levomefolic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4621 31690-09-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • L-methylfolate calcium
  • levomefolate magnesium
  • methylfolate
  • levomefolic acid
  • levomefolate calcium
  • metafolin
an ingredient in Contraceptives, Oral, Combined
  • Molecular weight: 459.46
  • Formula: C20H25N7O6
  • CLOGP: -0.74
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 7
  • TPSA: 198.48
  • ALOGS: -3.14
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPKAPK2,MARK4,MTOR,NTRK1,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 54
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,DYRK1B,EIF2AK3,EPHB4,GRK2,GRK3,MAP2K6,MAP3K14,MAPK7,PDK1,SIK2,STK33,TEK,TTK 17
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 24, 2010 FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Contraindicated product administered 135.58 11.53 3 42477 320136 90265831
Product dose omission issue 118.15 11.53 352 42128 291335 90294632
Glossodynia 111.26 11.53 11 42469 321768 90264199
Pericarditis 108.99 11.53 4 42476 270147 90315820
Systemic lupus erythematosus 107.14 11.53 20 42460 361876 90224091
Treatment failure 106.10 11.53 10 42470 303918 90282049
Product use in unapproved indication 102.98 11.53 17 42463 336219 90249748
Infusion related reaction 100.48 11.53 35 42445 416745 90169222
Diarrhoea 99.22 11.53 765 41715 938425 89647542
Off label use 92.78 11.53 241 42239 1102011 89483956
Maternal exposure during pregnancy 92.53 11.53 27 42453 360036 90225931
Drug intolerance 91.31 11.53 48 42432 447543 90138424
Wound 91.27 11.53 16 42464 302964 90283003
Fall 89.48 11.53 454 42026 481356 90104611
Helicobacter infection 89.33 11.53 4 42476 226846 90359121
Product use issue 82.48 11.53 26 42454 329893 90256074
Folliculitis 79.18 11.53 4 42476 204349 90381618
Unevaluable event 78.62 11.53 112 42368 54736 90531231
Device expulsion 74.71 11.53 94 42386 40792 90545175
Fatigue 72.60 11.53 842 41638 1153181 89432786
Feeling abnormal 67.78 11.53 202 42278 167033 90418934
Hepatic enzyme increased 67.40 11.53 43 42437 360693 90225274
Lower respiratory tract infection 65.84 11.53 18 42462 250641 90335326
Arthropathy 65.28 11.53 46 42434 366196 90219771
Nausea 59.34 11.53 786 41694 1109530 89476437
Full blood count decreased 58.66 11.53 71 42409 29618 90556349
Liver injury 58.48 11.53 6 42474 170561 90415406
Muscle spasms 56.58 11.53 251 42229 251632 90334335
Deep vein thrombosis 55.92 11.53 129 42351 91491 90494476
Type 2 diabetes mellitus 54.50 11.53 14 42466 203230 90382737
Device dislocation 52.22 11.53 69 42411 31413 90554554
General physical health deterioration 51.81 11.53 54 42426 355061 90230906
Therapy cessation 51.74 11.53 74 42406 36287 90549680
Dizziness 50.73 11.53 459 42021 588825 89997142
Therapeutic product effect decreased 50.59 11.53 34 42446 277537 90308430
Neuropathy peripheral 50.41 11.53 160 42320 136810 90449157
Toxicity to various agents 50.17 11.53 37 42443 287809 90298158
C-reactive protein increased 49.59 11.53 12 42468 181377 90404590
Intentional product use issue 49.22 11.53 20 42460 216872 90369095
Therapeutic product effect incomplete 47.16 11.53 16 42464 193880 90392087
Haemoglobin decreased 45.53 11.53 173 42307 161783 90424184
Blister 45.45 11.53 32 42448 254966 90331001
Drug hypersensitivity 44.71 11.53 94 42386 463515 90122452
Irritable bowel syndrome 44.12 11.53 21 42459 207427 90378540
Drug ineffective 43.78 11.53 427 42053 1383871 89202096
Ill-defined disorder 43.69 11.53 16 42464 184875 90401092
Headache 41.57 11.53 600 41880 862146 89723821
Constipation 41.06 11.53 248 42232 280147 90305820
Dehydration 40.10 11.53 189 42291 194258 90391709
Plasma cell myeloma 39.95 11.53 70 42410 40758 90545209
Discomfort 38.57 11.53 43 42437 274292 90311675
Joint swelling 38.45 11.53 115 42365 503185 90082782
Impaired healing 38.40 11.53 32 42448 234167 90351800
Flatulence 38.01 11.53 69 42411 41298 90544669
Joint range of motion decreased 37.02 11.53 9 42471 135634 90450333
Asthenia 36.29 11.53 396 42084 533355 90052612
Urinary tract infection 35.44 11.53 255 42225 305377 90280590
Back pain 35.28 11.53 262 42218 316913 90269054
Psoriasis 34.49 11.53 149 42331 147605 90438362
