11 | 123 | 99483 | 164344 | 64234782 |
Labile hypertension | 41.43 | 10.11 | 19 | 99587 | 515 | 64398611 |
Blood cholesterol | 41.43 | 10.11 | 17 | 99589 | 349 | 64398777 |
Blood pressure inadequately controlled | 41.01 | 10.11 | 46 | 99560 | 5338 | 64393788 |
Systemic lupus erythematosus | 40.59 | 10.11 | 36 | 99570 | 77576 | 64321550 |
Injection site erythema | 40.57 | 10.11 | 30 | 99576 | 70770 | 64328356 |
Drug intolerance | 40.06 | 10.11 | 152 | 99454 | 187840 | 64211286 |
Disease progression | 39.79 | 10.11 | 101 | 99505 | 141579 | 64257547 |
Neurologic neglect syndrome | 39.76 | 10.11 | 27 | 99579 | 1591 | 64397535 |
Hepatic enzyme increased | 39.38 | 10.11 | 89 | 99517 | 129854 | 64269272 |
Interstitial lung disease | 38.62 | 10.11 | 271 | 99335 | 97461 | 64301665 |
Electrolyte imbalance | 38.04 | 10.11 | 105 | 99501 | 25138 | 64373988 |
Febrile neutropenia | 37.90 | 10.11 | 155 | 99451 | 187502 | 64211624 |
Infection | 37.78 | 10.11 | 152 | 99454 | 184728 | 64214398 |
Gamma-glutamyltransferase increased | 37.13 | 10.11 | 161 | 99445 | 48349 | 64350777 |
Gastrointestinal angiodysplasia | 36.71 | 10.11 | 21 | 99585 | 912 | 64398214 |
Vertigo | 36.46 | 10.11 | 184 | 99422 | 58827 | 64340299 |
Jaundice | 36.36 | 10.11 | 160 | 99446 | 48352 | 64350774 |
Rhabdomyolysis | 35.46 | 10.11 | 253 | 99353 | 91473 | 64307653 |
Injection site reaction | 35.14 | 10.11 | 14 | 99592 | 46650 | 64352476 |
Skin haemorrhage | 35.10 | 10.11 | 54 | 99552 | 8531 | 64390595 |
Systemic infection | 34.78 | 10.11 | 38 | 99568 | 4283 | 64394843 |
Cholestatic liver injury | 34.32 | 10.11 | 35 | 99571 | 3644 | 64395482 |
Androgenetic alopecia | 34.27 | 10.11 | 12 | 99594 | 156 | 64398970 |
Abdominal discomfort | 34.12 | 10.11 | 155 | 99451 | 182167 | 64216959 |
Treatment failure | 33.80 | 10.11 | 82 | 99524 | 116734 | 64282392 |
Hospitalisation | 33.53 | 10.11 | 40 | 99566 | 75167 | 64323959 |
Therapy non-responder | 32.77 | 10.11 | 32 | 99574 | 65867 | 64333259 |
Bronchopulmonary aspergillosis allergic | 32.74 | 10.11 | 24 | 99582 | 1598 | 64397528 |
Hypersensitivity | 32.18 | 10.11 | 175 | 99431 | 196277 | 64202849 |
Basilar artery occlusion | 32.17 | 10.11 | 12 | 99594 | 189 | 64398937 |
Urinary hesitation | 32.03 | 10.11 | 33 | 99573 | 3477 | 64395649 |
Palpitations | 31.97 | 10.11 | 273 | 99333 | 104215 | 64294911 |
Intentional product misuse | 31.65 | 10.11 | 39 | 99567 | 72256 | 64326870 |
Sepsis | 31.57 | 10.11 | 217 | 99389 | 230124 | 64169002 |
Renal cyst haemorrhage | 31.40 | 10.11 | 15 | 99591 | 447 | 64398679 |
Neuropathy peripheral | 31.31 | 10.11 | 86 | 99520 | 117439 | 64281687 |
Rash | 30.61 | 10.11 | 511 | 99095 | 458038 | 63941088 |
Diffuse alopecia | 30.53 | 10.11 | 16 | 99590 | 583 | 64398543 |
Renal failure | 30.51 | 10.11 | 421 | 99185 | 181267 | 64217859 |
Tubulointerstitial nephritis | 30.43 | 10.11 | 111 | 99495 | 30798 | 64368328 |
Contraindicated product administered | 30.17 | 10.11 | 77 | 99529 | 107752 | 64291374 |
Ventricular extrasystoles | 29.54 | 10.11 | 76 | 99530 | 17453 | 64381673 |
Flatulence | 29.33 | 10.11 | 121 | 99485 | 35545 | 64363581 |
Chromaturia | 29.20 | 10.11 | 89 | 99517 | 22522 | 64376604 |
Drug resistance | 29.06 | 10.11 | 9 | 99597 | 35093 | 64364033 |
Injection site bruising | 28.92 | 10.11 | 10 | 99596 | 36363 | 64362763 |
Vasoplegia syndrome | 28.91 | 10.11 | 28 | 99578 | 2739 | 64396387 |
C-reactive protein abnormal | 28.90 | 10.11 | 5 | 99601 | 29042 | 64370084 |
Renal artery thrombosis | 28.65 | 10.11 | 14 | 99592 | 439 | 64398687 |
Urogenital haemorrhage | 28.63 | 10.11 | 16 | 99590 | 664 | 64398462 |
Hemiparesis | 28.43 | 10.11 | 106 | 99500 | 29721 | 64369405 |
Blood creatine phosphokinase increased | 28.40 | 10.11 | 171 | 99435 | 58387 | 64340739 |
Prothrombin time shortened | 28.22 | 10.11 | 28 | 99578 | 2821 | 64396305 |
Fibromyalgia | 28.11 | 10.11 | 10 | 99596 | 35721 | 64363405 |
Obstructive airways disorder | 27.86 | 10.11 | 89 | 99517 | 23096 | 64376030 |
Hypomagnesaemia | 27.80 | 10.11 | 123 | 99483 | 37253 | 64361873 |
Intraductal papillary mucinous neoplasm | 27.76 | 10.11 | 15 | 99591 | 582 | 64398544 |
Haematoma | 27.72 | 10.11 | 143 | 99463 | 46107 | 64353019 |
