levomethadone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4586 125-58-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levomethadone
  • levomethadone hydrochloride
  • levomethadone HCl
  • Molecular weight: 309.45
  • Formula: C21H27NO
  • CLOGP: 4.17
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 20.31
  • ALOGS: -4.72
  • ROTB: 7

Drug dosage:

DoseUnitRoute
15 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Logorrhoea 146.90 67.30 29 958 2397 34953547
Aggression 135.47 67.30 48 939 38916 34917028
Restlessness 110.18 67.30 37 950 25445 34930499
Bradykinesia 100.28 67.30 23 964 3870 34952074
Dysarthria 98.92 67.30 37 950 34745 34921199
Drug abuse 95.18 67.30 49 938 99047 34856897
Bradyphrenia 90.36 67.30 22 965 4776 34951168
Substance abuse 71.00 67.30 20 967 7621 34948323

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Aggression 211.71 68.89 62 1157 50896 79692273
Logorrhoea 172.24 68.89 33 1186 4332 79738837
Drug abuse 164.63 68.89 69 1150 162622 79580547
Restlessness 130.74 68.89 42 1177 46450 79696719
Patient uncooperative 130.44 68.89 20 1199 694 79742475
Dysarthria 115.32 68.89 42 1177 67580 79675589
Bradyphrenia 111.49 68.89 27 1192 10613 79732556
Bradykinesia 97.66 68.89 23 1196 8020 79735149
Substance abuse 96.52 68.89 24 1195 10502 79732667
Abnormal behaviour 86.53 68.89 29 1190 36392 79706777
Drug dependence 71.90 68.89 26 1193 40743 79702426

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N07BC05 NERVOUS SYSTEM
OTHER NERVOUS SYSTEM DRUGS
DRUGS USED IN ADDICTIVE DISORDERS
Drugs used in opioid dependence
CHEBI has role CHEBI:35482 narcotic analgesic
CHEBI has role CHEBI:51177 anti-tussive
CHEBI has role CHEBI:55322 mu-opioid agonists
CHEBI has role CHEBI:60643 N-methyl-D-aspartate receptor antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Opioid dependence indication 75544000 DOID:2559




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Opioid receptor GPCR Ki 8.70 CHEMBL

External reference:

IDSource
D08121 KEGG_DRUG
5967-73-7 SECONDARY_CAS_RN
CHEBI:136003 CHEBI
CHEMBL159659 ChEMBL_ID
5002 INN_ID
DB13515 DRUGBANK_ID
6Y75Z4E8NS UNII
236913 RXNORM
007175 NDDF
007176 NDDF
1156227003 SNOMEDCT_US
C0772241 UMLSCUI
22267 PUBCHEM_CID

Pharmaceutical products:

None