spinosad Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4623 168316-95-8

Description:

MoleculeDescription

Synonyms:

  • spinosad
  • natroba
combination of spinosyns A and D; isolated from Saccharopolyspora spinosa
  • Molecular weight: 1477.96
  • Formula: C83H132N2O20
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 111.22
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 18, 2011 FDA PARAPRO LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D007306 Insecticides
MeSH PA D010575 Pesticides
CHEBI has role CHEBI:38706 pediculicide

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pediculosis capitis indication 81000006 DOID:5501

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.9% NATROBA PARAPRO LLC N022408 Jan. 18, 2011 RX SUSPENSION TOPICAL 7030095 July 2, 2021 TOPICAL TREATMENT OF HEAD LICE INFESTATION IN PATIENTS FOUR (4) YEARS OF AGE AND OLDER
0.9% NATROBA PARAPRO LLC N022408 Jan. 18, 2011 RX SUSPENSION TOPICAL 6063771 July 25, 2023 NATROBA TOPICAL SUSPENSION IS A PEDICULICIDE INDICATED FOR THE TOPICAL TREATMENT OF HEAD LICE INFESTATION IN PATIENTS SIX (6) MONTHS OF AGE AND OLDER.

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Nicotinic acetylcholine receptor Ion channel AGONIST CHEMBL CHEMBL

External reference:

IDSource
D09384 KEGG_DRUG
4030415 VUID
N0000182400 NUI
C0961781 UMLSCUI
DB08823 DRUGBANK_ID
CHEBI:39211 CHEBI
XPA88EAP6V UNII
CHEMBL2040681 ChEMBL_ID
CHEMBL4297065 ChEMBL_ID
56841558 PUBCHEM_CID
C415329 MESH_SUPPLEMENTAL_RECORD_UI
763518006 SNOMEDCT_US
725677000 SNOMEDCT_US
299081 RXNORM
013617 NDDF
4030415 VANDF
27738 MMSL
193425 MMSL

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Spinosad HUMAN PRESCRIPTION DRUG LABEL 1 28595-570 SUSPENSION 9 mg TOPICAL NDA 18 sections
Natroba HUMAN PRESCRIPTION DRUG LABEL 1 52246-929 SUSPENSION 9 mg TOPICAL NDA 18 sections