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thiomersal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
mercury-containing drugs, antimicrobial or diuretic	4733	54-64-8

Description:

Molecule	Description
Synonyms: thiomersal ethylmercurithiosalicylate sodium salt mercurothiolate merthiolate merthiolate sodium sodium merthiolate thimerosal thimersalate thiomersalate	An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate. Molecular weight: 404.81 Formula: C9H9HgNaO2S CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

thiomersal
ethylmercurithiosalicylate sodium salt
mercurothiolate
merthiolate
merthiolate sodium
sodium merthiolate
thimerosal
thimersalate
thiomersalate

An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.

Molecular weight: 404.81
Formula: C9H9HgNaO2S
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrointestinal toxicity	378.42	79.87	80	2097	7661	63479184
Pulmonary toxicity	356.93	79.87	79	2098	9376	63477469
Neoplasm malignant	271.15	79.87	80	2097	29781	63457064
Joint injury	267.52	79.87	79	2098	29493	63457352
Hepatotoxicity	254.15	79.87	80	2097	36961	63449884
C-reactive protein abnormal	221.21	79.87	76	2101	46020	63440825
Therapy non-responder	198.04	79.87	80	2097	75821	63411024
Joint stiffness	196.80	79.87	68	2109	41801	63445044
Musculoskeletal pain	186.22	79.87	81	2096	92196	63394649
Drug hypersensitivity	152.67	79.87	107	2070	310580	63176265

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FDA Adverse Event Reporting System (Male)

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrointestinal toxicity	176.73	62.25	38	1299	8071	79734980
Pulmonary toxicity	159.13	62.25	38	1299	12876	79730175
Joint injury	125.74	62.25	38	1299	31297	79711754
Neoplasm malignant	125.18	62.25	38	1299	31772	79711279
Joint stiffness	111.81	62.25	37	1300	40793	79702258
Hepatotoxicity	107.30	62.25	38	1299	51314	79691737
Therapy non-responder	105.52	62.25	44	1293	92261	79650790
Drug hypersensitivity	97.65	62.25	61	1276	298855	79444196
C-reactive protein abnormal	94.25	62.25	34	1303	48333	79694718
Musculoskeletal pain	85.06	62.25	39	1298	102315	79640736

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
ATC	D08AK06	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Mercurial products
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants
CHEBI has role	CHEBI:86327	pharmaceutical fungicide
CHEBI has role	CHEBI:88188	allergenic drug
FDA CS	M0000728	Allergens
FDA EPC	N0000185508	Standardized Chemical Allergen
FDA PE	N0000175629	Increased Histamine Release
FDA PE	N0000184306	Cell-mediated Immunity
MeSH PA	D010592	Pharmaceutic Aids

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Drug Use | Suggest Off label Use Form| |View source of the data|

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🐶 Veterinary Drug Use

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🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

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Orange Book exclusivity data (new drug applications)

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Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN	Ki	6.70	DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	Ki	5.97	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	Ki	6.04	DRUG MATRIX
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN	Ki	5.56	DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN	Ki	7.07	DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	Ki	7.54	DRUG MATRIX
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN	Ki	6.14	DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN	IC50	5.52	DRUG MATRIX
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN	Ki	5.72	DRUG MATRIX
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN	Ki	5.25	CHEMBL

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External reference:

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ID	Source
T0M	PDB_CHEM_ID
003125	NDDF
016161	NDDF
10472	RXNORM
16684434	PUBCHEM_CID
2225PI3MOV	UNII
2548	INN_ID
3379001	SNOMEDCT_US
4017480	VUID
4017480	VANDF

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Pharmaceutical products:

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