All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

hydroxocobalamin acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4644	22465-48-1

Description:

Molecule	Description
Synonyms: hydroxocobalamin acetate acetatocobalamin hydroxycobalamine acetate	Molecular weight: 1388.41 Formula: C64H91CoN13O16P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 515.01 ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	117.66	23.77	74	3130	96065	50505855
Neutropenic sepsis	52.62	23.77	23	3181	14124	50587796
Forceps delivery	43.90	23.77	8	3196	185	50601735
Lethargy	43.34	23.77	31	3173	49401	50552519
Food refusal	39.81	23.77	8	3196	314	50601606
Pneumonia aspiration	38.13	23.77	24	3180	30980	50570940
Nystagmus	37.94	23.77	14	3190	5547	50596373
Somnolence	35.09	23.77	46	3158	154939	50446981
Acute kidney injury	34.61	23.77	56	3148	228002	50373918
Developmental hip dysplasia	33.41	23.77	9	3195	1282	50600638
Inappropriate antidiuretic hormone secretion	32.17	23.77	16	3188	13127	50588793
Haemorrhage in pregnancy	30.91	23.77	9	3195	1700	50600220
Pelvic deformity	30.17	23.77	6	3198	223	50601697
Drug ineffective	29.22	23.77	8	3196	819325	49782595
Coma scale abnormal	28.87	23.77	11	3193	4760	50597160
Urosepsis	26.95	23.77	15	3189	15450	50586470
Swelling face	24.84	23.77	23	3181	52572	50549348

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	36.31	27.24	68	2136	265199	29307124
Orthostatic hypotension	33.73	27.24	21	2183	22608	29549715
Loss of proprioception	31.72	27.24	7	2197	367	29571956
Confusional state	31.58	27.24	43	2161	127834	29444489
Hypomania	27.33	27.24	9	2195	2166	29570157

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	95.41	21.19	86	5166	148253	64345227
Acute kidney injury	73.55	21.19	131	5121	449109	64044371
Neutropenic sepsis	57.61	21.19	31	5221	23241	64470239
Pneumonia aspiration	45.35	21.19	38	5214	59233	64434247
Orthostatic hypotension	44.35	21.19	34	5218	46704	64446776
Confusional state	39.81	21.19	74	5178	261070	64232410
Swelling face	35.39	21.19	33	5219	59133	64434347
Dizziness	35.16	21.19	95	5157	430068	64063412
Food refusal	35.04	21.19	8	5244	447	64493033
Lethargy	29.73	21.19	33	5219	72561	64420919
Hallucination	29.66	21.19	33	5219	72755	64420725
Liver function test abnormal	29.65	21.19	30	5222	59371	64434109
Somnolence	28.88	21.19	56	5196	203589	64289891
Nystagmus	27.95	21.19	14	5238	9054	64484426
Skin abrasion	27.39	21.19	15	5237	11630	64481850
Forceps delivery	27.11	21.19	5	5247	95	64493385
Loss of proprioception	26.92	21.19	7	5245	675	64492805
Malaise	26.05	21.19	81	5171	396166	64097314
Lower respiratory tract infection	25.75	21.19	35	5217	94579	64398901
Lip swelling	25.52	21.19	21	5231	31886	64461594
Haemorrhage in pregnancy	22.56	21.19	7	5245	1273	64492207

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA EPC	N0000175429	Antidote
MeSH PA	D006397	Hematinics
MeSH PA	D006401	Hematologic Agents
MeSH PA	D018977	Micronutrients
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
CHEBI has role	CHEBI:75835	antianaemic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D02707	KEGG_DRUG
4017962	VUID
N0000146312	NUI
4017961	VANDF
4017962	VANDF
CHEBI:27786	CHEBI
I2A	PDB_CHEM_ID
CHEMBL2103737	ChEMBL_ID
S535M27N3Q	UNII
91663261	PUBCHEM_CID
44475014	PUBCHEM_CID
DB00200	DRUGBANK_ID
236302	RXNORM
4850	MMSL
7093	MMSL
d03133	MMSL
001044	NDDF
005609	NDDF
327529002	SNOMEDCT_US
409258004	SNOMEDCT_US
734651006	SNOMEDCT_US
C0771561	UMLSCUI
C0020316	UMLSCUI
D006879	MESH_DESCRIPTOR_UI
1043	INN_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Hydroxocobalamin	HUMAN PRESCRIPTION DRUG LABEL	1	0591-2888	INJECTION, SOLUTION	1000 ug	INTRAMUSCULAR	ANDA	16 sections
Hydroxocobalamin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3548	INJECTION, SOLUTION	1000 ug	INTRAMUSCULAR	ANDA	16 sections
ARONAMIN GOLD	HUMAN OTC DRUG LABEL	5	72689-0024	TABLET, FILM COATED	5.22 ug	ORAL	unapproved drug other	7 sections