All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sincalide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4627	25126-32-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sincalide cholecystokinin-8 SQ-19844 SQ 19844	An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas. Molecular weight: 1143.27 Formula: C49H62N10O16S3 CLOGP: -6.94 LIPINSKI: 3 HAC: 26 HDO: 13 TPSA: 426.80 ALOGS: -5.41 ROTB: 33 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 21, 1976	FDA	BRACCO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple use of single-use product	168.23	101.27	21	123	1061	56290862
Therapeutic product effect decreased	105.31	101.27	31	113	169421	56122502

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple use of single-use product	253.48	91.47	28	122	602	70927692
Therapeutic product effect decreased	146.07	91.47	37	113	142981	70785313

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V04CC03	VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for bile duct patency
FDA CS	M0004235	Cholecystokinin
FDA EPC	N0000175798	Cholecystokinin Analog

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diagnostic aid	indication	2949005
Diagnostic Test for Pancreas Function	indication
Gastrointestinal obstruction	contraindication	126765001
Pregnancy, function	contraindication	289908002
Gallstone Complications	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.68	acidic
pKa2	3.79	acidic
pKa3	12.75	acidic
pKa4	12.79	acidic
pKa5	13.18	acidic
pKa6	13.27	acidic
pKa7	13.67	acidic
pKa8	13.79	acidic
pKa9	8.42	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cholecystokinin receptor type A	GPCR	P32238	CCKAR_HUMAN		Ki	9.55		CHEMBL
Gastrin/cholecystokinin type B receptor	GPCR	P32239	GASR_HUMAN		Ki	9.55		CHEMBL
Cholecystokinin receptor type A	GPCR		CCKAR_RAT		Ki	10.05		CHEMBL
Gastrin/cholecystokinin type B receptor	GPCR		GASR_RAT		Ki	9.39		CHEMBL
Gastrin/cholecystokinin type B receptor	GPCR		GASR_MOUSE		IC50	9.52		CHEMBL
Cholecystokinin receptor type A	GPCR		CCKAR_CAVPO		Ki	9.55		CHEMBL
Cholecystokinin receptor	GPCR		CCKAR_MOUSE GASR_MOUSE		Ki	9.52		CHEMBL

External reference:

ID	Source
D05845	KEGG_DRUG
4017721	VUID
N0000146090	NUI
4017721	VANDF
CHEBI:135946	CHEBI
CHEMBL1121	ChEMBL_ID
C410885	MESH_SUPPLEMENTAL_RECORD_UI
3617	INN_ID
DB09142	DRUGBANK_ID
M03GIQ7Z6P	UNII
9800	RXNORM
5466	MMSL
d03895	MMSL
001215	NDDF
126222003	SNOMEDCT_US
35765001	SNOMEDCT_US
C0037167	UMLSCUI
D012844	MESH_DESCRIPTOR_UI
9833444	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
KINEVAC	HUMAN PRESCRIPTION DRUG LABEL	1	0270-0556	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 ug	INTRAVENOUS	NDA	24 sections
KINEVAC	HUMAN PRESCRIPTION DRUG LABEL	1	0270-0556	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 ug	INTRAVENOUS	NDA	24 sections
SIncalide	HUMAN PRESCRIPTION DRUG LABEL	1	51808-203	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	3 ug	INTRAVENOUS	Unapproved drug other	8 sections