betamethasone phosphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4667 151-73-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone phosphate
  • betamethasone sodium phosphate
  • betamethasone disodium phosphate
  • betnesol
  • durabetason
phosphate ester of betamethasone; RN given refers to the di-Na salt (11beta,16beta)-isomer; structure in Negwer,5th ed, 4975
  • Molecular weight: 472.45
  • Formula: C22H30FO8P
  • CLOGP: 0.32
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 141.36
  • ALOGS: -2.21
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 3, 1965 FDA MERCK SHARP DOHME

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure during pregnancy 62.02 53.53 17 103 25202 2332763

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.75 acidic
pKa2 6.8 acidic
pKa3 11.06 acidic
pKa4 13.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.43 DRUG MATRIX CHEMBL
Histamine H1 receptor GPCR Ki 5.93 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 5.78 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 5.87 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 5.78 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 5.25 DRUG MATRIX

External reference:

IDSource
D00972 KEGG_DRUG
4018646 VUID
N0000179655 NUI
C0700603 UMLSCUI
7BK02SCL3W UNII
CHEMBL1200762 ChEMBL_ID
CHEMBL1201207 ChEMBL_ID
DB14669 DRUGBANK_ID
107782 PUBCHEM_CID
C028994 MESH_SUPPLEMENTAL_RECORD_UI
DB00443 DRUGBANK_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CELESTONE SOLUSPAN HUMAN PRESCRIPTION DRUG LABEL 2 0085-0566 INJECTION, SUSPENSION 3 mg INTRAMUSCULAR NDA 12 sections
CELESTONE SOLUSPAN HUMAN PRESCRIPTION DRUG LABEL 2 0085-4320 INJECTION, SUSPENSION 3 mg INTRAMUSCULAR NDA 12 sections
Betamethasone Sodium Phosphate and Betamethasone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 0517-0720 INJECTION, SUSPENSION 3 mg INTRA-ARTICULAR ANDA 12 sections
Betamethasone Sodium Phosphate and Betamethasone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 0517-0791 INJECTION, SUSPENSION 3 mg INTRA-ARTICULAR ANDA 12 sections
Betamethasone Sodium Phosphate and Betamethasone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 0517-0799 INJECTION, SUSPENSION 3 mg INTRA-ARTICULAR ANDA 12 sections
Betamethasone Sodium Phosphate and Betamethasone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 51754-5060 INJECTION, SUSPENSION 3 mg INTRAMUSCULAR NDA AUTHORIZED GENERIC 12 sections
ReadySharp Betamethasone HUMAN PRESCRIPTION DRUG LABEL 2 53225-3665 INJECTION, SUSPENSION 3 mg INTRALESIONAL ANDA 12 sections
ReadySharp Anesthetics plus Betamethasone HUMAN PRESCRIPTION DRUG LABEL 2 53225-4105 KIT 3 mg INFILTRATION NDA 12 sections
ReadySharp Betamethasone HUMAN PRESCRIPTION DRUG LABEL 2 68788-7327 INJECTION, SUSPENSION 3 mg INTRALESIONAL ANDA 12 sections
Beta 1 Kit HUMAN PRESCRIPTION DRUG LABEL 2 69263-822 KIT 3 mg INTRA-ARTICULAR ANDA 12 sections
Betamethasone Sodium Phosphate and Betamethasone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 70518-0506 INJECTION, SUSPENSION 3 mg INTRA-ARTICULAR ANDA 12 sections
CELESTONE SOLUSPAN HUMAN PRESCRIPTION DRUG LABEL 2 70518-1879 INJECTION, SUSPENSION 3 mg INTRAMUSCULAR NDA 12 sections
H-Paxin HUMAN PRESCRIPTION DRUG LABEL 3 70529-051 KIT 3 mg None ANDA 17 sections
Betamethasone Sodium Phosphate and Betamethasone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 76420-007 INJECTION, SUSPENSION 3 mg INTRA-ARTICULAR ANDA 12 sections
Betaloan SUIK HUMAN PRESCRIPTION DRUG LABEL 2 76420-240 INJECTION, SUSPENSION 3 mg INTRA-ARTICULAR unapproved drug other 12 sections
Betalido Kit HUMAN PRESCRIPTION DRUG LABEL 4 76420-765 KIT 3 mg INTRA-ARTICULAR unapproved drug other 20 sections
Marbeta L Kit HUMAN PRESCRIPTION DRUG LABEL 4 76420-782 KIT 3 mg INTRA-ARTICULAR unapproved drug other 20 sections
Marbeta 25 Kit HUMAN PRESCRIPTION DRUG LABEL 4 76420-785 KIT 3 mg INTRA-ARTICULAR unapproved drug other 20 sections