levomethadone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4586 125-58-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levomethadone
  • levomethadone hydrochloride
  • levomethadone HCl
  • Molecular weight: 309.45
  • Formula: C21H27NO
  • CLOGP: 4.17
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 20.31
  • ALOGS: -4.72
  • ROTB: 7

Drug dosage:

DoseUnitRoute
15 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Logorrhoea 149.35 64.75 29 787 2259 29571452
Aggression 141.12 64.75 48 768 35493 29538218
Restlessness 108.03 64.75 35 781 22110 29551601
Dysarthria 104.16 64.75 37 779 30874 29542837
Bradykinesia 103.65 64.75 23 793 3424 29570287
Drug abuse 100.27 64.75 47 769 79836 29493875
Bradyphrenia 93.76 64.75 22 794 4192 29569519
Substance abuse 73.85 64.75 20 796 6767 29566944

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Aggression 213.48 71.15 62 998 46170 64451502
Logorrhoea 172.31 71.15 33 1027 4026 64493646
Drug abuse 170.34 71.15 68 992 132306 64365366
Patient uncooperative 133.63 71.15 20 1040 547 64497125
Restlessness 125.94 71.15 40 1020 39745 64457927
Dysarthria 117.77 71.15 42 1018 59364 64438308
Bradyphrenia 112.90 71.15 27 1033 9379 64488293
Bradykinesia 100.70 71.15 23 1037 6537 64491135
Substance abuse 97.80 71.15 24 1036 9268 64488404
Abnormal behaviour 86.79 71.15 29 1031 33593 64464079
Drug dependence 71.37 71.15 25 1035 33287 64464385

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N07BC05 NERVOUS SYSTEM
OTHER NERVOUS SYSTEM DRUGS
DRUGS USED IN ADDICTIVE DISORDERS
Drugs used in opioid dependence
CHEBI has role CHEBI:35482 narcotic analgesic
CHEBI has role CHEBI:51177 anti-tussive
CHEBI has role CHEBI:55322 mu-opioid agonists
CHEBI has role CHEBI:60643 N-methyl-D-aspartate receptor antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Opioid dependence indication 75544000 DOID:2559




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Opioid receptor GPCR Ki 8.70 CHEMBL

External reference:

IDSource
D08121 KEGG_DRUG
5967-73-7 SECONDARY_CAS_RN
CHEBI:136003 CHEBI
CHEMBL159659 ChEMBL_ID
5002 INN_ID
DB13515 DRUGBANK_ID
6Y75Z4E8NS UNII
22267 PUBCHEM_CID
236913 RXNORM
007175 NDDF
007176 NDDF
1156227003 SNOMEDCT_US
C0772241 UMLSCUI

Pharmaceutical products:

None