ubidecarenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists 4607 303-98-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • neuquinon
  • ubidecarenone
  • Vitamin Q
prevents hemorrhagic state
  • Molecular weight: 863.37
  • Formula: C59H90O4
  • CLOGP: 12
  • LIPINSKI: 2
  • HAC: 4
  • HDO: 0
  • TPSA: 52.60
  • ALOGS: -6.65
  • ROTB: 31

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle spasticity 430.04 13.36 186 20411 21608 63446817
Ear pain 385.73 13.36 202 20395 35916 63432509
Body temperature increased 343.84 13.36 189 20408 37003 63431422
Respiratory disorder 340.51 13.36 191 20406 38891 63429534
Night sweats 316.26 13.36 197 20400 48617 63419808
Insomnia 167.31 13.36 271 20326 214981 63253444
Back pain 157.69 13.36 296 20301 263849 63204576
Urticaria 150.05 13.36 224 20373 165578 63302847
Sinusitis 147.88 13.36 264 20333 226389 63242036
Peripheral swelling 142.80 13.36 285 20312 265657 63202768
Lower respiratory tract infection 128.69 13.36 185 20412 132122 63336303
Asthenia 124.27 13.36 337 20260 383267 63085158
Pruritus 107.59 13.36 308 20289 361145 63107280
Abdominal pain upper 103.27 13.36 215 20382 206229 63262196
Headache 68.89 13.36 394 20203 632847 62835578
Diarrhoea 67.60 13.36 429 20168 714937 62753488
Toxicity to various agents 61.47 13.36 5 20592 247245 63221180
Vaginal flatulence 61.29 13.36 27 20570 3266 63465159
Joint swelling 57.34 13.36 234 20363 327432 63140993
Rash 49.56 13.36 331 20266 560540 62907885
Proctitis 48.43 13.36 27 20570 5414 63463011
Vaginal discharge 42.24 13.36 30 20567 9168 63459257
Incorrect route of product administration 41.80 13.36 48 20549 27404 63441021
Radiculopathy 41.67 13.36 29 20568 8582 63459843
Pain 41.22 13.36 393 20204 740235 62728190
Female genital tract fistula 40.24 13.36 27 20570 7532 63460893
General physical health deterioration 36.64 13.36 10 20587 201392 63267033
Maternal exposure during pregnancy 34.66 13.36 14 20583 220048 63248377
Exposure during pregnancy 33.95 13.36 5 20592 155542 63312883
Acute kidney injury 33.70 13.36 22 20575 263393 63205032
Chronic sinusitis 29.52 13.36 28 20569 12815 63455610
Treatment failure 29.23 13.36 14 20583 199029 63269396
Procedural pain 25.20 13.36 33 20564 21536 63446889
Hand deformity 23.74 13.36 11 20586 159446 63308979
Systemic lupus erythematosus 23.42 13.36 20 20577 208898 63259527
Paraesthesia oral 23.33 13.36 30 20567 19226 63449199
Full blood count decreased 23.23 13.36 35 20562 25989 63442436
Fatigue 23.14 13.36 410 20187 887618 62580807
Death 22.99 13.36 55 20542 374326 63094099
Glossodynia 22.78 13.36 15 20582 178861 63289564
Pemphigus 22.61 13.36 16 20581 183710 63284715
Vomiting 21.80 13.36 277 20320 559340 62909085
Oral candidiasis 20.83 13.36 31 20566 22767 63445658
Frequent bowel movements 20.60 13.36 31 20566 22991 63445434
Constipation 19.89 13.36 133 20464 224810 63243615
COVID-19 19.85 13.36 6 20591 113097 63355328
Condition aggravated 19.60 13.36 66 20531 402151 63066274
Hypokalaemia 17.34 13.36 6 20591 103798 63364627
Irritable bowel syndrome 16.92 13.36 62 20535 82350 63386075
Low density lipoprotein increased 16.83 13.36 15 20582 6342 63462083
