sucrose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4610	57-50-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sucrose cane sugar saccharose D-Sucrose	A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener. Molecular weight: 342.30 Formula: C12H22O11 CLOGP: -3.09 LIPINSKI: 2 HAC: 11 HDO: 8 TPSA: 189.53 ALOGS: 0.38 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sucrose
cane sugar
saccharose
D-Sucrose

A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.

Molecular weight: 342.30
Formula: C12H22O11
CLOGP: -3.09
LIPINSKI: 2
HAC: 11
HDO: 8
TPSA: 189.53
ALOGS: 0.38
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	169.61	36.75	47	1899	8554	34946431
Appendicitis	144.42	36.75	47	1899	14760	34940225
Cardiogenic shock	117.49	36.75	47	1899	26571	34928414
Stress	114.89	36.75	48	1898	30299	34924686
Ventricular fibrillation	113.47	36.75	44	1902	22910	34932075
Blood phosphorus increased	110.95	36.75	33	1913	7688	34947297
Ascites	95.22	36.75	48	1898	46523	34908462
Abdominal distension	90.40	36.75	50	1896	58442	34896543
Myasthenia gravis	88.24	36.75	27	1919	6913	34948072
Blood uric acid increased	79.55	36.75	27	1919	9597	34945388
Dry mouth	79.43	36.75	37	1909	30128	34924857
Multiple organ dysfunction syndrome	75.44	36.75	49	1897	76517	34878468
Hyponatraemia	72.00	36.75	49	1897	82642	34872343
General physical health deterioration	60.93	36.75	53	1893	128216	34826769
Abdominal pain	57.24	36.75	57	1889	163561	34791424
Blood cholesterol increased	56.53	36.75	26	1920	20517	34934468
Constipation	54.03	36.75	51	1895	136931	34818054
Sepsis	42.26	36.75	49	1897	166512	34788473
Incorrect route of product administration	38.36	36.75	18	1928	14827	34940158

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	187.28	25.93	47	2996	8504	79732841
Appendicitis	145.98	25.93	47	2996	20747	79720598
Ventricular fibrillation	115.34	25.93	44	2999	31882	79709463
Cardiogenic shock	113.82	25.93	47	2996	41867	79699478
Blood phosphorus increased	109.20	25.93	32	3011	10315	79731030
Stress	96.27	25.93	51	2992	79561	79661784
Abdominal distension	94.47	25.93	58	2985	119592	79621753
Myasthenia gravis	87.46	25.93	27	3016	10372	79730973
Ascites	87.39	25.93	47	2996	75515	79665830
Blood uric acid increased	80.80	25.93	27	3016	13333	79728012
Multiple organ dysfunction syndrome	71.96	25.93	49	2994	120197	79621148
Dry mouth	60.20	25.93	39	3004	87980	79653365
Hyponatraemia	54.95	25.93	49	2994	177799	79563546
Constipation	50.66	25.93	58	2985	282992	79458353
General physical health deterioration	45.23	25.93	54	2989	275184	79466161
Abdominal pain	44.70	25.93	64	2979	389505	79351840
Sepsis	42.86	25.93	52	2991	269376	79471969
Drug therapy	38.58	25.93	9	3034	1192	79740153
Incorrect route of product administration	35.56	25.93	20	3023	34909	79706436
Hyperphosphataemia	35.05	25.93	12	3031	6364	79734981
Analgesic therapy	34.74	25.93	8	3035	1001	79740344
Sleep disorder therapy	34.62	25.93	8	3035	1016	79740329
Neuralgia	33.67	25.93	19	3024	33365	79707980
Blood cholesterol increased	31.79	25.93	26	3017	83694	79657651
Somnolence	28.42	25.93	40	3003	238941	79502404

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D005421	Flavoring Agents
MeSH PA	D005503	Food Additives
MeSH PA	D013549	Sweetening Agents
CHEBI has role	CHEBI:25728	osmolytes
CHEBI has role	CHEBI:50505	sweeteners
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:84735	algal metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.07	acidic
pKa2	13.11	acidic
pKa3	13.8	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D00025	KEGG_DRUG
4019358	VUID
N0000147528	NUI
4019358	VANDF
CHEBI:17992	CHEBI
SUC	PDB_CHEM_ID
CHEMBL253582	ChEMBL_ID
5411	IUPHAR_LIGAND_ID
DB02772	DRUGBANK_ID
C151H8M554	UNII
10159	RXNORM
NOCODE	MMSL
002598	NDDF
11320009	SNOMEDCT_US
9745007	SNOMEDCT_US
C0038636	UMLSCUI
D013395	MESH_DESCRIPTOR_UI
5988	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Select Brand Anti-Nausea	HUMAN OTC DRUG LABEL	2	15127-291	SOLUTION	3.74 g	ORAL	unapproved drug other	11 sections
Emetrol Cherry	HUMAN OTC DRUG LABEL	2	68788-9801	SOLUTION	3.74 g	ORAL	Unapproved drug other	13 sections