Fibromyalgia 34.04 11.53 28 42452 206241 90379726
Tremor 33.13 11.53 151 42329 153022 90432945
Intentional overdose 32.95 11.53 3 42477 93831 90492136
Pulmonary embolism 32.14 11.53 134 42346 130686 90455281
Bursitis 31.77 11.53 11 42469 131643 90454324
Hot flush 31.19 11.53 79 42401 59409 90526558
Injection site erythema 30.85 11.53 109 42371 98393 90487574
Pneumonia 30.76 11.53 444 42036 637615 89948352
Injection site pain 30.26 11.53 161 42319 173538 90412429
Prescribed overdose 29.71 11.53 5 42475 97620 90488347
Drug abuse 27.95 11.53 3 42477 82344 90503623
Influenza like illness 27.69 11.53 92 42388 80519 90505448
Wheezing 27.64 11.53 43 42437 238037 90347930
Grip strength decreased 27.61 11.53 5 42475 92571 90493396
Rheumatoid arthritis 27.57 11.53 83 42397 362531 90223436
Pelvic pain 27.56 11.53 35 42445 15322 90570645
Wound infection 27.25 11.53 8 42472 106394 90479573
Injection site haemorrhage 26.99 11.53 48 42432 28270 90557697
Alopecia 26.85 11.53 130 42350 494941 90091026
Mobility decreased 25.71 11.53 49 42431 250685 90335282
Blood potassium decreased 25.66 11.53 64 42416 47663 90538304
Obesity 25.14 11.53 9 42471 105498 90480469
Vaginal haemorrhage 24.81 11.53 49 42431 31222 90554745
Hip fracture 24.06 11.53 50 42430 33027 90552940
Peripheral venous disease 24.04 11.53 5 42475 83916 90502051
Hypersensitivity 23.73 11.53 121 42359 454556 90131411
Asthma 23.39 11.53 49 42431 242111 90343856
White blood cell count decreased 23.30 11.53 146 42334 166963 90419004
Eye swelling 23.26 11.53 46 42434 29340 90556627
Dyspnoea 22.58 11.53 556 41924 880399 89705568
Vision blurred 22.57 11.53 107 42373 110186 90475781
Nasal congestion 22.52 11.53 88 42392 83326 90502641
Exposure during pregnancy 22.40 11.53 49 42431 238361 90347606
Laboratory test abnormal 22.37 11.53 56 42424 41798 90544169
Skin discolouration 22.35 11.53 58 42422 44257 90541710
Depression 22.24 11.53 227 42253 300374 90285593
Hypervolaemia 22.08 11.53 48 42432 32709 90553258
Live birth 22.07 11.53 5 42475 79102 90506865
Atrial fibrillation 22.02 11.53 122 42358 133489 90452478
Epilepsy 21.39 11.53 6 42474 82200 90503767
Balance disorder 21.20 11.53 96 42384 96984 90488983
Anxiety 21.08 11.53 230 42250 309542 90276425
Blood cholesterol increased 21.02 11.53 41 42439 207971 90377996
Overdose 20.78 11.53 26 42454 157683 90428284
Gastrointestinal disorder 20.78 11.53 57 42423 256630 90329337
Cardiac failure congestive 20.38 11.53 96 42384 98598 90487369
Myalgia 20.21 11.53 146 42334 174979 90410988
Infection 19.66 11.53 95 42385 361999 90223968
Pulmonary arterial hypertension 19.54 11.53 40 42440 26147 90559820
Chills 19.46 11.53 117 42363 131864 90454103
Lung disorder 19.45 11.53 25 42455 149858 90436109
Sleep disorder 19.18 11.53 40 42440 197990 90387977
Pulmonary hypertension 18.78 11.53 53 42427 42470 90543497
Thrombosis 18.74 11.53 76 42404 73175 90512792
Pulmonary fibrosis 18.48 11.53 14 42466 107489 90478478
Swelling 18.37 11.53 118 42362 418940 90167027
Inflammation 18.22 11.53 35 42445 178557 90407410
Flushing 18.21 11.53 86 42394 88405 90497562
COVID-19 18.19 11.53 32 42448 168811 90417156
Dysgeusia 18.06 11.53 60 42420 52500 90533467
Fluid retention 17.68 11.53 85 42395 88006 90497961
Hypoxia 17.65 11.53 74 42406 72325 90513642
Autoimmune disorder 17.52 11.53 7 42473 76737 90509230
Multiple sclerosis relapse 17.34 11.53 59 42421 52246 90533721
Abdominal discomfort 17.26 11.53 142 42338 477186 90108781
Product complaint 17.07 11.53 26 42454 13474 90572493
Hypertension 17.05 11.53 135 42345 457397 90128570
Tooth disorder 17.04 11.53 42 42438 31048 90554919
Adverse event 16.94 11.53 18 42462 117400 90468567
Gallbladder disorder 16.89 11.53 32 42448 19771 90566196
Platelet count decreased 16.86 11.53 116 42364 136853 90449114
Injection site mass 16.79 11.53 34 42446 22056 90563911
Stomatitis 16.76 11.53 69 42411 274629 90311338
Red blood cell sedimentation rate increased 16.59 11.53 9 42471 82586 90503381
Condition aggravated 16.54 11.53 189 42291 595356 89990611
Bone pain 16.41 11.53 65 42415 61918 90524049
Dry skin 16.27 11.53 83 42397 87990 90497977
Dyspnoea exertional 16.17 11.53 72 42408 72216 90513751
Cellulitis 16.13 11.53 85 42395 91252 90494715
