polydatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4613 | 27208-80-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
from Polygonum cuspidatum
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22586 | antioxidants |
| CHEBI has role | CHEBI:25212 | metabolites |
| CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
| CHEBI has role | CHEBI:62868 | hepatoprotective agents |
| CHEBI has role | CHEBI:76595 | nephroprotective agents |
| CHEBI has role | CHEBI:176497 | geroprotectors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.51 | acidic |
| pKa2 | 8.82 | acidic |
| pKa3 | 11.99 | acidic |
| pKa4 | 12.61 | acidic |
| pKa5 | 13.44 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucose-6-phosphate 1-dehydrogenase | Enzyme | IC50 | 4.13 | CHEMBL | |||||
| Aldose reductase | Enzyme | IC50 | 4 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:8198 | CHEBI |
| CHEMBL142652 | ChEMBL_ID |
| C058229 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11263 | DRUGBANK_ID |
| XM261C37CQ | UNII |
| 1364277 | RXNORM |
| C0071538 | UMLSCUI |
| 5281718 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Sooryehan Pure-Whitening | HUMAN OTC DRUG LABEL | 1 | 53208-441 | CREAM | 0.22 mL | TOPICAL | unapproved drug other | 10 sections |
| Sooryehan Pure-Whitening Essence | HUMAN OTC DRUG LABEL | 1 | 53208-442 | CREAM | 0.22 1 | TOPICAL | unapproved drug other | 10 sections |
| Sooryehan Pure Whitening Spot Treatment | HUMAN OTC DRUG LABEL | 1 | 53208-444 | CREAM | 0.21 mL | TOPICAL | OTC monograph not final | 10 sections |