ubidecarenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists	4607	303-98-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: neuquinon ubidecarenone Vitamin Q	prevents hemorrhagic state Molecular weight: 863.37 Formula: C59H90O4 CLOGP: 12 LIPINSKI: 2 HAC: 4 HDO: 0 TPSA: 52.60 ALOGS: -6.65 ROTB: 31

Molecule

Description

Molfile Inchi Smiles

Synonyms:

neuquinon
ubidecarenone
Vitamin Q

prevents hemorrhagic state

Molecular weight: 863.37
Formula: C59H90O4
CLOGP: 12
LIPINSKI: 2
HAC: 4
HDO: 0
TPSA: 52.60
ALOGS: -6.65
ROTB: 31

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle spasticity	430.04	13.36	186	20411	21608	63446817
Ear pain	385.73	13.36	202	20395	35916	63432509
Body temperature increased	343.84	13.36	189	20408	37003	63431422
Respiratory disorder	340.51	13.36	191	20406	38891	63429534
Night sweats	316.26	13.36	197	20400	48617	63419808
Insomnia	167.31	13.36	271	20326	214981	63253444
Back pain	157.69	13.36	296	20301	263849	63204576
Urticaria	150.05	13.36	224	20373	165578	63302847
Sinusitis	147.88	13.36	264	20333	226389	63242036
Peripheral swelling	142.80	13.36	285	20312	265657	63202768
Lower respiratory tract infection	128.69	13.36	185	20412	132122	63336303
Asthenia	124.27	13.36	337	20260	383267	63085158
Pruritus	107.59	13.36	308	20289	361145	63107280
Abdominal pain upper	103.27	13.36	215	20382	206229	63262196
Headache	68.89	13.36	394	20203	632847	62835578
Diarrhoea	67.60	13.36	429	20168	714937	62753488
Toxicity to various agents	61.47	13.36	5	20592	247245	63221180
Vaginal flatulence	61.29	13.36	27	20570	3266	63465159
Joint swelling	57.34	13.36	234	20363	327432	63140993
Rash	49.56	13.36	331	20266	560540	62907885
Proctitis	48.43	13.36	27	20570	5414	63463011
Vaginal discharge	42.24	13.36	30	20567	9168	63459257
Incorrect route of product administration	41.80	13.36	48	20549	27404	63441021
Radiculopathy	41.67	13.36	29	20568	8582	63459843
Pain	41.22	13.36	393	20204	740235	62728190
Female genital tract fistula	40.24	13.36	27	20570	7532	63460893
General physical health deterioration	36.64	13.36	10	20587	201392	63267033
Maternal exposure during pregnancy	34.66	13.36	14	20583	220048	63248377
Exposure during pregnancy	33.95	13.36	5	20592	155542	63312883
Acute kidney injury	33.70	13.36	22	20575	263393	63205032
Chronic sinusitis	29.52	13.36	28	20569	12815	63455610
Treatment failure	29.23	13.36	14	20583	199029	63269396
Procedural pain	25.20	13.36	33	20564	21536	63446889
Hand deformity	23.74	13.36	11	20586	159446	63308979
Systemic lupus erythematosus	23.42	13.36	20	20577	208898	63259527
Paraesthesia oral	23.33	13.36	30	20567	19226	63449199
Full blood count decreased	23.23	13.36	35	20562	25989	63442436
Fatigue	23.14	13.36	410	20187	887618	62580807
Death	22.99	13.36	55	20542	374326	63094099
Glossodynia	22.78	13.36	15	20582	178861	63289564
Pemphigus	22.61	13.36	16	20581	183710	63284715
Vomiting	21.80	13.36	277	20320	559340	62909085
Oral candidiasis	20.83	13.36	31	20566	22767	63445658
Frequent bowel movements	20.60	13.36	31	20566	22991	63445434
Constipation	19.89	13.36	133	20464	224810	63243615
COVID-19	19.85	13.36	6	20591	113097	63355328
Condition aggravated	19.60	13.36	66	20531	402151	63066274
Hypokalaemia	17.34	13.36	6	20591	103798	63364627
Irritable bowel syndrome	16.92	13.36	62	20535	82350	63386075
Low density lipoprotein increased	16.83	13.36	15	20582	6342	63462083
Muscle spasms	16.72	13.36	97	20500	156053	63312372
Mitochondrial DNA deletion	16.71	13.36	3	20594	10	63468415
Macular degeneration	16.60	13.36	29	20568	24347	63444078
Drug ineffective	16.34	13.36	240	20357	1044525	62423900
Weight increased	16.22	13.36	142	20455	260650	63207775
Overdose	15.55	13.36	9	20588	115069	63353356
Drug intolerance	15.47	13.36	50	20547	308611	63159814
Colitis ulcerative	15.19	13.36	29	20568	26062	63442363
Dyspepsia	14.76	13.36	69	20528	102127	63366298
Seizure	14.49	13.36	13	20584	132621	63335804
Wound	13.51	13.36	20	20577	163243	63305182
Hyponatraemia	13.43	13.36	10	20587	111890	63356535