Circulatory collapse | 27.39 | 10.11 | 114 | 99492 | 33618 | 64365508 |
Heart rate | 27.25 | 10.11 | 8 | 99598 | 56 | 64399070 |
Peripheral arterial occlusive disease | 27.25 | 10.11 | 43 | 99563 | 6944 | 64392182 |
Peripheral swelling | 27.21 | 10.11 | 200 | 99406 | 208953 | 64190173 |
Vena cava injury | 27.12 | 10.11 | 11 | 99595 | 219 | 64398907 |
Hyperuricaemia | 27.10 | 10.11 | 53 | 99553 | 10138 | 64388988 |
Cardiac arrest | 27.05 | 10.11 | 134 | 99472 | 153930 | 64245196 |
Gangrene | 27.03 | 10.11 | 44 | 99562 | 7294 | 64391832 |
Multiple sclerosis relapse | 26.89 | 10.11 | 15 | 99591 | 41120 | 64358006 |
Drug dependence | 26.76 | 10.11 | 9 | 99597 | 33303 | 64365823 |
Seizure | 26.60 | 10.11 | 150 | 99456 | 166742 | 64232384 |
Malaise | 25.97 | 10.11 | 798 | 98808 | 395449 | 64003677 |
Sedation | 25.85 | 10.11 | 16 | 99590 | 41446 | 64357680 |
Anuria | 25.77 | 10.11 | 76 | 99530 | 18888 | 64380238 |
Hemiplegia | 25.39 | 10.11 | 59 | 99547 | 12709 | 64386417 |
Sleep disorder due to general medical condition, insomnia type | 25.11 | 10.11 | 5 | 99601 | 26265 | 64372861 |
Patient dissatisfaction with treatment | 24.59 | 10.11 | 9 | 99597 | 134 | 64398992 |
Inappropriate antidiuretic hormone secretion | 24.49 | 10.11 | 83 | 99523 | 22206 | 64376920 |
Carotid artery thrombosis | 24.30 | 10.11 | 21 | 99585 | 1774 | 64397352 |
Retinal artery occlusion | 24.19 | 10.11 | 26 | 99580 | 2877 | 64396249 |
Product quality issue | 24.03 | 10.11 | 8 | 99598 | 29791 | 64369335 |
Forced expiratory volume decreased | 23.71 | 10.11 | 40 | 99566 | 6827 | 64392299 |
Exposure during pregnancy | 23.69 | 10.11 | 53 | 99553 | 77622 | 64321504 |
Aphasia | 23.50 | 10.11 | 125 | 99481 | 40781 | 64358345 |
Musculoskeletal stiffness | 23.49 | 10.11 | 104 | 99502 | 123102 | 64276024 |
Rheumatoid arthritis | 23.39 | 10.11 | 153 | 99453 | 164141 | 64234985 |
Pancreatitis acute | 23.30 | 10.11 | 129 | 99477 | 42726 | 64356400 |
Accidental exposure to product | 23.23 | 10.11 | 6 | 99600 | 26358 | 64372768 |
Decreased appetite | 23.04 | 10.11 | 583 | 99023 | 280706 | 64118420 |
SARS-CoV-2 antibody test positive | 22.97 | 10.11 | 10 | 99596 | 239 | 64398887 |
Folliculitis | 22.69 | 10.11 | 9 | 99597 | 30068 | 64369058 |
White blood cell count decreased | 22.46 | 10.11 | 147 | 99459 | 157690 | 64241436 |
No adverse event | 22.46 | 10.11 | 8 | 99598 | 28553 | 64370573 |
Lung hernia | 22.40 | 10.11 | 7 | 99599 | 62 | 64399064 |
Vertigo positional | 22.39 | 10.11 | 25 | 99581 | 2886 | 64396240 |
Acute cutaneous lupus erythematosus | 22.33 | 10.11 | 11 | 99595 | 351 | 64398775 |
Helicobacter infection | 22.31 | 10.11 | 16 | 99590 | 38346 | 64360780 |
Renal artery angioplasty | 21.90 | 10.11 | 5 | 99601 | 10 | 64399116 |
Myelosuppression | 21.83 | 10.11 | 5 | 99601 | 23825 | 64375301 |
Hepatic function abnormal | 21.80 | 10.11 | 172 | 99434 | 64141 | 64334985 |
Barotrauma | 21.75 | 10.11 | 9 | 99597 | 189 | 64398937 |
Hypoxia | 21.66 | 10.11 | 67 | 99539 | 88082 | 64311044 |
Gastrointestinal disorder | 21.47 | 10.11 | 69 | 99537 | 89640 | 64309486 |
Cerebral haematoma | 21.12 | 10.11 | 39 | 99567 | 7146 | 64391980 |
Neurotoxicity | 21 | 10.11 | 8 | 99598 | 27396 | 64371730 |
Disorientation | 21.00 | 10.11 | 153 | 99453 | 55675 | 64343451 |
Duodenal ulcer | 20.72 | 10.11 | 59 | 99547 | 14376 | 64384750 |
Total cholesterol/HDL ratio increased | 20.64 | 10.11 | 9 | 99597 | 216 | 64398910 |
Aortic dissection | 20.53 | 10.11 | 26 | 99580 | 3426 | 64395700 |
Psoriatic arthropathy | 20.40 | 10.11 | 22 | 99584 | 43259 | 64355867 |
Haematoma muscle | 20.36 | 10.11 | 19 | 99587 | 1774 | 64397352 |
Melaena | 20.28 | 10.11 | 147 | 99459 | 53401 | 64345725 |
Device issue | 20.25 | 10.11 | 5 | 99601 | 22643 | 64376483 |
Atrioventricular block second degree | 20.20 | 10.11 | 36 | 99570 | 6418 | 64392708 |
Haematuria | 20.10 | 10.11 | 161 | 99445 | 60310 | 64338816 |
Spinal osteoarthritis | 19.99 | 10.11 | 58 | 99548 | 14283 | 64384843 |
Intraventricular haemorrhage | 19.68 | 10.11 | 28 | 99578 | 4125 | 64395001 |
Abdominal pain lower | 19.60 | 10.11 | 87 | 99519 | 26382 | 64372744 |
Dyspnoea at rest | 19.42 | 10.11 | 35 | 99571 | 6294 | 64392832 |
Poisoning | 19.24 | 10.11 | 5 | 99601 | 21874 | 64377252 |