Lethargy 15.75 11.53 65 42415 63074 90522893
International normalised ratio increased 15.36 11.53 53 42427 47263 90538704
Hypophagia 15.10 11.53 44 42436 35893 90550074
Body height decreased 15.09 11.53 23 42457 11926 90574041
Oedema peripheral 15.08 11.53 186 42294 257729 90328238
Ageusia 15.00 11.53 27 42453 16049 90569918
Injection site bruising 14.78 11.53 56 42424 52251 90533716
Osteoarthritis 14.71 11.53 45 42435 195685 90390282
Administration site swelling 14.66 11.53 9 42471 1490 90584477
Pleural effusion 14.47 11.53 96 42384 111895 90474072
Pollakiuria 14.44 11.53 41 42439 32964 90553003
Hospice care 14.17 11.53 20 42460 9684 90576283
Restless legs syndrome 14.10 11.53 32 42448 22438 90563529
Drug-induced liver injury 14.00 11.53 13 42467 90305 90495662
Upper limb fracture 13.84 11.53 31 42449 21547 90564420
Injection site reaction 13.81 11.53 82 42398 91998 90493969
Multiple allergies 13.58 11.53 25 42455 15121 90570846
Plasma cell myeloma recurrent 13.44 11.53 13 42467 4215 90581752
Red blood cell count decreased 13.41 11.53 50 42430 46301 90539666
Intestinal dilatation 13.31 11.53 10 42470 2300 90583667
Swelling face 13.21 11.53 74 42406 81278 90504689
Liver disorder 13.05 11.53 23 42457 121246 90464721
Cardiac pacemaker insertion 12.98 11.53 13 42467 4394 90581573
Suicide attempt 12.72 11.53 10 42470 75389 90510578
Nervousness 12.71 11.53 40 42440 34016 90551951
Cough 12.65 11.53 243 42237 368719 90217248
Intentional product misuse 12.63 11.53 14 42466 89590 90496377
Heavy menstrual bleeding 12.62 11.53 29 42451 20501 90565466
Weight decreased 12.61 11.53 249 42231 379661 90206306
Bladder disorder 12.58 11.53 20 42460 10752 90575215
Complication associated with device 12.54 11.53 28 42452 19421 90566546
Bronchitis 12.52 11.53 118 42362 152809 90433158
Nail disorder 12.52 11.53 6 42474 59061 90526906
Therapeutic response unexpected 12.46 11.53 30 42450 21850 90564117
Endometriosis 12.43 11.53 15 42465 6233 90579734
Cardiac disorder 12.24 11.53 56 42424 56816 90529151
DNA antibody negative 12.10 11.53 3 42477 39 90585928
Drug interaction 12.02 11.53 78 42402 276375 90309592
Gait disturbance 12 11.53 180 42300 260316 90325651
Haematocrit decreased 12.00 11.53 45 42435 41787 90544180
Anaemia 11.97 11.53 232 42248 352570 90233397
Chest discomfort 11.95 11.53 108 42372 138257 90447710
Therapy change 11.93 11.53 17 42463 8305 90577662
Epistaxis 11.62 11.53 74 42406 85051 90500916
Multiple sclerosis 11.61 11.53 34 42446 27806 90558161
Insomnia 11.55 11.53 220 42260 333254 90252713

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 128.30 12.32 105 24054 638230 41958946
Product use in unapproved indication 84.56 12.32 5 24154 184451 42412725
Fatigue 70.31 12.32 454 23705 435187 42161989
Plasma cell myeloma 54.23 12.32 97 24062 47481 42549695
Drug abuse 47.50 12.32 3 24156 104768 42492408
Diarrhoea 45.13 12.32 428 23731 460421 42136755
Full blood count decreased 43.60 12.32 56 24103 20504 42576672
Asthenia 42.90 12.32 289 23870 280504 42316672
Product dose omission issue 42.73 12.32 187 23972 154178 42442998
Fall 40.49 12.32 249 23910 234271 42362905
Laboratory test abnormal 38.74 12.32 56 24103 22922 42574254
White blood cell count decreased 37.07 12.32 142 24017 110254 42486922
Completed suicide 35.47 12.32 6 24153 96459 42500717
Toxicity to various agents 32.28 12.32 50 24109 229086 42368090
Psoriasis 30.78 12.32 78 24081 48526 42548650
Drug interaction 29.09 12.32 68 24091 266931 42330245
COVID-19 28.62 12.32 15 24144 115933 42481243
Adverse drug reaction 27.91 12.32 64 24095 37370 42559806
Dizziness 27.60 12.32 238 23921 249016 42348160
Drug ineffective 26.29 12.32 230 23929 629967 41967209
Pneumonia 25.81 12.32 358 23801 421791 42175385
Viral infection 23.29 12.32 44 24115 22439 42574737
General physical health deterioration 23.26 12.32 31 24128 151215 42445961
Neuropathy peripheral 20.68 12.32 113 24046 101740 42495436
Muscle spasms 20.63 12.32 100 24059 85944 42511232
Intentional product misuse 20.36 12.32 5 24154 61895 42535281
Sinusitis 19.41 12.32 65 24094 47227 42549949
Intentional overdose 19.36 12.32 3 24156 51453 42545723
Constipation 19.00 12.32 157 24002 162134 42435042
