spinosad 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4623	168316-95-8

Description:

Molecule

Description

Synonyms:

spinosad
natroba

combination of spinosyns A and D; isolated from Saccharopolyspora spinosa

Molecular weight: 1477.96
Formula: C83H132N2O20
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 111.22
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 18, 2011	FDA	PARAPRO LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D007306	Insecticides
MeSH PA	D010575	Pesticides
FDA EPC	N0000181811	Pediculicide
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:38706	pediculicides

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pediculosis capitis	indication	81000006	DOID:5501

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Kills fleas	Indication
Cats	Flea infestations caused by Ctenocephalides felis	Indication
Dogs	Kills fleas	Indication
Dogs	Flea infestations caused by Ctenocephalides felis	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Comfortis	Elanco US Inc.	1
Trifexis	Elanco US Inc.	2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.9%	NATROBA	PARAPRO LLC	N022408	Jan. 18, 2011	RX	SUSPENSION	TOPICAL	6063771	July 25, 2023	NATROBA TOPICAL SUSPENSION IS A PEDICULICIDE INDICATED FOR THE TOPICAL TREATMENT OF HEAD LICE INFESTATION IN PATIENTS SIX (6) MONTHS OF AGE AND OLDER.
0.9%	NATROBA	PARAPRO LLC	N022408	Jan. 18, 2011	RX	SUSPENSION	TOPICAL	9895388	Nov. 25, 2033	THE PRODUCT COMPOSITION (NATROBA) IS FOR THE TOPICAL TREATMENT OF HUMAN SCABIES MITE INFESTATIONS BY MELTING AND DELIVERING THE ACTIVE INGREDIENT, SPINOSAD, TO THE STRATUM CORNEUM WHERE SCABIES MITES LIVE AND BREED

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
0.9%	NATROBA	PARAPRO LLC	N022408	Jan. 18, 2011	RX	SUSPENSION	TOPICAL	April 28, 2024	FOR THE TOPICAL TREATMENT OF SCABIES INFESTATIONS IN ADULT AND PEDIATRIC PATIENTS 4 YEARS OF AGE AND OLDER

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Nicotinic acetylcholine receptor	Ion channel		E0VB18_PEDHC E0VB20_PEDHC E0VDF4_PEDHC E0VDF5_PEDHC E0VDF7_PEDHC E0VP62_PEDHC	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
D09384	KEGG_DRUG
4030415	VUID
N0000182400	NUI
4030415	VANDF
CHEBI:39211	CHEBI
CHEMBL4297065	ChEMBL_ID
CHEMBL2040681	ChEMBL_ID
C415329	MESH_SUPPLEMENTAL_RECORD_UI
DB08823	DRUGBANK_ID
XPA88EAP6V	UNII
1085817	RXNORM
179433	MMSL
193425	MMSL
27738	MMSL
013617	NDDF
725677000	SNOMEDCT_US
763518006	SNOMEDCT_US
C0961781	UMLSCUI
56841558	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Spinosad	HUMAN PRESCRIPTION DRUG LABEL	1	28595-570	SUSPENSION	9 mg	TOPICAL	NDA	29 sections
Spinosad	HUMAN PRESCRIPTION DRUG LABEL	1	28595-570	SUSPENSION	9 mg	TOPICAL	NDA	29 sections
Natroba	HUMAN PRESCRIPTION DRUG LABEL	1	52246-929	SUSPENSION	9 mg	TOPICAL	NDA	27 sections