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fatigue	78.17	16.33	232	8299	370421	34577979
Blindness cortical	41.27	16.33	11	8520	382	34948018
Asthenia	32.56	16.33	132	8399	245119	34703281
Full blood count decreased	24.55	16.33	26	8505	18062	34930338
Dysgeusia	24.09	16.33	31	8500	26466	34921934
Constipation	21.63	16.33	78	8453	136904	34811496
Toxicity to various agents	21.57	16.33	11	8520	200351	34748049
Protein total increased	19.42	16.33	10	8521	2277	34946123
Abdominal discomfort	19.19	16.33	44	8487	59791	34888609
Dizziness	18.94	16.33	104	8427	218417	34729983
Diarrhoea	18.55	16.33	160	8371	389752	34558648
Plasma cell myeloma	18.25	16.33	35	8496	42002	34906398
Peripheral swelling	17.97	16.33	50	8481	76491	34871909
Tendon calcification	17.57	16.33	4	8527	71	34948329
Myalgia	16.92	16.33	52	8479	84058	34864342

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle spasticity	204.31	12.58	106	22245	21369	79700668
Ear pain	197.52	12.58	120	22231	32749	79689288
Night sweats	151.86	12.58	122	22229	51973	79670064
Body temperature increased	142.33	12.58	110	22241	44310	79677727
Respiratory disorder	139.20	12.58	109	22242	44747	79677290
Back pain	95.23	12.58	241	22110	303939	79418098
Insomnia	87.11	12.58	204	22147	244966	79477071
Peripheral swelling	80.61	12.58	210	22141	269407	79452630
Asthenia	76.14	12.58	314	22037	511375	79210662
Toxicity to various agents	72.43	12.58	15	22336	421525	79300512
Vaginal flatulence	67.93	12.58	26	22325	2549	79719488
Sinusitis	65.42	12.58	159	22192	195342	79526695
Fatigue	52.88	12.58	442	21909	929285	78792752
Urticaria	50.99	12.58	140	22211	185061	79536976
Vaginal discharge	49.36	12.58	29	22322	7434	79714603
Completed suicide	48.33	12.58	6	22345	245761	79476276
Proctitis	47.89	12.58	27	22324	6405	79715632
Pruritus	47.84	12.58	228	22123	394420	79327617
Lower respiratory tract infection	47.43	12.58	109	22242	129111	79592926
Abdominal pain upper	47.22	12.58	154	22197	223665	79498372
Female genital tract fistula	46.99	12.58	26	22325	5949	79716088
Headache	44.35	12.58	324	22027	653448	79068589
Diarrhoea	43.99	12.58	407	21944	880082	78841955
Radiculopathy	42.44	12.58	28	22323	8796	79713241
General physical health deterioration	41.09	12.58	13	22338	275225	79446812
Pain	37.99	12.58	331	22020	703471	79018566
Drug abuse	34.48	12.58	3	22348	162688	79559349
Macular degeneration	34.05	12.58	27	22324	11269	79710768
Chronic sinusitis	32.71	12.58	28	22323	12998	79709039
Acute kidney injury	32.56	12.58	60	22291	519344	79202693
COVID-19	30.62	12.58	4	22347	157670	79564367
Incorrect route of product administration	30.45	12.58	43	22308	34886	79687151
Blindness cortical	29.79	12.58	11	22340	976	79721061
Myalgia	29.13	12.58	116	22235	185525	79536512
Overdose	28.76	12.58	8	22343	184198	79537839
Paraesthesia oral	28.75	12.58	32	22319	20439	79701598
Rash	27.09	12.58	264	22087	578094	79143943
