diamorphine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| opioid receptor antagonists/agonists, morphinan derivates | 4412 | 561-27-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.31 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 212.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.06 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug abuse | 3985.56 | 176.44 | 678 | 674 | 11348 | 2345385 |
| Toxicity to various agents | 1608.82 | 176.44 | 386 | 966 | 32368 | 2324365 |
| Cardio-respiratory arrest | 775.61 | 176.44 | 171 | 1181 | 8975 | 2347758 |
| Respiratory arrest | 501.96 | 176.44 | 112 | 1240 | 6066 | 2350667 |
| Cardiac arrest | 431.77 | 176.44 | 118 | 1234 | 14812 | 2341921 |
| Death | 406.66 | 176.44 | 171 | 1181 | 81297 | 2275436 |
| Completed suicide | 387.41 | 176.44 | 117 | 1235 | 20917 | 2335816 |
| Intentional product misuse | 250.08 | 176.44 | 70 | 1282 | 9419 | 2347314 |
| Overdose | 230.23 | 176.44 | 78 | 1274 | 19829 | 2336904 |
| Poisoning | 210.94 | 176.44 | 48 | 1304 | 2772 | 2353961 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug abuse | 10889.71 | 235.30 | 1954 | 1166 | 11735 | 1731926 |
| Toxicity to various agents | 4044.17 | 235.30 | 1024 | 2096 | 28117 | 1715544 |
| Intentional product misuse | 909.85 | 235.30 | 243 | 2877 | 7115 | 1736546 |
| Respiratory arrest | 812.61 | 235.30 | 212 | 2908 | 5627 | 1738034 |
| Cardio-respiratory arrest | 799.47 | 235.30 | 231 | 2889 | 9062 | 1734599 |
| Overdose | 713.27 | 235.30 | 243 | 2877 | 16458 | 1727203 |
| Death | 642.39 | 235.30 | 366 | 2754 | 87077 | 1656584 |
| Poisoning | 619.86 | 235.30 | 145 | 2975 | 2387 | 1741274 |
| Cardiac arrest | 572.00 | 235.30 | 204 | 2916 | 15726 | 1727935 |
| Drug dependence | 467.04 | 235.30 | 122 | 2998 | 3205 | 1740456 |
| Pulmonary oedema | 393.01 | 235.30 | 124 | 2996 | 6462 | 1737199 |
| Substance abuse | 334.15 | 235.30 | 74 | 3046 | 929 | 1742732 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N07BC06 | NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS DRUGS USED IN ADDICTIVE DISORDERS Drugs used in opioid dependence |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35482 | opioid analgesic |
| CHEBI has role | CHEBI:55322 | mu-opioid receptor agonist |
| CHEBI has role | CHEBI:50266 | prodrug |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Severe pain | indication | 76948002 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.18 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D003932 | MESH_DESCRIPTOR_UI |
| D07286 | KEGG_DRUG |
| C0282128 | UMLSCUI |
| 70D95007SX | UNII |
| CHEMBL1616 | ChEMBL_ID |
| CHEMBL459324 | ChEMBL_ID |
| DB01452 | DRUGBANK_ID |
| CHEBI:27808 | CHEBI |
| 9082 | IUPHAR_LIGAND_ID |
| CHEMBL2106627 | ChEMBL_ID |
| 5462328 | PUBCHEM_CID |
| 3304 | RXNORM |
| 387341002 | SNOMEDCT_US |
| d03877 | MMSL |
| 60881009 | SNOMEDCT_US |
| 003843 | NDDF |
| DB00295 | DRUGBANK_ID |
Pharmaceutical products:
None