gadoxetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diagnostic agents, gadolinium derivatives	4646	135326-22-6

Description:

Molecule

Description

Synonyms:

gadoxetate disodium
gadoxetate
eovist

Molecular weight: 679.74
Formula: C23H28GdN3O11
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	0.21 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	3.57 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.90 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.95 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
July 3, 2008	FDA	BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rubber sensitivity	65.96	53.88	12	488	2319	63486203
Urticaria	56.76	53.88	27	473	165775	63322747

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria	73.98	59.22	34	621	185167	79558566
Rubber sensitivity	68.86	59.22	12	643	1737	79741996

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D003287	Contrast Media
MeSH PA	D064907	Diagnostic Uses of Chemicals

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4027907	VUID
N0000177924	NUI
4027906	VANDF
4027907	VANDF
CHEMBL2221312	ChEMBL_ID
CHEMBL1201768	ChEMBL_ID
C073590	MESH_SUPPLEMENTAL_RECORD_UI
DB08884	DRUGBANK_ID
637320	RXNORM
147121	MMSL
25733	MMSL
d05531	MMSL
011541	NDDF
440223009	SNOMEDCT_US
C2356037	UMLSCUI
CHEMBL2103740	ChEMBL_ID
25203894	PUBCHEM_CID
HOY74VZE0M	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
EOVIST	HUMAN PRESCRIPTION DRUG LABEL	1	50419-320	INJECTION, SOLUTION	181.43 mg	INTRAVENOUS	NDA	29 sections
EOVIST	HUMAN PRESCRIPTION DRUG LABEL	1	50419-320	INJECTION, SOLUTION	181.43 mg	INTRAVENOUS	NDA	29 sections