Feeling abnormal 18.86 12.32 84 24075 69702 42527474
Treatment failure 18.85 12.32 6 24153 62618 42534558
Memory impairment 18.85 12.32 67 24092 50155 42547021
Rash 18.58 12.32 239 23920 276715 42320461
Influenza 18.46 12.32 77 24082 62098 42535078
Peripheral swelling 18.22 12.32 100 24059 90170 42507006
Intentional product use issue 18.15 12.32 9 24150 71824 42525352
Interstitial lung disease 18.13 12.32 11 24148 78451 42518725
Febrile neutropenia 18.10 12.32 50 24109 185653 42411523
Multiple organ dysfunction syndrome 18.07 12.32 17 24142 97018 42500158
Overdose 17.84 12.32 20 24139 105244 42491932
Unevaluable event 17.66 12.32 51 24108 34237 42562939
Haemoglobin decreased 17.06 12.32 131 24028 132340 42464836
Influenza like illness 17.02 12.32 48 24111 31792 42565384
Dehydration 16.51 12.32 137 24022 141630 42455546
Cardiac disorder 16.45 12.32 63 24096 48869 42548307
Cytokine release syndrome 15.86 12.32 3 24156 44524 42552652
Hepatic function abnormal 15.41 12.32 5 24154 51562 42545614
Small intestinal obstruction 14.79 12.32 31 24128 17030 42580146
Drug ineffective for unapproved indication 14.66 12.32 4 24155 46159 42551017
Coma 14.64 12.32 6 24153 53548 42543628
Flatulence 14.52 12.32 39 24120 25113 42572063
Mental status changes 13.97 12.32 54 24105 42061 42555115
Myelosuppression 13.84 12.32 3 24156 40458 42556718
Blood testosterone decreased 13.07 12.32 15 24144 4887 42592289
Platelet count decreased 12.62 12.32 127 24032 138454 42458722
Headache 12.60 12.32 198 23961 239171 42358005
Hypervolaemia 12.49 12.32 35 24124 23090 42574086
Back pain 12.46 12.32 129 24030 141647 42455529
Multiple sclerosis relapse 12.46 12.32 26 24133 14238 42582938

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 181.94 11.27 270 52201 1499915 109036913
Product use in unapproved indication 152.71 11.27 17 52454 447360 110089468
Product dose omission issue 115.13 11.27 375 52096 321407 110215421
Treatment failure 104.15 11.27 7 52464 277227 110259601
Contraindicated product administered 103.91 11.27 3 52468 248264 110288564
Fall 103.37 11.27 561 51910 602921 109933907
Completed suicide 88.52 11.27 7 52464 242374 110294454
Drug intolerance 85.56 11.27 43 52428 406469 110130359
Device expulsion 82.65 11.27 87 52384 30804 110506024
Diarrhoea 81.75 11.27 862 51609 1138643 109398185
Fatigue 77.69 11.27 899 51572 1215059 109321769
Infusion related reaction 76.26 11.27 43 52428 381119 110155709
Systemic lupus erythematosus 74.51 11.27 15 52456 254323 110282505
Toxicity to various agents 73.25 11.27 72 52399 480483 110056345
Dizziness 72.26 11.27 572 51899 697621 109839207
Plasma cell myeloma 68.65 11.27 114 52357 62822 110474006
Duodenal ulcer perforation 68.18 11.27 4 52467 177696 110359132
Drug abuse 68.05 11.27 4 52467 177407 110359421
Glossodynia 67.35 11.27 12 52459 221992 110314836
Helicobacter infection 67.12 11.27 5 52466 181872 110354956
Product use issue 67.03 11.27 32 52439 311663 110225165
Drug ineffective 63.15 11.27 443 52028 1520097 109016731
Pericarditis 61.97 11.27 14 52457 219100 110317728
Asthenia 61.44 11.27 546 51925 688453 109848375
Feeling abnormal 60.45 11.27 206 52265 180505 110356323
Lower respiratory tract infection 60.39 11.27 20 52451 243086 110293742
Deep vein thrombosis 60.18 11.27 174 52297 139713 110397115
Dehydration 58.37 11.27 275 52196 279236 110257592
General physical health deterioration 56.79 11.27 71 52400 425224 110111604
Haemoglobin decreased 56.60 11.27 251 52220 248476 110288352
Intentional product use issue 55.56 11.27 24 52447 247882 110288946
Therapy cessation 54.02 11.27 85 52386 44772 110492056
Maternal exposure during pregnancy 53.53 11.27 27 52444 254856 110281972
Full blood count decreased 50.51 11.27 69 52402 32030 110504798
Hepatic enzyme increased 50.12 11.27 47 52424 320845 110215983
Therapeutic product effect incomplete 49.62 11.27 22 52449 223783 110313045
Unevaluable event 47.65 11.27 94 52377 59133 110477695
Folliculitis 46.83 11.27 11 52460 167642 110369186
Nausea 46.80 11.27 834 51637 1234856 109301972
Drug hypersensitivity 46.17 11.27 91 52380 453999 110082829
Device dislocation 45.19 11.27 65 52406 31639 110505189
C-reactive protein increased 44.40 11.27 24 52447 217895 110318933
