All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sodium pyrophosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4630	7722-88-5

Description:

Molecule	Description
Synonyms: sodium pyrophosphate sodium diphosphate tetrasodium diphosphate tetrasodium pyrophosphate	Molecular weight: 265.90 Formula: Na4O7P2 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 135.61 ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	107.76	36.26	18	351	1448	31695527
Respiratory tract infection viral	102.05	36.26	18	351	1996	31694979
Respiratory tract infection	67.80	36.26	19	350	17542	31679433
Cytokine release syndrome	55.16	36.26	16	353	16626	31680349

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	108.57	29.90	18	641	1719	70926066
Respiratory tract infection viral	95.76	29.90	18	641	3523	70924262
Cytokine release syndrome	64.11	29.90	19	640	26448	70901337
Respiratory tract infection	55.30	29.90	19	640	42379	70885406
Pulmonary embolism	31.59	29.90	19	640	155848	70771937

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:38161	Chelating agent
CHEBI has role	CHEBI:63047	food emulsifiers
CHEBI has role	CHEBI:77970	thickening agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Farnesyl pyrophosphate synthase	Enzyme	P14324	FPPS_HUMAN		Ki	4.53		CHEMBL

External reference:

ID	Source
D05873	KEGG_DRUG
4020402	VUID
N0000179245	NUI
4019113	VANDF
CHEBI:71240	CHEBI
CHEMBL450079	ChEMBL_ID
C003319	MESH_SUPPLEMENTAL_RECORD_UI
O352864B8Z	UNII
1364532	RXNORM
28992	MMSL
NOCODE	MMSL
004831	NDDF
009844	NDDF
C0074764	UMLSCUI
24403	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Pyrophosphate	HUMAN PRESCRIPTION DRUG LABEL	1	51808-218	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	27.60 mg	INTRAVENOUS	Unapproved drug other	5 sections
Technescan PYP	HUMAN PRESCRIPTION DRUG LABEL	2	69945-094	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	11.90 mg	INTRAVENOUS	NDA	17 sections
EXODEN ALL IN ONE	HUMAN OTC DRUG LABEL	4	70602-010	PASTE	3.40 g	TOPICAL	unapproved drug other	8 sections
ONETOOTHCLINIC TOOTH	HUMAN OTC DRUG LABEL	3	73527-0001	PASTE	0.50 g	DENTAL	unapproved drug other	7 sections
ONETOOTH CLINIC TOOTH	HUMAN OTC DRUG LABEL	3	73527-0002	PASTE	0.50 g	DENTAL	unapproved drug other	7 sections
MIMIBO PREMIUM TOOTH	HUMAN OTC DRUG LABEL	3	73527-0003	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
MIMIBO PREMIUM TOOTH	HUMAN OTC DRUG LABEL	3	73527-0004	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
DR.CHOIS TOOTHPASTE CARE PLUS	HUMAN OTC DRUG LABEL	3	73666-0500	PASTE, DENTIFRICE	0.50 g	TOPICAL	unapproved drug other	10 sections
DR.CHOIS TOOTHPASTE CARE	HUMAN OTC DRUG LABEL	3	73666-0510	PASTE, DENTIFRICE	0.50 g	TOPICAL	unapproved drug other	10 sections
DR.CHOIS TOOTHPASTE FRESH	HUMAN OTC DRUG LABEL	4	73666-0520	PASTE, DENTIFRICE	0.50 g	TOPICAL	unapproved drug other	10 sections
ORAL PROJEQT O1 TOOTHPASTETABLETS	HUMAN OTC DRUG LABEL	4	76058-500	TABLET	1 g	ORAL	unapproved drug other	7 sections
Dr. DADDYS Tooth	HUMAN OTC DRUG LABEL	2	76884-0003	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
Dr. DADDYS GumToothpaste	HUMAN OTC DRUG LABEL	4	76884-0006	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
Dr.DADDYS Junior Toothpaste(Mint flavor)	HUMAN OTC DRUG LABEL	3	76884-0007	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
Dr. DADDYS Junior Toothpaste(Green grape)	HUMAN OTC DRUG LABEL	3	76884-0008	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
Dr. DADDYS Kids Tooth	HUMAN OTC DRUG LABEL	3	76884-0010	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
Dr. DADDYS Kids Toothpaste(Raspberry flavor)	HUMAN OTC DRUG LABEL	3	76884-0011	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
Dr. DADDYS GumToothpaste	HUMAN OTC DRUG LABEL	4	76884-0012	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
Mastikis Gold II	HUMAN OTC DRUG LABEL	2	79814-002	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	8 sections
Mastikis Qingjie Shine Mastic	HUMAN OTC DRUG LABEL	3	79814-004	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	8 sections
Mastikids II	HUMAN OTC DRUG LABEL	3	79814-005	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	8 sections
Mastikis Qingxin Care Mastic	HUMAN OTC DRUG LABEL	3	79814-006	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	8 sections
Vontee	HUMAN OTC DRUG LABEL	4	80687-010	TABLET	1 g	ORAL	unapproved drug other	10 sections
QUANTUMTOOTHCARE TOOTH	HUMAN OTC DRUG LABEL	3	81659-0001	PASTE, DENTIFRICE	0.50 g	DENTAL	unapproved drug other	7 sections
Dr.NOAH SOLIDTOOTHPASTE	HUMAN OTC DRUG LABEL	4	82359-0003	TABLET	0.01 g	ORAL	unapproved drug other	7 sections
Innoble ONECHEWTOOTHPASTE	HUMAN OTC DRUG LABEL	4	82709-001	TABLET	1 g	ORAL	unapproved drug other	7 sections