levmetamfetamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anorexics 4641 33817-09-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • l-Desoxyephedrine
  • levmetamfetamine
  • (R)-Deoxyephedrine
  • (R)-Methamphetamine
  • (R)-Methylamphetamine
  • D-Methamphetamine
  • l-Methamphetamine
  • l-Methylamphetamine
  • levomethamphetamine
sympathomimetic vasoconstrictor used as nasal decongestant
  • Molecular weight: 149.24
  • Formula: C10H15N
  • CLOGP: 1.89
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -2.21
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Nasal congestion indication 68235000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Trace amine-associated receptor 1 GPCR AGONIST EC50 5.48 CHEMBL SCIENTIFIC LITERATURE
Trace amine-associated receptor 1 GPCR EC50 5.60 CHEMBL
Trace amine-associated receptor 1 GPCR EC50 6.63 CHEMBL
Trace amine-associated receptor 1 GPCR EC50 6.07 CHEMBL

External reference:

IDSource
D02291 KEGG_DRUG
C0724614 UMLSCUI
DB09571 DRUGBANK_ID
CHEBI:136013 CHEBI
Y24T9BT2Q2 UNII
7900 INN_ID
CHEMBL1927030 ChEMBL_ID
36604 PUBCHEM_CID
386995007 SNOMEDCT_US
7551 MMSL
17315 MMSL
1314416 RXNORM
001838 NDDF
012299 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Vapor Inhaler HUMAN OTC DRUG LABEL 1 0363-0564 INHALANT 50 mg NASAL OTC monograph final 13 sections
Sinu Inhaler HUMAN OTC DRUG LABEL 1 13709-281 INHALANT 50 mg NASAL OTC monograph final 13 sections
Vapor Inhaler HUMAN OTC DRUG LABEL 1 49781-045 INHALANT 50 mg NASAL OTC monograph final 13 sections
Nasal Decongestant Inhaler HUMAN OTC DRUG LABEL 1 54884-050 INHALANT 50 mg NASAL OTC monograph final 13 sections
Vapor Inhaler HUMAN OTC DRUG LABEL 1 63868-267 INHALANT 50 mg NASAL OTC monograph final 13 sections