Sensitivity to weather change | 19.18 | 10.11 | 36 | 99570 | 6678 | 64392448 |
Non-cardiogenic pulmonary oedema | 19.13 | 10.11 | 16 | 99590 | 1292 | 64397834 |
Glomerular filtration rate decreased | 19.02 | 10.11 | 70 | 99536 | 19502 | 64379624 |
Paradoxical drug reaction | 18.98 | 10.11 | 34 | 99572 | 6086 | 64393040 |
Respiratory tract inflammation | 18.98 | 10.11 | 13 | 99593 | 777 | 64398349 |
Intentional overdose | 18.96 | 10.11 | 73 | 99533 | 89871 | 64309255 |
Skull fracture | 18.81 | 10.11 | 17 | 99589 | 1524 | 64397602 |
Blood hyposmosis | 18.80 | 10.11 | 5 | 99601 | 23 | 64399103 |
Purpura senile | 18.77 | 10.11 | 11 | 99595 | 500 | 64398626 |
Pneumobilia | 18.66 | 10.11 | 8 | 99598 | 184 | 64398942 |
Faeces discoloured | 18.63 | 10.11 | 84 | 99522 | 25645 | 64373481 |
Altered state of consciousness | 18.58 | 10.11 | 111 | 99495 | 37791 | 64361335 |
Cytomegalovirus infection | 18.57 | 10.11 | 18 | 99588 | 37181 | 64361945 |
Blood pressure measurement | 18.56 | 10.11 | 10 | 99596 | 386 | 64398740 |
Gastrointestinal ischaemia | 18.49 | 10.11 | 10 | 99596 | 389 | 64398737 |
Polyuria | 18.47 | 10.11 | 52 | 99554 | 12591 | 64386535 |
Multiple drug therapy | 18.45 | 10.11 | 20 | 99586 | 2234 | 64396892 |
Injection site swelling | 18.43 | 10.11 | 22 | 99584 | 41331 | 64357795 |
Unevaluable event | 18.39 | 10.11 | 31 | 99575 | 50458 | 64348668 |
Haematemesis | 18.37 | 10.11 | 130 | 99476 | 46869 | 64352257 |
Full blood count decreased | 18.32 | 10.11 | 6 | 99600 | 22576 | 64376550 |
Oral lichen planus | 18.27 | 10.11 | 12 | 99594 | 669 | 64398457 |
Anxiety disorder due to a general medical condition | 18.24 | 10.11 | 4 | 99602 | 6 | 64399120 |
Cerebral haemorrhage | 18.07 | 10.11 | 138 | 99468 | 50952 | 64348174 |
Pallor | 18.02 | 10.11 | 112 | 99494 | 38669 | 64360457 |
Hepatocellular carcinoma | 18.01 | 10.11 | 40 | 99566 | 8363 | 64390763 |
Renal artery stent placement | 17.98 | 10.11 | 5 | 99601 | 28 | 64399098 |
Actinic keratosis | 17.72 | 10.11 | 30 | 99576 | 5135 | 64393991 |
Respiratory depression | 17.71 | 10.11 | 7 | 99599 | 23436 | 64375690 |
Hypochromic anaemia | 17.64 | 10.11 | 20 | 99586 | 2348 | 64396778 |
Device malfunction | 17.62 | 10.11 | 3 | 99603 | 17630 | 64381496 |
Irritable bowel syndrome | 17.61 | 10.11 | 19 | 99587 | 37350 | 64361776 |
Clostridium difficile infection | 17.47 | 10.11 | 18 | 99588 | 36145 | 64362981 |
Discomfort | 17.47 | 10.11 | 65 | 99541 | 80813 | 64318313 |
Acute myocardial infarction | 17.21 | 10.11 | 174 | 99432 | 69544 | 64329582 |
Glycosylated haemoglobin increased | 17.03 | 10.11 | 59 | 99547 | 15960 | 64383166 |
Premature delivery | 16.83 | 10.11 | 4 | 99602 | 18585 | 64380541 |
Pain in jaw | 16.79 | 10.11 | 23 | 99583 | 40732 | 64358394 |
Hepatitis acute | 16.64 | 10.11 | 52 | 99554 | 13337 | 64385789 |
Supine hypertension | 16.59 | 10.11 | 9 | 99597 | 352 | 64398774 |
Therapeutic product effect incomplete | 16.48 | 10.11 | 93 | 99513 | 103389 | 64295737 |
Hypozincaemia | 16.45 | 10.11 | 5 | 99601 | 40 | 64399086 |
Therapeutic response decreased | 16.41 | 10.11 | 35 | 99571 | 52153 | 64346973 |
Mental status changes postoperative | 16.41 | 10.11 | 7 | 99599 | 159 | 64398967 |
Hypertension | 16.39 | 10.11 | 520 | 99086 | 258741 | 64140385 |
Paresis cranial nerve | 16.34 | 10.11 | 5 | 99601 | 41 | 64399085 |
Renovascular hypertension | 16.34 | 10.11 | 5 | 99601 | 41 | 64399085 |
Productive cough | 16.33 | 10.11 | 179 | 99427 | 73024 | 64326102 |
Wrong strength | 16.33 | 10.11 | 7 | 99599 | 161 | 64398965 |
Tarsal tunnel syndrome | 16.29 | 10.11 | 10 | 99596 | 495 | 64398631 |
Respiratory arrest | 16.28 | 10.11 | 36 | 99570 | 52949 | 64346177 |
Carotid arteriosclerosis | 16.24 | 10.11 | 18 | 99588 | 2061 | 64397065 |
Coronavirus infection | 16.24 | 10.11 | 30 | 99576 | 5500 | 64393626 |
Lichen planus | 16.23 | 10.11 | 19 | 99587 | 2309 | 64396817 |
Occult blood | 16.20 | 10.11 | 15 | 99591 | 1387 | 64397739 |
Basal ganglia haemorrhage | 16.16 | 10.11 | 15 | 99591 | 1391 | 64397735 |
Hemiataxia | 16.13 | 10.11 | 5 | 99601 | 43 | 64399083 |
Confusional state | 16.04 | 10.11 | 522 | 99084 | 260622 | 64138504 |
Adrenal insufficiency | 15.97 | 10.11 | 73 | 99533 | 22414 | 64376712 |
