tonzonium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4605 553-08-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tonzonium
  • thonzonium bromide
  • tonzonium bromide
  • thonzide
  • thonzonium
a surfactant with antifungal activity; also inhibits osteoclast formation
  • Molecular weight: 511.82
  • Formula: C32H55N4O
  • CLOGP: 6.43
  • LIPINSKI: 2
  • HAC: 5
  • HDO: 0
  • TPSA: 38.25
  • ALOGS: -7.48
  • ROTB: 22

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 17, 1962 FDA PAR STERILE PRODUCTS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Mastoidectomy Cavity Infections indication
Chronic purulent otitis media off-label use 38394007 DOID:14247
Herpes zoster auricularis contraindication 21954000 DOID:9210
Bullous myringitis contraindication 33528003 DOID:13791
Perforation of tympanic membrane contraindication 60442001
Herpes simplex contraindication 88594005 DOID:8566
Tuberculosis of ear contraindication 186269001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.47 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Insulin-degrading enzyme Enzyme EC50 4.27 CHEMBL
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Kinase AC50 5.03 CHEMBL

External reference:

IDSource
D02140 KEGG_DRUG
4018647 VUID
N0000146960 NUI
25466-36-8 SECONDARY_CAS_RN
4018647 VANDF
C0772395 UMLSCUI
CHEBI:94514 CHEBI
5456 PUBCHEM_CID
DB09552 DRUGBANK_ID
CHEMBL1200883 ChEMBL_ID
CHEMBL1201322 ChEMBL_ID
C000609116 MESH_SUPPLEMENTAL_RECORD_UI
1559 INN_ID
JI2B19CR0R UNII
221171 RXNORM
5576 MMSL
007523 NDDF
007524 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cortisporin-TC HUMAN PRESCRIPTION DRUG LABEL 4 54868-0564 SUSPENSION 0.50 mg AURICULAR (OTIC) NDA 22 sections
Cortisporin TC HUMAN PRESCRIPTION DRUG LABEL 4 63481-529 SUSPENSION 0.50 mg AURICULAR (OTIC) NDA 22 sections