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chloramphenicol succinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4653 | 982-57-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
inactive precursor (PRODRUGS) of chloramphenicol; used for parenteral administration of chloramphenicol; RN given refers to (R-(R*,R*))-isomer
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 82 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 56 | |||
| kinase-selectivity-class | AXL,BRAF,CDK9,DYRK1B,GRK2,MAP2K6,MAPK7,STK33,TEK,TTK | 10 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 8, 1950 | FDA | PARKEDALE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Grey syndrome neonatal | 43.17 | 30.45 | 3 | 3 | 3 | 42621326 |
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA EXT | N0000175479 | Amphenicols |
| FDA EPC | N0000175480 | Amphenicol-class Antibacterial |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:48001 | protein synthesis inhibitor |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
| CHEBI has role | CHEBI:131604 | <em>Mycoplasma genitalium</em> metabolite |
| CHEBI has role | CHEBI:176497 | geroprotector |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Typhoid fever | indication | 4834000 | DOID:13258 |
| Salmonella infection | indication | 302231008 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.37 | acidic |
| pKa2 | 10.37 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D02185 | KEGG_DRUG |
| 3544-94-3 | SECONDARY_CAS_RN |
| 4018199 | VANDF |
| 4018200 | VANDF |
| CHEBI:3606 | CHEBI |
| CL8 | PDB_CHEM_ID |
| CLM | PDB_CHEM_ID |
| CHEMBL1201281 | ChEMBL_ID |
| CHEMBL1200729 | ChEMBL_ID |
| C026016 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB07565 | DRUGBANK_ID |
| ZCX619U9A1 | UNII |
| 20769 | RXNORM |
| 3887 | MMSL |
| 4406 | MMSL |
| 4407 | MMSL |
| 6083 | MMSL |
| d00025 | MMSL |
| 002767 | NDDF |
| 002769 | NDDF |
| 005428 | NDDF |
| 372777009 | SNOMEDCT_US |
| 57191001 | SNOMEDCT_US |
| 6612003 | SNOMEDCT_US |
| C0055339 | UMLSCUI |
| C0008168 | UMLSCUI |
| DB00446 | DRUGBANK_ID |
| 656580 | PUBCHEM_CID |
| 5959 | PUBCHEM_CID |
| 977 | INN_ID |
| D002701 | MESH_DESCRIPTOR_UI |
| CHEBI:17698 | CHEBI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Chloramphenicol Sodium Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-011 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 19 sections |