methylatropine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 4660 31610-87-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylatropine
  • methylatropinium
  • atropine methonitrate
  • atropine methobromide
  • methylatropine nitrate
  • Molecular weight: 304.41
  • Formula: C18H26NO3
  • CLOGP: -3.02
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -4.78
  • ROTB: 5

Drug dosage:

DoseUnitRoute
3 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03BB02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
BELLADONNA AND DERIVATIVES, PLAIN
Belladonna alkaloids, semisynthetic, quaternary ammonium compounds
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.24 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M2 GPCR Kd 8.57 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Kd 8.60 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Kd 8.59 CHEMBL
Muscarinic acetylcholine receptor DM1 GPCR Ki 8.62 CHEMBL

External reference:

IDSource
D01077 KEGG_DRUG
52-88-0 SECONDARY_CAS_RN
4018467 VANDF
CHEBI:134749 CHEBI
CHEMBL1179176 ChEMBL_ID
CHEMBL1187724 ChEMBL_ID
C006649 MESH_SUPPLEMENTAL_RECORD_UI
DB13833 DRUGBANK_ID
656598 PUBCHEM_CID
001716 NDDF
006113 NDDF
391795000 SNOMEDCT_US
C0066332 UMLSCUI
CHEMBL516476 ChEMBL_ID
436 INN_ID
80719I460H UNII

Pharmaceutical products:

None