Cornea verticillata | 15.88 | 10.11 | 6 | 99600 | 98 | 64399028 |
Internal haemorrhage | 15.88 | 10.11 | 36 | 99570 | 7631 | 64391495 |
Bronchiectasis | 15.84 | 10.11 | 53 | 99553 | 14087 | 64385039 |
Dyschezia | 15.70 | 10.11 | 19 | 99587 | 2391 | 64396735 |
Disturbance in attention | 15.69 | 10.11 | 113 | 99493 | 40961 | 64358165 |
Unresponsive to stimuli | 15.68 | 10.11 | 34 | 99572 | 50359 | 64348767 |
Idiopathic pulmonary fibrosis | 15.67 | 10.11 | 24 | 99582 | 3776 | 64395350 |
Blister | 15.64 | 10.11 | 68 | 99538 | 80899 | 64318227 |
Muscular weakness | 15.63 | 10.11 | 280 | 99326 | 127058 | 64272068 |
Tetany | 15.60 | 10.11 | 18 | 99588 | 2154 | 64396972 |
Mesenteric artery thrombosis | 15.59 | 10.11 | 10 | 99596 | 535 | 64398591 |
Treatment noncompliance | 15.56 | 10.11 | 27 | 99579 | 43455 | 64355671 |
Vertebral artery stenosis | 15.53 | 10.11 | 7 | 99599 | 182 | 64398944 |
Wrong technique in product usage process | 15.53 | 10.11 | 50 | 99556 | 64924 | 64334202 |
Fungal infection | 15.50 | 10.11 | 18 | 99588 | 34233 | 64364893 |
Sinonasal obstruction | 15.39 | 10.11 | 7 | 99599 | 186 | 64398940 |
Total lung capacity decreased | 15.37 | 10.11 | 16 | 99590 | 1706 | 64397420 |
Aortic arteriosclerosis | 15.37 | 10.11 | 35 | 99571 | 7441 | 64391685 |
Diarrhoea | 15.34 | 10.11 | 1305 | 98301 | 721399 | 63677727 |
Asthma | 15.30 | 10.11 | 219 | 99387 | 95006 | 64304120 |
Psoas abscess | 15.22 | 10.11 | 12 | 99594 | 891 | 64398235 |
Abdominal wall haemorrhage | 15.22 | 10.11 | 9 | 99597 | 416 | 64398710 |
Coronary artery stenosis | 15.21 | 10.11 | 45 | 99561 | 11203 | 64387923 |
International normalised ratio increased | 15.18 | 10.11 | 188 | 99418 | 78979 | 64320147 |
Vasculitic rash | 15.15 | 10.11 | 17 | 99589 | 1974 | 64397152 |
Cardiac failure chronic | 15.03 | 10.11 | 39 | 99567 | 9002 | 64390124 |
Confusion postoperative | 14.96 | 10.11 | 7 | 99599 | 199 | 64398927 |
Injection site pruritus | 14.94 | 10.11 | 22 | 99584 | 37804 | 64361322 |
Tinnitus | 14.88 | 10.11 | 97 | 99509 | 34036 | 64365090 |
Renal function test abnormal | 14.87 | 10.11 | 24 | 99582 | 3950 | 64395176 |
Small intestinal obstruction | 14.83 | 10.11 | 9 | 99597 | 23564 | 64375562 |
Sinus rhythm | 14.82 | 10.11 | 10 | 99596 | 583 | 64398543 |
Acute abdomen | 14.82 | 10.11 | 20 | 99586 | 2804 | 64396322 |
Spider naevus | 14.81 | 10.11 | 6 | 99600 | 119 | 64399007 |
Proteinuria | 14.77 | 10.11 | 83 | 99523 | 27640 | 64371486 |
Costovertebral angle tenderness | 14.61 | 10.11 | 7 | 99599 | 210 | 64398916 |
Tenderness | 14.56 | 10.11 | 6 | 99600 | 19596 | 64379530 |
Cytokine release syndrome | 14.50 | 10.11 | 7 | 99599 | 20822 | 64378304 |
Bradyarrhythmia | 14.48 | 10.11 | 23 | 99583 | 3735 | 64395391 |
Nocturia | 14.47 | 10.11 | 44 | 99562 | 11121 | 64388005 |
Deep vein thrombosis | 14.43 | 10.11 | 99 | 99507 | 105083 | 64294043 |
Device lead damage | 14.35 | 10.11 | 3 | 99603 | 3 | 64399123 |
Wound | 14.30 | 10.11 | 65 | 99541 | 76412 | 64322714 |
Mobility decreased | 14.30 | 10.11 | 76 | 99530 | 85764 | 64313362 |
Urticaria | 14.23 | 10.11 | 152 | 99454 | 147165 | 64251961 |
Cystitis escherichia | 14.19 | 10.11 | 9 | 99597 | 472 | 64398654 |
Impaired healing | 14.13 | 10.11 | 47 | 99559 | 60426 | 64338700 |
Joint injury | 14.11 | 10.11 | 9 | 99597 | 22938 | 64376188 |
Product use in unapproved indication | 14.09 | 10.11 | 190 | 99416 | 176428 | 64222698 |
Iron deficiency | 14.09 | 10.11 | 33 | 99573 | 7144 | 64391982 |
Prostatomegaly | 14.06 | 10.11 | 20 | 99586 | 2947 | 64396179 |
Aortic valve incompetence | 13.99 | 10.11 | 36 | 99570 | 8265 | 64390861 |
Vestibular migraine | 13.91 | 10.11 | 6 | 99600 | 140 | 64398986 |
Hypocalcaemia | 13.78 | 10.11 | 111 | 99495 | 41642 | 64357484 |
Adjustment disorder | 13.74 | 10.11 | 19 | 99587 | 2726 | 64396400 |
Haemophagocytic lymphohistiocytosis | 13.73 | 10.11 | 5 | 99601 | 17604 | 64381522 |
Urinary retention | 13.72 | 10.11 | 126 | 99480 | 49075 | 64350051 |
Adverse event | 13.70 | 10.11 | 25 | 99581 | 39464 | 64359662 |
Shock hypoglycaemic | 13.67 | 10.11 | 7 | 99599 | 243 | 64398883 |
Cold sweat | 13.66 | 10.11 | 56 | 99550 | 16399 | 64382727 |
Rales | 13.59 | 10.11 | 53 | 99553 | 15176 | 64383950 |