Muscle spasms 16.72 13.36 97 20500 156053 63312372
Mitochondrial DNA deletion 16.71 13.36 3 20594 10 63468415
Macular degeneration 16.60 13.36 29 20568 24347 63444078
Drug ineffective 16.34 13.36 240 20357 1044525 62423900
Weight increased 16.22 13.36 142 20455 260650 63207775
Overdose 15.55 13.36 9 20588 115069 63353356
Drug intolerance 15.47 13.36 50 20547 308611 63159814
Colitis ulcerative 15.19 13.36 29 20568 26062 63442363
Dyspepsia 14.76 13.36 69 20528 102127 63366298
Seizure 14.49 13.36 13 20584 132621 63335804
Wound 13.51 13.36 20 20577 163243 63305182
Hyponatraemia 13.43 13.36 10 20587 111890 63356535

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fatigue 78.17 16.33 232 8299 370421 34577979
Blindness cortical 41.27 16.33 11 8520 382 34948018
Asthenia 32.56 16.33 132 8399 245119 34703281
Full blood count decreased 24.55 16.33 26 8505 18062 34930338
Dysgeusia 24.09 16.33 31 8500 26466 34921934
Constipation 21.63 16.33 78 8453 136904 34811496
Toxicity to various agents 21.57 16.33 11 8520 200351 34748049
Protein total increased 19.42 16.33 10 8521 2277 34946123
Abdominal discomfort 19.19 16.33 44 8487 59791 34888609
Dizziness 18.94 16.33 104 8427 218417 34729983
Diarrhoea 18.55 16.33 160 8371 389752 34558648
Plasma cell myeloma 18.25 16.33 35 8496 42002 34906398
Peripheral swelling 17.97 16.33 50 8481 76491 34871909
Tendon calcification 17.57 16.33 4 8527 71 34948329
Myalgia 16.92 16.33 52 8479 84058 34864342

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle spasticity 204.31 12.58 106 22245 21369 79700668
Ear pain 197.52 12.58 120 22231 32749 79689288
Night sweats 151.86 12.58 122 22229 51973 79670064
Body temperature increased 142.33 12.58 110 22241 44310 79677727
Respiratory disorder 139.20 12.58 109 22242 44747 79677290
Back pain 95.23 12.58 241 22110 303939 79418098
Insomnia 87.11 12.58 204 22147 244966 79477071
Peripheral swelling 80.61 12.58 210 22141 269407 79452630
Asthenia 76.14 12.58 314 22037 511375 79210662
Toxicity to various agents 72.43 12.58 15 22336 421525 79300512
Vaginal flatulence 67.93 12.58 26 22325 2549 79719488
Sinusitis 65.42 12.58 159 22192 195342 79526695
Fatigue 52.88 12.58 442 21909 929285 78792752
Urticaria 50.99 12.58 140 22211 185061 79536976
Vaginal discharge 49.36 12.58 29 22322 7434 79714603
Completed suicide 48.33 12.58 6 22345 245761 79476276
Proctitis 47.89 12.58 27 22324 6405 79715632
Pruritus 47.84 12.58 228 22123 394420 79327617
Lower respiratory tract infection 47.43 12.58 109 22242 129111 79592926
Abdominal pain upper 47.22 12.58 154 22197 223665 79498372
Female genital tract fistula 46.99 12.58 26 22325 5949 79716088
Headache 44.35 12.58 324 22027 653448 79068589
Diarrhoea 43.99 12.58 407 21944 880082 78841955
Radiculopathy 42.44 12.58 28 22323 8796 79713241
General physical health deterioration 41.09 12.58 13 22338 275225 79446812
Pain 37.99 12.58 331 22020 703471 79018566
Drug abuse 34.48 12.58 3 22348 162688 79559349
Macular degeneration 34.05 12.58 27 22324 11269 79710768
Chronic sinusitis 32.71 12.58 28 22323 12998 79709039
Acute kidney injury 32.56 12.58 60 22291 519344 79202693
