daunorubicinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastics, daunorubicin derivatives	4719	28008-55-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

daunorubicinol
daunomycinol
dihydrodaunomycin
duborimycin
Leukaemomycin D
daunorubicinol hydrochloride

main metabolite of daunomycin

Molecular weight: 529.54
Formula: C27H31NO10
CLOGP: 1.30
LIPINSKI: 3
HAC: 11
HDO: 6
TPSA: 189
ALOGS: -2.78
ROTB: 4

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	25 %	Benet LZ, Broccatelli F, Oprea TI

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1964	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.03	acidic
pKa2	10.09	acidic
pKa3	13.98	acidic
pKa4	8.6	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN					WOMBAT-PK
DNA topoisomerase 2-alpha	Enzyme	P11388	TOP2A_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 1	Transporter	P33527	MRP1_HUMAN					WOMBAT-PK
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 6	Transporter	O95255	MRP6_HUMAN					WOMBAT-PK

External reference:

ID	Source
C0057159	UMLSCUI
CHEBI:31059	CHEBI
C000847	MESH_SUPPLEMENTAL_RECORD_UI
YDU8YIP30L	UNII
443832	PUBCHEM_CID

Pharmaceutical products:

None