pH body fluid increased | 13.57 | 10.11 | 5 | 99601 | 76 | 64399050 |
Staphylococcal infection | 13.55 | 10.11 | 37 | 99569 | 50641 | 64348485 |
Knee arthroplasty | 13.55 | 10.11 | 13 | 99593 | 26986 | 64372140 |
Urinary tract infection | 13.54 | 10.11 | 264 | 99342 | 231332 | 64167794 |
Dehydration | 13.49 | 10.11 | 434 | 99172 | 216329 | 64182797 |
Musculoskeletal pain | 13.48 | 10.11 | 188 | 99418 | 81106 | 64318020 |
Ill-defined disorder | 13.48 | 10.11 | 30 | 99576 | 44022 | 64355104 |
Metabolic acidosis | 13.38 | 10.11 | 168 | 99438 | 70790 | 64328336 |
Respiratory failure | 13.37 | 10.11 | 172 | 99434 | 161011 | 64238115 |
Food aversion | 13.35 | 10.11 | 10 | 99596 | 688 | 64398438 |
Ear infection | 13.30 | 10.11 | 10 | 99596 | 23394 | 64375732 |
Mucosal haemorrhage | 13.28 | 10.11 | 17 | 99589 | 2264 | 64396862 |
Choroidal detachment | 13.21 | 10.11 | 9 | 99597 | 533 | 64398593 |
Necrotising myositis | 13.21 | 10.11 | 11 | 99595 | 883 | 64398243 |
Kussmaul respiration | 13.16 | 10.11 | 8 | 99598 | 389 | 64398737 |
Skin texture abnormal | 13.16 | 10.11 | 8 | 99598 | 389 | 64398737 |
Periorbital discomfort | 13.16 | 10.11 | 4 | 99602 | 32 | 64399094 |
Desmoplastic melanoma | 13.16 | 10.11 | 4 | 99602 | 32 | 64399094 |
Gerstmann's syndrome | 13.14 | 10.11 | 3 | 99603 | 6 | 64399120 |
Macular ischaemia | 13.05 | 10.11 | 5 | 99601 | 85 | 64399041 |
Brain stem infarction | 12.91 | 10.11 | 15 | 99591 | 1808 | 64397318 |
Arthralgia | 12.90 | 10.11 | 555 | 99051 | 441705 | 63957421 |
Asthenia | 12.83 | 10.11 | 795 | 98811 | 427249 | 63971877 |
Tonsillar ulcer | 12.77 | 10.11 | 8 | 99598 | 411 | 64398715 |
Sputum retention | 12.76 | 10.11 | 11 | 99595 | 926 | 64398200 |
Diabetic nephropathy | 12.74 | 10.11 | 18 | 99588 | 2636 | 64396490 |
Therapy cessation | 12.73 | 10.11 | 19 | 99587 | 32470 | 64366656 |
Joint range of motion decreased | 12.72 | 10.11 | 7 | 99599 | 19336 | 64379790 |
Pancreatic disorder | 12.67 | 10.11 | 19 | 99587 | 2935 | 64396191 |
Anti-erythropoietin antibody negative | 12.63 | 10.11 | 7 | 99599 | 286 | 64398840 |
Palmar-plantar erythrodysaesthesia syndrome | 12.62 | 10.11 | 82 | 99524 | 28737 | 64370389 |
Alopecia universalis | 12.58 | 10.11 | 6 | 99600 | 178 | 64398948 |
Histamine intolerance | 12.55 | 10.11 | 4 | 99602 | 38 | 64399088 |
Exercise tolerance decreased | 12.55 | 10.11 | 33 | 99573 | 7677 | 64391449 |
Subarachnoid haemorrhage | 12.46 | 10.11 | 59 | 99547 | 18379 | 64380747 |
Cardiac murmur functional | 12.46 | 10.11 | 4 | 99602 | 39 | 64399087 |
Metastases to fallopian tube | 12.37 | 10.11 | 4 | 99602 | 40 | 64399086 |
Flushing | 12.35 | 10.11 | 71 | 99535 | 78577 | 64320549 |
Ischaemic stroke | 12.34 | 10.11 | 82 | 99524 | 28953 | 64370173 |
Adverse drug reaction | 12.30 | 10.11 | 33 | 99573 | 45431 | 64353695 |
Acute right ventricular failure | 12.26 | 10.11 | 7 | 99599 | 303 | 64398823 |
Complication associated with device | 12.24 | 10.11 | 4 | 99602 | 15076 | 64384050 |
Encephalopathy | 12.23 | 10.11 | 48 | 99558 | 58771 | 64340355 |
Depression suicidal | 12.19 | 10.11 | 17 | 99589 | 2458 | 64396668 |
Xanthopsia | 12.19 | 10.11 | 7 | 99599 | 306 | 64398820 |
Hyperthyroidism | 12.16 | 10.11 | 58 | 99548 | 18121 | 64381005 |
Loss of personal independence in daily activities | 12.15 | 10.11 | 64 | 99542 | 72390 | 64326736 |
Eczema nummular | 12.13 | 10.11 | 7 | 99599 | 309 | 64398817 |
Supraventricular tachyarrhythmia | 12.13 | 10.11 | 5 | 99601 | 104 | 64399022 |
Therapy interrupted | 12.12 | 10.11 | 8 | 99598 | 20028 | 64379098 |
Irritability | 12.10 | 10.11 | 24 | 99582 | 36722 | 64362404 |
Eczema | 12.08 | 10.11 | 83 | 99523 | 29637 | 64369489 |
Lower respiratory tract infection | 12.04 | 10.11 | 91 | 99515 | 94523 | 64304603 |
Haemorrhage subcutaneous | 11.99 | 10.11 | 23 | 99583 | 4338 | 64394788 |
Depression | 11.95 | 10.11 | 205 | 99401 | 183086 | 64216040 |
Fracture | 11.95 | 10.11 | 59 | 99547 | 18696 | 64380430 |
Atypical fibroxanthoma | 11.94 | 10.11 | 6 | 99600 | 200 | 64398926 |
Atrioventricular block complete | 11.92 | 10.11 | 49 | 99557 | 14369 | 64384757 |
Cardio-respiratory arrest | 11.88 | 10.11 | 96 | 99510 | 98297 | 64300829 |
Pulmonary fibrosis | 11.88 | 10.11 | 83 | 99523 | 29795 | 64369331 |
