metizoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antihistaminics or local vasoconstrictors, antazoline derivatives | 4671 | 17692-22-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R01AA10 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain |
| CHEBI has role | CHEBI:24527 | herbicides |
| CHEBI has role | CHEBI:26841 | synthetic auxins |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Nasal congestion | indication | 68235000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.44 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Nischarin | Membrane receptor | Ki | 9.20 | CHEMBL | |||||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 5.83 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 4.86 | CHEMBL | |||||
| Nischarin | Unclassified | Ki | 8.89 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D05006 | KEGG_DRUG |
| 3813-05-6 | SECONDARY_CAS_RN |
| 5090-37-9 | SECONDARY_CAS_RN |
| CHEBI:136017 | CHEBI |
| CHEMBL1370446 | ChEMBL_ID |
| C010242 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2380 | INN_ID |
| DB13614 | DRUGBANK_ID |
| Z27L8N105U | UNII |
| C0604284 | UMLSCUI |
| CHEMBL266155 | ChEMBL_ID |
| CHEMBL2106879 | ChEMBL_ID |
| 28688 | PUBCHEM_CID |
Pharmaceutical products:
None