paraoxon 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4683	311-45-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

paraoxon
oxyparathion
ethyl paraoxon
paraoxan
phosphachole
phosphacol
mintacol

An organophosphate cholinesterase inhibitor that is used as a pesticide.

Molecular weight: 275.20
Formula: C10H14NO6P
CLOGP: 1.88
LIPINSKI: 0
HAC: 7
HDO: 0
TPSA: 90.58
ALOGS: -2.28
ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	S01EB10	SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Parasympathomimetics
MeSH PA	D018678	Cholinergic Agents
MeSH PA	D002800	Cholinesterase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D007306	Insecticides
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D010575	Pesticides
CHEBI has role	CHEBI:38462	acetylcholinesterase inhibitors
CHEBI has role	CHEBI:75771	Mus musculus metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		IC50	7.23		CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		IC50	6.47		CHEMBL
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	8		CHEMBL
Cholinesterase	Enzyme	P06276	CHLE_HUMAN		IC50	8.15		CHEMBL
Carbonic anhydrase 13	Enzyme		CAH13_MOUSE		IC50	5.99		CHEMBL
Acetylcholinesterase	Enzyme		ACES_MOUSE		IC50	7.89		CHEMBL
Cannabinoid receptor 1	GPCR		CNR1_MOUSE		IC50	5.92		CHEMBL
Monoglyceride lipase	Enzyme		MGLL_MOUSE		IC50	5.92		CHEMBL
Fatty-acid amide hydrolase 1	Enzyme		FAAH1_MOUSE		IC50	6.27		CHEMBL

External reference:

ID	Source
D10529	KEGG_DRUG
CHEBI:27827	CHEBI
CHEMBL23838	ChEMBL_ID
C121104	MESH_SUPPLEMENTAL_RECORD_UI
DB13495	DRUGBANK_ID
Q9CX8P80JW	UNII
C0030480	UMLSCUI
D010261	MESH_DESCRIPTOR_UI
9395	PUBCHEM_CID

Pharmaceutical products:

None