Leiomyoma | 11.85 | 10.11 | 7 | 99599 | 323 | 64398803 |
Injection site haemorrhage | 11.83 | 10.11 | 12 | 99594 | 24266 | 64374860 |
Toxic skin eruption | 11.82 | 10.11 | 60 | 99546 | 19224 | 64379902 |
Product storage error | 11.79 | 10.11 | 3 | 99603 | 13315 | 64385811 |
Breast discomfort | 11.79 | 10.11 | 7 | 99599 | 326 | 64398800 |
Gastroenteritis viral | 11.77 | 10.11 | 8 | 99598 | 19721 | 64379405 |
Pregnancy | 11.75 | 10.11 | 9 | 99597 | 20856 | 64378270 |
Coronary artery bypass | 11.70 | 10.11 | 27 | 99579 | 5788 | 64393338 |
Wheezing | 11.65 | 10.11 | 182 | 99424 | 80397 | 64318729 |
Laboratory test abnormal | 11.60 | 10.11 | 12 | 99594 | 24051 | 64375075 |
Nasal congestion | 11.58 | 10.11 | 50 | 99556 | 59608 | 64339518 |
Muscle rupture | 11.53 | 10.11 | 19 | 99587 | 3181 | 64395945 |
Renin increased | 11.47 | 10.11 | 6 | 99600 | 218 | 64398908 |
Visual acuity reduced transiently | 11.44 | 10.11 | 6 | 99600 | 219 | 64398907 |
Cardiovascular insufficiency | 11.43 | 10.11 | 17 | 99589 | 2607 | 64396519 |
Drug metabolising enzyme decreased | 11.42 | 10.11 | 3 | 99603 | 13 | 64399113 |
Dermatosis | 11.39 | 10.11 | 8 | 99598 | 498 | 64398628 |
Blood uric acid increased | 11.37 | 10.11 | 33 | 99573 | 8130 | 64390996 |
Drug dose titration not performed | 11.35 | 10.11 | 9 | 99597 | 674 | 64398452 |
Transaminases increased | 11.34 | 10.11 | 112 | 99494 | 44482 | 64354644 |
Diverticulum intestinal | 11.31 | 10.11 | 31 | 99575 | 7389 | 64391737 |
Duodenal ulcer haemorrhage | 11.26 | 10.11 | 28 | 99578 | 6297 | 64392829 |
Transient ischaemic attack | 11.26 | 10.11 | 111 | 99495 | 44071 | 64355055 |
Lip infection | 11.24 | 10.11 | 5 | 99601 | 126 | 64399000 |
COVID-19 | 11.23 | 10.11 | 57 | 99549 | 65083 | 64334043 |
Eosinophilic pneumonia | 11.21 | 10.11 | 23 | 99583 | 4554 | 64394572 |
Aortic valve stenosis | 11.20 | 10.11 | 23 | 99583 | 4557 | 64394569 |
Lichen sclerosus | 11.15 | 10.11 | 10 | 99596 | 887 | 64398239 |
Chest wall mass | 11.10 | 10.11 | 5 | 99601 | 130 | 64398996 |
Ophthalmoplegia | 11.05 | 10.11 | 17 | 99589 | 2685 | 64396441 |
Abdominal pain | 11.05 | 10.11 | 589 | 99017 | 311786 | 64087340 |
Musculoskeletal disorder | 11.04 | 10.11 | 7 | 99599 | 17899 | 64381227 |
Psychotic disorder | 11.03 | 10.11 | 23 | 99583 | 34555 | 64364571 |
Pharyngeal enanthema | 11.03 | 10.11 | 4 | 99602 | 58 | 64399068 |
Nephrogenic anaemia | 11.00 | 10.11 | 19 | 99587 | 3306 | 64395820 |
Drug ineffective for unapproved indication | 10.96 | 10.11 | 84 | 99522 | 31049 | 64368077 |
Atrioventricular block first degree | 10.95 | 10.11 | 39 | 99567 | 10695 | 64388431 |
Gastroenteritis | 10.93 | 10.11 | 81 | 99525 | 29630 | 64369496 |
Disease recurrence | 10.88 | 10.11 | 20 | 99586 | 31490 | 64367636 |
Anaemia folate deficiency | 10.85 | 10.11 | 6 | 99600 | 244 | 64398882 |
Post concussion syndrome | 10.83 | 10.11 | 8 | 99598 | 539 | 64398587 |
Injury | 10.82 | 10.11 | 47 | 99559 | 55945 | 64343181 |
Aortic dilatation | 10.71 | 10.11 | 12 | 99594 | 1391 | 64397735 |
Bundle branch block left | 10.70 | 10.11 | 37 | 99569 | 9997 | 64389129 |
Immune reconstitution inflammatory syndrome | 10.68 | 10.11 | 3 | 99603 | 12467 | 64386659 |
Gallbladder cancer | 10.66 | 10.11 | 7 | 99599 | 390 | 64398736 |
Intentional product use issue | 10.64 | 10.11 | 95 | 99511 | 95269 | 64303857 |
Plasma cell myeloma | 10.63 | 10.11 | 36 | 99570 | 46039 | 64353087 |
B-cell lymphoma stage IV | 10.61 | 10.11 | 4 | 99602 | 65 | 64399061 |
Hepatitis cholestatic | 10.60 | 10.11 | 42 | 99564 | 12113 | 64387013 |
Eczema eyelids | 10.59 | 10.11 | 5 | 99601 | 145 | 64398981 |
Pericarditis constrictive | 10.56 | 10.11 | 8 | 99598 | 560 | 64398566 |
Bronchial hyperreactivity | 10.55 | 10.11 | 16 | 99590 | 2496 | 64396630 |
Abortion spontaneous | 10.55 | 10.11 | 14 | 99592 | 25129 | 64373997 |
Abdominal pain upper | 10.51 | 10.11 | 349 | 99257 | 174681 | 64224445 |
Renal-limited thrombotic microangiopathy | 10.48 | 10.11 | 3 | 99603 | 19 | 64399107 |
Retroperitoneal fibrosis | 10.47 | 10.11 | 8 | 99598 | 567 | 64398559 |
Neutrophil count decreased | 10.42 | 10.11 | 73 | 99533 | 77123 | 64322003 |
Neuroleptic malignant syndrome | 10.41 | 10.11 | 14 | 99592 | 24982 | 64374144 |
