levomethadone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4586 125-58-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levomethadone
  • levomethadone hydrochloride
  • levomethadone HCl
  • Molecular weight: 309.45
  • Formula: C21H27NO
  • CLOGP: 4.17
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 20.31
  • ALOGS: -4.72
  • ROTB: 7

Drug dosage:

DoseUnitRoute
15 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N07BC05 NERVOUS SYSTEM
OTHER NERVOUS SYSTEM DRUGS
DRUGS USED IN ADDICTIVE DISORDERS
Drugs used in opioid dependence
CHEBI has role CHEBI:35482 narcotic analgesics
CHEBI has role CHEBI:51177 cough suppressant
CHEBI has role CHEBI:55322 mu opioid agonist
CHEBI has role CHEBI:60643 n-methyl-d-aspartate receptor antagonists

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Opioid dependence indication 75544000 DOID:2559

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Opioid receptor GPCR Ki 8.70 CHEMBL

External reference:

IDSource
D08121 KEGG_DRUG
5967-73-7 SECONDARY_CAS_RN
C0772241 UMLSCUI
CHEBI:136003 CHEBI
CHEMBL159659 ChEMBL_ID
DB13515 DRUGBANK_ID
5002 INN_ID
6Y75Z4E8NS UNII
22267 PUBCHEM_CID
236913 RXNORM
007175 NDDF
007176 NDDF

Pharmaceutical products:

None