levomethadone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4586	125-58-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

levomethadone
levomethadone hydrochloride
levomethadone HCl

Molecular weight: 309.45
Formula: C21H27NO
CLOGP: 4.17
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 20.31
ALOGS: -4.72
ROTB: 7

Drug dosage:

Dose	Unit	Route
15	mg	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Logorrhoea	149.35	64.75	29	787	2259	29571452
Aggression	141.12	64.75	48	768	35493	29538218
Restlessness	108.03	64.75	35	781	22110	29551601
Dysarthria	104.16	64.75	37	779	30874	29542837
Bradykinesia	103.65	64.75	23	793	3424	29570287
Drug abuse	100.27	64.75	47	769	79836	29493875
Bradyphrenia	93.76	64.75	22	794	4192	29569519
Substance abuse	73.85	64.75	20	796	6767	29566944

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aggression	213.48	71.15	62	998	46170	64451502
Logorrhoea	172.31	71.15	33	1027	4026	64493646
Drug abuse	170.34	71.15	68	992	132306	64365366
Patient uncooperative	133.63	71.15	20	1040	547	64497125
Restlessness	125.94	71.15	40	1020	39745	64457927
Dysarthria	117.77	71.15	42	1018	59364	64438308
Bradyphrenia	112.90	71.15	27	1033	9379	64488293
Bradykinesia	100.70	71.15	23	1037	6537	64491135
Substance abuse	97.80	71.15	24	1036	9268	64488404
Abnormal behaviour	86.79	71.15	29	1031	33593	64464079
Drug dependence	71.37	71.15	25	1035	33287	64464385

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N07BC05	NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS DRUGS USED IN ADDICTIVE DISORDERS Drugs used in opioid dependence
CHEBI has role	CHEBI:35482	narcotic analgesic
CHEBI has role	CHEBI:51177	anti-tussive
CHEBI has role	CHEBI:55322	mu-opioid agonists
CHEBI has role	CHEBI:60643	N-methyl-D-aspartate receptor antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Opioid dependence	indication	75544000	DOID:2559

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.55	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Opioid receptor	GPCR		OPRD_RAT OPRM_RAT OPRK_RAT SGMR1_RAT		Ki	8.70		CHEMBL

External reference:

ID	Source
D08121	KEGG_DRUG
5967-73-7	SECONDARY_CAS_RN
CHEBI:136003	CHEBI
CHEMBL159659	ChEMBL_ID
5002	INN_ID
DB13515	DRUGBANK_ID
6Y75Z4E8NS	UNII
22267	PUBCHEM_CID
236913	RXNORM
007175	NDDF
007176	NDDF
1156227003	SNOMEDCT_US
C0772241	UMLSCUI

Pharmaceutical products:

None