Aplasia pure red cell | 10.39 | 10.11 | 29 | 99577 | 6985 | 64392141 |
Lung perforation | 10.39 | 10.11 | 4 | 99602 | 69 | 64399057 |
Therapeutic drug monitoring analysis not performed | 10.35 | 10.11 | 11 | 99595 | 1201 | 64397925 |
Vascular compression | 10.29 | 10.11 | 6 | 99600 | 270 | 64398856 |
Congenital anomaly in offspring | 10.28 | 10.11 | 4 | 99602 | 71 | 64399055 |
Malignant neoplasm of pleura | 10.28 | 10.11 | 5 | 99601 | 155 | 64398971 |
Upper gastrointestinal haemorrhage | 10.23 | 10.11 | 91 | 99515 | 35129 | 64363997 |
Uterine dilation and evacuation | 10.22 | 10.11 | 3 | 99603 | 21 | 64399105 |
Oversensing | 10.22 | 10.11 | 3 | 99603 | 21 | 64399105 |
Anastomotic infection | 10.22 | 10.11 | 3 | 99603 | 21 | 64399105 |
Lung opacity | 10.21 | 10.11 | 18 | 99588 | 3181 | 64395945 |
Female reproductive tract disorder | 10.21 | 10.11 | 6 | 99600 | 274 | 64398852 |
Hypervolaemia | 10.20 | 10.11 | 28 | 99578 | 38257 | 64360869 |
Brain stem stroke | 10.20 | 10.11 | 7 | 99599 | 420 | 64398706 |
Basal cell carcinoma | 10.19 | 10.11 | 82 | 99524 | 30756 | 64368370 |
Chronic obstructive pulmonary disease | 10.18 | 10.11 | 66 | 99540 | 70982 | 64328144 |
Flail chest | 10.18 | 10.11 | 4 | 99602 | 73 | 64399053 |
Paresis | 10.17 | 10.11 | 19 | 99587 | 3513 | 64395613 |
Neoplasm progression | 10.16 | 10.11 | 31 | 99575 | 40933 | 64358193 |
Haemorrhagic cyst | 10.15 | 10.11 | 6 | 99600 | 277 | 64398849 |
Osteochondrosis | 10.14 | 10.11 | 12 | 99594 | 1475 | 64397651 |
Prerenal failure | 10.12 | 10.11 | 18 | 99588 | 3204 | 64395922 |
None
Source | Code | Description |
---|---|---|
ATC | C09CA06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN Angiotensin II receptor blockers (ARBs), plain |
ATC | C09DA06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and diuretics |
ATC | C09DB07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DX06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
FDA MoA | N0000000070 | Angiotensin 2 Receptor Antagonists |
FDA EPC | N0000175561 | Angiotensin 2 Receptor Blocker |
MeSH PA | D047228 | Angiotensin II Type 1 Receptor Blockers |
MeSH PA | D057911 | Angiotensin Receptor Antagonists |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Diabetic renal disease | off-label use | 127013003 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Oliguria | contraindication | 83128009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Surgical procedure | contraindication | 387713003 | |
Azotemia | contraindication | 445009001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.25 | acidic |
pKa2 | 3.2 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Type-1 angiotensin II receptor | GPCR | ANTAGONIST | IC50 | 9.16 | CHEMBL | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.52 | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 5.76 | CHEMBL | |||||
Beta-3 adrenergic receptor | GPCR | Ki | 5.49 | CHEMBL | |||||
Adenosine receptor A3 | GPCR | Ki | 6.16 | CHEMBL | |||||
Cytochrome P450 2C9 | Enzyme | IC50 | 5.52 | CHEMBL | |||||
Epidermal growth factor receptor | Kinase | IC50 | 5.48 | CHEMBL | |||||
Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | EC50 | 5.38 | CHEMBL | |||||
Receptor tyrosine-protein kinase erbB-2 | Kinase | IC50 | 5.23 | CHEMBL | |||||
Thromboxane-A synthase | Enzyme | IC50 | 5.51 | CHEMBL | |||||
DNA polymerase kappa | Enzyme | IC50 | 5.25 | CHEMBL | |||||
DNA polymerase iota | Enzyme | IC50 | 5.21 | CHEMBL | |||||
DNA polymerase eta | Enzyme | IC50 | 4.95 | CHEMBL | |||||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.05 | CHEMBL | |||||
NEDD8-activating enzyme E1 regulatory subunit | Enzyme | IC50 | 4.78 | CHEMBL | |||||
Type-1 angiotensin II receptor | GPCR | IC50 | 6.96 | CHEMBL | |||||
Cruzipain | Enzyme | IC50 | 4.38 | CHEMBL | |||||
Type-1 angiotensin II receptor | GPCR | Ki | 9.19 | CHEMBL |
ID | Source |
---|---|
4021148 | VUID |
N0000179517 | NUI |
D00522 | KEGG_DRUG |
135481 | RXNORM |
C0527379 | UMLSCUI |
CHEBI:3348 | CHEBI |
CHEBI:149509 | CHEBI |
CHEMBL1014 | ChEMBL_ID |
DB00796 | DRUGBANK_ID |
C077793 | MESH_SUPPLEMENTAL_RECORD_UI |
8352 | IUPHAR_LIGAND_ID |
C081643 | MESH_SUPPLEMENTAL_RECORD_UI |
587 | IUPHAR_LIGAND_ID |
