tonzonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 4605 | 553-08-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a surfactant with antifungal activity; also inhibits osteoclast formation
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 17, 1962 | FDA | PAR STERILE PRODUCTS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Otitis externa | indication | 3135009 | |
| Mastoidectomy Cavity Infections | indication | ||
| Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
| Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
| Bullous myringitis | contraindication | 33528003 | DOID:13791 |
| Perforation of tympanic membrane | contraindication | 60442001 | |
| Herpes simplex | contraindication | 88594005 | DOID:8566 |
| Tuberculosis of ear | contraindication | 186269001 | |
| Viral ear infection | contraindication | 312137007 | |
| Fungal ear infection | contraindication | 312148000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.47 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Insulin-degrading enzyme | Enzyme | EC50 | 4.27 | CHEMBL | |||||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Kinase | AC50 | 5.03 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02140 | KEGG_DRUG |
| 4018647 | VUID |
| N0000146960 | NUI |
| 25466-36-8 | SECONDARY_CAS_RN |
| 4018647 | VANDF |
| C0772395 | UMLSCUI |
| CHEBI:94514 | CHEBI |
| CHEMBL1201322 | ChEMBL_ID |
| 5456 | PUBCHEM_CID |
| DB09552 | DRUGBANK_ID |
| CHEMBL1200883 | ChEMBL_ID |
| C000609116 | MESH_SUPPLEMENTAL_RECORD_UI |
| 221171 | RXNORM |
| 5576 | MMSL |
| 007523 | NDDF |
| 007524 | NDDF |
| 1559 | INN_ID |
| JI2B19CR0R | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Cortisporin-TC | HUMAN PRESCRIPTION DRUG LABEL | 4 | 54868-0564 | SUSPENSION | 0.50 mg | AURICULAR (OTIC) | NDA | 22 sections |
| Cortisporin TC | HUMAN PRESCRIPTION DRUG LABEL | 4 | 63481-529 | SUSPENSION | 0.50 mg | AURICULAR (OTIC) | NDA | 22 sections |