eugenol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4648 97-53-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eugenol
  • allylguaiacol
  • bioxeda
  • caryophyllic acid
  • dentogum
  • eugenic acid
A cinnamate derivative of the shikamate pathway found in CLOVE OIL and other PLANTS.
  • Molecular weight: 164.20
  • Formula: C10H12O2
  • CLOGP: 2.40
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.46
  • ALOGS: -2.06
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
FDA EPC N0000185508 Standardized Chemical Allergen
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA CS M0000728 Allergens
MeSH PA D000890 Anti-Infective Agents
MeSH PA D012997 Solvents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.12 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme IC50 4.96 CHEMBL

External reference:

IDSource
D005054 MESH_DESCRIPTOR_UI
D04117 KEGG_DRUG
4019118 VUID
N0000147369 NUI
C0015153 UMLSCUI
3T8H1794QW UNII
CHEMBL42710 ChEMBL_ID
EOL PDB_CHEM_ID
DB09086 DRUGBANK_ID
CHEBI:4917 CHEBI
3314 PUBCHEM_CID
2425 IUPHAR_LIGAND_ID
411361005 SNOMEDCT_US
255924000 SNOMEDCT_US
4186 RXNORM
4019118 VANDF
NOCODE MMSL
001106 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dry Socket HUMAN PRESCRIPTION DRUG LABEL 2 0699-0404 PASTE 0.04 g DENTAL unapproved drug other 9 sections
Red Cross Toothache HUMAN OTC DRUG LABEL 1 10742-0009 LIQUID 850 mg TOPICAL OTC monograph not final 9 sections
DenTek Eugenol HUMAN OTC DRUG LABEL 1 60630-566 LIQUID 850 mg DENTAL OTC monograph not final 12 sections
Walgreens Natural Eugenol/Toothache Medication HUMAN OTC DRUG LABEL 1 60630-608 LIQUID 850 mg DENTAL OTC monograph not final 9 sections
DenTek Eugenol HUMAN OTC DRUG LABEL 1 67659-400 LIQUID 850 mg DENTAL OTC monograph not final 12 sections
Walgreens Natural Eugenol/Toothache Medication HUMAN OTC DRUG LABEL 1 67659-405 LIQUID 850 mg DENTAL OTC monograph not final 9 sections
Eugenol Toothache Medication HUMAN OTC DRUG LABEL 1 67659-415 LIQUID 850 mg DENTAL OTC monograph not final 11 sections
Nuby Teething Gel HUMAN OTC DRUG LABEL 1 70797-230 GEL 13 mg TOPICAL OTC monograph not final 8 sections
Nuby Teething Gel HUMAN OTC DRUG LABEL 1 71552-231 GEL 8 mg TOPICAL OTC monograph not final 8 sections