139481-59-7 | SECONDARY_CAS_RN |
R85M2X0D68 | UNII |
2540 | PUBCHEM_CID |
2541 | PUBCHEM_CID |
DB13919 | DRUGBANK_ID |
188909 | MMSL |
7490 | MMSL |
d04322 | MMSL |
007275 | NDDF |
007276 | NDDF |
108587008 | SNOMEDCT_US |
372512008 | SNOMEDCT_US |
386878000 | SNOMEDCT_US |
4021148 | VANDF |
4021151 | VANDF |
C0717550 | UMLSCUI |
CHEMBL1016 | ChEMBL_ID |
7239 | INN_ID |
S8Q36MD2XX | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Candesartan Cilexetil and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-3001 | TABLET | 16 mg | ORAL | ANDA | 21 sections |
Candesartan Cilexetil and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-3002 | TABLET | 32 mg | ORAL | ANDA | 21 sections |
Candesartan Cilexetil and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-3003 | TABLET | 32 mg | ORAL | ANDA | 21 sections |
candesartan cilexetil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3224 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
candesartan cilexetil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3225 | TABLET | 8 mg | ORAL | ANDA | 27 sections |
candesartan cilexetil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3231 | TABLET | 16 mg | ORAL | ANDA | 27 sections |
candesartan cilexetil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3232 | TABLET | 32 mg | ORAL | ANDA | 27 sections |
Candesartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7034 | TABLET | 32 mg | ORAL | ANDA | 28 sections |
Candesartan | Human Prescription Drug Label | 1 | 33342-114 | TABLET | 4 mg | ORAL | ANDA | 28 sections |
Candesartan | Human Prescription Drug Label | 1 | 33342-115 | TABLET | 8 mg | ORAL | ANDA | 28 sections |
Candesartan | Human Prescription Drug Label | 1 | 33342-116 | TABLET | 16 mg | ORAL | ANDA | 28 sections |
Candesartan | Human Prescription Drug Label | 1 | 33342-117 | TABLET | 32 mg | ORAL | ANDA | 28 sections |
Candesartan Cilexetil and Hydrochlorothiazide | Human Prescription Drug Label | 2 | 33342-131 | TABLET | 16 mg | ORAL | ANDA | 19 sections |
Candesartan Cilexetil and Hydrochlorothiazide | Human Prescription Drug Label | 2 | 33342-132 | TABLET | 32 mg | ORAL | ANDA | 19 sections |
Candesartan Cilexetil and Hydrochlorothiazide | Human Prescription Drug Label | 2 | 33342-133 | TABLET | 32 mg | ORAL | ANDA | 19 sections |
candesartan cilexetil and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43547-459 | TABLET | 16 mg | ORAL | ANDA | 22 sections |
candesartan cilexetil and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43547-460 | TABLET | 32 mg | ORAL | ANDA | 22 sections |
candesartan cilexetil and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43547-461 | TABLET | 32 mg | ORAL | ANDA | 22 sections |
CANDESARTAN CILEXETIL | Human Prescription Drug Label | 1 | 46708-060 | TABLET | 32 mg | ORAL | ANDA | 27 sections |
CANDESARTAN CILEXETIL | Human Prescription Drug Label | 1 | 46708-341 | TABLET | 4 mg | ORAL | ANDA | 28 sections |
CANDESARTAN CILEXETIL | Human Prescription Drug Label | 1 | 46708-342 | TABLET | 8 mg | ORAL | ANDA | 28 sections |
CANDESARTAN CILEXETIL | Human Prescription Drug Label | 1 | 46708-343 | TABLET | 16 mg | ORAL | ANDA | 28 sections |
Candesartan cilexetil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-658 | TABLET | 4 mg | ORAL | NDA authorized generic | 27 sections |
Candesartan cilexetil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-659 | TABLET | 8 mg | ORAL | NDA authorized generic | 27 sections |
Candesartan cilexetil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-660 | TABLET | 16 mg | ORAL | NDA authorized generic | 27 sections |
Candesartan cilexetil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-661 | TABLET | 32 mg | ORAL | NDA authorized generic | 27 sections |
ATACAND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4413 | TABLET | 16 mg | ORAL | NDA | 27 sections |
ATACAND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4612 | TABLET | 32 mg | ORAL | NDA | 27 sections |
ATACAND HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-4729 | TABLET | 16 mg | ORAL | NDA | 22 sections |
ATACAND HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-4869 | TABLET | 32 mg | ORAL | NDA | 22 sections |