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tacalcitol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| Vitamin D analogues/derivatives | 4727 | 57333-96-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,CDK5,EIF2AK3,GRK2,ITK,PDK1,PDK2,PDK4,PRKDC | 9 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D05AX04 | DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR TOPICAL USE Other antipsoriatics for topical use |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:50748 | antipsoriatic |
| CHEBI has role | CHEBI:139503 | vitamin D receptor agonist |
Related Drugs by ATC class:
D05AX Other antipsoriatics for topical use 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Plaque psoriasis | indication | 200965009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.7 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin D3 receptor | Nuclear hormone receptor | AGONIST | Kd | 8.50 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D08554 | KEGG_DRUG |
| CHEBI:32176 | CHEBI |
| CHEMBL2105611 | ChEMBL_ID |
| C023850 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2780 | IUPHAR_LIGAND_ID |
| DB13689 | DRUGBANK_ID |
| C2W72OJ5ZU | UNII |
| 291204 | RXNORM |
| 005930 | NDDF |
| 332214000 | SNOMEDCT_US |
| 395893005 | SNOMEDCT_US |
| C0953467 | UMLSCUI |
| 6822 | INN_ID |
| 5283734 | PUBCHEM_CID |
| C2W72OJ5ZU | INXIGHT DRUGS |
Pharmaceutical products:
None