diosmetin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4601 520-34-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • diosmetine
  • diosmetin
a 5,7-dihydroxyflavone
  • Molecular weight: 300.27
  • Formula: C16H12O6
  • CLOGP: 2.75
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 96.22
  • ALOGS: -3.60
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:48422 angiogenesis antagonist
CHEBI has role CHEBI:50646 antiosteoporotic
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77307 cardioprotective agents
CHEBI has role CHEBI:140489 TrkB receptor agonist

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.68 acidic
pKa2 9.12 acidic
pKa3 10.43 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Multidrug resistance-associated protein 1 Transporter IC50 5.52 CHEMBL
Cytochrome P450 1B1 Enzyme IC50 7.54 CHEMBL
Lysine-specific histone demethylase 1A Enzyme IC50 4.55 CHEMBL
Inositol polyphosphate multikinase Kinase IC50 5.14 CHEMBL
Inositol hexakisphosphate kinase 2 Kinase IC50 6.05 CHEMBL

External reference:

IDSource
CHEBI:4630 CHEBI
J8D PDB_CHEM_ID
CHEMBL90568 ChEMBL_ID
C039602 MESH_SUPPLEMENTAL_RECORD_UI
DB11259 DRUGBANK_ID
TWZ37241OT UNII
5281612 PUBCHEM_CID
1314347 RXNORM
C0114217 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
GONGJINHYANG SEOL WHITENING HUMAN OTC DRUG LABEL 1 53208-372 CREAM 0.10 g TOPICAL OTC monograph not final 6 sections
ISA KNOX WXII PLUS WHITENING REVOLUTION SERUM HUMAN OTC DRUG LABEL 1 53208-424 CREAM 0.11 mL TOPICAL OTC monograph not final 5 sections
Whoo Gongjinhyang Seol Whitening Jin Essence HUMAN OTC DRUG LABEL 1 53208-427 CREAM 0.06 mL TOPICAL unapproved drug other 6 sections
ISAKNOX X202 WHITENING SECRET ESSENCE HUMAN OTC DRUG LABEL 1 53208-531 CREAM 0.06 mL TOPICAL unapproved drug other 9 sections