COVID-19 30.62 12.58 4 22347 157670 79564367
Incorrect route of product administration 30.45 12.58 43 22308 34886 79687151
Blindness cortical 29.79 12.58 11 22340 976 79721061
Myalgia 29.13 12.58 116 22235 185525 79536512
Overdose 28.76 12.58 8 22343 184198 79537839
Paraesthesia oral 28.75 12.58 32 22319 20439 79701598
Rash 27.09 12.58 264 22087 578094 79143943
Procedural pain 25.64 12.58 32 22319 23052 79698985
Dyspepsia 24.91 12.58 77 22274 108610 79613427
Joint swelling 23.62 12.58 150 22201 288496 79433541
Oral candidiasis 22.25 12.58 34 22317 29594 79692443
Full blood count decreased 21.89 12.58 32 22319 26787 79695250
C-reactive protein increased 21.29 12.58 5 22346 129022 79593015
Muscle spasms 21.14 12.58 101 22250 174629 79547408
Feeling abnormal 20.71 12.58 94 22257 159105 79562932
Constipation 18.93 12.58 140 22211 282910 79439127
Drug interaction 18.77 12.58 57 22294 415126 79306911
Dysgeusia 18.55 12.58 46 22305 57131 79664906
Coma 18.50 12.58 3 22348 100646 79621391
Frequent bowel movements 16.91 12.58 30 22321 29509 79692528
Hyponatraemia 16.86 12.58 15 22336 177833 79544204
Mitochondrial DNA deletion 16.72 12.58 3 22348 12 79722025
Low density lipoprotein increased 16.66 12.58 16 22335 8606 79713431
Treatment failure 16.62 12.58 14 22337 170472 79551565
Intentional overdose 15.80 12.58 5 22346 105955 79616082
Hypokalaemia 15.09 12.58 11 22340 144029 79578008
Febrile neutropenia 15.06 12.58 26 22325 230973 79491064
Hypotension 14.95 12.58 68 22283 440249 79281788
Cardio-respiratory arrest 14.69 12.58 6 22345 108504 79613533
Exposure during pregnancy 14.68 12.58 5 22346 101127 79620910
Weight increased 14.64 12.58 130 22221 277256 79444781
Thrombocytopenia 14.58 12.58 33 22318 265226 79456811
Pain in extremity 14.46 12.58 161 22190 364377 79357660
Tendon calcification 14.11 12.58 4 22347 152 79721885
Colitis ulcerative 13.50 12.58 30 22321 34712 79687325

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01EB09 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:173084 ferroptosis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Congestive heart failure indication 42343007 DOID:6000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01065 KEGG_DRUG
4021303 VUID
N0000148739 NUI
4021303 VANDF
CHEBI:46245 CHEBI
CHEMBL454801 ChEMBL_ID
C010524 MESH_SUPPLEMENTAL_RECORD_UI
3463 INN_ID
DB09270 DRUGBANK_ID
EJ27X76M46 UNII
21406 RXNORM
15490 MMSL
194138 MMSL
233517 MMSL
270084 MMSL
33141 MMSL
33199 MMSL
33200 MMSL
365406 MMSL
37841 MMSL
41597 MMSL
46285 MMSL
74202 MMSL
d04523 MMSL
003911 NDDF
012958 NDDF
412129003 SNOMEDCT_US
412130008 SNOMEDCT_US
C0041536 UMLSCUI
U10 PDB_CHEM_ID
5281915 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
IQQU Acne Serum HUMAN OTC DRUG LABEL 3 50403-226 LOTION 0.00 g TOPICAL UNAPPROVED DRUG OTHER 9 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 65121-301 CAPSULE, GELATIN COATED 50 mg ORAL unapproved drug other 5 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 69677-050 CAPSULE, GELATIN COATED 50 mg ORAL unapproved drug other 5 sections
Zyrexal HUMAN PRESCRIPTION DRUG LABEL 8 72380-915 TABLET 75 mg ORAL unapproved drug other 8 sections