Intentional overdose 42.80 11.27 6 52465 132495 110404333
COVID-19 41.78 11.27 33 52438 245027 110291801
Type 2 diabetes mellitus 41.59 11.27 16 52455 177216 110359612
Wound 40.69 11.27 31 52440 234406 110302422
Arthropathy 40.49 11.27 46 52425 287476 110249352
Irritable bowel syndrome 39.92 11.27 14 52457 164201 110372627
Pneumonia 39.87 11.27 610 51861 876104 109660724
Liver injury 39.83 11.27 11 52460 150402 110386426
Joint swelling 38.26 11.27 97 52374 442748 110094080
Muscle spasms 38.05 11.27 244 52227 277913 110258915
Dyspnoea 38.00 11.27 736 51735 1106136 109430692
Hypervolaemia 37.99 11.27 77 52394 49383 110487445
Intentional product misuse 36.57 11.27 9 52462 132895 110403933
Drug interaction 36.31 11.27 119 52352 500064 110036764
Headache 36.00 11.27 603 51868 881774 109655054
Fibromyalgia 34.56 11.27 19 52452 170890 110365938
Myelosuppression 33.67 11.27 3 52468 94337 110442491
Ill-defined disorder 32.35 11.27 17 52454 156836 110379992
Fluid retention 31.95 11.27 108 52363 94199 110442629
Influenza like illness 31.51 11.27 103 52368 88309 110448519
Overdose 31.21 11.27 39 52432 233755 110303073
Cardiac failure congestive 31.07 11.27 148 52323 150852 110385976
Flatulence 30.75 11.27 73 52398 52076 110484752
Therapeutic product effect decreased 30.33 11.27 43 52428 244273 110292555
Mental status changes 30.17 11.27 92 52379 76030 110460798
Bursitis 30.03 11.27 12 52459 129906 110406922
Hospice care 29.64 11.27 33 52438 12440 110524388
Joint range of motion decreased 28.58 11.27 11 52460 121821 110415007
Hip fracture 28.52 11.27 56 52415 35095 110501733
Blister 28.24 11.27 40 52431 227336 110309492
Constipation 28.01 11.27 276 52195 357510 110179318
Urinary tract infection 27.67 11.27 256 52215 326026 110210802
Injection site pain 27.42 11.27 161 52310 177761 110359067
Hypercholesterolaemia 27.34 11.27 5 52466 90832 110445996
Mobility decreased 27.33 11.27 44 52427 237378 110299450
Haematocrit decreased 27.23 11.27 81 52390 66036 110470792
Multiple sclerosis relapse 27.14 11.27 68 52403 50172 110486656
White blood cell count decreased 27.04 11.27 194 52277 229196 110307632
Injection site erythema 26.90 11.27 102 52369 94074 110442754
Pelvic pain 26.19 11.27 35 52436 15907 110520921
Tremor 26.18 11.27 175 52296 202057 110334771
Back pain 26.09 11.27 280 52191 370716 110166112
Blood potassium decreased 25.90 11.27 70 52401 54044 110482784
Rheumatoid arthritis 25.57 11.27 66 52405 299547 110237281
Dyspnoea exertional 25.16 11.27 107 52364 103953 110432875
Grip strength decreased 25.04 11.27 4 52467 80170 110456658
Cellulitis 24.84 11.27 122 52349 125894 110410934
Viral infection 24.70 11.27 68 52403 53071 110483757
Asthma 24.69 11.27 51 52420 250240 110286588
Peripheral venous disease 24.54 11.27 5 52466 84112 110452716
International normalised ratio increased 23.98 11.27 93 52378 86679 110450149
Cytokine release syndrome 23.14 11.27 3 52468 70303 110466525
Pulmonary hypertension 23.07 11.27 68 52403 55152 110481676
Pulmonary arterial hypertension 23.01 11.27 49 52422 32519 110504309
Depression 23.01 11.27 241 52230 317094 110219734
Vaginal haemorrhage 22.88 11.27 42 52429 25032 110511796
Anxiety 22.69 11.27 257 52214 344821 110192007
Injection site haemorrhage 22.54 11.27 49 52422 32979 110503849
Flushing 22.53 11.27 104 52367 104632 110432196
Obesity 22.34 11.27 13 52458 113338 110423490
Pulmonary embolism 22.24 11.27 176 52295 214298 110322530
Small intestinal obstruction 22.23 11.27 48 52423 32165 110504663
Nasal congestion 22.19 11.27 99 52372 98183 110438645
Epilepsy 21.97 11.27 10 52461 100199 110436629
Chills 21.78 11.27 160 52311 190420 110346408
Complication associated with device 21.40 11.27 36 52435 20037 110516791
Eye swelling 21.39 11.27 48 52423 33000 110503828
Coma 21.20 11.27 15 52456 117854 110418974
Hypoxia 21.13 11.27 119 52352 129396 110407432
Discomfort 20.96 11.27 44 52427 214663 110322165
Oedema peripheral 20.81 11.27 243 52228 328417 110208411
Neuropathy peripheral 20.76 11.27 151 52320 179126 110357702
Therapeutic response decreased 20.58 11.27 10 52461 96489 110440339
Live birth 20.54 11.27 4 52467 69480 110467348
Cardiac disorder 20.47 11.27 81 52390 76199 110460629