Procedural pain	25.64	12.58	32	22319	23052	79698985
Dyspepsia	24.91	12.58	77	22274	108610	79613427
Joint swelling	23.62	12.58	150	22201	288496	79433541
Oral candidiasis	22.25	12.58	34	22317	29594	79692443
Full blood count decreased	21.89	12.58	32	22319	26787	79695250
C-reactive protein increased	21.29	12.58	5	22346	129022	79593015
Muscle spasms	21.14	12.58	101	22250	174629	79547408
Feeling abnormal	20.71	12.58	94	22257	159105	79562932
Constipation	18.93	12.58	140	22211	282910	79439127
Drug interaction	18.77	12.58	57	22294	415126	79306911
Dysgeusia	18.55	12.58	46	22305	57131	79664906
Coma	18.50	12.58	3	22348	100646	79621391
Frequent bowel movements	16.91	12.58	30	22321	29509	79692528
Hyponatraemia	16.86	12.58	15	22336	177833	79544204
Mitochondrial DNA deletion	16.72	12.58	3	22348	12	79722025
Low density lipoprotein increased	16.66	12.58	16	22335	8606	79713431
Treatment failure	16.62	12.58	14	22337	170472	79551565
Intentional overdose	15.80	12.58	5	22346	105955	79616082
Hypokalaemia	15.09	12.58	11	22340	144029	79578008
Febrile neutropenia	15.06	12.58	26	22325	230973	79491064
Hypotension	14.95	12.58	68	22283	440249	79281788
Cardio-respiratory arrest	14.69	12.58	6	22345	108504	79613533
Exposure during pregnancy	14.68	12.58	5	22346	101127	79620910
Weight increased	14.64	12.58	130	22221	277256	79444781
Thrombocytopenia	14.58	12.58	33	22318	265226	79456811
Pain in extremity	14.46	12.58	161	22190	364377	79357660
Tendon calcification	14.11	12.58	4	22347	152	79721885
Colitis ulcerative	13.50	12.58	30	22321	34712	79687325

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01EB09	CARDIOVASCULAR SYSTEM CARDIAC THERAPY OTHER CARDIAC PREPARATIONS Other cardiac preparations
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:173084	ferroptosis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Congestive heart failure	indication	42343007	DOID:6000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D01065	KEGG_DRUG
4021303	VUID
N0000148739	NUI
4021303	VANDF
CHEBI:46245	CHEBI
CHEMBL454801	ChEMBL_ID
C010524	MESH_SUPPLEMENTAL_RECORD_UI
3463	INN_ID
DB09270	DRUGBANK_ID
EJ27X76M46	UNII
21406	RXNORM
15490	MMSL
194138	MMSL
233517	MMSL
270084	MMSL
33141	MMSL
33199	MMSL
33200	MMSL
365406	MMSL
37841	MMSL
41597	MMSL
46285	MMSL
74202	MMSL
d04523	MMSL
003911	NDDF
012958	NDDF
412129003	SNOMEDCT_US
412130008	SNOMEDCT_US
C0041536	UMLSCUI
U10	PDB_CHEM_ID
5281915	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
IQQU Acne Serum	HUMAN OTC DRUG LABEL	3	50403-226	LOTION	0.00 g	TOPICAL	UNAPPROVED DRUG OTHER	9 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	65121-301	CAPSULE, GELATIN COATED	50 mg	ORAL	unapproved drug other	5 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	69677-050	CAPSULE, GELATIN COATED	50 mg	ORAL	unapproved drug other	5 sections
Zyrexal	HUMAN PRESCRIPTION DRUG LABEL	8	72380-915	TABLET	75 mg	ORAL	unapproved drug other	8 sections