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fumaric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3229 | 110-17-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 62 | |||
| kinase-selectivity-class | ACVR2B,AXL,BMX,BRAF,CDK4,CDK9,DDR1,DYRK1B,DYRK3,EIF2AK3,EPHB4,ERBB2,FGFR1,GRK2,HIPK2,IKBKB,JAK2,MAP2K6,MAP3K14,MAP3K2,MAPK12,MAPK7,MAPK8,PIK3CB,PIM3,PRKDC,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ZAP70 | 33 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D05AX01 | DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR TOPICAL USE Other antipsoriatics for topical use |
| CHEBI has role | CHEBI:50748 | antipsoriatic |
| CHEBI has role | CHEBI:64049 | food acidity regulator |
| CHEBI has role | CHEBI:78675 | fundamental metabolite |
| CHEBI has role | CHEBI:176497 | geroprotector |
Related Drugs by ATC class:
D05AX Other antipsoriatics for topical use 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Psoriasis | indication | 9014002 | DOID:8893 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.46 | acidic |
| pKa2 | 4.93 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Egl nine homolog 1 | Enzyme | IC50 | 4.72 | CHEMBL | |||||
| Egl nine homolog 3 | Enzyme | IC50 | 4.22 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020189 | VUID |
| N0000179140 | NUI |
| D02308 | KEGG_DRUG |
| 4020189 | VANDF |
| C0060825 | UMLSCUI |
| CHEBI:18012 | CHEBI |
| FUM | PDB_CHEM_ID |
| CHEMBL503160 | ChEMBL_ID |
| DB01677 | DRUGBANK_ID |
| C032005 | MESH_SUPPLEMENTAL_RECORD_UI |
| 88XHZ13131 | UNII |
| 444972 | PUBCHEM_CID |
| 25389 | RXNORM |
| NOCODE | MMSL |
| 006838 | NDDF |
| 88XHZ13131 | INXIGHT DRUGS |
Pharmaceutical products:
None