hydroxocobalamin acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4644 22465-48-1

Description:

MoleculeDescription

Synonyms:

  • hydroxocobalamin acetate
  • acetatocobalamin
  • hydroxycobalamine acetate
  • Molecular weight: 1388.41
  • Formula: C64H91CoN13O16P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 515.01
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 117.66 23.77 74 3130 96065 50505855
Neutropenic sepsis 52.62 23.77 23 3181 14124 50587796
Forceps delivery 43.90 23.77 8 3196 185 50601735
Lethargy 43.34 23.77 31 3173 49401 50552519
Food refusal 39.81 23.77 8 3196 314 50601606
Pneumonia aspiration 38.13 23.77 24 3180 30980 50570940
Nystagmus 37.94 23.77 14 3190 5547 50596373
Somnolence 35.09 23.77 46 3158 154939 50446981
Acute kidney injury 34.61 23.77 56 3148 228002 50373918
Developmental hip dysplasia 33.41 23.77 9 3195 1282 50600638
Inappropriate antidiuretic hormone secretion 32.17 23.77 16 3188 13127 50588793
Haemorrhage in pregnancy 30.91 23.77 9 3195 1700 50600220
Pelvic deformity 30.17 23.77 6 3198 223 50601697
Drug ineffective 29.22 23.77 8 3196 819325 49782595
Coma scale abnormal 28.87 23.77 11 3193 4760 50597160
Urosepsis 26.95 23.77 15 3189 15450 50586470
Swelling face 24.84 23.77 23 3181 52572 50549348

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 36.31 27.24 68 2136 265199 29307124
Orthostatic hypotension 33.73 27.24 21 2183 22608 29549715
Loss of proprioception 31.72 27.24 7 2197 367 29571956
Confusional state 31.58 27.24 43 2161 127834 29444489
Hypomania 27.33 27.24 9 2195 2166 29570157

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 95.41 21.19 86 5166 148253 64345227
Acute kidney injury 73.55 21.19 131 5121 449109 64044371
Neutropenic sepsis 57.61 21.19 31 5221 23241 64470239
Pneumonia aspiration 45.35 21.19 38 5214 59233 64434247
Orthostatic hypotension 44.35 21.19 34 5218 46704 64446776
Confusional state 39.81 21.19 74 5178 261070 64232410
Swelling face 35.39 21.19 33 5219 59133 64434347
Dizziness 35.16 21.19 95 5157 430068 64063412
Food refusal 35.04 21.19 8 5244 447 64493033
Lethargy 29.73 21.19 33 5219 72561 64420919
Hallucination 29.66 21.19 33 5219 72755 64420725
Liver function test abnormal 29.65 21.19 30 5222 59371 64434109
Somnolence 28.88 21.19 56 5196 203589 64289891
Nystagmus 27.95 21.19 14 5238 9054 64484426
Skin abrasion 27.39 21.19 15 5237 11630 64481850
Forceps delivery 27.11 21.19 5 5247 95 64493385
Loss of proprioception 26.92 21.19 7 5245 675 64492805
Malaise 26.05 21.19 81 5171 396166 64097314
Lower respiratory tract infection 25.75 21.19 35 5217 94579 64398901
Lip swelling 25.52 21.19 21 5231 31886 64461594
Haemorrhage in pregnancy 22.56 21.19 7 5245 1273 64492207

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA EPC N0000175429 Antidote
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:75835 antianaemic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02707 KEGG_DRUG
4017962 VUID
N0000146312 NUI
4017961 VANDF
4017962 VANDF
CHEBI:27786 CHEBI
I2A PDB_CHEM_ID
CHEMBL2103737 ChEMBL_ID
S535M27N3Q UNII
91663261 PUBCHEM_CID
44475014 PUBCHEM_CID
DB00200 DRUGBANK_ID
236302 RXNORM
4850 MMSL
7093 MMSL
d03133 MMSL
001044 NDDF
005609 NDDF
327529002 SNOMEDCT_US
409258004 SNOMEDCT_US
734651006 SNOMEDCT_US
C0771561 UMLSCUI
C0020316 UMLSCUI
D006879 MESH_DESCRIPTOR_UI
1043 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydroxocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0591-2888 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 16 sections
Hydroxocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 50090-3548 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 16 sections
ARONAMIN GOLD HUMAN OTC DRUG LABEL 5 72689-0024 TABLET, FILM COATED 5.22 ug ORAL unapproved drug other 7 sections