Prescribed overdose 20.39 11.27 8 52463 87573 110449255
Impaired healing 20.33 11.27 39 52432 196678 110340150
Dysgeusia 20.15 11.27 76 52395 69909 110466919
Gastrointestinal disorder 20.11 11.27 54 52417 241898 110294930
Wheezing 19.71 11.27 59 52412 255171 110281657
Pleural effusion 19.63 11.27 148 52323 177561 110359267
Weight decreased 19.43 11.27 321 52150 467736 110069092
Inflammation 19.37 11.27 39 52432 193199 110343629
Platelet count decreased 19.12 11.27 180 52291 230263 110306565
Product complaint 18.97 11.27 28 52443 13944 110522884
Autoimmune disorder 18.88 11.27 4 52467 65479 110471349
Drug ineffective for unapproved indication 18.61 11.27 13 52458 102825 110434003
Lung disorder 18.34 11.27 36 52435 180011 110356817
Drug-induced liver injury 18.24 11.27 18 52453 120049 110416779
Bronchitis 18.03 11.27 132 52339 156900 110379928
Hepatic function abnormal 17.94 11.27 10 52461 89285 110447543
Eosinophilia 17.85 11.27 3 52468 57933 110478895
Infective pulmonary exacerbation of cystic fibrosis 17.80 11.27 28 52443 14743 110522085
Wound infection 17.72 11.27 12 52459 96453 110440375
Liver disorder 17.68 11.27 25 52446 142218 110394610
Condition aggravated 17.67 11.27 244 52227 734592 109802236
Transfusion 17.62 11.27 38 52433 25434 110511394
Myalgia 17.61 11.27 172 52299 222209 110314619
Psoriasis 17.43 11.27 120 52351 139873 110396955
Bone pain 17.34 11.27 69 52402 65064 110471764
Hypersensitivity 16.98 11.27 117 52354 403881 110132947
Gastrointestinal haemorrhage 16.70 11.27 135 52336 165383 110371445
Vision blurred 16.30 11.27 111 52360 128911 110407917
Laryngeal pain 16.29 11.27 17 52454 5958 110530870
Atelectasis 16.10 11.27 46 52425 36666 110500162
Hot flush 16.04 11.27 68 52403 65968 110470860
Atrial fibrillation 15.98 11.27 173 52298 229469 110307359
Stomatitis 15.89 11.27 70 52401 270172 110266656
Abdominal pain 15.81 11.27 336 52135 512653 110024175
Depressed level of consciousness 15.75 11.27 18 52453 112260 110424568
Multiple organ dysfunction syndrome 15.74 11.27 30 52441 151680 110385148
Agranulocytosis 15.47 11.27 5 52466 61755 110475073
Illness 15.39 11.27 10 52461 82161 110454667
Red blood cell count decreased 15.33 11.27 67 52404 65856 110470972
Gallbladder disorder 15.28 11.27 32 52439 20997 110515831
Chest pain 15.20 11.27 257 52214 376118 110160710
Infection 15.16 11.27 105 52366 362095 110174733
Suicide attempt 15.14 11.27 16 52455 103378 110433450
Pain in jaw 15.09 11.27 56 52415 51121 110485707
Hypertension 15.05 11.27 162 52309 509922 110026906
Hypophagia 15.03 11.27 57 52414 52569 110484259
Interstitial lung disease 14.95 11.27 27 52444 139307 110397521
Cholestasis 14.84 11.27 6 52465 64512 110472316
Heavy menstrual bleeding 14.42 11.27 27 52444 16338 110520490
Cytomegalovirus infection 14.38 11.27 4 52467 54440 110482388
Disease progression 14.37 11.27 178 52293 243856 110292972
Exposure during pregnancy 14.19 11.27 37 52434 167387 110369441
Alopecia 14.18 11.27 108 52363 364645 110172183
Drug reaction with eosinophilia and systemic symptoms 14.05 11.27 11 52460 82084 110454744
Thrombosis 14.03 11.27 94 52377 108568 110428260
Nail disorder 13.97 11.27 5 52466 57930 110478898
Rotator cuff syndrome 13.92 11.27 27 52444 16767 110520061
Sleep disorder 13.88 11.27 48 52423 198596 110338232
Pulmonary fibrosis 13.63 11.27 17 52454 102025 110434803
Application site erythema 13.60 11.27 15 52456 5595 110531233
Osteoarthritis 13.54 11.27 43 52428 182580 110354248
Gait disturbance 13.52 11.27 196 52275 278012 110258816
Bone erosion 13.03 11.27 3 52468 46368 110490460
Blood glucose decreased 12.98 11.27 37 52434 29451 110507377
Blepharospasm 12.78 11.27 5 52466 54846 110481982
Lethargy 12.72 11.27 82 52389 93494 110443334
Rib fracture 12.62 11.27 40 52431 33730 110503098
Granulocytopenia 12.50 11.27 22 52449 12693 110524135
Balance disorder 12.26 11.27 96 52375 116464 110420364
Cardiac pacemaker insertion 12.19 11.27 15 52456 6286 110530542
Application site pain 12.13 11.27 14 52457 5485 110531343
DNA antibody negative 12.06 11.27 3 52468 39 110536789
Influenza 12.04 11.27 128 52343 168973 110367855
Hepatitis 12.03 11.27 15 52456 90039 110446789
Application site discolouration 12.00 11.27 7 52464 1042 110535786
