esatenolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 4702 93379-54-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • s-atenolol
  • (-)-Atenolol
  • (S)-Atenolol
  • esatenolol
  • Molecular weight: 266.34
  • Formula: C14H22N2O3
  • CLOGP: -0.11
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 84.58
  • ALOGS: -2.79
  • ROTB: 8

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AB11 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
CHEBI has role CHEBI:35530 beta-adrenergic blockers

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.92 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR Ki 6.82 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5 CHEMBL
Adenosine receptor A3 GPCR IC50 8.75 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.93 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.62 CHEMBL
Urease Enzyme IC50 4.19 CHEMBL

External reference:

IDSource
D01471 KEGG_DRUG
CHEBI:31556 CHEBI
CHEMBL343633 ChEMBL_ID
CHEMBL24 ChEMBL_ID
7337 INN_ID
DB13443 DRUGBANK_ID
DPF757BOSR UNII
C3652674 UMLSCUI
175540 PUBCHEM_CID

Pharmaceutical products:

None