Stem definition | Drug id | CAS RN |
---|---|---|
mercury-containing drugs, antimicrobial or diuretic | 4733 | 54-64-8 |
Molecule | Description |
---|---|
Synonyms:
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An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.
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MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Gastrointestinal toxicity | 184.79 | 129.46 | 36 | 829 | 4641 | 50599618 |
Pulmonary toxicity | 172.61 | 129.46 | 35 | 830 | 5527 | 50598732 |
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MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 96.97 | 96.74 | 40 | 345 | 237775 | 64260572 |
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Source | Code | Description |
---|---|---|
ATC | D08AK06 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Mercurial products |
FDA CS | M0000728 | Allergens |
MeSH PA | D010592 | Pharmaceutic Aids |
MeSH PA | D011310 | Preservatives, Pharmaceutical |
CHEBI has role | CHEBI:48218 | antiseptics |
CHEBI has role | CHEBI:48219 | disinfectants |
CHEBI has role | CHEBI:86327 | pharmaceutical fungicide |
CHEBI has role | CHEBI:88188 | allergenic drug |
FDA PE | N0000175629 | Increased Histamine Release |
FDA PE | N0000184306 | Cell-mediated Immunity |
FDA EPC | N0000185508 | Standardized Chemical Allergen |
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Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-2A adrenergic receptor | GPCR | Ki | 6.70 | DRUG MATRIX | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.97 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 6.04 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.56 | DRUG MATRIX | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 7.07 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 7.54 | DRUG MATRIX | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.14 | DRUG MATRIX | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 5.52 | DRUG MATRIX | |||||
Adenosine receptor A3 | GPCR | Ki | 5.72 | DRUG MATRIX | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 5.25 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 5.16 | CHEMBL | |||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 5.14 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 5.23 | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 4.96 | CHEMBL | |||||
Toll-like receptor 9 | Membrane receptor | IC50 | 5.20 | CHEMBL | |||||
Carbonic anhydrase 3 | Enzyme | Ki | 5.20 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Ki | 5.29 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 5.18 | CHEMBL | |||||
Mitogen-activated protein kinase 3 | Kinase | IC50 | 6.11 | DRUG MATRIX | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 5.16 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 4.77 | CHEMBL |
ID | Source |
---|---|
D00864 | KEGG_DRUG |
4017480 | VUID |
N0000145868 | NUI |
4017480 | VANDF |
CHEBI:9546 | CHEBI |
T0M | PDB_CHEM_ID |
CHEMBL508338 | ChEMBL_ID |
DB11590 | DRUGBANK_ID |
16684434 | PUBCHEM_CID |
10472 | RXNORM |
5568 | MMSL |
NOCODE | MMSL |
003125 | NDDF |
016161 | NDDF |
3379001 | SNOMEDCT_US |
411211004 | SNOMEDCT_US |
D013849 | MESH_DESCRIPTOR_UI |
C0039867 | UMLSCUI |
2548 | INN_ID |
2225PI3MOV | UNII |
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