Transient ischaemic attack 11.93 11.27 61 52410 63921 110472907
Pollakiuria 11.91 11.27 47 52424 44148 110492680
Aspartate aminotransferase increased 11.83 11.27 122 52349 159814 110377014
Febrile neutropenia 11.75 11.27 95 52376 316672 110220156
Sleep disorder due to a general medical condition 11.74 11.27 5 52466 52107 110484721
Hospitalisation 11.66 11.27 111 52360 142382 110394446
Red blood cell sedimentation rate increased 11.60 11.27 12 52459 78290 110458538
Anaphylactic shock 11.52 11.27 5 52466 51541 110485287
Swelling face 11.40 11.27 79 52392 92242 110444586

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0008658 Folic Acid
FDA EPC N0000178369 Folate Analog
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:75835 anti-anaemic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Contraception indication 13197004
Acne vulgaris indication 88616000
Polycystic ovaries off-label use 69878008
Hyperlipoproteinemia contraindication 3744001 DOID:1168
Hypocalcemia contraindication 5291005
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Myocardial infarction contraindication 22298006 DOID:5844
Diplopia contraindication 24982008
Retinal hemorrhage contraindication 28998008
Depressive disorder contraindication 35489007
Chloasma contraindication 36209000
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Body fluid retention contraindication 43498006
Thrombosis of retinal vein contraindication 46085004
Humoral hypercalcemia of malignancy contraindication 47709007
Chronic heart failure contraindication 48447003
Dementia contraindication 52448006
Hepatic porphyria contraindication 55056006 DOID:3133
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Acute nephropathy contraindication 58574008
Thrombophlebitis contraindication 64156001 DOID:3875
Intermenstrual bleeding - irregular contraindication 64996003
Diabetes mellitus contraindication 73211009 DOID:9351
Epilepsy contraindication 84757009 DOID:1826
Breast lump contraindication 89164003
Kidney disease contraindication 90708001 DOID:557
Uterine leiomyoma contraindication 95315005 DOID:13223
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Endometriosis contraindication 129103003
Bed-ridden contraindication 160685001
Mammography abnormal contraindication 168750009
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Thrombophilia contraindication 234467004 DOID:2452
Disease of liver contraindication 235856003 DOID:409
Endometrial carcinoma contraindication 254878006 DOID:2871
Chorea contraindication 271700006
Pregnancy, function contraindication 289908002
Hypertriglyceridemia contraindication 302870006
Functional visual loss contraindication 313165001
Malignant tumor of ovary contraindication 363443007 DOID:2394
Thromboembolic disorder contraindication 371039008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Cardiovascular event risk contraindication 395112001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Estrogen receptor positive tumor contraindication 416053008
Porphyria contraindication 418470004
Optic disc edema contraindication 423341008 DOID:146
Family history of malignant neoplasm of breast contraindication 429740004
Hypertensive urgency contraindication 443482000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 4.77 acidic
pKa3 11.04 acidic
pKa4 12.96 acidic
pKa5 5.7 Basic
pKa6 5.28 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
3MG,N/A;0.02MG,N/A;0.451MG,0.451MG BEYAZ BAYER HLTHCARE N022532 Sept. 24, 2010 RX TABLET ORAL 11617751 July 17, 2030 PREVENTION OF PREGNANCY
3MG,N/A;0.02MG,N/A;0.451MG,0.451MG BEYAZ BAYER HLTHCARE N022532 Sept. 24, 2010 RX TABLET ORAL 11617751 July 17, 2030 RAISE FOLATE LEVELS IN WOMEN WHO CHOOSE TO USE AN ORAL CONTRACEPTIVE AS THEIR METHOD OF CONTRACEPTION FOR THE PURPOSE OF REDUCING THE RISK OF A NEURAL TUBE DEFECT IN A PREGNANCY
3MG,N/A;0.02MG,N/A;0.451MG,0.451MG BEYAZ BAYER HLTHCARE N022532 Sept. 24, 2010 RX TABLET ORAL 11617751 July 17, 2030 TREATMENT OF MODERATE ACNE VULGARIS IN WOMEN AT LEAST 14 YEARS OF AGE IF THE PATIENT DESIRES AN ORAL CONTRACEPTIVE FOR BIRTH CONTROL
