creatine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4661 57-00-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • creatine
  • methylguanidoacetic acid
An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.
  • Molecular weight: 131.14
  • Formula: C4H9N3O2
  • CLOGP: -1.51
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 90.41
  • ALOGS: -1.50
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 209.65 63.73 52 381 66915 79677040
Coma 183.95 63.73 51 382 100598 79643357
Gastrooesophageal reflux disease 182.18 63.73 51 382 104195 79639760
Somnolence 144.32 63.73 52 381 238929 79505026
Underdose 89.35 63.73 23 410 33128 79710827

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.48 acidic
pKa2 11.13 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4024927 VUID
N0000170276 NUI
4024927 VANDF
CHEBI:16919 CHEBI
CRN PDB_CHEM_ID
CHEMBL283800 ChEMBL_ID
4496 IUPHAR_LIGAND_ID
DB00148 DRUGBANK_ID
MU72812GK0 UNII
2907 RXNORM
NOCODE MMSL
d04417 MMSL
008272 NDDF
C0010286 UMLSCUI
D003401 MESH_DESCRIPTOR_UI
586 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ginsamin Energy HUMAN OTC DRUG LABEL 5 44738-7001 LIQUID 10000 mg ORAL unapproved drug other 6 sections