pleconaril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antivirals 4690 153168-05-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pleconaril
  • picovir
  • Molecular weight: 381.36
  • Formula: C18H18F3N3O3
  • CLOGP: 4.89
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 74.18
  • ALOGS: -4.24
  • ROTB: 7

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 70 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.673 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.327 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 3.656 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 26.242 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.100 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 0.400 % High 1
herg hERG pIC50 4.959 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 10.093 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 13.032 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.340 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC,STK33,TEK 21
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.092 High 1
mh-clint Mouse hepatocyte intrinsic clearance 27.606 High 1
mppb Mouse plasma protein binding (% unbound) 0.130 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.139 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 1
pppb Pig plasma protein binding (% unbound) 0.160 % High 1
rh-clint Rat hepatocyte intrinsic clearance 14.125 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 1.070 % High 1
rppb Rat plasma protein binding (% unbound) 0.190 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 2.938 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J05AX06 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Other antivirals
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents

Related Drugs by ATC class:

J05AX Other antivirals 15 drugs
amenamevirbaloxavir marboxilbulevirtideenfuvirtidefavipiravirfostemsaviribalizumabinosine pranobexlenacapavirletermovirmaravirocmaribavir show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor EC50 6.60 CHEMBL
Protease Enzyme EC50 7.24 CHEMBL
Genome polyprotein Polyprotein EC50 8.40 CHEMBL

External reference:

IDSource
D05528 KEGG_DRUG
C0759032 UMLSCUI
CHEMBL29609 ChEMBL_ID
DB05105 DRUGBANK_ID
C115201 MESH_SUPPLEMENTAL_RECORD_UI
7617 INN_ID
9H4570Q89D UNII
1684 PUBCHEM_CID
CHEBI:46479 CHEBI
W11 PDB_CHEM_ID

Pharmaceutical products:

None