3MG,N/A;0.02MG,N/A;0.451MG,0.451MG BEYAZ BAYER HLTHCARE N022532 Sept. 24, 2010 RX TABLET ORAL 11617751 July 17, 2030 TREATMENT OF MOOD CHANGES AND/OR ANXIETY AS SYMPTOMS OF PREMENSTRUAL DYSPHORIC DISORDER (PMDD) IN WOMEN WHO CHOOSE TO USE AN ORAL CONTRACEPTIVE AS THEIR METHOD OF CONTRACEPTION
3MG,N/A;0.03MG,N/A;0.451MG,0.451MG SAFYRAL BAYER HLTHCARE N022574 Dec. 16, 2010 RX TABLET ORAL 11617751 July 17, 2030 PREVENTION OF PREGNANCY
3MG,N/A;0.03MG,N/A;0.451MG,0.451MG SAFYRAL BAYER HLTHCARE N022574 Dec. 16, 2010 RX TABLET ORAL 11617751 July 17, 2030 RAISE FOLATE LEVELS IN WOMEN WHO CHOOSE TO USE AN ORAL CONTRACEPTIVE AS THEIR METHOD OF CONTRACEPTION FOR THE PURPOSE OF REDUCING THE RISK OF A NEURAL TUBE DEFECT IN A PREGNANCY

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme WOMBAT-PK

External reference:

IDSource
D09353 KEGG_DRUG
1429498-11-2 SECONDARY_CAS_RN
151533-22-1 SECONDARY_CAS_RN
4030850 VANDF
CHEBI:136009 CHEBI
CHEMBL1231574 ChEMBL_ID
CHEMBL1615371 ChEMBL_ID
C005984 MESH_SUPPLEMENTAL_RECORD_UI
C569381 MESH_SUPPLEMENTAL_RECORD_UI
8917 INN_ID
DB11256 DRUGBANK_ID
8S95DH25XC UNII
1025342 RXNORM
172826 MMSL
27556 MMSL
27740 MMSL
362111 MMSL
d07578 MMSL
007202 NDDF
015780 NDDF
432164001 SNOMEDCT_US
432165000 SNOMEDCT_US
449236003 SNOMEDCT_US
C2825462 UMLSCUI
C2F PDB_CHEM_ID
THH PDB_CHEM_ID
135398561 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 0.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1020 ug ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 0.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1020 ug ORAL unapproved drug other 14 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 35 ug ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 81 ug ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 108 ug ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 108 ug ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 108 ug ORAL UNAPPROVED DRUG OTHER 12 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 600 ug ORAL UNAPPROVED DRUG OTHER 12 sections
Multitol-M HUMAN PRESCRIPTION DRUG LABEL 17 59088-005 TABLET 2040 ug ORAL unapproved drug other 11 sections
Finazol HUMAN PRESCRIPTION DRUG LABEL 24 59088-008 TABLET 1000 ug ORAL unapproved drug other 13 sections
Prenatol-M HUMAN PRESCRIPTION DRUG LABEL 20 59088-009 TABLET 2040 ug ORAL unapproved drug other 13 sections
Multivitamin HUMAN PRESCRIPTION DRUG LABEL 11 59088-018 TABLET, CHEWABLE 1000 ug ORAL unapproved drug other 11 sections
Boostervite HUMAN PRESCRIPTION DRUG LABEL 16 59088-022 TABLET 1000 ug ORAL unapproved drug other 15 sections
Vitalux HUMAN PRESCRIPTION DRUG LABEL 20 59088-139 TABLET 1000 ug ORAL unapproved drug other 13 sections
Menatrol HUMAN PRESCRIPTION DRUG LABEL 6 59088-156 CAPSULE 1000 ug ORAL unapproved drug other 17 sections
Davimet-M HUMAN PRESCRIPTION DRUG LABEL 11 59088-158 TABLET, CHEWABLE 1000 ug ORAL unapproved drug other 11 sections
Davimet with Iron HUMAN PRESCRIPTION DRUG LABEL 12 59088-160 TABLET 1000 ug ORAL unapproved drug other 13 sections
Diatrol HUMAN PRESCRIPTION DRUG LABEL 17 59088-162 TABLET 1000 ug ORAL unapproved drug other 11 sections
Davimet with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 59088-170 TABLET, CHEWABLE 1000 ug ORAL unapproved drug other 10 sections
Inflamex HUMAN PRESCRIPTION DRUG LABEL 5 59088-191 CAPSULE 1700 ug ORAL unapproved drug other 11 sections
Folixate HUMAN PRESCRIPTION DRUG LABEL 2 59088-301 TABLET 1000 ug ORAL unapproved drug other 10 sections
Livita Adults HUMAN PRESCRIPTION DRUG LABEL 17 59088-659 LIQUID 1000 ug ORAL unapproved drug other 10 sections
Livita Children HUMAN PRESCRIPTION DRUG LABEL 17 59088-660 LIQUID 333 ug ORAL unapproved drug other 10 sections
PaxLyte HUMAN PRESCRIPTION DRUG LABEL 18 64661-217 CAPSULE 7 mg ORAL unapproved drug other 9 sections
EnBrace HR HUMAN PRESCRIPTION DRUG LABEL 16 64661-650 CAPSULE, DELAYED RELEASE PELLETS 5.23 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Biopar delta-FORTE HUMAN PRESCRIPTION DRUG LABEL 6 64661-793 CAPSULE 7 mg ORAL unapproved drug other 11 sections
PRENATE DHA HUMAN PRESCRIPTION DRUG LABEL 11 75854-312 CAPSULE, GELATIN COATED 600 ug ORAL unapproved drug other 12 sections
Prenate Essential HUMAN PRESCRIPTION DRUG LABEL 14 75854-313 CAPSULE, GELATIN COATED 600 ug ORAL unapproved drug other 13 sections