camphor 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
470 76-22-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • camphor
  • alphanon
  • borneo camphor
  • DL-Camphor
  • root bark oil
  • 2-Bornanone
  • 2-Camphanone
  • camphor (synthetic)
  • camphor (natural)
  • camphor, (synthetic)
  • camphor, (+/-)-
  • camphora
A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
  • Molecular weight: 152.24
  • Formula: C10H16O
  • CLOGP: 2.18
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS: -2.24
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 191.79 14.91 44 5475 2359 63481144
Urticaria thermal 51.35 14.91 11 5508 428 63483075
Administration site erythema 40.21 14.91 10 5509 755 63482748
Pigmentation disorder 36.08 14.91 14 5505 4625 63478878
Drug hypersensitivity 30.91 14.91 77 5442 310610 63172893
Nail bed tenderness 30.02 14.91 7 5512 402 63483101
Hypercholesterolaemia 29.45 14.91 20 5499 21314 63462189
Scratch 28.22 14.91 13 5506 6552 63476951
Vitamin B12 deficiency 27.59 14.91 12 5507 5291 63478212
Dizziness postural 23.81 14.91 12 5507 7364 63476139
Cyanosis 23.67 14.91 16 5503 16919 63466584
Secretion discharge 23.17 14.91 14 5505 12217 63471286
Autonomic neuropathy 22.79 14.91 7 5512 1152 63482351
Skin plaque 19.67 14.91 11 5508 8309 63475194
Accidental exposure to product by child 18.46 14.91 6 5513 1187 63482316
Vulvovaginal swelling 18.29 14.91 5 5514 546 63482957
Anxiety disorder 17.35 14.91 8 5511 4042 63479461
Osteoarthritis 15.65 14.91 29 5490 95314 63388189

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 198.03 20.70 45 1969 3536 34951381
Haemolysis 30.77 20.70 13 2001 8081 34946836
Anticholinergic syndrome 25.02 20.70 7 2007 1262 34953655
Erythema multiforme 23.57 20.70 11 2003 8638 34946279
Pruritus 21.36 20.70 33 1981 141948 34812969

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 376.47 14.59 86 5684 5471 79733147
Urticaria thermal 53.21 14.59 11 5759 434 79738184
Administration site erythema 49.24 14.59 10 5760 361 79738257
Pigmentation disorder 35.97 14.59 14 5756 5604 79733014
Pruritus 33.31 14.59 82 5688 394566 79344052
Nail bed tenderness 31.21 14.59 7 5763 407 79738211
Cyanosis 29.77 14.59 20 5750 25162 79713456
Scratch 27.49 14.59 13 5757 8350 79730268
Vitamin B12 deficiency 26.11 14.59 12 5758 7229 79731389
Accidental exposure to product by child 24.97 14.59 9 5761 2917 79735701
Dizziness postural 23.53 14.59 13 5757 11536 79727082
Drug hypersensitivity 22.98 14.59 60 5710 298856 79439762
Haemolysis 22.27 14.59 13 5757 12799 79725819
Autonomic neuropathy 20.67 14.59 7 5763 1888 79736730
Vulvovaginal swelling 20.61 14.59 5 5765 410 79738208
Secretion discharge 20.36 14.59 13 5757 15009 79723609
Skin plaque 18.93 14.59 11 5759 10734 79727884
Anticholinergic syndrome 16.28 14.59 7 5763 3604 79735014
Dermatitis exfoliative 16.26 14.59 10 5760 10819 79727799
Skin discolouration 15.65 14.59 17 5753 41017 79697601
Nervousness 14.81 14.59 15 5755 33400 79705218

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01EB02 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:27311 essential oil component
CHEBI has role CHEBI:76924 plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Skin irritation contraindication 367466007
Cardiovascular event risk contraindication 395112001
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Acetylcholinesterase Enzyme Ki 4.30 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Ion channel GATING INHIBITOR IC50 4.20 IUPHAR

External reference:

IDSource
4017533 VUID
N0000145916 NUI
D00098 KEGG_DRUG
464-49-3 SECONDARY_CAS_RN
1298738 RXNORM
C0006809 UMLSCUI
CHEBI:36773 CHEBI
CAM PDB_CHEM_ID
CHEMBL504760 ChEMBL_ID
DB01744 DRUGBANK_ID
D002164 MESH_DESCRIPTOR_UI
2537 PUBCHEM_CID
2422 IUPHAR_LIGAND_ID
C436264 MESH_SUPPLEMENTAL_RECORD_UI
DB11288 DRUGBANK_ID
DB14156 DRUGBANK_ID
4343 MMSL
6005 MMSL
111136003 SNOMEDCT_US
412108007 SNOMEDCT_US
46137002 SNOMEDCT_US
4017533 VANDF
5TJD82A1ET UNII
001385 NDDF
001993 NDDF
005178 NDDF
006104 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Major Camphor and Phenol HUMAN OTC DRUG LABEL 2 00904-7851 LIQUID 10.80 g TOPICAL OTC monograph final 12 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0049 SPRAY 5.50 mg TOPICAL OTC monograph not final 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0049 SPRAY 5.50 mg TOPICAL OTC monograph not final 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0050 LOTION 5.50 mg TOPICAL OTC monograph not final 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0050 LOTION 5.50 mg TOPICAL OTC monograph not final 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0063 LOTION 5.50 mg TOPICAL OTC monograph not final 14 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0063 LOTION 5.50 mg TOPICAL OTC monograph not final 14 sections
Sarna HUMAN OTC DRUG LABEL 2 0316-0229 LOTION 5 mg TOPICAL OTC monograph not final 13 sections
Sarna HUMAN OTC DRUG LABEL 2 0316-0229 LOTION 5 mg TOPICAL OTC monograph not final 13 sections
Vaporizing HUMAN OTC DRUG LABEL 1 0363-0055 INHALANT 62 mg RESPIRATORY (INHALATION) OTC monograph final 16 sections
Vaporizing HUMAN OTC DRUG LABEL 1 0363-0055 INHALANT 62 mg RESPIRATORY (INHALATION) OTC monograph final 16 sections
WALGREENS MEDICATED PAIN RELIEVING HUMAN OTC DRUG LABEL 3 0363-0149 PATCH 7.10 mg TOPICAL OTC monograph not final 14 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 30 mg TOPICAL OTC monograph not final 10 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 30 mg TOPICAL OTC monograph not final 10 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 3.10 g TOPICAL OTC monograph not final 11 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 3.10 g TOPICAL OTC monograph not final 11 sections
Walgreens Chest Rub HUMAN OTC DRUG LABEL 3 0363-1001 OINTMENT 48 mg TOPICAL OTC monograph final 12 sections
Walgreens Chest Rub HUMAN OTC DRUG LABEL 3 0363-1001 OINTMENT 48 mg TOPICAL OTC monograph final 12 sections
Walgreens Chest Rub HUMAN OTC DRUG LABEL 3 0363-1001 OINTMENT 48 mg TOPICAL OTC monograph final 12 sections
Walgreens Pain Relieving Analgesic HUMAN OTC DRUG LABEL 3 0363-1199 CREAM 40 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
No Touch Application Chest RubWell at Walgreens HUMAN OTC DRUG LABEL 3 0363-3267 STICK 4.80 g TOPICAL OTC monograph final 7 sections
Walgreen Anti Itch HUMAN OTC DRUG LABEL 2 0363-4262 LOTION 0.50 g TOPICAL OTC monograph not final 12 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6040 SALVE 1.70 mg TOPICAL OTC monograph not final 9 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6080 STICK 1.70 mg TOPICAL OTC monograph not final 9 sections
Chest Rub HUMAN OTC DRUG LABEL 3 0363-8480 LOTION 4.80 kg TOPICAL OTC monograph final 15 sections
Walgreens Camphor Phenol Gel HUMAN OTC DRUG LABEL 2 0363-9425 GEL 10.80 mg TOPICAL OTC monograph not final 8 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 1.20 1 TOPICAL OTC monograph not final 12 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 1.20 g TOPICAL OTC monograph not final 12 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 3.10 g TOPICAL OTC monograph not final 13 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 3.10 g TOPICAL OTC monograph not final 13 sections